Gene

KWMTBOMO11279

Pre Gene Modal

BGIBMGA002764

Annotation

PREDICTED:_Bardet-Biedl_syndrome_2_protein_homolog_[Bombyx_mori]

Location

Bomo_Chr19(+):2385936-2387350      View in EpiBrowser

Full name

Bardet-Biedl syndrome 2 protein homolog      

Location in the cell

Nuclear   Reliability : 1.168

CDS

ATGATCACTTTTGACTTTGACAGAGACGGTGAAAGTGAGCTGATTGTCGGCTCAGAAGATTCCTTTATTAGAGTGCTCAAGAACAATCAGTTCGTTGCGGAAATAGCAGAAACAGGGCCCGTGGTGTGCTTGTCCGTCATATCCGATGTGCGATTTGCATACGGATTAGCTAACGGTACCATAGGTATTTATGAGGACGGTGTGCGACTGTGGAGAGTTAAGGTGAATAGATTAAAGTTTAAAGTTAGCTTTATGAATTAG

Protein

MITFDFDRDGESELIVGSEDSFIRVLKNNQFVAEIAETGPVVCLSVISDVRFAYGLANGTIGIYEDGVRLWRVKVNRLKFKVSFMN

Description

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization (By similarity).

Subunit

Part of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Interacts (via C-terminus) with BBS7. Interacts (via coiled coil domain) with MKKS. Interacts with CCDC28B (By similarity).

Keywords

Cell membrane   Cell projection   Cilium   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Membrane   Protein transport   Reference proteome   Transport  

Feature

chain  Bardet-Biedl syndrome 2 protein homolog

Uniprot

H9IZS9   A0A2H1WYF7   A0A2A4JYS1   A0A3S2NMF8   A0A0L7LBP7   A0A212FNR8   + More
A0A2Z5U736   A0A194QKR5   A0A194QVK1   A0A2P2ICG5   A0A1S3D5R4   A0A2D4HMB0   A0A3P7BNA2   A0A0N4YQM8   U3JYK5   A0A0N4YLA9   A0A2D4GL04   A0A183IS31   A0A3S0Z4T9   A0A2D4ME38   A0A2R7W4X5   A0A0B1S0X9   A0A0K0DQS2   A0A3M0K9D0   A0A1V4K116   A0A091WIB8   A0A218UK11   H0Z855   A0A2J7RNG0   A0A0A9WZM5   A0A2J7RNF1   A0A2J7RNG3   A0A183FHN5   A0A3P7Y4X5   A0A369RRQ7   B3S5T1   A0A093QRB5   A0A067R1E4   A0A2I0M0I4   D6WSV9   A0A093PNL5   A0A1S3HWG6   A0A091F2R3   A0A1I8IL10   A0A1I8H331   A0A091NAH7   A0A093IA05   A0A1I8F2M2   A0A0J7L6G1   A0A267DKI8   A0A1D5PWG7   A0A267DR63   A0A267FT21   A0A195BAJ6   A0A0Q3TTZ7   A0A091KPG2   A0A087VFA9   A0A093JX48   A0A0N5E0Z5   A0A091HXX1   A0A091SL53   A0A091M2S2   A0A091P413   A0A3L8SFE6   A0A151MR61   A0A099ZJL7   A0A094LER9   A0A087QX93   A0A091GGZ7   A0A091K773   A0A151MR52   A0A093FET5   A0A091SYM0   A0A0A0A1H6   A0A091VES4   A0A210QZK0   A0A093NXT7   A0A091JXT9   K1RHW2   A0A3Q0HDC8   A0A151MR49   A0A0B2UXS5   A0A077YX28   E9IR89   H3B555   K7FYE3   A0A183U234   A0A0B1T1C4   A0A0P4VUN9   A0A1L8GEJ7   A0A2K6T6M8   A0A0N4VQP4   A0A0C9RQM1   A0A0V0SAE1   A0A093BGX6   A0A158NBF3   A0A2K5RR76   G3W852   Q99MH9   A0A016WWP3  

Pubmed

19121390    26227816    22118469    26354079    20360741    25401762    + More
30042472    18719581    24845553    23371554    18362917    19820115    26383154    26392545    15592404    30282656    22293439    28812685    22992520    21282665    9215903    17381049    27762356    21347285    21709235    11285252    25730766   

EMBL

BABH01039963    ODYU01012011    SOQ58078.1    NWSH01000348    PCG77171.1    RSAL01000034    + More
RVE51408.1    JTDY01001778    KOB72908.1    AGBW02004849    OWR55363.1    AP017484    BBB06739.1    KQ459053    KPJ04046.1    KQ461073    KPJ09563.1    IACF01006112    LAB71695.1    IACK01040135    LAA73120.1    UYSL01024273    VDL83285.1    AGTO01000569    UYSL01023034    VDL81601.1    IACJ01134850    LAA60116.1    UZAM01009747    VDP10007.1    RQTK01001345    RUS70724.1    IACM01082680    LAB31258.1    KK854291    PTY14241.1    KN610650    KHJ77551.1    QRBI01000116    RMC09141.1    LSYS01005191    OPJ78126.1    KK735695    KFR15319.1    MUZQ01000251    OWK54075.1    ABQF01035934    NEVH01002541    PNF42359.1    GBHO01033304    JAG10300.1    PNF42360.1    PNF42358.1    UZAH01025638    VDO67747.1    NOWV01000247    RDD37377.1    DS985251    EDV21848.1    KL429034    KFW91076.1    KK852996    KDR12698.1    AKCR02000054    PKK23189.1    KQ971352    EFA06343.1    KL669222    KFW75850.1    KK719362    KFO63102.1    KK844153    KFP86072.1    KK558108    KFV99519.1    LBMM01000488    KMQ98241.1    NIVC01003987    PAA49062.1    AADN05000561    NIVC01003495    PAA51154.1    NIVC01000825    PAA76394.1    KQ976540    KYM81209.1    LMAW01001170    KQK84198.1    KK748908    KFP41150.1    KL491133    KFO11301.1    KL206526    KFV83039.1    KL217899    KFP00003.1    KK474942    KFQ58715.1    KL309851    KFP52851.1    KK651192    KFQ01838.1    QUSF01000023    RLW01200.1    AKHW03005442    KYO27017.1    KL895498    KGL82624.1    KL288917    KFZ69225.1    KL225962    KFM05847.1    KL447421    KFO73397.1    KK502030    KFP19631.1    KYO27018.1    KK624614    KFV52776.1    KK938071    KFQ48491.1    KL870139    KGL86870.1    KL410965    KFR01644.1    NEDP02001154    OWF54157.1    KL224844    KFW64907.1    KK534323    KFP28956.1    JH817540    EKC41095.1    KYO27016.1    JPKZ01002602    KHN75846.1    HG805814    CDW52033.1    GL765107    EFZ16903.1    AFYH01035557    AFYH01035558    AGCU01102456    AGCU01102457    AGCU01102458    AGCU01102459    UYWY01002636    VDM28260.1    KN552384    KHJ91044.1    GDRN01095223    JAI59582.1    CM004473    OCT82270.1    UXUI01014909    VDD97739.1    GBYB01010784    GBYB01010785    JAG80551.1    JAG80552.1    JYDL01000022    KRX23631.1    KN126203    KFU87550.1    ADTU01011036    AEFK01021919    AEFK01021920    AEFK01021921    AEFK01021922    AEFK01021923    AEFK01021924    AF342738    JARK01000084    EYC43682.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000037510    UP000007151    UP000053268    + More
UP000053240    UP000079169    UP000271162    UP000038043    UP000016665    UP000050793    UP000271974    UP000035642    UP000269221    UP000190648    UP000053605    UP000197619    UP000007754    UP000235965    UP000050761    UP000253843    UP000009022    UP000027135    UP000053872    UP000007266    UP000053258    UP000085678    UP000052976    UP000095280    UP000036403    UP000215902    UP000000539    UP000078540    UP000051836    UP000053584    UP000046395    UP000054308    UP000276834    UP000050525    UP000053641    UP000053286    UP000053760    UP000053119    UP000053858    UP000053283    UP000242188    UP000054081    UP000005408    UP000189705    UP000031036    UP000030665    UP000008672    UP000007267    UP000050794    UP000267007    UP000186698    UP000233220    UP000038041    UP000274131    UP000054630    UP000005205    UP000233040    UP000007648    UP000002494    UP000024635   

PRIDE

H9IZS9    Q99MH9   

Pfam

PF14781   BBS2_N        + More
PF14783   BBS2_Mid
PF14782   BBS2_C

Interpro

IPR029429   BBS2_Mid        + More
IPR029430   BBS2_N       
IPR016616   Bardet-Biedl_syndrome_2_prot       
IPR029333   BBS2_C       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR011047   Quinoprotein_ADH-like_supfam       
IPR036322   WD40_repeat_dom_sf       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR000504   RRM_dom       
IPR001841   Znf_RING       
IPR003954   RRM_dom_euk       
IPR013083   Znf_RING/FYVE/PHD       
IPR035979   RBD_domain_sf       
IPR000571   Znf_CCCH       
IPR039515   NOT4_mRING-HC-C4C4       
IPR034261   CNOT4_RRM       

SUPFAM

SSF50998   SSF50998        + More
SSF50978   SSF50978       
SSF54928   SSF54928       

Gene 3D

2.130.10.10     3.30.40.10     3.30.70.330    

CDD

cd12438  RRM_CNOT4
cd16618  mRING-HC-C4C4_CNOT4

ProteinModelPortal

H9IZS9   A0A2H1WYF7   A0A2A4JYS1   A0A3S2NMF8   A0A0L7LBP7   A0A212FNR8   + More
A0A2Z5U736   A0A194QKR5   A0A194QVK1   A0A2P2ICG5   A0A1S3D5R4   A0A2D4HMB0   A0A3P7BNA2   A0A0N4YQM8   U3JYK5   A0A0N4YLA9   A0A2D4GL04   A0A183IS31   A0A3S0Z4T9   A0A2D4ME38   A0A2R7W4X5   A0A0B1S0X9   A0A0K0DQS2   A0A3M0K9D0   A0A1V4K116   A0A091WIB8   A0A218UK11   H0Z855   A0A2J7RNG0   A0A0A9WZM5   A0A2J7RNF1   A0A2J7RNG3   A0A183FHN5   A0A3P7Y4X5   A0A369RRQ7   B3S5T1   A0A093QRB5   A0A067R1E4   A0A2I0M0I4   D6WSV9   A0A093PNL5   A0A1S3HWG6   A0A091F2R3   A0A1I8IL10   A0A1I8H331   A0A091NAH7   A0A093IA05   A0A1I8F2M2   A0A0J7L6G1   A0A267DKI8   A0A1D5PWG7   A0A267DR63   A0A267FT21   A0A195BAJ6   A0A0Q3TTZ7   A0A091KPG2   A0A087VFA9   A0A093JX48   A0A0N5E0Z5   A0A091HXX1   A0A091SL53   A0A091M2S2   A0A091P413   A0A3L8SFE6   A0A151MR61   A0A099ZJL7   A0A094LER9   A0A087QX93   A0A091GGZ7   A0A091K773   A0A151MR52   A0A093FET5   A0A091SYM0   A0A0A0A1H6   A0A091VES4   A0A210QZK0   A0A093NXT7   A0A091JXT9   K1RHW2   A0A3Q0HDC8   A0A151MR49   A0A0B2UXS5   A0A077YX28   E9IR89   H3B555   K7FYE3   A0A183U234   A0A0B1T1C4   A0A0P4VUN9   A0A1L8GEJ7   A0A2K6T6M8   A0A0N4VQP4   A0A0C9RQM1   A0A0V0SAE1   A0A093BGX6   A0A158NBF3   A0A2K5RR76   G3W852   Q99MH9   A0A016WWP3  

KEGG

101744987    K16747 Bardet-Biedl syndrome 2 protein | (RefSeq) Bardet-Biedl syndrome 2 protein homolog

GO

GO:1905515   GO:0034464   GO:0005737   GO:0005856   GO:0016021   GO:0031514   GO:0001103   GO:0040018   GO:0051216   GO:0032420   GO:0045494   GO:0048854   GO:0007288   GO:0010629   GO:0007601   GO:0005902   GO:0040015   GO:0038108   GO:0043001   GO:0021766   GO:0060170   GO:0014824   GO:0060296   GO:0033365   GO:0036064   GO:0042311   GO:0030534   GO:0045444   GO:0021987   GO:0021756   GO:0060271   GO:0016020   GO:0043005   GO:0005815   GO:0046872   GO:0003723   GO:0007368   GO:0051877   GO:0032402   GO:0007369   GO:0070121   GO:0005515   GO:0003678   GO:0005524   GO:0006270   GO:0042555   GO:0006260   GO:0006811   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR32465  

Subcellular location

Cell projection  
Cilium membrane  
Cytoplasm  
Cytoskeleton  
Microtubule organizing center  
Centrosome  
Centriolar satellite  

Length:

86

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.26127

Exp number, first 60 AAs:

0.18062

Total prob of N-in:

0.24762

outside

1  -  86

 

 

Pi

128.235734

Theta

50.25942

Tajima's D

1.250203

CLR

0

CSRT

0.727463626818659

Interpretation

Uncertain