Gene

KWMTBOMO11256  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012581

Annotation

PREDICTED:_pyroglutamyl-peptidase_1_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr19(-):2045831-2048799      View in EpiBrowser

Full name

Pyroglutamyl-peptidase 1      

Alternative Name

5-oxoprolyl-peptidase
Pyroglutamyl aminopeptidase I
Pyroglutamyl-peptidase I
Pyrrolidone-carboxylate peptidase

Location in the cell

Cytoplasmic   Reliability : 2.065

CDS

ATGTCTAATGACTTAGATTTTTTATTTAAACCCATAATAATGGTAACTGGTTTCGGCCCGTTTGCTAATCATCCAGTGAACGCAAGTTGGGAAGCCGTGAAACTTTTAGATAAACAAGAAATAGAAAATAAACACAGGTGCGAGCTTGTTTTGATTGAAATACCAGTAACTTATGAAAACGTGGATGAGTTTGTACCTGCGCTGTGGGAGACACACACCCCTAAGCTAATGATCCATGTGGGGGTGTCCAGTATAGCTAATGAACTGACTCTAGAGGTTCAAGCACATAAGAAAGGCTATCAACGTTTGGATTATTTTGACAAATGTCCTGCTAATCATGTCTGTACAGCAGACGGAGCAGTCAGGATCCATACTAAGCTTAATGTTGAAAGAATATGTAAGGAATTCAATGATGCAAGCCCTGAAGACTCCACCAGGGCTGTGAGCTCCAAAGATGCTGGCAGATATTTGTGTGAGTACATCTACTACACATCGCTGTCCGTGGATAATAGCCGTACATTGTTTGTCCACGTCCCGGACACTAATGTGTACTCGTCGGAACAAACCGCTCGAGGCTTGCAGCGCATCATAGAGCTCTGCATCGAACAGATCCACGAGGCCGAAGCAGCGACCCGCCTCGCAGCCACTTTGCGAGACACTGGGCTCGCTGACGCCGAGAAGGAAGCGATCGATAACAAAATATGA

Protein

MSNDLDFLFKPIIMVTGFGPFANHPVNASWEAVKLLDKQEIENKHRCELVLIEIPVTYENVDEFVPALWETHTPKLMIHVGVSSIANELTLEVQAHKKGYQRLDYFDKCPANHVCTADGAVRIHTKLNVERICKEFNDASPEDSTRAVSSKDAGRYLCEYIYYTSLSVDNSRTLFVHVPDTNVYSSEQTARGLQRIIELCIEQIHEAEAATRLAATLRDTGLADAEKEAIDNKI

Description

Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

Catalytic Activity

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.

Subunit

Monomer.

Similarity

Belongs to the peptidase C15 family.

Keywords

Complete proteome   Cytoplasm   Hydrolase   Protease   Reference proteome   Thiol protease   Alternative splicing  

Feature

chain  Pyroglutamyl-peptidase 1
splice variant  In isoform 2.

Uniprot

H9JSS0   A0A0N0P9F5   A0A212F2H9   A0A2A4JUJ9   A0A2H1VI39   A0A2W1BRH9   + More
A0A0N0PAP3   A0A0L7LC28   A0A310SD72   A0A1B6MIU3   A0A2P8YKU8   A0A1B6ETX2   A0A067R088   N6TWM3   U4U6T9   R7UQZ6   K7IZ60   A0A232F0R1   A0A1B6HXA1   A0A088AUA3   A0A2W1BU95   A0A2A4JTD9   A0A026X2B0   A0A1W4X8V3   A0A0J7KYK1   A0A1B6CF49   A0A195CG94   E9J327   A0A195BP08   A0A158NDJ0   A0A1W2WRK7   A0A0P5EBC4   A0A195F408   A0A0P5SRS1   G3U831   A0A2Y9E162   A0A0P6IY00   A0A3Q1J390   I3JW96   H3B848   E9GVL9   A0A154PMF0   A0A3Q3LH84   A0A3Q0SR15   A0A0P5WTZ2   A0A340XI21   A0A3Q3IC38   F7DWR4   M3YVW7   Q9ESW8   E1BN15   Q76IC5   U6CWQ3   A0A2Y9IXV4   A0A3P4NM46   A0A2Y9GHZ7   A0A2U3YRV4   G3RNX9   A0A2I3HNV5   A0A3Q7Q5W4   A0A2R9ABG4   A0A2U3W8U2   H2NY33   H2QFT0   Q9NXJ5   A0A3Q2P0A7   K1RI78   D6WQP3   A0A250XW98   A0A2K5SJH8   A0A2K5M4F2   A0A337SSF8   A0A3Q1GXG0   A0A286XD03   A0A3Q7X119   A0A2K6MYK8   A0A0A0MW47   G7PWZ2   F7GUB6   A0A2Y9TJI8   A0A3Q1BHP2   A0A3P8THZ2   I3M3B1   A0A2G8KPX1   A0A2U9BKS2   A0A2K6G1Z1   A0A3B4UIV7   A0A2K6TML9   A0A2K6QVY8   A0A3B4AYL8   A0A0B8S033   A0A287A7X7   A0A1A6HEA6   U3F2T7   H0XC16   A0A2T7NG70   A0A341D8D6   V4BLK9  

EC Number

3.4.19.3

Pubmed

19121390    26354079    22118469    28756777    26227816    29403074    + More
24845553    23537049    23254933    20075255    28648823    24508170    30249741    21282665    21347285    12203911    25186727    9215903    21292972    17495919    12651114    16141072    15489334    21183079    19393038    14600395    22398555    22722832    16136131    14702039    15057824    22992520    18362917    19820115    28087693    17975172    21993624    22002653    17431167    25319552    29023486    25362486    25463417    30723633    25243066   

EMBL

BABH01035995    KQ459449    KPJ00883.1    AGBW02010741    OWR47937.1    NWSH01000613    + More
PCG75304.1    ODYU01002684    SOQ40505.1    KZ149965    PZC76215.1    KQ461184    KPJ07526.1    JTDY01001734    KOB73043.1    KQ775154    OAD52277.1    GEBQ01027212    GEBQ01024855    GEBQ01020351    GEBQ01004109    JAT12765.1    JAT15122.1    JAT19626.1    JAT35868.1    PYGN01000522    PSN44877.1    GECZ01028402    JAS41367.1    KK852804    KDR16265.1    APGK01049399    KB741150    ENN73675.1    KB632095    ERL88782.1    AMQN01006692    KB298957    ELU08570.1    NNAY01001428    OXU23998.1    GECU01034736    GECU01028398    JAS72970.1    JAS79308.1    PZC76216.1    PCG75305.1    KK107020    QOIP01000004    EZA62455.1    RLU24263.1    LBMM01001895    KMQ95592.1    GEDC01025249    JAS12049.1    KQ977827    KYM99416.1    GL768055    EFZ12786.1    KQ976424    KYM88252.1    ADTU01012615    GDIP01144011    JAJ79391.1    KQ981820    KYN35198.1    GDIP01136252    JAL67462.1    GEBF01006680    JAN96952.1    AERX01001299    AFYH01045573    AFYH01045574    AFYH01045575    AFYH01045576    GL732568    EFX76434.1    KQ434977    KZC12917.1    GDIP01082489    JAM21226.1    AEYP01051423    AEYP01051424    AEYP01051425    AEYP01051426    AJ278829    AK003373    AK012658    AK047835    AK049632    BC051938    BC098645    AB098134    HAAF01002456    CCP74282.1    CYRY02025921    VCW98545.1    CABD030112305    CABD030112306    ADFV01090303    ADFV01090304    ADFV01090305    ADFV01090306    ADFV01090307    ADFV01090308    AJFE02060359    AJFE02060360    AJFE02060361    AJFE02060362    AJFE02060363    ABGA01293369    ABGA01293370    ABGA01293371    ABGA01293372    NDHI03003519    PNJ28431.1    AACZ04031542    GABF01006781    GABE01005924    NBAG03000278    JAA15364.1    JAA38815.1    PNI50483.1    AJ278828    AK000215    AK289968    AK294497    AC008397    CH471106    BC042138    JH816364    EKC41260.1    KQ971354    EFA06046.2    GFFV01004318    JAV35627.1    AANG04000016    AAKN02046889    AHZZ02013801    AQIA01034795    CM001294    EHH59366.1    JSUE03021150    JSUE03021151    JU473664    CM001271    AFH30468.1    EHH29814.1    AGTP01071281    MRZV01000439    PIK49990.1    CP026249    AWP04286.1    GBZA01000480    JAG69288.1    AEMK02000010    DQIR01158432    HDB13909.1    LZPO01034887    OBS76601.1    GAMT01009563    GAMS01007274    GAMQ01001062    GAMP01003266    JAB02298.1    JAB15862.1    JAB40789.1    JAB49489.1    AAQR03128801    AAQR03128802    AAQR03128803    AAQR03128804    AAQR03128805    AAQR03128806    AAQR03128807    AAQR03128808    PZQS01000013    PVD20177.1    KB202567    ESO89584.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000218220    UP000053240    UP000037510    + More
UP000245037    UP000027135    UP000019118    UP000030742    UP000014760    UP000002358    UP000215335    UP000005203    UP000053097    UP000279307    UP000192223    UP000036403    UP000078542    UP000078540    UP000005205    UP000078541    UP000007646    UP000248480    UP000265040    UP000005207    UP000008672    UP000000305    UP000076502    UP000261640    UP000261340    UP000265300    UP000261600    UP000002280    UP000000715    UP000000589    UP000009136    UP000002494    UP000248482    UP000248481    UP000245341    UP000001519    UP000001073    UP000286641    UP000240080    UP000245340    UP000001595    UP000002277    UP000005640    UP000265000    UP000005408    UP000007266    UP000233040    UP000233060    UP000011712    UP000257200    UP000005447    UP000286642    UP000233180    UP000028761    UP000009130    UP000233100    UP000006718    UP000248484    UP000257160    UP000265080    UP000005215    UP000230750    UP000246464    UP000233160    UP000261420    UP000233220    UP000233200    UP000261520    UP000008227    UP000092124    UP000008225    UP000005225    UP000245119    UP000252040    UP000030746   

PRIDE

H9JSS0    Q9ESW8    Q76IC5    Q9NXJ5   

Pfam

PF01470   Peptidase_C15        + More
PF05485   THAP
PF14712   Snapin_Pallidin

Interpro

IPR000816   Peptidase_C15        + More
IPR029761   PGP-I_metazoa       
IPR036440   Peptidase_C15-like_sf       
IPR016125   Peptidase_C15-like       
IPR006612   THAP_Znf       
IPR038441   THAP_Znf_sf       
IPR033693   PGPEP1_Glu_AS       
IPR033694   PGPEP1_Cys_AS       
IPR028119   Snapin/Pallidin/Snn1       

SUPFAM

SSF53182   SSF53182       

Gene 3D

3.40.630.20     3.30.40.180    

CDD

cd00501  Peptidase_C15

ProteinModelPortal

H9JSS0   A0A0N0P9F5   A0A212F2H9   A0A2A4JUJ9   A0A2H1VI39   A0A2W1BRH9   + More
A0A0N0PAP3   A0A0L7LC28   A0A310SD72   A0A1B6MIU3   A0A2P8YKU8   A0A1B6ETX2   A0A067R088   N6TWM3   U4U6T9   R7UQZ6   K7IZ60   A0A232F0R1   A0A1B6HXA1   A0A088AUA3   A0A2W1BU95   A0A2A4JTD9   A0A026X2B0   A0A1W4X8V3   A0A0J7KYK1   A0A1B6CF49   A0A195CG94   E9J327   A0A195BP08   A0A158NDJ0   A0A1W2WRK7   A0A0P5EBC4   A0A195F408   A0A0P5SRS1   G3U831   A0A2Y9E162   A0A0P6IY00   A0A3Q1J390   I3JW96   H3B848   E9GVL9   A0A154PMF0   A0A3Q3LH84   A0A3Q0SR15   A0A0P5WTZ2   A0A340XI21   A0A3Q3IC38   F7DWR4   M3YVW7   Q9ESW8   E1BN15   Q76IC5   U6CWQ3   A0A2Y9IXV4   A0A3P4NM46   A0A2Y9GHZ7   A0A2U3YRV4   G3RNX9   A0A2I3HNV5   A0A3Q7Q5W4   A0A2R9ABG4   A0A2U3W8U2   H2NY33   H2QFT0   Q9NXJ5   A0A3Q2P0A7   K1RI78   D6WQP3   A0A250XW98   A0A2K5SJH8   A0A2K5M4F2   A0A337SSF8   A0A3Q1GXG0   A0A286XD03   A0A3Q7X119   A0A2K6MYK8   A0A0A0MW47   G7PWZ2   F7GUB6   A0A2Y9TJI8   A0A3Q1BHP2   A0A3P8THZ2   I3M3B1   A0A2G8KPX1   A0A2U9BKS2   A0A2K6G1Z1   A0A3B4UIV7   A0A2K6TML9   A0A2K6QVY8   A0A3B4AYL8   A0A0B8S033   A0A287A7X7   A0A1A6HEA6   U3F2T7   H0XC16   A0A2T7NG70   A0A341D8D6   V4BLK9  

PDB

4HPS     E-value=6.32337e-10,     Score=151

KEGG

101746384    K01304 pyroglutamyl-peptidase [EC:3.4.19.3] | (RefSeq) pyroglutamyl-peptidase 1

GO

GO:0005829   GO:0016920   GO:0003677   GO:0004177   GO:0006508   GO:0008234   GO:0008233   GO:0003735   GO:0006412   GO:0015935   GO:0006811   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR23402   PTHR23402:SF16  

Subcellular location

Cytoplasm  

Length:

234

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.16686

Exp number, first 60 AAs:

0.16545

Total prob of N-in:

0.02457

outside

1  -  234

 

 

Pi

25.357206

Theta

121.673289

Tajima's D

-2.403151

CLR

537.4096

CSRT

0.00144992750362482

Interpretation

Possibly Positive selection