Gene

KWMTBOMO11174  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA012642

Annotation

PREDICTED:_ATP-dependent_(S)-NAD(P)H-hydrate_dehydratase-like_[Papilio_polytes]

Location

Bomo_Chr19(-):54604-56495      View in EpiBrowser

Full name

ATP-dependent (S)-NAD(P)H-hydrate dehydratase      

Alternative Name

ATP-dependent NAD(P)HX dehydratase
Carbohydrate kinase domain-containing protein

Location in the cell

PlasmaMembrane   Reliability : 1.504

CDS

ATGACTCCAAGTTTCAATATAATTCTTGTTATCTTACAAGTGATTTTGTTTACTTTCCAAATTACTAATGGCAATGAGTGTAAAATGAACTTCCTTACTTCTAAAGATATTTTAAAGAAATTAACAAGTAATATTGTTCCAACACTCAATGGAAAATCAAAAGGCGATCTTGGTAGAATAGGAATAATAGGAGGGTCAGTTGAATATACAGGGGCTCCGTACTTCTCAGCCATTGCTGCTTTCAAGGCAGGAGCGGATATAGTTTACGTAATTACTACTGAAGACGCAGCGCCAGTTATTAAAATTTACAGTCCTGATCTCATAGTCTATCCATTTCTAAACAAAAAGTATGCATCGAAAATAAGTTCTCTATTACCTAAAATGGACGCGATCGTTATTGGACCGGGCTTAGGAAGAGAAGATGAAACAATGAAACTAACGTATGACATAATAGAAAGCTGTAAAGTATTGGAGAAGCCCATAGTCATCGACGCCGATGGCTTATACGCTATTTCAAAAAACATATCCATTATTCAGGATTATCCAAAGGCAGGCGCCATTTTGACACCGAACGGACGCGAATCGAAGAAGTTGATGGAATCGATAAATTCGAATGGATCTAATTGGTTCAACTATTGGGGGGAAAACGTTTCGGTTTTAGAAAAAGGCGAAACTGATAAATTTCATTCAAGAGTACCATCGTACAACTGGGCTTCGTCCGAAGGTGGCTCGGAGAGACGCGTTGGTGGTCAAGGAGACTTCCTATCAGGCTCGCTGGCTACATTTTATCATTGGGCGTTAACAAGCGATGTGTGCCAAGGCGAACAACACGGACAAATTTCACAAAGCTTGGCGAGCTACGCCGCAGCCCGACTAGTCAGAACTTGTAATTCTCAAGCATTCGAAAAATACGGAAGAAGCATGATGGCTTCTGATATGATTAAAGAAATTCATTCGGCATACAAAAAAGTGTTTGAAGATTAG

Protein

MTPSFNIILVILQVILFTFQITNGNECKMNFLTSKDILKKLTSNIVPTLNGKSKGDLGRIGIIGGSVEYTGAPYFSAIAAFKAGADIVYVITTEDAAPVIKIYSPDLIVYPFLNKKYASKISSLLPKMDAIVIGPGLGREDETMKLTYDIIESCKVLEKPIVIDADGLYAISKNISIIQDYPKAGAILTPNGRESKKLMESINSNGSNWFNYWGENVSVLEKGETDKFHSRVPSYNWASSEGGSERRVGGQGDFLSGSLATFYHWALTSDVCQGEQHGQISQSLASYAAARLVRTCNSQAFEKYGRSMMASDMIKEIHSAYKKVFED

Description

Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Catalytic Activity

(6S)-NADHX + ATP = ADP + H(+) + NADH + phosphate
(6S)-NADPHX + ATP = ADP + H(+) + NADPH + phosphate

Cofactor

Mg(2+)

Similarity

Belongs to the NnrD/CARKD family.

Keywords

ATP-binding   Complete proteome   Lyase   NAD   NADP   Nucleotide-binding   Phosphoprotein   Reference proteome  

Feature

chain  ATP-dependent (S)-NAD(P)H-hydrate dehydratase

Uniprot

H9JSY0   A0A3S2PH94   A0A2A4JQN8   A0A2H1VHQ2   A0A2W1BLJ7   A0A194QX99   + More
A0A194QKQ1   A0A0L7L9V0   A0A212ELH0   S4PYH5   A0A194QE15   A0A0N0PB69   A0A1W4WUV7   I4DKG2   W8CBZ9   A0A0A1XMD9   D2A165   A0A336MQX3   A0A084W4C8   A0A182YBP1   A0A182P1B5   A0A182KF66   A0A0K8WJP1   A0A182M4U5   A0A182W243   A0A182T8E0   Q7PZM4   A0A1S4H960   A0A182VG41   A0A182TRU9   A0A182XFP3   A0A182KLK5   A0A182HHR3   A0A182FTR1   A0A2M4BVH0   B0WFR7   A0A182ITQ0   A0A182GFJ0   A0A182RTT8   E3XDZ8   A0A182QVA8   B0X3P2   A0A023EPL3   A0A034WTI1   Q17NP0   S4NNX7   A0A2K7P681   B4GKK0   A0A1A9W1H1   A0A2A4ISC7   A0A2H6N9G3   B4JPR5   A0A2D4JZN6   A0A1A9XSG9   A0A1B0AQJ0   D3TPM6   A0A2H1WP72   B5DHB2   B4KJ08   A0A1W7RII4   A0A0K8RX33   A0A0L0CII9   A0A1A9VBS9   A0A1B0G896   A0A1A9Z657   A0A3Q3XIT8   A0A1U7QYJ4   G1KF06   A0A093GSX8   A0A250XXZ3   A0A2P8Y5H1   A0A093IGX3   A0A1U7RN45   F7G4N6   A0A1Y1LBW2   G1NPT3   A0A1Y1LFP5   A0A1U7QN53   H2TJQ2   G3I1T8   A0A250XYT0   A0A1I8QBS2   A0A1Q3FCL6   K7GAK3   A0A3B0JWY2   A0A099YYI4   T1PAK8   M7B4B6   A0A3Q1EAY7   A0A3Q3H2W7   A0A2K5N9X0   G1MF67   A0A2K5N9R0   A0A2Y9NM89   A0A3Q2TUU0   A0A1I8M1R3   A0A341C4Q1   A0A091EV02   A0A091KRU6   F1P2P4  

EC Number

4.2.1.93

Pubmed

19121390    28756777    26354079    26227816    22118469    23622113    + More
22651552    24495485    25830018    18362917    19820115    24438588    25244985    12364791    20966253    26483478    20920257    24945155    25348373    17510324    17994087    20353571    15632085    26358130    25727380    26108605    28087693    29403074    18464734    28004739    20838655    21551351    21804562    17381049    23624526    20010809    15592404    25315136   

EMBL

BABH01038922    RSAL01000034    RVE51418.1    NWSH01000823    PCG74018.1    ODYU01002616    + More
SOQ40349.1    KZ149982    PZC75778.1    KQ461073    KPJ09575.1    KQ459053    KPJ04036.1    JTDY01002029    KOB72283.1    AGBW02014073    OWR42317.1    GAIX01003278    JAA89282.1    KQ459144    KPJ03717.1    KQ461133    KPJ08889.1    AK401780    BAM18402.1    GAMC01004346    JAC02210.1    GBXI01002126    JAD12166.1    KQ971338    EFA02619.2    UFQT01002206    SSX32924.1    ATLV01020314    KE525298    KFB45072.1    GDHF01001050    JAI51264.1    AXCM01006746    AAAB01008986    EAA00337.3    APCN01002433    GGFJ01007926    MBW57067.1    DS231920    EDS26411.1    JXUM01059631    JXUM01124920    KQ566885    KQ562063    KXJ69760.1    KXJ76765.1    ADMH02002000    ETN60029.1    AXCN02001802    DS232318    EDS39934.1    GAPW01002662    JAC10936.1    GAKP01001452    JAC57500.1    CH477198    GAIX01012094    JAA80466.1    CH479184    EDW37166.1    NWSH01008411    PCG62569.1    IACI01062313    IACI01062315    LAA27526.1    CH916372    EDV98895.1    IACL01017628    LAB01959.1    JXJN01001901    EZ423378    ADD19654.1    ODYU01010043    SOQ54871.1    CH379058    CH933807    EDW13521.1    GDAY02000451    JAV50962.1    GBKC01000587    JAG45483.1    JRES01000349    KNC32022.1    CCAG010000213    KL205652    KFV72466.1    GFFV01003722    JAV36223.1    PYGN01000906    PSN39493.1    KL215656    KFV65981.1    GEZM01060252    JAV71159.1    GEZM01060251    JAV71160.1    JH001092    EGW03841.1    GFFV01003417    JAV36528.1    GFDL01009729    JAV25316.1    AGCU01062208    AGCU01062209    AGCU01062210    OUUW01000010    SPP85583.1    KL886197    KGL73625.1    KA645806    AFP60435.1    KB543129    EMP31944.1    ACTA01004421    ACTA01012421    ACTA01196408    AADN05000386    KK718990    KFO60836.1    KK752333    KFP42188.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053240    UP000053268    UP000037510    + More
UP000007151    UP000192223    UP000007266    UP000030765    UP000076408    UP000075885    UP000075881    UP000075883    UP000075920    UP000075901    UP000007062    UP000075903    UP000075902    UP000076407    UP000075882    UP000075840    UP000069272    UP000002320    UP000075880    UP000069940    UP000249989    UP000075900    UP000000673    UP000075886    UP000008820    UP000008744    UP000091820    UP000001070    UP000092443    UP000092460    UP000001819    UP000009192    UP000037069    UP000078200    UP000092444    UP000092445    UP000261620    UP000189706    UP000001646    UP000053584    UP000245037    UP000053875    UP000189705    UP000002279    UP000001645    UP000005226    UP000001075    UP000095300    UP000007267    UP000268350    UP000053641    UP000031443    UP000257200    UP000264800    UP000233060    UP000008912    UP000248483    UP000000539    UP000095301    UP000252040    UP000052976   

PRIDE

H9JSY0    B5DHB2    G3I1T8   

Pfam

PF01256   Carb_kinase

Interpro

IPR017953   Carbohydrate_kinase_pred_CS        + More
IPR029056   Ribokinase-like       
IPR000631   CARKD       

SUPFAM

SSF53613   SSF53613       

Gene 3D

3.40.1190.20    

CDD

cd01171  YXKO-related

ProteinModelPortal

H9JSY0   A0A3S2PH94   A0A2A4JQN8   A0A2H1VHQ2   A0A2W1BLJ7   A0A194QX99   + More
A0A194QKQ1   A0A0L7L9V0   A0A212ELH0   S4PYH5   A0A194QE15   A0A0N0PB69   A0A1W4WUV7   I4DKG2   W8CBZ9   A0A0A1XMD9   D2A165   A0A336MQX3   A0A084W4C8   A0A182YBP1   A0A182P1B5   A0A182KF66   A0A0K8WJP1   A0A182M4U5   A0A182W243   A0A182T8E0   Q7PZM4   A0A1S4H960   A0A182VG41   A0A182TRU9   A0A182XFP3   A0A182KLK5   A0A182HHR3   A0A182FTR1   A0A2M4BVH0   B0WFR7   A0A182ITQ0   A0A182GFJ0   A0A182RTT8   E3XDZ8   A0A182QVA8   B0X3P2   A0A023EPL3   A0A034WTI1   Q17NP0   S4NNX7   A0A2K7P681   B4GKK0   A0A1A9W1H1   A0A2A4ISC7   A0A2H6N9G3   B4JPR5   A0A2D4JZN6   A0A1A9XSG9   A0A1B0AQJ0   D3TPM6   A0A2H1WP72   B5DHB2   B4KJ08   A0A1W7RII4   A0A0K8RX33   A0A0L0CII9   A0A1A9VBS9   A0A1B0G896   A0A1A9Z657   A0A3Q3XIT8   A0A1U7QYJ4   G1KF06   A0A093GSX8   A0A250XXZ3   A0A2P8Y5H1   A0A093IGX3   A0A1U7RN45   F7G4N6   A0A1Y1LBW2   G1NPT3   A0A1Y1LFP5   A0A1U7QN53   H2TJQ2   G3I1T8   A0A250XYT0   A0A1I8QBS2   A0A1Q3FCL6   K7GAK3   A0A3B0JWY2   A0A099YYI4   T1PAK8   M7B4B6   A0A3Q1EAY7   A0A3Q3H2W7   A0A2K5N9X0   G1MF67   A0A2K5N9R0   A0A2Y9NM89   A0A3Q2TUU0   A0A1I8M1R3   A0A341C4Q1   A0A091EV02   A0A091KRU6   F1P2P4  

PDB

6EFX     E-value=1.20912e-34,     Score=366

KEGG

101737541    K17757 ATP-dependent NAD(P)H-hydrate dehydratase [EC:4.2.1.93] | (RefSeq) ATP-dependent (S)-NAD(P)H-

GO

GO:0046496   GO:0005524   GO:0047453   GO:0052855   GO:0016301   GO:0005739   GO:0016021  

Subcellular location

Mitochondrion  

SignalP

Position:   1 - 24,         Likelihood:  0.961148

 

 

Length:

327

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

16.92537

Exp number, first 60 AAs:

15.60581

Total prob of N-in:

0.78155

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  22

outside

23  -  327

 

 

Pi

215.860284

Theta

197.859483

Tajima's D

1.015921

CLR

0

CSRT

0.661666916654167

Interpretation

Possibly Positive selection