Gene

KWMTBOMO11280

Pre Gene Modal

BGIBMGA002764

Annotation

PREDICTED:_Bardet-Biedl_syndrome_2_protein_homolog_[Bombyx_mori]

Location

Bomo_Chr19(+):2389546-2397656      View in EpiBrowser

Full name

Bardet-Biedl syndrome 2 protein homolog       + More
Bardet-Biedl syndrome 2 protein      

Location in the cell

Golgi   Reliability : 1.095

CDS

ATGAGAGCCAGTGCAGCTGCAATGCTTTTGGCGGACTATAGAGCTCTGGGCACTCCAGATCTTGTCTGTGTTTCGGTTAGAGGAGAAGTTTTAGGCTATTCTCCAACGCAAGAGAGTAGCGGATTCAACGATACCACCAAGAATCCAGCAACAGAGGAAGACCGCCTGGCAATAACAGAGTTATTGAACAAAAAACAGGCTCTGATGCTAGAGTTACAGCATTATGAAGCTAACGCTGCAAGTGCGGTTATGCCTGATTTAGAAGACGATCGTCCTACTACCGCAATGCCTACTAATACCAGATTACAGGTTGCCGTTGTCCATTCTCTGGACGAGGGTTGTTTAAATCTTGCCATATCGACGAACAACGAGACCATCGTCAGAGCAGCGCTAATATTAGCTGAAGGTATATTTGAATCAGGCGAAACATTGGCGCGTCACCCGCCGCTTTCCCAAATCCGTCCCATATTACACGTGCCTTTGCACCCCCCCAGAGATGTACCCGTCGATGTGCACATCAAAGCTCTCGTCGGCTATCCGAACAGCGAGCAGTACCACATCTTTGAAATGACGAAACAACTACCAAGATTTGCCATGTACACAATGAATTACAATGCTACAAACCGAATTAATTATAACAGCAGTTACGTGACTTTTCAAATAACAGAGAGGCTCCAAAGAATTTGTATTTGGGCTAACCAGAACTTTCTGTTGGAGAACGAGTTGGAATTGAACTCGGAGGATGCTAAAGAGTTTCATGTCAATTTGACGTGTCTGAGAGATCAGTCTACGTTGGATATGAACTTTAATGTTGATGGTAATGTGAAGATCACCACTAGTGATATGAGGCTCGCCGGAGATTTGGTGCAAAGTTTGGCGGTTTTCTTGAATTTGACAGATTTAAAGTCAACAGCAAACTTCGTAGAAGCTGAAAAGAAATTACGCGAAGAAATGGAAAATGCATCTCAAGCAGGGGAAATGAGATCGCGCTTAGCTGCCGAAACAGCAGAACGAGCTCAACTGATAACAGCTTTATTACCAGCTGCACAAGACGCCGCATCATATGATTTGAAAGAAATGCTGAATAGGTATAAAGAGGTGGTGATGTTAAACGAAGAACTCATAGCAGCATGCCACGTACGACGCGCTACACAAGAACATGCCGTGGCTTCACTCAAAACTTTACATACTATTTTACAACAAGCGGCGCGGTTAAGAGTGGGTAAATACAGCAAGGCTGTTGTAAGCGCAAGTAGGAATGCAGTGAAGGAAAATAACGTGGAAGCGCTGATTAAAATCATTCAAGTCGGAGAGTCGCTATAA

Protein

MRASAAAMLLADYRALGTPDLVCVSVRGEVLGYSPTQESSGFNDTTKNPATEEDRLAITELLNKKQALMLELQHYEANAASAVMPDLEDDRPTTAMPTNTRLQVAVVHSLDEGCLNLAISTNNETIVRAALILAEGIFESGETLARHPPLSQIRPILHVPLHPPRDVPVDVHIKALVGYPNSEQYHIFEMTKQLPRFAMYTMNYNATNRINYNSSYVTFQITERLQRICIWANQNFLLENELELNSEDAKEFHVNLTCLRDQSTLDMNFNVDGNVKITTSDMRLAGDLVQSLAVFLNLTDLKSTANFVEAEKKLREEMENASQAGEMRSRLAAETAERAQLITALLPAAQDAASYDLKEMLNRYKEVVMLNEELIAACHVRRATQEHAVASLKTLHTILQQAARLRVGKYSKAVVSASRNAVKENNVEALIKIIQVGESL

Description

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization.

Subunit

Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts (via C-terminus) with BBS7. Interacts (via coiled coil domain) with MKKS. Interacts with CCDC28B and ALDOB.

Keywords

Bardet-Biedl syndrome   Cell membrane   Cell projection   Ciliopathy   Cilium   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Disease mutation   Membrane   Mental retardation   Obesity   Polymorphism   Protein transport   Reference proteome   Retinitis pigmentosa   Sensory transduction   Transport   Vision  

Feature

chain  Bardet-Biedl syndrome 2 protein
sequence variant  In BBS2.

Uniprot

A0A2A4JYS1   A0A2H1WYF7   A0A3S2NMF8   A0A194QKR5   D6WSV9   A0A2J7RNG0   + More
A0A2J7RNG3   A0A067R1E4   F7C228   A0A091NAH7   M1EJR8   E0V980   U3JYK5   A0A091F2R3   A0A091K773   M3WA02   A0A091LQI4   A0A093PNL5   A0A091VES4   A0A093JX48   A0A091SL53   A0A093NXT7   A0A2I0M0I4   A0A091P413   A0A091WIB8   A0A3L8SFE6   M3XWM7   A0A099ZJL7   A0A091KPG2   U6CW78   A0A093FET5   A0A091M2S2   A0A087QX93   H0Z855   U3IYU1   A0A087VFA9   G3UV52   A0A093BGX6   H3B555   A0A1L8GEJ7   A0A091JXT9   G1MQN7   A0A2Y9KN22   I3M6W3   A0A3Q7SV98   A0A0A0A1H6   D2GTV7   G1ME56   E2RRL8   A0A287D506   A0A384D278   A0A3Q7WJD7   A0A3Q0H8T4   A0A094LER9   A0A1V4K116   A0A3P4RBB7   G5BMR9   A0A1D5PWG7   A0A0N8EUP2   F6UN54   A0A3Q0HDC8   A0A3Q7TCR4   A0A091GGZ7   A0A151MR49   Q5R9U3   Q5ZI17   A0A151MR61   A0A218UK11   S4RL84   H2NQY4   A0A151MR52   A0A2J8VYV7   A0A2K5ZL76   K7FYE3   A0A091SYM0   G3W852   A0A093IA05   H9EVX2   A0A2Y9IGB6   G3RIZ2   A0A0Q3TTZ7   A0A383YXP4   A0A2U3VLL9   R7VBN6   G7Q158   A0A3Q0D4F1   A0A2K6ART2   A0A2K5V5J4   A0A096NII1   A0A2K5N1R7   G7NPC3   F6ZBL6   A0A2U4CNC3   A0A2Y9EPT2   A0A2R9ANA3   H2QB48   Q9BXC9  

Pubmed

26354079    18362917    19820115    24845553    20431018    23236062    + More
20566863    17975172    23371554    30282656    20360741    23749191    20838655    9215903    27762356    20010809    16341006    24813606    21993625    15592404    18464734    22293439    15642098    17381049    21709235    25319552    22398555    23254933    22002653    26319212    17431167    22722832    16136131    11285252    14702039    15489334    16823392    16327777    17574030    18000879    20080638    22072986    25541840    11567139    12677556    12872256    12920096    15666242    15770229    20120035    21344540   

EMBL

NWSH01000348    PCG77171.1    ODYU01012011    SOQ58078.1    RSAL01000034    RVE51408.1    + More
KQ459053    KPJ04046.1    KQ971352    EFA06343.1    NEVH01002541    PNF42359.1    PNF42358.1    KK852996    KDR12698.1    AAMC01067010    AAMC01067011    AAMC01067012    AAMC01067013    AAMC01067014    KK844153    KFP86072.1    JP006375    AER94972.1    DS234989    EEB09936.1    AGTO01000569    KK719362    KFO63102.1    KK502030    KFP19631.1    AANG04002512    KK506062    KFP61391.1    KL669222    KFW75850.1    KL410965    KFR01644.1    KL206526    KFV83039.1    KK474942    KFQ58715.1    KL224844    KFW64907.1    AKCR02000054    PKK23189.1    KK651192    KFQ01838.1    KK735695    KFR15319.1    QUSF01000023    RLW01200.1    AEYP01015488    AEYP01015489    KL895498    KGL82624.1    KK748908    KFP41150.1    HAAF01002271    CCP74097.1    KK624614    KFV52776.1    KL309851    KFP52851.1    KL225962    KFM05847.1    ABQF01035934    ADON01001161    ADON01001162    KL491133    KFO11301.1    KN126203    KFU87550.1    AFYH01035557    AFYH01035558    CM004473    OCT82270.1    KK534323    KFP28956.1    AGTP01009392    KL870139    KGL86870.1    GL192338    EFB22213.1    ACTA01016788    ACTA01024788    AAEX03001584    KL288917    KFZ69225.1    LSYS01005191    OPJ78126.1    CYRY02041340    VCX31436.1    JH171108    EHB10580.1    AADN05000561    GEBF01001027    JAO02606.1    AAPN01239237    AAPN01239238    AAPN01239239    AAPN01239240    KL447421    KFO73397.1    AKHW03005442    KYO27016.1    CR859289    CAH91467.1    AJ720967    CAG32626.1    KYO27017.1    MUZQ01000251    OWK54075.1    ABGA01401043    ABGA01401044    ABGA01401045    ABGA01401046    KYO27018.1    NDHI03003406    PNJ62656.1    AGCU01102456    AGCU01102457    AGCU01102458    AGCU01102459    KK938071    KFQ48491.1    AEFK01021919    AEFK01021920    AEFK01021921    AEFK01021922    AEFK01021923    AEFK01021924    KK558108    KFV99519.1    JU322775    AFE66531.1    CABD030101195    LMAW01001170    KQK84198.1    AMQN01004326    KB293237    ELU16233.1    CM001295    EHH60396.1    AQIA01042986    AHZZ02018774    JV044378    CM001272    AFI34449.1    EHH31674.1    JSUE03026263    AJFE02083912    AJFE02083913    AACZ04057484    GABC01006152    GABF01006046    JAA05186.1    JAA16099.1    AF342736    AK027635    BC014140   

Proteomes

UP000218220    UP000283053    UP000053268    UP000007266    UP000235965    UP000027135    + More
UP000008143    UP000009046    UP000016665    UP000052976    UP000053119    UP000011712    UP000053258    UP000053283    UP000053584    UP000054081    UP000053872    UP000053605    UP000276834    UP000000715    UP000053641    UP000053286    UP000007754    UP000016666    UP000001645    UP000008672    UP000186698    UP000248482    UP000005215    UP000286640    UP000053858    UP000008912    UP000002254    UP000261680    UP000291021    UP000286642    UP000189705    UP000190648    UP000006813    UP000000539    UP000002279    UP000053760    UP000050525    UP000197619    UP000245300    UP000001595    UP000233140    UP000007267    UP000007648    UP000248481    UP000001519    UP000051836    UP000261681    UP000245340    UP000014760    UP000009130    UP000189706    UP000233120    UP000233100    UP000028761    UP000233060    UP000006718    UP000245320    UP000248484    UP000240080    UP000002277    UP000005640   

PRIDE

Q9BXC9   

Pfam

PF14782   BBS2_C        + More
PF14783   BBS2_Mid
PF14781   BBS2_N

Interpro

IPR029429   BBS2_Mid        + More
IPR029430   BBS2_N       
IPR016616   Bardet-Biedl_syndrome_2_prot       
IPR036322   WD40_repeat_dom_sf       
IPR029333   BBS2_C       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR011047   Quinoprotein_ADH-like_supfam       

SUPFAM

SSF50978   SSF50978        + More
SSF50998   SSF50998       

Gene 3D

2.130.10.10    

ProteinModelPortal

A0A2A4JYS1   A0A2H1WYF7   A0A3S2NMF8   A0A194QKR5   D6WSV9   A0A2J7RNG0   + More
A0A2J7RNG3   A0A067R1E4   F7C228   A0A091NAH7   M1EJR8   E0V980   U3JYK5   A0A091F2R3   A0A091K773   M3WA02   A0A091LQI4   A0A093PNL5   A0A091VES4   A0A093JX48   A0A091SL53   A0A093NXT7   A0A2I0M0I4   A0A091P413   A0A091WIB8   A0A3L8SFE6   M3XWM7   A0A099ZJL7   A0A091KPG2   U6CW78   A0A093FET5   A0A091M2S2   A0A087QX93   H0Z855   U3IYU1   A0A087VFA9   G3UV52   A0A093BGX6   H3B555   A0A1L8GEJ7   A0A091JXT9   G1MQN7   A0A2Y9KN22   I3M6W3   A0A3Q7SV98   A0A0A0A1H6   D2GTV7   G1ME56   E2RRL8   A0A287D506   A0A384D278   A0A3Q7WJD7   A0A3Q0H8T4   A0A094LER9   A0A1V4K116   A0A3P4RBB7   G5BMR9   A0A1D5PWG7   A0A0N8EUP2   F6UN54   A0A3Q0HDC8   A0A3Q7TCR4   A0A091GGZ7   A0A151MR49   Q5R9U3   Q5ZI17   A0A151MR61   A0A218UK11   S4RL84   H2NQY4   A0A151MR52   A0A2J8VYV7   A0A2K5ZL76   K7FYE3   A0A091SYM0   G3W852   A0A093IA05   H9EVX2   A0A2Y9IGB6   G3RIZ2   A0A0Q3TTZ7   A0A383YXP4   A0A2U3VLL9   R7VBN6   G7Q158   A0A3Q0D4F1   A0A2K6ART2   A0A2K5V5J4   A0A096NII1   A0A2K5N1R7   G7NPC3   F6ZBL6   A0A2U4CNC3   A0A2Y9EPT2   A0A2R9ANA3   H2QB48   Q9BXC9  

KEGG

101744987    K16747 Bardet-Biedl syndrome 2 protein | (RefSeq) Bardet-Biedl syndrome 2 protein homolog

GO

GO:1905515   GO:0034464   GO:0005737   GO:0005856   GO:0016020   GO:0043005   GO:0031514   GO:0060271   GO:0036064   GO:0051877   GO:0007369   GO:0007368   GO:0032402   GO:0060170   GO:0070121   GO:0001103   GO:0040018   GO:0051216   GO:0032420   GO:0045494   GO:0048854   GO:0007288   GO:0010629   GO:0007601   GO:0005902   GO:0040015   GO:0038108   GO:0043001   GO:0021766   GO:0014824   GO:0060296   GO:0033365   GO:0042311   GO:0030534   GO:0045444   GO:0021987   GO:0021756   GO:0005815   GO:0005829   GO:0008104  

PANTHER

PTHR32465  

Subcellular location

Cell projection  
Cilium membrane  
Cytoplasm  
Cytoskeleton  
Microtubule organizing center  
Centrosome  
Centriolar satellite  

Length:

440

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0013

Exp number, first 60 AAs:

0.00041

Total prob of N-in:

0.00301

outside

1  -  440

 

 

Pi

58.353377

Theta

196.34403

Tajima's D

0.199368

CLR

0.725934

CSRT

0.426178691065447

Interpretation

Uncertain