Gene

KWMTBOMO11300

Annotation

PREDICTED:_FAS-associated_factor_1_[Bombyx_mori]

Location

Bomo_Chr19(-):2650123-2669125      View in EpiBrowser

Full name

FAS-associated factor 1      

Alternative Name

UBX domain-containing protein 12
UBX domain-containing protein 3A

Location in the cell

Cytoplasmic   Reliability : 2.188 Nuclear   Reliability : 1.973

CDS

ATGGCAGAAAACAGAGAAGAAATCTTAGCAAACTTCCAGGGTATAACAGCCATTGAAGACGTTGCTGAAGCTATCTATCACCTTGACGAGTCCAACTGGGATTTACTGACAGCTATAAACCGAGTGATGCCGCAGGATCAAAACGCCGCCGCCGCGGACGCACAAGATGACACTCACAACGTTGAAATGATAGACGACGATATATCTGTGATAACGCCAAAAACACACCCACCAGATAGAGAAGATAATAATCAAGCTTCAACATCATCGATTAATAGGAACAGTACGAACGGTTTTGTTGAGCTACAAATAAACTGGAATAACAAAATGTATGGAATTAAAATTAATGGCACAGCCACTGTTAGTGATTTAAAGAAACATCTAGAATTAATAAGCGGGGTGCCGTCGTGCAGACAACTGATATCGGGTTTGGGGGGATCGAAGGCGGTCCCCTCGGCCACCCTGGGCAGTCTCGGGCTCGTGAAGAACGCCGTCGTCAGACTGAAATCTGCCGATCAGCAAATGGTTGCCGACGATGATGTGGCGGAGAGATTGACGACAACGTACACGCTTCACATCAAACACAATGACAGGGACTACACCCTTAAGTACCCCGGAACGAAATCTGTGAGGGAAGTGAAGAACGACATCTACTCACTTACGGACATACCGGCCAGGCATCAGTCGTGGACAGGGTGGCCGTCAGTGTCGGGGCTGGACGACACGGTGCTGGCAATGGTCGGCCTGGACCTGCCGCAACACGAGCTCACAGTCAAAAGGGCGCCCGCCAAACCACTCAAGGAATACAAGAGGATAATAGTCGAAAGTTCAGACAGCGAGAACAGTTCTGTCGAAGAAGTGGAAGACACCGGCTTCACGGGAGAAGACGACATGTTCGTCGACATAGCTAATTCGGAGAGGTTGCAGCCACTCATGTCGGAAAACGTAGAAGACGAGGCGCTGGGCTGCATAGAGTTCGCGAGTCGGTTCCGAGCCCGCTACGGACCCAACATACCGAACTTCTTCGAGGGAACCCTCCAGGACGCCATCAAGGAGTCCTGTCTCAAACCTGCCAAAGAAAGAAAGCTCCTGGGCGTGTACCTGCACCACGAGCAGTCCGTGCTGTCCAACGTGTTCTGCGCGCAGCTGCTGGGCAGCGACGCCGTGCTGCAGACGCTGTCCGCTAACTTCGTCATATACGGATGGGATCTCACGCATCCCAATAATAATAATCTATTGTTAACGTCAGTAGCGACAGCTTTGGGTTCGGTCGCGAGCATGACGATACAGAGCATCCCCGTCGACAGACTACCAGCCTTGGTCATCATAATGAGAGTTCGTTCTAATACCGAAATATACTCTGTTATTAATGGCAATGTCGGCGTGTCAGAGCTGGTCGGCGGCCTAGTGGAAGCGTTGGAGCGGTTCGCGATACAGCGGGACGAGGACGCGAGACTGGAGCGGGAACGGGACGCGAGGCAGCGCGTCAAACTCGAACAAGACGAGGCCTACATGAGGAGTCTTGAAGCTGACAGGTAG

Protein

MAENREEILANFQGITAIEDVAEAIYHLDESNWDLLTAINRVMPQDQNAAAADAQDDTHNVEMIDDDISVITPKTHPPDREDNNQASTSSINRNSTNGFVELQINWNNKMYGIKINGTATVSDLKKHLELISGVPSCRQLISGLGGSKAVPSATLGSLGLVKNAVVRLKSADQQMVADDDVAERLTTTYTLHIKHNDRDYTLKYPGTKSVREVKNDIYSLTDIPARHQSWTGWPSVSGLDDTVLAMVGLDLPQHELTVKRAPAKPLKEYKRIIVESSDSENSSVEEVEDTGFTGEDDMFVDIANSERLQPLMSENVEDEALGCIEFASRFRARYGPNIPNFFEGTLQDAIKESCLKPAKERKLLGVYLHHEQSVLSNVFCAQLLGSDAVLQTLSANFVIYGWDLTHPNNNNLLLTSVATALGSVASMTIQSIPVDRLPALVIIMRVRSNTEIYSVINGNVGVSELVGGLVEALERFAIQRDEDARLERERDARQRVKLEQDEAYMRSLEADR

Description

Ubiquitin-binding protein (By similarity). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (By similarity). Potentiates but cannot initiate FAS-induced apoptosis (PubMed:8524870).
Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity).

Subunit

Interacts with CDT1 and ATPase VCP/p97. Interacts (via UBA domain) with FAS (via death domain). Interacts (via UBA domain) with NLRP12 (via DAPIN/PYRIN domain).
Interacts with CDT1 and ATPase VCP/p97 (PubMed:26842564). Interacts (via UBA domain) with FAS (via death domain) (PubMed:10462485). Interacts (via UBA domain) with NLRP12 (via DAPIN/PYRIN domain) (PubMed:21978668).

Keywords

Apoptosis   Complete proteome   Nucleus   Phosphoprotein   Reference proteome   3D-structure   Alternative splicing  

Feature

chain  FAS-associated factor 1
splice variant  In isoform Short.

Uniprot

A0A3S2M5F9   A0A1E1WT10   A0A2A4JDS6   A0A212EZI1   A0A194QGK4   A0A194QW61   + More
A0A2A4JC99   A0A067QUL8   A0A2J7PT23   A0A2J7PT38   A0A2J7PT25   A0A139WEN9   K4Q3F5   A0A1B6DVE3   A0A2P8YAT4   A0A158P2J2   A0A195EQH8   E2BF77   A0A195AWB5   A0A0J7KLC3   A0A151K249   F4W627   A0A026WKH2   A0A151WP55   A0A195DMP1   A0A3L8DZL0   N6TA97   U4UQ88   A0A1W4XDD2   A0A1B6IYX8   A0A154PGI5   E0VAG3   A0A0N0BDQ3   A0A2A3E970   A0A088ABZ9   A0A0L7RBW0   A0A1B6MT65   A0A1Y1MRI8   A0A232F0M0   K7J837   A0A1L8DM76   A0A1B0CF30   A0A0P5ESG8   A0A0P5JZ96   A0A0P5JAX5   A0A0N8AS53   A0A0P5J7I1   A0A0P5J3F1   A0A0P5G2R4   A0A0P5N633   A0A0P5ZCT5   A0A0P5KNE1   A0A0P5XE82   A0A0P6HKJ0   A0A0P5T7U3   A0A0P5M4U5   E9G3E1   A0A0P6EVQ9   A0A0P4WG76   T1J5Q1   A0A0P4WAL3   V9KLB1   A0A0A9WH59   A0A0K8T1G9   A0A1J1IVY2   B4KQB8   Q16FJ3   A0A3Q2EK99   A0A250Y3V0   A0A3Q1IYZ2   G3GVX8   A0A3Q1HJ49   P54731   A0A287D667   A0A3B5AXA7   Q9UNN5   G3RBT6   A0A2I3SXQ0   U3JS28   A0A3B4T1U2   A0A218VEX9   H0ZE93   A0A2K5QAK7   A0A3B4WPX5   A0A3Q1LU56   A0A2Y9IUE4   U3DW65   A0A2K5EGB1   A0A3Q1BWT9   A0A3P8U3X2   A0A1W7RHE9   A0A0F7ZBJ1   A0A2K6V6K6   A0A3Q7P0X4   A0A2Y9GLG8   A0A2U3VXV2  

Pubmed

22118469    26354079    24845553    18362917    19820115    23635314    + More
29403074    21347285    20798317    21719571    24508170    30249741    23537049    20566863    28004739    28648823    20075255    21292972    24402279    25401762    26823975    17994087    17510324    28087693    21804562    8524870    19468303    15489334    21183079    10462485    10810093    16710414    17974005    18669648    19690332    20068231    21269460    21978668    23186163    26842564    11243799    19722279    22398555    16136131    20360741    19393038    25243066    26358130   

EMBL

RSAL01000034    RVE51396.1    GDQN01001088    JAT89966.1    NWSH01001952    PCG69580.1    + More
AGBW02011289    OWR46893.1    KQ459053    KPJ04065.1    KQ461073    KPJ09544.1    PCG69581.1    KK853244    KDR09433.1    NEVH01021921    PNF19490.1    PNF19489.1    PNF19491.1    KQ971354    KYB26413.1    AB758246    BAM63554.1    GEDC01007683    JAS29615.1    PYGN01000749    PSN41351.1    ADTU01006889    ADTU01006890    KQ982021    KYN30431.1    GL447952    EFN85663.1    KQ976731    KYM76342.1    LBMM01005990    KMQ91036.1    LKEX01012869    KYN50204.1    GL887707    EGI70162.1    KK107163    EZA56540.1    KQ982892    KYQ49610.1    KQ980724    KYN14165.1    QOIP01000002    RLU25369.1    APGK01045628    KB741037    ENN74653.1    KB632319    ERL92301.1    GECU01015571    JAS92135.1    KQ434899    KZC10917.1    DS235006    EEB10369.1    KQ435851    KOX70781.1    KZ288338    PBC27822.1    KQ414617    KOC68318.1    GEBQ01000898    JAT39079.1    GEZM01023547    JAV88313.1    NNAY01001369    OXU24214.1    GFDF01006518    JAV07566.1    AJWK01009604    GDIP01143982    JAJ79420.1    GDIQ01191452    JAK60273.1    GDIQ01208399    GDIQ01208398    JAK43326.1    GDIQ01253090    GDIQ01251791    GDIQ01250334    GDIQ01248787    GDIQ01248235    GDIQ01205694    GDIQ01205693    JAK03490.1    GDIQ01204143    GDIQ01149070    GDIQ01101239    JAK47582.1    GDIQ01207149    GDIQ01207147    JAK44576.1    GDIQ01251793    GDIQ01251792    GDIQ01250336    GDIQ01250335    GDIQ01248236    GDIQ01205692    JAK01389.1    GDIQ01204142    GDIQ01149071    GDIQ01088334    GDIQ01052616    JAL02655.1    GDIQ01208397    GDIP01045563    LRGB01001574    JAK43328.1    JAM58152.1    KZS11650.1    GDIQ01207148    JAK44577.1    GDIP01074954    JAM28761.1    GDIQ01018027    JAN76710.1    GDIP01132091    JAL71623.1    GDIQ01160607    JAK91118.1    GL732531    EFX85757.1    GDIQ01070102    JAN24635.1    GDRN01059093    JAI65530.1    JH431866    GDRN01059094    JAI65529.1    JW866318    AFO98835.1    GBHO01039414    GDHC01021170    JAG04190.1    JAP97458.1    GBRD01006448    JAG59373.1    CVRI01000063    CRL04435.1    CH933808    EDW09246.1    CH478424    EAT33009.1    GFFV01001638    JAV38307.1    JH000045    EGV97917.1    U39643    AL627188    AL627392    CH466527    BC065098    AGTP01043130    AGTP01043131    AGTP01043132    AGTP01043133    AGTP01043134    AGTP01043135    AF106798    AF094700    AF136173    AJ271408    AF132938    AC091610    AC118557    AL049637    AL359977    AL603746    CH471059    BC004970    BC067100    AL133631    CABD030003147    CABD030003148    CABD030003149    CABD030003150    CABD030003151    CABD030003152    CABD030003153    CABD030003154    CABD030003155    CABD030003156    AACZ04058297    AACZ04058298    AACZ04058299    AACZ04058300    AACZ04058301    GABC01000539    GABF01009212    GABD01005085    GABE01005639    NBAG03000229    JAA10799.1    JAA12933.1    JAA28015.1    JAA39100.1    PNI71593.1    AGTO01001183    MUZQ01000002    OWK64398.1    ABQF01030951    ABQF01030952    ABQF01030953    ABQF01030954    ABQF01030955    ABQF01030956    GAMT01009761    GAMS01009156    GAMR01002914    GAMQ01005154    GAMP01006446    JAB02100.1    JAB13980.1    JAB31018.1    JAB36697.1    JAB46309.1    GDAY02000871    JAV50556.1    GBEX01001248    JAI13312.1   

Proteomes

UP000283053    UP000218220    UP000007151    UP000053268    UP000053240    UP000027135    + More
UP000235965    UP000007266    UP000245037    UP000005205    UP000078541    UP000008237    UP000078540    UP000036403    UP000078542    UP000007755    UP000053097    UP000075809    UP000078492    UP000279307    UP000019118    UP000030742    UP000192223    UP000076502    UP000009046    UP000053105    UP000242457    UP000005203    UP000053825    UP000215335    UP000002358    UP000092461    UP000076858    UP000000305    UP000183832    UP000009192    UP000008820    UP000265020    UP000265040    UP000001075    UP000000589    UP000005215    UP000261400    UP000005640    UP000001519    UP000002277    UP000016665    UP000261420    UP000197619    UP000007754    UP000233040    UP000261360    UP000009136    UP000248482    UP000008225    UP000233020    UP000257160    UP000265080    UP000233220    UP000286641    UP000248481    UP000245340   

PRIDE

G3GVX8    P54731    Q9UNN5   

Pfam

PF14560   Ubiquitin_2        + More
PF00789   UBX
PF00240   ubiquitin
PF00226   DnaJ
PF01556   DnaJ_C

Interpro

IPR000626   Ubiquitin_dom        + More
IPR001012   UBX_dom       
IPR029071   Ubiquitin-like_domsf       
IPR006577   UAS       
IPR036249   Thioredoxin-like_sf       
IPR033043   FAF1_UBX       
IPR001623   DnaJ_domain       
IPR008971   HSP40/DnaJ_pept-bd       
IPR002939   DnaJ_C       
IPR018253   DnaJ_domain_CS       
IPR036869   J_dom_sf       
IPR009060   UBA-like_sf       

SUPFAM

SSF54236   SSF54236        + More
SSF52833   SSF52833       
SSF49493   SSF49493       
SSF46565   SSF46565       
SSF46934   SSF46934       

Gene 3D

1.10.287.110    

CDD

cd01771  Faf1_UBX
cd06257  DnaJ

ProteinModelPortal

A0A3S2M5F9   A0A1E1WT10   A0A2A4JDS6   A0A212EZI1   A0A194QGK4   A0A194QW61   + More
A0A2A4JC99   A0A067QUL8   A0A2J7PT23   A0A2J7PT38   A0A2J7PT25   A0A139WEN9   K4Q3F5   A0A1B6DVE3   A0A2P8YAT4   A0A158P2J2   A0A195EQH8   E2BF77   A0A195AWB5   A0A0J7KLC3   A0A151K249   F4W627   A0A026WKH2   A0A151WP55   A0A195DMP1   A0A3L8DZL0   N6TA97   U4UQ88   A0A1W4XDD2   A0A1B6IYX8   A0A154PGI5   E0VAG3   A0A0N0BDQ3   A0A2A3E970   A0A088ABZ9   A0A0L7RBW0   A0A1B6MT65   A0A1Y1MRI8   A0A232F0M0   K7J837   A0A1L8DM76   A0A1B0CF30   A0A0P5ESG8   A0A0P5JZ96   A0A0P5JAX5   A0A0N8AS53   A0A0P5J7I1   A0A0P5J3F1   A0A0P5G2R4   A0A0P5N633   A0A0P5ZCT5   A0A0P5KNE1   A0A0P5XE82   A0A0P6HKJ0   A0A0P5T7U3   A0A0P5M4U5   E9G3E1   A0A0P6EVQ9   A0A0P4WG76   T1J5Q1   A0A0P4WAL3   V9KLB1   A0A0A9WH59   A0A0K8T1G9   A0A1J1IVY2   B4KQB8   Q16FJ3   A0A3Q2EK99   A0A250Y3V0   A0A3Q1IYZ2   G3GVX8   A0A3Q1HJ49   P54731   A0A287D667   A0A3B5AXA7   Q9UNN5   G3RBT6   A0A2I3SXQ0   U3JS28   A0A3B4T1U2   A0A218VEX9   H0ZE93   A0A2K5QAK7   A0A3B4WPX5   A0A3Q1LU56   A0A2Y9IUE4   U3DW65   A0A2K5EGB1   A0A3Q1BWT9   A0A3P8U3X2   A0A1W7RHE9   A0A0F7ZBJ1   A0A2K6V6K6   A0A3Q7P0X4   A0A2Y9GLG8   A0A2U3VXV2  

PDB

2EC4     E-value=1.76302e-29,     Score=323

KEGG

101737520    K20703 FAS-associated factor 1 | (RefSeq) FAS-associated factor 1

PATHWAY

04624    Toll and Imd signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0008219   GO:0006457   GO:0051082   GO:0045861   GO:0002814   GO:0061060   GO:0007253   GO:1903364   GO:0048471   GO:0010942   GO:0045740   GO:0034098   GO:0031072   GO:0006915   GO:0031334   GO:0031625   GO:0005635   GO:0051059   GO:0030155   GO:0043130   GO:0042176   GO:0005634   GO:0005829   GO:1902043   GO:0019901   GO:0019904   GO:0005737   GO:0051216   GO:0031101   GO:0060037   GO:0043161   GO:0031265   GO:0043065   GO:0019887  

Subcellular location

Nucleus  

Length:

512

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.1863

Exp number, first 60 AAs:

0.00082

Total prob of N-in:

0.00398

outside

1  -  512

 

 

Pi

197.31117

Theta

154.08231

Tajima's D

0.721923

CLR

0.393128

CSRT

0.578521073946303

Interpretation

Uncertain