Gene

KWMTBOMO11161  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008595

Annotation

PREDICTED:_26S_proteasome_non-ATPase_regulatory_subunit_8_[Papilio_machaon]

Location

Bomo_Chr18(-):15208615-15211682      View in EpiBrowser

Full name

26S proteasome non-ATPase regulatory subunit 8      

Alternative Name

26S proteasome regulatory subunit RPN12
26S proteasome regulatory subunit S14

Location in the cell

Cytoplasmic   Reliability : 2.182

CDS

ATGGCTACTGTAAAAGACGTCGCTACATTATATCAAAATCTGAAGACCGAGTGGGCAAAGAAGCCAAGAAAGCTGGACAAATGTGGAGAGCTCTTAAACAAAATAAAGATTGCTCTTACACAGTTAACGTTTCTTCCAAGTAATAATGTCGCAGCAAACCAAAAAGAGTTGATTTTGGCTAGAGATGTATTGGAAATAGGTGCACAATGGGCCGTCGCCGTGAAAGACGTCAAAGCTTTCGAGAGATACATGTCTCAACTCAAGTGTTATTATTTCGATTACAAAGACCACCTCCCGGAGTCTGCATTCACAAACCAACTGTTAGGATTGAATCTATTATACCTGCTTTCTCAAAACCGAGTGGCCGAGTTTCACACAGAACTTGAGCGTCTTCCAGTTGATGTTATAAGAACAGATCTTTATATCAGACACCCGCTTGCTCTAGAACAGTATTTAATGGAGGGCAGCTACAACAAAATATTCTTAGCAAAGGGTAATGTGCCAGCAGAGAGCTACACCTTCTTCATGGATACACTTTTAGAAACAGTTCGTGGAGAGATTGCAGCTTGCATTGAGAAAGCTTACCACACAATCCCTTGTGCCGAAGCCGCTAGACGACTTAACTTGTCTTCTCAACAAGCAGTACTTGAGTATGGAAAGAAGCGTAACTGGAGGTTAGGTCCTGACAACTGCTACCGGTTCACAAGCGAAGAATTAACATCTGTGGCCTTCTCGGGCATTCTTCCATCTGCTGAACTGGCTCAACAGACCATTGAGTATGCCAGACATCTTGAGATGATTGTATAA

Protein

MATVKDVATLYQNLKTEWAKKPRKLDKCGELLNKIKIALTQLTFLPSNNVAANQKELILARDVLEIGAQWAVAVKDVKAFERYMSQLKCYYFDYKDHLPESAFTNQLLGLNLLYLLSQNRVAEFHTELERLPVDVIRTDLYIRHPLALEQYLMEGSYNKIFLAKGNVPAESYTFFMDTLLETVRGEIAACIEKAYHTIPCAEAARRLNLSSQQAVLEYGKKRNWRLGPDNCYRFTSEELTSVAFSGILPSAELAQQTIEYARHLEMIV

Description

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.

Subunit

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD8, a base containing 6 ATPases and few additional components. Interacts with DDI2 (By similarity).

Similarity

Belongs to the proteasome subunit S14 family.

Keywords

Complete proteome   Isopeptide bond   Proteasome   Reference proteome   Ubl conjugation  

Feature

chain  26S proteasome non-ATPase regulatory subunit 8

Uniprot

H9JGE8   A0A194RIJ1   I4DKA5   A0A212FHJ4   A0A1E1WJR7   A0A2H1WAV7   + More
S4P3H8   A0A3S2N3L9   A0A2P8XL95   A0A2J7RLF3   A0A1B6MMZ6   A0A2R7X488   A0A067QUP6   A0A023F8V4   R4G8D6   M9W042   A0A069DRQ0   A0A224XHX4   A0A0A9XXZ0   A0A3B4D5Y9   A0A3S2PMX2   A2RV94   A0A1L8F911   A0A3B1IZZ0   Q6NU38   A0A3B3B5D9   E2C8I6   E2AVX2   A0A3Q3VUA1   A0A0V0G604   A0A1S3HD68   E9II76   A0A151IM23   A3KMH9   Q6NTJ8   A0A1L8F3Y1   A0A060YRV1   H2TMF9   A0A3B4WSB0   A0A3B4VF98   C1BGR0   C1BJM3   A0A195D815   A0A195ERH8   B5XAB2   A0A232FH51   A0A146WEV2   K7J594   V4BX33   Q05AY5   H2LAC7   A0A3P9HBJ0   Q4RRE0   A0A026WM63   A0A210QRL2   E3TFR8   A0A151X525   A0A3P9AK56   D2A2W4   A0A3Q3E6M3   Q3TW90   E3TBX3   A0A3Q2QZ26   A0A1W5AN99   A0A158NE08   A0A3L8DKU1   A0A195BRC9   A0A1W5B388   Q9CPS5   A0A0P6CFW9   F4X1S7   Q3B8P5   Q3TVY0   A0A3L7H7Q0   Q99JB5   H3B6U6   A0A0B7AZ06   C1BI19   K1QVR0   Q9CX56   Q3TI95   G5AMB7   A0A1U7R5B2   A0A151PK60   A0A0N0BEV9   F7ACH7   A0A3Q2C9F3   A0A3Q2TQ19   F1LMQ3   G3SUK7   A0A3B3SU68   V9L154   A0A2Y9E6K0   A0A2A3EM46   A0A088A0Z2   I3MMZ3   Q8BKP5   A0A091DH60   T1JGC0   A0A2K6V682  

Pubmed

19121390    26354079    22651552    22118469    23622113    29403074    + More
24845553    25474469    29136191    26334808    25401762    26823975    27762356    25329095    29451363    20798317    21282665    24755649    21551351    20433749    28648823    20075255    23254933    17554307    15496914    24508170    28812685    20634964    25069045    18362917    19820115    10349636    11042159    11076861    11217851    12466851    16141073    21347285    30249741    19468303    21183079    21719571    15489334    29704459    9215903    22992520    16141072    16857966    21993625    28071753    22293439    17495919    15057822    29398115    29240929    24402279   

EMBL

BABH01033562    BABH01033563    KQ460154    KPJ17259.1    AK401723    KQ458880    + More
BAM18345.1    KPJ04610.1    AGBW02008501    OWR53213.1    GDQN01003829    JAT87225.1    ODYU01007436    SOQ50211.1    GAIX01009497    JAA83063.1    RSAL01002136    RVE40572.1    PYGN01001796    PSN32765.1    NEVH01002690    PNF41663.1    GEBQ01002663    JAT37314.1    KK856672    PTY26230.1    KK852929    KDR13661.1    GBBI01000862    JAC17850.1    ACPB03001320    GAHY01001157    JAA76353.1    KC683804    QKKF02012754    AGJ84698.1    RZF43470.1    GBGD01002543    JAC86346.1    GFTR01004330    JAW12096.1    GBHO01018800    GBRD01016925    GDHC01005369    JAG24804.1    JAG48902.1    JAQ13260.1    CM012449    RVE65169.1    BC133237    AAI33238.1    CM004480    OCT68074.1    BC068763    BC097621    BC106280    AAH68763.1    AAH97621.1    AAI06281.1    GL453666    EFN75716.1    GL443213    EFN62394.1    GECL01003399    JAP02725.1    GL763392    EFZ19728.1    KQ977074    KYN05938.1    BC131885    AAI31886.1    BC068963    AAH68963.1    CM004481    OCT66303.1    FR912386    CDQ91860.1    BT073789    ACO08213.1    BT074802    ACO09226.1    KQ981153    KYN09013.1    KQ981993    KYN30828.1    BT047981    BT058673    BT060388    ACI67782.1    ACN10386.1    ACN12748.1    NNAY01000239    OXU29788.1    GCES01057780    JAR28543.1    AAZX01000332    KB201891    ESO93619.1    BC123112    AAI23113.1    CAAE01015002    CAG09042.1    KK107152    EZA57053.1    NEDP02002277    OWF51361.1    GU589202    ADO29154.1    KQ982548    KYQ55318.1    KQ971338    EFA02229.1    AK159795    BAE35376.1    GU587850    ADO27809.1    ADTU01013085    QOIP01000007    RLU20458.1    KQ976424    KYM88514.1    AC164564    AK002921    AK003436    AK027973    AK150493    AK150982    AK159216    AK166718    BAB22458.2    BAB22789.2    BAC25683.1    BAE29609.1    GDIP01002590    JAN01126.1    GL888551    EGI59584.1    BC105894    AAI05895.1    AK159926    BAE35488.1    RAZU01000274    RLQ61351.1    BC004075    BC005717    AAH04075.1    AAH05717.1    AFYH01009887    AFYH01009888    HACG01039118    CEK85983.1    BT074248    ACO08672.1    JH818228    EKC33025.1    AK020132    AK167948    BAE39951.1    JH165993    EHA98177.1    AKHW03000044    KYO49145.1    KQ435821    KOX72468.1    AC118147    JW872507    AFP05025.1    KZ288215    PBC32574.1    AGTP01108620    AK051257    BAC34576.1    KN122579    KFO29605.1    JH432201   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000283053    UP000245037    + More
UP000235965    UP000027135    UP000015103    UP000291343    UP000261440    UP000186698    UP000018467    UP000261560    UP000008237    UP000000311    UP000261620    UP000085678    UP000078542    UP000193380    UP000005226    UP000261360    UP000261420    UP000078492    UP000078541    UP000087266    UP000215335    UP000002358    UP000030746    UP000001038    UP000265180    UP000265200    UP000007303    UP000053097    UP000242188    UP000221080    UP000075809    UP000265140    UP000007266    UP000264820    UP000265000    UP000192224    UP000005205    UP000279307    UP000078540    UP000000589    UP000007755    UP000273346    UP000008672    UP000005408    UP000006813    UP000189706    UP000050525    UP000053105    UP000002280    UP000265020    UP000002494    UP000007646    UP000261540    UP000248480    UP000242457    UP000005203    UP000005215    UP000028990    UP000233220   

PRIDE

H9JGE8    Q3B8P5    Q9CX56    F1LMQ3   

Pfam

PF10075   CSN8_PSD8_EIF3K

Interpro

IPR033464   CSN8_PSD8_EIF3K        + More
IPR006746   26S_Psome_Rpn12       
IPR000717   PCI_dom       
IPR036390   WH_DNA-bd_sf       
IPR036716   Pest_crys_N_sf       

SUPFAM

SSF46785   SSF46785        + More
SSF56849   SSF56849       

ProteinModelPortal

H9JGE8   A0A194RIJ1   I4DKA5   A0A212FHJ4   A0A1E1WJR7   A0A2H1WAV7   + More
S4P3H8   A0A3S2N3L9   A0A2P8XL95   A0A2J7RLF3   A0A1B6MMZ6   A0A2R7X488   A0A067QUP6   A0A023F8V4   R4G8D6   M9W042   A0A069DRQ0   A0A224XHX4   A0A0A9XXZ0   A0A3B4D5Y9   A0A3S2PMX2   A2RV94   A0A1L8F911   A0A3B1IZZ0   Q6NU38   A0A3B3B5D9   E2C8I6   E2AVX2   A0A3Q3VUA1   A0A0V0G604   A0A1S3HD68   E9II76   A0A151IM23   A3KMH9   Q6NTJ8   A0A1L8F3Y1   A0A060YRV1   H2TMF9   A0A3B4WSB0   A0A3B4VF98   C1BGR0   C1BJM3   A0A195D815   A0A195ERH8   B5XAB2   A0A232FH51   A0A146WEV2   K7J594   V4BX33   Q05AY5   H2LAC7   A0A3P9HBJ0   Q4RRE0   A0A026WM63   A0A210QRL2   E3TFR8   A0A151X525   A0A3P9AK56   D2A2W4   A0A3Q3E6M3   Q3TW90   E3TBX3   A0A3Q2QZ26   A0A1W5AN99   A0A158NE08   A0A3L8DKU1   A0A195BRC9   A0A1W5B388   Q9CPS5   A0A0P6CFW9   F4X1S7   Q3B8P5   Q3TVY0   A0A3L7H7Q0   Q99JB5   H3B6U6   A0A0B7AZ06   C1BI19   K1QVR0   Q9CX56   Q3TI95   G5AMB7   A0A1U7R5B2   A0A151PK60   A0A0N0BEV9   F7ACH7   A0A3Q2C9F3   A0A3Q2TQ19   F1LMQ3   G3SUK7   A0A3B3SU68   V9L154   A0A2Y9E6K0   A0A2A3EM46   A0A088A0Z2   I3MMZ3   Q8BKP5   A0A091DH60   T1JGC0   A0A2K6V682  

PDB

6EPF     E-value=2.67376e-86,     Score=810

KEGG

101737946    K03031 26S proteasome regulatory subunit N12 | (RefSeq) 26S proteasome non-ATPase regulatory subunit

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0006508   GO:0005838   GO:0090729   GO:0043161   GO:0008541   GO:0005829   GO:0022624   GO:0000502  

PANTHER

PTHR12387  

Length:

268

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01543

Exp number, first 60 AAs:

0.00306

Total prob of N-in:

0.07479

outside

1  -  268

 

 

Pi

13.97499

Theta

17.344907

Tajima's D

-0.479801

CLR

1.835403

CSRT

0.246087695615219

Interpretation

Uncertain