Gene

KWMTBOMO11247

Pre Gene Modal

BGIBMGA012620

Annotation

PREDICTED:_protein_prickle-like_[Bombyx_mori]

Location

Bomo_Chr19(+):1869615-1883578      View in EpiBrowser

Full name

Metalloendopeptidase       + More
Protein prickle      
Protein espinas      

Alternative Name

Protein spiny legs

Location in the cell

Nuclear   Reliability : 2.617

CDS

ATGTCGCTATCCCCCCATCCAGTGCCTCAAGGGAAGTTCAGGGGTCTACTAGAACACGCTGAACGGTTGATGAAACCAGTGGATCCTCATCGGCATTCTCAAAGCGACGACGATTCCGGATGTGCTTTGGAAGAGTATACGTGGGTTCCGCCTGGATTGAGACCAGAACAGGTCCATCTTTACTTCTCAGCACTTCCGGAAGACAAGGTCCCGTACGTGAATAGCGTAGGGGAGAGGTACCGCCTCAAGCAACTACTTCAACAACTTCCACCTCAAGATAATGAGGTTCGGTACTGCCATGCTTTATCTGATGAAGAGAGGAAGGAGTTGAGGCTGTTCAGCGCACAGAGGAAACGCGAGGCCCTGGGTAGAGGACAGGCGAGGCAGCTCCACGCATCGGCGCCTTGCGAGAGGAGTGGATCGTGA

Protein

MSLSPHPVPQGKFRGLLEHAERLMKPVDPHRHSQSDDDSGCALEEYTWVPPGLRPEQVHLYFSALPEDKVPYVNSVGERYRLKQLLQQLPPQDNEVRYCHALSDEERKELRLFSAQRKREALGRGQARQLHASAPCERSGS

Description

Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye (By similarity).
Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. Correct expression of the alternative isoforms is required for PCP signaling in imaginal disks. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye.

Cofactor

Zn(2+)

Subunit

Interacts with dsh; PET and LIM domains interact with dsh DEP domain, in wing cells. Interacts with Vang in photoreceptor cells (By similarity).
Interacts with dsh; PET and LIM domains interact with dsh DEP domain, in wing cells. Interacts with Vang in photoreceptor cells.

Similarity

Belongs to the prickle / espinas / testin family.

Keywords

Cell membrane   Complete proteome   Developmental protein   LIM domain   Membrane   Metal-binding   Reference proteome   Repeat   Zinc   Alternative splicing  

Feature

chain  Protein prickle
splice variant  In isoform B.

Uniprot

A0A2H1V5P8   A0A212F2G1   A0A3S2NPD8   A0A2A4JX68   A0A2W1BSM4   H9JSV8   + More
A0A0N0P9S6   A0A1B6MDH1   A0A1B6GXL9   A0A1W4WID4   A0A1B6DJX5   D6WPW4   U4U4V9   A0A336K203   A0A336LMA4   A0A336K8B4   A0A1Y1NDG2   W5JT26   A0A182FIB0   A0A2M4AG89   A0A2M4AFY9   A0A182TBX7   A0A1B0AYM5   A0A2M4AEA4   A0A2M4AEI1   A0A2M4AE79   A0A182WIT6   A0A182QDT9   A0A2S2NDT6   A0A182MN04   A0A182NHP1   A0A182P9V8   A0A182RFQ4   A0A1A9W160   A0A034V1S2   B4QE78   A0A182XZH5   A0A1B0AAU4   A0A1J1I8E1   A0A182X6G2   Q7QJT4   A0A182I3R6   A0A182JEV1   A0A182KRW2   A0A0L7LM11   A0A2P2HYN0   A0A2R7X3E7   E9G6K1   A0A0A1X7J1   B4GCL9   A0A2S2N8J4   A0A2S2QRT3   B4J3Z0   A0A0K8TYQ3   B4MPX6   A0A1I8MQV6   Q292U5   A1Z6W3-2   A0A2H8TJM4   F3YDG0   A0A0Q5WPJ4   B4QDW0   E2QC70   Q9U1I1   B3NAF9   A1Z6W3   A1Z6W3-3   J9JLZ2   A0A3B0JI68   B4HQQ2   B4P1E1   A0A0P6G1G6   A0A0B4KED7   B3MHQ1   A0A0B4KEK5   B4J405   A0A0J9R8C4   A0A0P5C5Q7   A0A1W4V1C8   B3NAH4   A0A0P5CI28   A0A0J9TV34   B4MFG1   A0A0P6F0X0   A0A0P5LCT1   W8BTE7   A0A0J9R8C8   A0A0P6FNR5   A0A0P6G6B4   A0A0P5G7V5   A0A1W4V210   B4GCM4   A0A0P5G751   A0A3B0IYY3   A0A0A1XE64   A0A1W4VF77   A0A0P5LHW2   A0A0R3NRM5   A0A0K8TX40  

EC Number

3.4.24.-

Pubmed

22118469    28756777    19121390    26354079    18362917    19820115    + More
23537049    28004739    20920257    23761445    25348373    17994087    25244985    12364791    20966253    26227816    21292972    25830018    25315136    15632085    10485852    10731132    12537572    12015986    12941693    12642492    15937478    12537568    12537573    12537574    16110336    17569856    17569867    12537569    17550304    22936249    24495485   

EMBL

ODYU01000784    SOQ36096.1    AGBW02010753    OWR47914.1    RSAL01000017    RVE52914.1    + More
NWSH01000411    PCG76591.1    KZ149965    PZC76207.1    BABH01035978    BABH01035979    BABH01035980    KQ459449    KPJ00894.1    GEBQ01005994    JAT33983.1    GECZ01002612    JAS67157.1    GEDC01011388    JAS25910.1    KQ971354    EFA06885.1    KB631648    ERL85005.1    UFQS01000067    UFQT01000067    SSW98994.1    SSX19376.1    SSW98992.1    SSX19374.1    SSW98993.1    SSX19375.1    GEZM01005749    GEZM01005748    JAV95942.1    ADMH02000160    ETN67532.1    GGFK01006475    MBW39796.1    GGFK01006379    MBW39700.1    JXJN01005875    JXJN01005876    JXJN01005877    JXJN01005878    JXJN01005879    GGFK01005759    MBW39080.1    GGFK01005868    MBW39189.1    GGFK01005772    MBW39093.1    AXCN02000591    GGMR01002668    MBY15287.1    AXCM01000153    GAKP01023256    JAC35700.1    CM000362    EDX05987.1    CVRI01000043    CRK96002.1    AAAB01008807    APCN01000218    JTDY01000684    KOB76236.1    IACF01001157    LAB66873.1    KK856713    PTY26312.1    GL732533    EFX84948.1    GBXI01007033    JAD07259.1    CH479181    EDW31467.1    GGMR01000922    MBY13541.1    GGMS01011264    MBY80467.1    CH916367    EDW01573.1    GDHF01032921    JAI19393.1    CH963849    EDW74165.1    CM000071    EAL24766.1    AJ243708    AJ243710    AJ243709    AE013599    AAF59281.2    CAB57345.3    GFXV01002542    MBW14347.1    BT126321    AEB66928.1    CH954177    KQS70970.1    EDX05972.1    AAM68907.1    AJ251892    AY094898    BT030763    AAF59292.2    AAM11251.1    CAB64381.1    EDV59713.1    ABLF02031445    ABLF02031456    ABLF02031459    OUUW01000001    SPP73099.1    CH480816    EDW46712.1    CM000157    EDW89143.2    GDIQ01042199    JAN52538.1    AGB93293.1    CH902619    EDV35887.2    AGB93294.1    EDW01588.1    CM002911    KMY91919.1    GDIP01175122    JAJ48280.1    EDV59728.2    GDIP01175123    JAJ48279.1    KMY91925.1    CH940667    EDW57330.2    GDIQ01056544    JAN38193.1    GDIQ01173399    JAK78326.1    GAMC01010064    JAB96491.1    KMY91924.1    GDIQ01056543    JAN38194.1    GDIQ01056542    JAN38195.1    GDIQ01245332    JAK06393.1    EDW31472.1    GDIQ01245331    GDIQ01245330    JAK06395.1    SPP73107.1    GBXI01005057    JAD09235.1    GDIQ01173400    JAK78325.1    KRT01536.1    GDHF01033265    JAI19049.1   

Proteomes

UP000007151    UP000283053    UP000218220    UP000005204    UP000053268    UP000192223    + More
UP000007266    UP000030742    UP000000673    UP000069272    UP000075901    UP000092460    UP000075920    UP000075886    UP000075883    UP000075884    UP000075885    UP000075900    UP000091820    UP000000304    UP000076408    UP000092445    UP000183832    UP000076407    UP000007062    UP000075840    UP000075880    UP000075882    UP000037510    UP000000305    UP000008744    UP000001070    UP000007798    UP000095301    UP000001819    UP000000803    UP000008711    UP000007819    UP000268350    UP000001292    UP000002282    UP000007801    UP000192221    UP000008792   

PRIDE

H9JSV8    Q7QJT4    A1Z6W3    Q9U1I1   

Pfam

PF06297   PET        + More
PF00412   LIM
PF01400   Astacin

Interpro

IPR033723   PET_prickle        + More
IPR010442   PET_domain       
IPR033726   LIM2_prickle       
IPR033727   LIM3_prickle       
IPR001781   Znf_LIM       
IPR033725   LIM1_prickle       
IPR001190   SRCR       
IPR001506   Peptidase_M12A       
IPR034035   Astacin-like_dom       
IPR006026   Peptidase_Metallo       
IPR024079   MetalloPept_cat_dom_sf       
IPR029063   SAM-dependent_MTases       

SUPFAM

SSF53335   SSF53335       

Gene 3D

3.40.390.10    

CDD

cd09827  PET_Prickle
cd09418  LIM2_Prickle
cd09420  LIM3_Prickle
cd09415  LIM1_Prickle
cd04280  ZnMc_astacin_like

ProteinModelPortal

A0A2H1V5P8   A0A212F2G1   A0A3S2NPD8   A0A2A4JX68   A0A2W1BSM4   H9JSV8   + More
A0A0N0P9S6   A0A1B6MDH1   A0A1B6GXL9   A0A1W4WID4   A0A1B6DJX5   D6WPW4   U4U4V9   A0A336K203   A0A336LMA4   A0A336K8B4   A0A1Y1NDG2   W5JT26   A0A182FIB0   A0A2M4AG89   A0A2M4AFY9   A0A182TBX7   A0A1B0AYM5   A0A2M4AEA4   A0A2M4AEI1   A0A2M4AE79   A0A182WIT6   A0A182QDT9   A0A2S2NDT6   A0A182MN04   A0A182NHP1   A0A182P9V8   A0A182RFQ4   A0A1A9W160   A0A034V1S2   B4QE78   A0A182XZH5   A0A1B0AAU4   A0A1J1I8E1   A0A182X6G2   Q7QJT4   A0A182I3R6   A0A182JEV1   A0A182KRW2   A0A0L7LM11   A0A2P2HYN0   A0A2R7X3E7   E9G6K1   A0A0A1X7J1   B4GCL9   A0A2S2N8J4   A0A2S2QRT3   B4J3Z0   A0A0K8TYQ3   B4MPX6   A0A1I8MQV6   Q292U5   A1Z6W3-2   A0A2H8TJM4   F3YDG0   A0A0Q5WPJ4   B4QDW0   E2QC70   Q9U1I1   B3NAF9   A1Z6W3   A1Z6W3-3   J9JLZ2   A0A3B0JI68   B4HQQ2   B4P1E1   A0A0P6G1G6   A0A0B4KED7   B3MHQ1   A0A0B4KEK5   B4J405   A0A0J9R8C4   A0A0P5C5Q7   A0A1W4V1C8   B3NAH4   A0A0P5CI28   A0A0J9TV34   B4MFG1   A0A0P6F0X0   A0A0P5LCT1   W8BTE7   A0A0J9R8C8   A0A0P6FNR5   A0A0P6G6B4   A0A0P5G7V5   A0A1W4V210   B4GCM4   A0A0P5G751   A0A3B0IYY3   A0A0A1XE64   A0A1W4VF77   A0A0P5LHW2   A0A0R3NRM5   A0A0K8TX40  

KEGG

101737057    K04511 prickle | (RefSeq) protein prickle-like

GO

GO:0008270   GO:0016020   GO:0005044   GO:0004222   GO:0005886   GO:0001736   GO:0007164   GO:0009948   GO:0005737   GO:0005829   GO:0045185   GO:0001738   GO:0007163   GO:0001737   GO:0060071   GO:0030951   GO:0045773   GO:0030424   GO:0098930   GO:0045184   GO:0042067   GO:1902669   GO:0070593   GO:0050660   GO:0016491   GO:0004190   GO:0006508   GO:0005515   GO:0006811   GO:0005622   GO:0006810   GO:0003824  

Subcellular location

Cell membrane  

Length:

141

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02884

outside

1  -  141

 

 

Pi

184.595971

Theta

189.321202

Tajima's D

0.279651

CLR

1.916109

CSRT

0.449627518624069

Interpretation

Uncertain