Gene

KWMTBOMO11313  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002071

Annotation

PREDICTED:_5-formyltetrahydrofolate_cyclo-ligase-like_isoform_X2_[Amyelois_transitella]

Location

Bomo_Chr19(+):3030975-3039027      View in EpiBrowser

Full name

5-formyltetrahydrofolate cyclo-ligase      

Alternative Name

5,10-methenyl-tetrahydrofolate synthetase

Location in the cell

Mitochondrial   Reliability : 2.143

CDS

ATGAGTCCAATAAAACCAAATCCTGCCAAAGCCTTGCTACGTAACGAAATTGCCGCTAAAATCGCCGCCTTGACGAATGAAGAGAAAAAAAGACAATCTCAAATTGTTTATGAAAAGGTTATCAACCACTCATGGTACAAATCATCAAGTCGTATTGCTCTCTACATGAGCACCGAAAATGAGATAGACACTGCTCCTCTAATCAAACACATCCAAGCCAGAGGGGCTGCGGCCTTCGTGCCACAGTACGCCGGAGGGCGCATGAGGATGTTACACTTGGAGACCGGTGATGAGCAGACCATGCCAAAAACTAAACACGGGATATCTCAGCATGGGAAAGACCAAGCCAGGGACGATGCTCTAGAAACAGGTGGATTAGATCTGATCATAGCTCCAGGGGTGGCGTTTTCTCGTTCCGGAGACAGGCTGGGACACGGAGGTGGATACTACGACAAGTTCATCACTAATTTGAGGCTCAATCCAGAAACAGCTCCGAAGATAGTTGCAGTGGCTTTTAACTGTCAAGTTGTCGACGAGGTGCCGACTAACGAACAAGACCAGAAAGTGGACGAGGTTATATTCGCTGAATAA

Protein

MSPIKPNPAKALLRNEIAAKIAALTNEEKKRQSQIVYEKVINHSWYKSSSRIALYMSTENEIDTAPLIKHIQARGAAAFVPQYAGGRMRMLHLETGDEQTMPKTKHGISQHGKDQARDDALETGGLDLIIAPGVAFSRSGDRLGHGGGYYDKFITNLRLNPETAPKIVAVAFNCQVVDEVPTNEQDQKVDEVIFAE

Description

Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10-methenyltetrahydrofolate (By similarity).

Catalytic Activity

5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate

Cofactor

Mg(2+)

Subunit

Monomer.

Similarity

Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

Keywords

3D-structure   Acetylation   Alternative splicing   ATP-binding   Complete proteome   Cytoplasm   Folate-binding   Ligase   Magnesium   Metal-binding   Nucleotide-binding   Polymorphism   Reference proteome  

Feature

chain  5-formyltetrahydrofolate cyclo-ligase
splice variant  In isoform 2.
sequence variant  In dbSNP:rs8923.

Uniprot

H9IXT8   A0A2H1WK73   A0A2W1BHP1   A0A2A4IWE7   A0A2A4IY02   A0A3S2NXC3   + More
A0A194QGL2   A0A194QVN7   A0A212FFP3   J3JVY5   A0A232FEM7   K7JH06   U4U6T3   D6WQI7   A0A0C9RNG4   A0A1W4X470   A0A3L8D8P2   N6THY6   A0A2G8JXW3   A0A088A7I3   A0A0M8ZMZ8   A0A151IJY0   A0A2A3ED96   A0A026X241   A0A0D9RRA7   A0A0P4WHX0   A0A2U3Y8J2   A0A151WTA5   A0A195EHD9   A0A2Y9GE88   A0A2K5SGM8   A0A2K5LTS3   G7P997   F6VVW7   F6YZ79   A0A096NMX4   A0A1S3JK03   U3CWB8   H2NNZ8   A0A0P4WD20   U3FH71   A0A2K5D223   A0A2K6MAJ0   A0A2K6PB55   F6SFK7   A0A2I3FPQ7   A0A2I2UGT6   A0A0J7KQF3   A0A195B048   P49914   G3R914   A0A2K6A0D3   A0A2K5JX60   H2Q9X5   A0A158NKF9   U5EYE0   A0A2T7NFU6   A0A2U3W637   A0A1B6CAN7   A0A2K6CEG9   A0A1B6DQ05   Q96EE9   D2I5Q7   A0A0L7QNH6   A0A3Q7QT93   A0A1U7TBM6   G1LCH4   G3GTB3   I3MCZ0   F7C3A9   A0A3B5KFU0   A0A0N8EUE8   G3T1C1   A0A1A6HUR1   L7N466   A0A154PMF8   A0A1Y1MCK7   Q9D110   A0A3B4DW17   E2RR20   A0A3Q7WX09   H3ABJ5   Q3TYX5   A0A250YBY9   A0A3Q3M0N9   A0A3Q7SHP9   Q5M9F6   A0A0G2L0J2   A0A226DK10   A0A2Y9LNF9   A0A3P8V7K9   A0A341BA42   A0A2U4C7R9   A0A340WJ40   A0A384B3Z1   R7T3G1   A0A210PY18   A0A3B5AGJ6   A0A3B1JLE9   H0X584  

EC Number

6.3.3.2

Pubmed

19121390    28756777    26354079    22118469    22516182    28648823    + More
20075255    23537049    18362917    19820115    30249741    29023486    24508170    22002653    17431167    25319552    12481130    15114417    25243066    25362486    17495919    17975172    8522195    16572171    15489334    3801490    19413330    22814378    19738041    16136131    21347285    20010809    21804562    19892987    21551351    19468303    21183079    28004739    16141072    16341006    9215903    10349636    11042159    11076861    11217851    12466851    16141073    28087693    15057822    15632090    23594743    24487278    23254933    28812685    25329095   

EMBL

BABH01015585    BABH01015586    BABH01015587    ODYU01009166    SOQ53407.1    KZ150054    + More
PZC74358.1    NWSH01005325    PCG64287.1    PCG64288.1    RSAL01000034    RVE51390.1    KQ459053    KPJ04075.1    KQ461073    KPJ09537.1    AGBW02008791    OWR52554.1    BT127403    AEE62365.1    NNAY01000332    OXU29145.1    KB632095    ERL88777.1    KQ971354    EFA06068.1    GBYB01008621    JAG78388.1    QOIP01000011    RLU16674.1    APGK01025866    KB740605    ENN80019.1    MRZV01001107    PIK40573.1    KQ436033    KOX67535.1    KQ977294    KYN03946.1    KZ288279    PBC29688.1    KK107021    EZA62385.1    AQIB01145754    GDRN01049135    JAI66603.1    KQ982762    KYQ51063.1    KQ978881    KYN27688.1    AQIA01063441    AQIA01063442    AQIA01063443    CM001282    EHH63272.1    JSUE03038848    JSUE03038849    JSUE03038850    JU323084    JU474017    JV045948    CM001259    AFE66840.1    AFH30821.1    AFI36019.1    EHH27528.1    AHZZ02031365    AHZZ02031366    GAMT01007704    GAMS01009331    GAMR01010065    GAMP01007133    JAB04157.1    JAB13805.1    JAB23867.1    JAB45622.1    ABGA01219171    ABGA01219172    ABGA01269314    ABGA01269315    ABGA01269316    ABGA01269317    ABGA01269318    ABGA01269319    GDRN01049134    JAI66604.1    GAMQ01004356    JAB37495.1    ADFV01087605    ADFV01087606    ADFV01087607    AANG04002993    LBMM01004329    KMQ92563.1    KQ976692    KYM77831.1    L38928    AC015871    AC021483    BC019921    CK002935    CABD030097388    CABD030097389    CABD030097390    AACZ04052725    GABC01008601    GABF01010635    GABD01005894    GABE01009334    JAA02737.1    JAA11510.1    JAA27206.1    JAA35405.1    ADTU01018821    GANO01002057    JAB57814.1    PZQS01000013    PVD20002.1    GEDC01026750    GEDC01018168    GEDC01014074    GEDC01004956    GEDC01003269    JAS10548.1    JAS19130.1    JAS23224.1    JAS32342.1    JAS34029.1    GEDC01031681    GEDC01029328    GEDC01027988    GEDC01027181    GEDC01017528    GEDC01011532    GEDC01009548    GEDC01007612    JAS05617.1    JAS07970.1    JAS09310.1    JAS10117.1    JAS19770.1    JAS25766.1    JAS27750.1    JAS29686.1    BC012417    AAH12417.1    GL194762    EFB25996.1    KQ414851    KOC60180.1    ACTA01180869    ACTA01188867    ACTA01196865    JH000018    EGV94500.1    AGTP01003694    AGTP01003695    AGTP01003696    GEBF01001779    JAO01854.1    LZPO01008151    OBS82188.1    AC163666    CT030710    KQ434978    KZC13023.1    GEZM01035129    GEZM01035128    JAV83393.1    AK004092    AC135634    CT030686    AAEX03002384    AFYH01020396    AFYH01020397    AFYH01020398    AFYH01020399    AK158264    BAE34435.1    GFFW01003651    JAV41137.1    AC120938    BC087144    CH473954    AAH87144.1    EDL77576.1    CABZ01029544    CABZ01029545    CABZ01029546    CU695017    LNIX01000017    OXA45460.1    AMQN01003670    KB312450    ELT87198.1    NEDP02005404    OWF41377.1    AAQR03026739    AAQR03026740    AAQR03026741   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000053240    UP000007151    + More
UP000215335    UP000002358    UP000030742    UP000007266    UP000192223    UP000279307    UP000019118    UP000230750    UP000005203    UP000053105    UP000078542    UP000242457    UP000053097    UP000029965    UP000245341    UP000075809    UP000078492    UP000248481    UP000233040    UP000233060    UP000009130    UP000233100    UP000006718    UP000008144    UP000028761    UP000085678    UP000008225    UP000001595    UP000233020    UP000233180    UP000233200    UP000002280    UP000001073    UP000011712    UP000036403    UP000078540    UP000005640    UP000001519    UP000233140    UP000233080    UP000002277    UP000005205    UP000245119    UP000245340    UP000233120    UP000053825    UP000286641    UP000189704    UP000008912    UP000001075    UP000005215    UP000002281    UP000005226    UP000007646    UP000092124    UP000000589    UP000076502    UP000261440    UP000002254    UP000286642    UP000008672    UP000261640    UP000286640    UP000002494    UP000000437    UP000198287    UP000248483    UP000265120    UP000252040    UP000245320    UP000265300    UP000261681    UP000014760    UP000242188    UP000261400    UP000018467    UP000005225   

PRIDE

H9IXT8    P49914    G3GTB3    L7N466    Q9D110   

Pfam

PF01812   5-FTHF_cyc-lig

Interpro

IPR002698   FTHF_cligase        + More
IPR037171   NagB/RpiA_transferase-like       
IPR024185   FTHF_cligase-like_sf       

SUPFAM

SSF100950   SSF100950       

Gene 3D

3.40.50.10420    

ProteinModelPortal

H9IXT8   A0A2H1WK73   A0A2W1BHP1   A0A2A4IWE7   A0A2A4IY02   A0A3S2NXC3   + More
A0A194QGL2   A0A194QVN7   A0A212FFP3   J3JVY5   A0A232FEM7   K7JH06   U4U6T3   D6WQI7   A0A0C9RNG4   A0A1W4X470   A0A3L8D8P2   N6THY6   A0A2G8JXW3   A0A088A7I3   A0A0M8ZMZ8   A0A151IJY0   A0A2A3ED96   A0A026X241   A0A0D9RRA7   A0A0P4WHX0   A0A2U3Y8J2   A0A151WTA5   A0A195EHD9   A0A2Y9GE88   A0A2K5SGM8   A0A2K5LTS3   G7P997   F6VVW7   F6YZ79   A0A096NMX4   A0A1S3JK03   U3CWB8   H2NNZ8   A0A0P4WD20   U3FH71   A0A2K5D223   A0A2K6MAJ0   A0A2K6PB55   F6SFK7   A0A2I3FPQ7   A0A2I2UGT6   A0A0J7KQF3   A0A195B048   P49914   G3R914   A0A2K6A0D3   A0A2K5JX60   H2Q9X5   A0A158NKF9   U5EYE0   A0A2T7NFU6   A0A2U3W637   A0A1B6CAN7   A0A2K6CEG9   A0A1B6DQ05   Q96EE9   D2I5Q7   A0A0L7QNH6   A0A3Q7QT93   A0A1U7TBM6   G1LCH4   G3GTB3   I3MCZ0   F7C3A9   A0A3B5KFU0   A0A0N8EUE8   G3T1C1   A0A1A6HUR1   L7N466   A0A154PMF8   A0A1Y1MCK7   Q9D110   A0A3B4DW17   E2RR20   A0A3Q7WX09   H3ABJ5   Q3TYX5   A0A250YBY9   A0A3Q3M0N9   A0A3Q7SHP9   Q5M9F6   A0A0G2L0J2   A0A226DK10   A0A2Y9LNF9   A0A3P8V7K9   A0A341BA42   A0A2U4C7R9   A0A340WJ40   A0A384B3Z1   R7T3G1   A0A210PY18   A0A3B5AGJ6   A0A3B1JLE9   H0X584  

PDB

3HY6     E-value=1.44929e-38,     Score=396

KEGG

101740948    K01934 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2] | (RefSeq) 5-formyltetrahydrofolate cyclo-

PATHWAY

00670    One carbon pool by folate - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0046872   GO:0030272   GO:0005739   GO:0009396   GO:0035999   GO:0006536   GO:0005829   GO:0005759   GO:0046657   GO:0005542   GO:0046653   GO:0005737   GO:0015942   GO:0046655  

PANTHER

PTHR23407:SF1  

Subcellular location

Cytoplasm  

Length:

196

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00167

Exp number, first 60 AAs:

0

Total prob of N-in:

0.06537

outside

1  -  196

 

 

Pi

247.549598

Theta

170.499114

Tajima's D

1.297799

CLR

0.387179

CSRT

0.743712814359282

Interpretation

Uncertain