Gene

KWMTBOMO11253  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012582

Annotation

PREDICTED:_cleavage_and_polyadenylation_specificity_factor_73_[Bombyx_mori]

Location

Bomo_Chr19(-):2023298-2027979      View in EpiBrowser

Full name

Ubiquitinyl hydrolase 1      

Location in the cell

Cytoplasmic   Reliability : 1.225 PlasmaMembrane   Reliability : 1.739

CDS

ATGACTACAAATCCAAGAAAAGGCACTGATCCAGTGCCTGCGGAGGAAAGCGATCAATTGACAATAAGACCACTTGGAGCTGGCCAAGAAGTTGGCAGATCATGCATCATGTTGGAGTTCAAAGGGAAAAAGATAATGTTGGACTGTGGCATCCATCCTGGTTTGTCTGGAATGGACGCCCTACCCTTCATAGACCTTATAGAGGCAGACGAAGTGGATCTTCTGTTAGTTTCACATTTTCATTTGGACCACAGTGGAGCCCTTCCGTGGTTCCTGACGAAGACTTCCTTCAAAGGTCGAGTTTTCATGACACATGCCACTAAGGCTATCTACAGATGGCTCGTTTCTGATTATATTAAAGTTAGCAACATATCAACAGAACAAATGTTGTATACGGAATCGGATCTAGAAAATTCAATGGACAGAATAGAAACTATAAACTTCCATGAAGAAAGAGATGTACGGGGTGTCAAATTTTGGGCTTACAATGCTGGACATGTACTCGGAGCAGCCATGTTTATGATTGAAATAGCTGGAGTCAAGATATTATACACGGGAGATTTTTCAAGACAAGAGGATAGACATTTGATGGCTGCAGAGATACCGACGGTTCATCCTGATGTTTTGATTACTGAGTCCACGTACGGCACGCACATCCACGAGAAGCGCGAGGAGCGGGAGAGTCGCTTCACGGGGCTGGTCAGCGACATCGTGGGGCGCGGCGGCCGCTGCCTCATCCCCGTGTTCGCGCTGGGCCGCGCGCAGGAGCTGCTGCTCATACTCGACGAGTACTGGTCGCTGCACCCCGAGCTGCAAGACATTCCCATATACTACGCGTCCTCACTGGCCAAGAAGTGCATGGCGGTGTACCAGACCTATGTTAACGCGATGAACGACCGCATCCGGCGCCAGATCGCTATCAACAACCCCTTCGTGTTTAGACACATCTCCAACCTGAAGTTGGGCACAAATGACTTTAACTCTGTCTAA

Protein

MTTNPRKGTDPVPAEESDQLTIRPLGAGQEVGRSCIMLEFKGKKIMLDCGIHPGLSGMDALPFIDLIEADEVDLLLVSHFHLDHSGALPWFLTKTSFKGRVFMTHATKAIYRWLVSDYIKVSNISTEQMLYTESDLENSMDRIETINFHEERDVRGVKFWAYNAGHVLGAAMFMIEIAGVKILYTGDFSRQEDRHLMAAEIPTVHPDVLITESTYGTHIHEKREERESRFTGLVSDIVGRGGRCLIPVFALGRAQELLLILDEYWSLHPELQDIPIYYASSLAKKCMAVYQTYVNAMNDRIRRQIAINNPFVFRHISNLKLGTNDFNSV

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Similarity

Belongs to the peptidase C19 family.

Uniprot

A0A2H1VQI7   A0A2A4JX46   A0A0N1IMS2   A0A0N1IEX9   A0A212F2I3   A0A2J7R5C5   + More
A0A067RDR8   A0A139WFW0   A0A1Y1LBJ4   A0A1B6DJS3   E2AIH9   A0A1B6HGW1   A0A1B6ET64   A0A1B6KSK1   A0A2A3EHP0   A0A088A3T2   A0A154PS55   A0A0L7QWD3   A0A1B6I2X2   A0A026WY67   K7J2M9   A0A232F768   A0A0J7KBN9   E9J3A8   A0A195B7C4   A0A195FNY7   A0A158NGY1   A0A151ID90   A0A195DWF4   F4X126   T1JIA8   E2BWA8   B0X8N8   A0A1Q3F4J9   A0A0P5UYR6   A0A0P5B7F1   A0A0P5UET1   E9H6R0   A0A0P5ZCM9   A0A0P5VMA9   A0A0P4Y968   A0A0P5MRA6   A0A0P5LUC8   A0A0P5HI95   A0A0P5RC32   A0A0P6G968   Q170J6   L7LUX8   A0A224YLX6   A0A131Z7V5   A0A151XD31   A0A0P6F1X4   A0A0P5VCY2   A0A336MGA6   A0A336M7S8   A0A1B0GJR3   A0A0A9YYP8   A0A1L8DH05   A0A023F454   T1HZV1   A0A069DVS5   A0A0V0G9S7   A0A0P5V502   B7P2D2   A0A1L8DGC9   V5H4V8   A0A0L0CNN5   A0A2R7X216   A0A1I8PMU4   A0A2R5LL73   A0A1A9W2T5   A0A1A9Y9E4   A0A1A9ZEA1   A0A1I8MBA9   A0A1B0BGV6   E0VDY7   W8CAQ0   A0A0K8VB67   A0A1A9V5Z7   A0A0A1WZH2   A0A034VDT8   A0A084W029   A0A131XG05   A0A182IZ35   A0A1W4UK58   A0A182LYH6   A0A1J1IAV5   A0A182K254   B4M3X4   A0A0P6BGC3   A0A182VW06   B4K8L8   A0A182X9D1   Q299N6   B4G5H0   A0A182YHX5   A0A182L8K4   A0A182TS82   A0A182HKB7   A0A182RSD2  

EC Number

3.4.19.12

Pubmed

26354079    22118469    24845553    18362917    19820115    28004739    + More
20798317    24508170    30249741    20075255    28648823    21282665    21347285    21719571    21292972    17510324    25576852    28797301    26830274    25401762    26823975    25474469    26334808    25765539    26108605    25315136    20566863    24495485    25830018    25348373    24438588    28049606    17994087    15632085    25244985    20966253   

EMBL

ODYU01003846    SOQ43113.1    NWSH01000411    PCG76587.1    KQ459449    KPJ00887.1    + More
KQ461184    KPJ07521.1    AGBW02010741    OWR47933.1    NEVH01006994    PNF36035.1    KK852527    KDR22016.1    KQ971352    KYB26687.1    GEZM01063106    JAV69305.1    GEDC01011420    JAS25878.1    GL439791    EFN66769.1    GECU01033749    JAS73957.1    GECZ01028698    GECZ01022214    JAS41071.1    JAS47555.1    GEBQ01025544    JAT14433.1    KZ288239    PBC31295.1    KQ435041    KZC14174.1    KQ414714    KOC62927.1    GECU01026432    JAS81274.1    KK107063    QOIP01000005    EZA60982.1    RLU23084.1    NNAY01000831    OXU26288.1    LBMM01010055    KMQ87697.1    GL768061    EFZ12664.1    KQ976574    KYM80155.1    KQ981387    KYN42027.1    ADTU01015321    KQ977985    KYM98347.1    KQ980204    KYN17240.1    GL888525    EGI59837.1    JH431327    GL451103    EFN80012.1    DS232495    EDS42630.1    GFDL01012592    JAV22453.1    GDIP01107537    JAL96177.1    GDIP01189028    JAJ34374.1    GDIP01115436    JAL88278.1    GL732598    EFX72593.1    GDIP01045707    GDIQ01036911    LRGB01002993    JAM58008.1    JAN57826.1    KZS05118.1    GDIP01098137    JAM05578.1    GDIP01234527    JAI88874.1    GDIQ01175248    JAK76477.1    GDIQ01175249    JAK76476.1    GDIQ01227098    JAK24627.1    GDIQ01102840    JAL48886.1    GDIQ01055463    JAN39274.1    CH477473    EAT40345.1    GACK01009622    JAA55412.1    GFPF01006809    MAA17955.1    GEDV01002306    JAP86251.1    KQ982294    KYQ58286.1    GDIQ01055462    JAN39275.1    GDIP01102041    JAM01674.1    UFQS01000883    UFQT01000883    SSX07493.1    SSX27833.1    UFQS01000673    UFQT01000673    SSX06015.1    SSX26372.1    AJWK01022144    AJWK01022145    AJWK01022146    GBHO01007381    GBHO01007380    GBRD01013468    GDHC01004914    JAG36223.1    JAG36224.1    JAG52358.1    JAQ13715.1    GFDF01008345    JAV05739.1    GBBI01002432    JAC16280.1    ACPB03022312    GBGD01000691    JAC88198.1    GECL01001986    JAP04138.1    GDIP01104938    JAL98776.1    ABJB010540581    DS621961    EEC00754.1    GFDF01008566    JAV05518.1    GANP01006423    JAB78045.1    JRES01000142    KNC33866.1    KK856473    PTY25849.1    GGLE01006137    MBY10263.1    JXJN01014010    DS235088    EEB11593.1    GAMC01005546    JAC01010.1    GDHF01016201    JAI36113.1    GBXI01010226    JAD04066.1    GAKP01018690    GAKP01018688    JAC40262.1    ATLV01019081    KE525262    KFB43573.1    GEFH01003074    JAP65507.1    AXCM01001239    CVRI01000044    CRK96692.1    CH940652    EDW59335.1    GDIP01015566    JAM88149.1    CH933806    EDW14417.1    CM000070    EAL27667.2    CH479179    EDW24836.1    APCN01000825   

Proteomes

UP000218220    UP000053268    UP000053240    UP000007151    UP000235965    UP000027135    + More
UP000007266    UP000000311    UP000242457    UP000005203    UP000076502    UP000053825    UP000053097    UP000279307    UP000002358    UP000215335    UP000036403    UP000078540    UP000078541    UP000005205    UP000078542    UP000078492    UP000007755    UP000008237    UP000002320    UP000000305    UP000076858    UP000008820    UP000075809    UP000092461    UP000015103    UP000001555    UP000037069    UP000095300    UP000091820    UP000092443    UP000092445    UP000095301    UP000092460    UP000009046    UP000078200    UP000030765    UP000075880    UP000192221    UP000075883    UP000183832    UP000075881    UP000008792    UP000075920    UP000009192    UP000076407    UP000001819    UP000008744    UP000076408    UP000075882    UP000075902    UP000075840    UP000075900   

Pfam

PF10996   Beta-Casp        + More
PF16661   Lactamase_B_6
PF07521   RMMBL
PF11718   CPSF73-100_C
PF00753   Lactamase_B
PF07690   MFS_1
PF17807   zf-UBP_var
PF02148   zf-UBP
PF00443   UCH
PF00627   UBA

Interpro

IPR011108   RMMBL        + More
IPR036866   RibonucZ/Hydroxyglut_hydro       
IPR022712   Beta_Casp       
IPR021718   CPSF73-100_C       
IPR001279   Metallo-B-lactamas       
IPR013087   Znf_C2H2_type       
IPR020846   MFS_dom       
IPR011701   MFS       
IPR036259   MFS_trans_sf       
IPR041432   UBP13_Znf-UBP_var       
IPR018200   USP_CS       
IPR038765   Papain-like_cys_pep_sf       
IPR015940   UBA       
IPR001394   Peptidase_C19_UCH       
IPR001607   Znf_UBP       
IPR013083   Znf_RING/FYVE/PHD       
IPR028889   USP_dom       

SUPFAM

SSF56281   SSF56281        + More
SSF103473   SSF103473       
SSF54001   SSF54001       

Gene 3D

3.60.15.10     3.30.40.10    

CDD

cd06174  MFS

ProteinModelPortal

A0A2H1VQI7   A0A2A4JX46   A0A0N1IMS2   A0A0N1IEX9   A0A212F2I3   A0A2J7R5C5   + More
A0A067RDR8   A0A139WFW0   A0A1Y1LBJ4   A0A1B6DJS3   E2AIH9   A0A1B6HGW1   A0A1B6ET64   A0A1B6KSK1   A0A2A3EHP0   A0A088A3T2   A0A154PS55   A0A0L7QWD3   A0A1B6I2X2   A0A026WY67   K7J2M9   A0A232F768   A0A0J7KBN9   E9J3A8   A0A195B7C4   A0A195FNY7   A0A158NGY1   A0A151ID90   A0A195DWF4   F4X126   T1JIA8   E2BWA8   B0X8N8   A0A1Q3F4J9   A0A0P5UYR6   A0A0P5B7F1   A0A0P5UET1   E9H6R0   A0A0P5ZCM9   A0A0P5VMA9   A0A0P4Y968   A0A0P5MRA6   A0A0P5LUC8   A0A0P5HI95   A0A0P5RC32   A0A0P6G968   Q170J6   L7LUX8   A0A224YLX6   A0A131Z7V5   A0A151XD31   A0A0P6F1X4   A0A0P5VCY2   A0A336MGA6   A0A336M7S8   A0A1B0GJR3   A0A0A9YYP8   A0A1L8DH05   A0A023F454   T1HZV1   A0A069DVS5   A0A0V0G9S7   A0A0P5V502   B7P2D2   A0A1L8DGC9   V5H4V8   A0A0L0CNN5   A0A2R7X216   A0A1I8PMU4   A0A2R5LL73   A0A1A9W2T5   A0A1A9Y9E4   A0A1A9ZEA1   A0A1I8MBA9   A0A1B0BGV6   E0VDY7   W8CAQ0   A0A0K8VB67   A0A1A9V5Z7   A0A0A1WZH2   A0A034VDT8   A0A084W029   A0A131XG05   A0A182IZ35   A0A1W4UK58   A0A182LYH6   A0A1J1IAV5   A0A182K254   B4M3X4   A0A0P6BGC3   A0A182VW06   B4K8L8   A0A182X9D1   Q299N6   B4G5H0   A0A182YHX5   A0A182L8K4   A0A182TS82   A0A182HKB7   A0A182RSD2  

PDB

2I7V     E-value=6.61516e-161,     Score=1455

KEGG

101737197    K14403 cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] | (RefSeq) cleavage a

PATHWAY

03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)

GO

GO:0008409   GO:0006398   GO:0004521   GO:0005847   GO:0003723   GO:0006378   GO:0003676   GO:0004527   GO:0016021   GO:0055085   GO:0016579   GO:0036459   GO:0008270   GO:0006511  

Length:

329

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

11.7882

Exp number, first 60 AAs:

0.00544

Total prob of N-in:

0.52977

outside

1  -  329

 

 

Pi

227.966377

Theta

189.135586

Tajima's D

0.601723

CLR

0.133622

CSRT

0.542872856357182

Interpretation

Uncertain