Gene

KWMTBOMO11327

Pre Gene Modal

BGIBMGA001978

Annotation

PREDICTED:_sodium/potassium/calcium_exchanger_Nckx30C_[Papilio_machaon]

Location

Bomo_Chr19(-):3341797-3367730      View in EpiBrowser

Full name

Sodium/potassium/calcium exchanger Nckx30C      

Alternative Name

Na(+)/K(+)/Ca(2+)-exchange protein Nckx30C

Location in the cell

PlasmaMembrane   Reliability : 4.435

CDS

ATGATACACACCATCGATCCGATGCACGATGGTGAGTTAGGTAAAGTAGATGAAAAGGCAACGCAGCTTCATGCGATCGCGTCACTCAAGGTACTGCTGGAAGCAACGAGGCCGACAGCGGGTGGAGCCGGTGCAGCTGCTGCGAAGCACACAGCTGCAGCCGCAACCCAGGGTCAGCAGGCCAAGGAGACGCCTCTAGACCTGCCGAACGGTGGCCTTGCTGGAGACGTCCAATTAGATGCTATAGAAGAGATAGGAGACCTGGAGGAAGACACGACTCCGCTGGATATGTCGTGGCCCTCAGGGTTCCGTAAGCGGCTGACGTATGTGTTGGTCGCTCCGATTGTCTTCCCATTATGGATCACCCTCCCGGACACAAGAACTCCGAGAGGTAAAGGTCTGTTCCCTGTAACGTTTATAGGGTCAATAGTTTGGATAGCGTTTTTCTCTTATTTAATGGTGTGGTGGGCCAACGTAGCGGGGTCGACAGCTCAGGTGCCACCGGAGGTGATGGGGCTCACGCTTCTGGCCGCGGGGACTTCGGTGCCTGATCTCATAACGTCGGTCATAGTGGCCAGGAAGGGCTTCGGGGACATGGCGGTCTCAAGTTCTGTGGGCAGCAACATCTTTGATGTCACTGTTGGGCTGCCTCTCCCCTGGCTTCTGTATGGCCTGATCAACTCAGAGCCAGTCCTTGTGAACTCCAAGGGCATGGTCTGCAGCATAGTGCTGTTGTTCGCTATGCTGATCTTCGTCATCCTCAGCATAGCCTGCTTCAAGTGGAAGATGAACAAGGGACTGGGATTCACCATGTTCCTATTGTATTTTGTCTTCGTTGCCGTCAGCCTTGGACTGGAGTACGACTACTTACATTGTCCGAGTTAA

Protein

MIHTIDPMHDGELGKVDEKATQLHAIASLKVLLEATRPTAGGAGAAAAKHTAAAATQGQQAKETPLDLPNGGLAGDVQLDAIEEIGDLEEDTTPLDMSWPSGFRKRLTYVLVAPIVFPLWITLPDTRTPRGKGLFPVTFIGSIVWIAFFSYLMVWWANVAGSTAQVPPEVMGLTLLAAGTSVPDLITSVIVARKGFGDMAVSSSVGSNIFDVTVGLPLPWLLYGLINSEPVLVNSKGMVCSIVLLFAMLIFVILSIACFKWKMNKGLGFTMFLLYFVFVAVSLGLEYDYLHCPS

Description

May function in the removal and maintenance of calcium homeostasis during signaling in the adult and in signaling events during embryogenesis and patterning of imaginal disks. Transports one Ca(2+) and 1 K(+) in exchange for 4 Na(+).

Similarity

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.

Keywords

Alternative splicing   Antiport   Calcium   Calcium transport   Complete proteome   Glycoprotein   Ion transport   Membrane   Potassium   Potassium transport   Reference proteome   Repeat   RNA editing   Sodium   Sodium transport   Symport   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Sodium/potassium/calcium exchanger Nckx30C
splice variant  In isoform E and isoform F.

Uniprot

H9IXJ5   A0A194QX38   A0A212FNQ6   A0A2W1BH04   A0A2H1VT26   A0A194QFA0   + More
A0A2A4JED1   A0A0L0CND0   T1PPC7   Q17BY8   A0A1W7R6P4   A0A0Q9XHN3   A0A0Q9X6E9   B4KID4   A0A0Q9WRF4   W8B0H0   A0A139WE42   W8B4I2   B4N1D0   A0A0R3NS33   A0A0R3NRM9   A0A3B0KBX9   A0A139WE34   Q29NB7   A0A3B0JZ17   A0A3B0KKJ5   A0A0P9BRA9   A0A0N8NZG7   B4JZG9   A0A1Y1K4I4   A0A154PLV3   A0A1S4G840   B3MUY0   A0A1W4WA07   A0A1W4W9J1   A0A0Q5WAA6   A0A0J9QYX5   A0A0Q5WH41   Q9U6A0-4   M9PCP1   A0A0J9R096   A0A0R1DTH5   A0A088A2K6   A0A1W4VXP2   B4HW94   A0A0R1DKY4   A0A139WEB1   B3N8H2   A0A0J9R0A1   Q9U6A0-2   A0A067RC81   B4NY71   A0A1I8Q6Y0   A0A1I8Q6T4   V9IIE1   A0A1I8Q6X5   A0A182TFU1   A0A1J1I3K9   A0A158NDL2   A0A3L8DY02   A0A084W5S3   A0A0Q9X6V3   A0A0Q9WRQ2   A0A182F1X7   A0A182QT49   A0A182Y3A7   A0A0R3NRS6   A0A0R3NX49   A0A0Q9X686   A0A182J780   W8BFE1   A0A0C9QWL2   W8BR27   A0A0R3NZ27   A0A0P8Y5A8   A0A0P8ZHU5   A0A1I8Q6U1   A0A1I8Q6V8   A0A1I8Q6T2   A0A195D9U8   A0A0P8XHJ2   A0A1W4W8P7   A0A1W4VXN7   D6WTN1   A0A1I8Q6T6   A0A139WE20   A0A195BQQ7   A0A0Q5WLU7   A0A0J9QZG5   A0A0Q5WNB9   A0A195F3K2   A0A1W4VXQ1   A0A0J9TJP2   A0A0R1DL19   A0A0R1DSE9   Q9U6A0-3   M9MRG0   B4LQC7   A0A0Q5WA71   B0WXC6  

Pubmed

19121390    26354079    22118469    28756777    26108605    17510324    + More
17994087    24495485    18362917    19820115    15632085    28004739    22936249    10545508    10731132    12537572    12537569    17018572    12537568    12537573    12537574    16110336    17569856    17569867    17550304    18057021    24845553    21347285    30249741    24438588    25244985    23185243   

EMBL

BABH01018257    BABH01018258    BABH01018259    BABH01018260    BABH01018261    KQ461073    + More
KPJ09525.1    AGBW02004770    OWR55375.1    KZ150054    PZC74342.1    ODYU01004262    SOQ43948.1    KQ459053    KPJ04089.1    NWSH01001896    PCG69763.1    JRES01000147    KNC33796.1    KA649868    AFP64497.1    CH477314    EAT43832.1    GEHC01000821    JAV46824.1    CH933807    KRG03761.1    KRG03756.1    EDW13431.2    CH963920    KRF98815.1    GAMC01014605    GAMC01014603    JAB91952.1    KQ971355    KYB26194.1    GAMC01014607    JAB91948.1    EDW78103.2    CH379060    KRT03817.1    KRT03816.1    OUUW01000010    SPP85670.1    KYB26196.1    EAL33425.2    SPP85672.1    SPP85671.1    CH902624    KPU74274.1    KPU74276.1    CH916379    EDV94091.1    GEZM01093035    JAV56372.1    KQ434977    KZC12861.1    EDV33045.1    CH954177    KQS70387.1    CM002910    KMY89307.1    KQS70389.1    AF190455    AE014134    AY094674    BT099704    AGB92831.1    KMY89310.1    KMY89314.1    CM000157    KRJ97974.1    CH480818    EDW52289.1    KRJ97975.1    KYB26195.1    EDV58395.1    KQS70388.1    KMY89308.1    KMY89319.1    KK852552    KDR21491.1    EDW88673.1    JR049242    AEY60908.1    CVRI01000038    CRK94180.1    ADTU01012708    ADTU01012709    ADTU01012710    ADTU01012711    ADTU01012712    ADTU01012713    QOIP01000002    RLU25321.1    ATLV01020691    KE525305    KFB45567.1    KRG03757.1    KRF98816.1    AXCN02000807    KRT03815.1    KRT03819.1    KRT03821.1    KRG03759.1    GAMC01014604    JAB91951.1    GBYB01005067    JAG74834.1    GAMC01014608    GAMC01014606    JAB91949.1    KRT03814.1    KPU74273.1    KPU74277.1    KPU74275.1    KQ981082    KYN09695.1    KPU74272.1    EFA07201.2    KYB26193.1    KQ976424    KYM88296.1    KQS70386.1    KMY89318.1    KQS70392.1    KQ981820    KYN35160.1    KMY89311.1    KMY89315.1    KRJ97972.1    KRJ97977.1    ADV37011.1    CH940649    EDW63377.2    KQS70390.1    DS232162    EDS36456.1   

Proteomes

UP000005204    UP000053240    UP000007151    UP000053268    UP000218220    UP000037069    + More
UP000008820    UP000009192    UP000007798    UP000007266    UP000001819    UP000268350    UP000007801    UP000001070    UP000076502    UP000192221    UP000008711    UP000000803    UP000002282    UP000005203    UP000001292    UP000027135    UP000095300    UP000075902    UP000183832    UP000005205    UP000279307    UP000030765    UP000069272    UP000075886    UP000076408    UP000075880    UP000078492    UP000078540    UP000078541    UP000008792    UP000002320   

PRIDE

H9IXJ5    Q9U6A0    M9MRG0   

Pfam

PF01699   Na_Ca_ex

Interpro

IPR004481   K/Na/Ca-exchanger        + More
IPR004837   NaCa_Exmemb       
IPR030243   NCKX30C-like       

ProteinModelPortal

H9IXJ5   A0A194QX38   A0A212FNQ6   A0A2W1BH04   A0A2H1VT26   A0A194QFA0   + More
A0A2A4JED1   A0A0L0CND0   T1PPC7   Q17BY8   A0A1W7R6P4   A0A0Q9XHN3   A0A0Q9X6E9   B4KID4   A0A0Q9WRF4   W8B0H0   A0A139WE42   W8B4I2   B4N1D0   A0A0R3NS33   A0A0R3NRM9   A0A3B0KBX9   A0A139WE34   Q29NB7   A0A3B0JZ17   A0A3B0KKJ5   A0A0P9BRA9   A0A0N8NZG7   B4JZG9   A0A1Y1K4I4   A0A154PLV3   A0A1S4G840   B3MUY0   A0A1W4WA07   A0A1W4W9J1   A0A0Q5WAA6   A0A0J9QYX5   A0A0Q5WH41   Q9U6A0-4   M9PCP1   A0A0J9R096   A0A0R1DTH5   A0A088A2K6   A0A1W4VXP2   B4HW94   A0A0R1DKY4   A0A139WEB1   B3N8H2   A0A0J9R0A1   Q9U6A0-2   A0A067RC81   B4NY71   A0A1I8Q6Y0   A0A1I8Q6T4   V9IIE1   A0A1I8Q6X5   A0A182TFU1   A0A1J1I3K9   A0A158NDL2   A0A3L8DY02   A0A084W5S3   A0A0Q9X6V3   A0A0Q9WRQ2   A0A182F1X7   A0A182QT49   A0A182Y3A7   A0A0R3NRS6   A0A0R3NX49   A0A0Q9X686   A0A182J780   W8BFE1   A0A0C9QWL2   W8BR27   A0A0R3NZ27   A0A0P8Y5A8   A0A0P8ZHU5   A0A1I8Q6U1   A0A1I8Q6V8   A0A1I8Q6T2   A0A195D9U8   A0A0P8XHJ2   A0A1W4W8P7   A0A1W4VXN7   D6WTN1   A0A1I8Q6T6   A0A139WE20   A0A195BQQ7   A0A0Q5WLU7   A0A0J9QZG5   A0A0Q5WNB9   A0A195F3K2   A0A1W4VXQ1   A0A0J9TJP2   A0A0R1DL19   A0A0R1DSE9   Q9U6A0-3   M9MRG0   B4LQC7   A0A0Q5WA71   B0WXC6  

PDB

3V5U     E-value=0.000622172,     Score=100

KEGG

101737661    K13750 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 | (RefSeq) sodium/pot

GO

GO:0016021   GO:0008273   GO:0055085   GO:0070588   GO:0048749   GO:0015293   GO:0006814   GO:0006816   GO:0005887   GO:0006874   GO:0005262   GO:0006516   GO:0008270   GO:0005515   GO:0042555   GO:0006260   GO:0006811   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR10846   PTHR10846:SF44  

Subcellular location

Membrane  

Length:

294

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

124.60132

Exp number, first 60 AAs:

0.00928

Total prob of N-in:

0.19906

outside

1  -  106

TMhelix

107  -  124

inside

125  -  132

TMhelix

133  -  155

outside

156  -  169

TMhelix

170  -  192

inside

193  -  204

TMhelix

205  -  227

outside

228  -  236

TMhelix

237  -  259

inside

260  -  265

TMhelix

266  -  285

outside

286  -  294

 

 

Pi

206.229224

Theta

150.449667

Tajima's D

1.566727

CLR

0.530491

CSRT

0.796060196990151

Interpretation

Uncertain