Gene

KWMTBOMO11157

Pre Gene Modal

BGIBMGA008597

Annotation

PREDICTED:_insulin-like_peptide_receptor_[Papilio_polytes]

Location

Bomo_Chr18(-):15166727-15182272      View in EpiBrowser

Full name

Tyrosine-protein kinase receptor       + More
Insulin-like receptor      
Receptor protein-tyrosine kinase      

Location in the cell

PlasmaMembrane   Reliability : 3.897

CDS

ATGGGCAGCCTACAATTGTCTATTATGGAGCGCACTAAGAAGCAAGACTTTAAAAATATTAGTTTTCCGAACCTCAGAGAGGTGACCCATTTCCTTCTAGTATACAGAGTGCAAGGTCTCCAGTCACTAGGTATTCTCTTTCCGAATCTAGCTCGTATAAGAGGAGAAGTATTACTGAACAACTATGCTCTGATTATATACGATATGCCGAAACTTAAAGAAATCGGCCTCTACAGTCTATTGAAGATAGATCGGGGCGGGGTCATCATTTGGGGCTTGCCTCAAGCATGCTACGTGGACACGGTTTACTGGAAAATTATAGCTCCGCGCGCGAGGCACGTTATCAGTCCGCCGGACAAGCATTCTCTGCGACCCTGCAACGTATGCAGATGTAGCCTTAACTCCTCTCTTAACCACTGTTGGAATAATATGAAATGTCAACGCTACCTCGAAGGGCCGGAAGGTGAAGTGTGCGACAAGCAGTGTCTGGGATGTCGCAAAACGAACGCAACAGTGTGTTCTGTGTGTCGACACTTTACATATAGAGGAAACTGTTTGCCGGAGTGTCCCAATTCTACGATTTTGTTAGGCACCAGCAAATATTGCATCACAGCCGAAGACTGCCATGACATGGACGGTTGGACCTGGAACAAAACCTGTATCTTCCAGTGTCCAGTCGATTACCTTCAGGTCCGCAAGCCAGACGGAAAGACTTGTGAATATTGTCGAAACTGTCATCAGACCTGTGAGAGTCTAACAGTCCAGACAACGGAAAGTATCCAATTAGTTGAGCGGTGCGTCTACATCAATGGCTCCCTCACCATACACCTCGGAAGTTTGATCGAAGCTATGACTGAACTACGGACCTTTTTAAGCCGAATCGAAGTAATATCAGAATACCTTGTCATCTACAGCTCTTCTACGGTCACAAGCCTCGACTTTTTGTCATCACTTCGACACATAAAAGGCAATAAACTAGTGGGTGAAAAGTTTAGTCTCGTAATCCATGACATGATAAATCTTCATTCACTTTTCAATGAGAACGTCAGCAAAAACCTTCAAATAGATCACGGGACATATCAGATGTTTAACAATCCGTTGCTCTGCATGAGTCATATTGATAAGATAAAGGACTTATTTCCCGAGGAACCTGCAGAGGAAGACGTAATCCAAGGCACTAATGGCTATGGGGGGAACTGTGAGGAAGCTTCTGTAGATATCCAGATACAAGTGGTAAACGAAACATGTGCCGTTGTCATGTTTTCTCCTCTACCGGATCCTGACGTTCATTATTCAGTGTTGTACGTTCGAATGCCCCCGGAAATAAATAAAGCAATTTTACCGGAGACGTGTAGTCAGCTAGAATGGTTCGCTGAAGCGGTTCCCACAAAGTTTGGTCAGAATGTAATCGTGCAGCTCACGTCTTTGCGTCCTGCATCCACGTATGCCGTTTGCATCGAAACTTATGATCCAGTGTATCATAGATTAGCTAGAAGTAGAATTTTGAATTTCACTACTCTTGTGGGGATACCTGAACCGCCGTTTATAATAGAATCTGTGGCATCGTCTTATGACGTTATTGTTTTGAGTTGGGTCGATCACAAAGATTATAGACGTCTTATATCTAGCTATGAACTTGATGTTGTCTTGATTGATACGCAAGAAATCCTACTGAGAAATAACTGCAAAAGTATGGGGGATGAATTTTTTGATATTGACTACACAAGACATGCTGTAGTGATGAGACCACCTCCAGAATATGGTAAAAGTTGTGAGTCCATGTGCGGGTTCTTGTCGACAGTGACTGCTGGAGCGCTGGTGGAAGATCACTTTGATGTTTGCGACAACACCCTCTTGGGTTGTAAGATTCAAAAAGACCCAAGACCGGGAAATACGTCATTCAATAATTACGTCAAAACTTTATCGCTTAATATCACCGGACCCAAGAACGCATTTCAAATTGGTAACTTAGCTCCATACAGGGATTATAGCTTCAGATTACGGGCTTGTTTCAACAGTAGCTGCAGCAGATCAACCAAGAGCATTGTGAGGACGTTACGGGCGTTTAACCATGTGGATGTGCCCAGAGAAACGGTGGCTACTATCAAAGACAGCCGGATAGTAGTAAGCTGGAAGCCACCCGAAATAACCAATGGACCAATATTGGCTTATACTGTTGAACTATTGCCAAAAATTGAACAAACATCATATTTGATTCCGCAATCTTGGTGTGTAATGGGTAACATAACGAGTTTTGAGATTGTGAATTTGGTGGCTAGCACAAATAAAGTTAGAGTCTGTTCCAAGACCCTGGCTTCATTAAACACTTGTAATGAATGGATTCTAGTTACATTTTCGAAACCAGTGTTAAGATCCTGGGCTTGGTGGAGTTTACTCTTTGGGTTTATGCTATATGGTCTGTCTCTCTTGGTCGGCAGTTTGTGGAGGCAAAGGGAAGATCGCAGTGATACAGTTAGCTTAGTGGAGTGGACAAATAATTAA

Protein

MGSLQLSIMERTKKQDFKNISFPNLREVTHFLLVYRVQGLQSLGILFPNLARIRGEVLLNNYALIIYDMPKLKEIGLYSLLKIDRGGVIIWGLPQACYVDTVYWKIIAPRARHVISPPDKHSLRPCNVCRCSLNSSLNHCWNNMKCQRYLEGPEGEVCDKQCLGCRKTNATVCSVCRHFTYRGNCLPECPNSTILLGTSKYCITAEDCHDMDGWTWNKTCIFQCPVDYLQVRKPDGKTCEYCRNCHQTCESLTVQTTESIQLVERCVYINGSLTIHLGSLIEAMTELRTFLSRIEVISEYLVIYSSSTVTSLDFLSSLRHIKGNKLVGEKFSLVIHDMINLHSLFNENVSKNLQIDHGTYQMFNNPLLCMSHIDKIKDLFPEEPAEEDVIQGTNGYGGNCEEASVDIQIQVVNETCAVVMFSPLPDPDVHYSVLYVRMPPEINKAILPETCSQLEWFAEAVPTKFGQNVIVQLTSLRPASTYAVCIETYDPVYHRLARSRILNFTTLVGIPEPPFIIESVASSYDVIVLSWVDHKDYRRLISSYELDVVLIDTQEILLRNNCKSMGDEFFDIDYTRHAVVMRPPPEYGKSCESMCGFLSTVTAGALVEDHFDVCDNTLLGCKIQKDPRPGNTSFNNYVKTLSLNITGPKNAFQIGNLAPYRDYSFRLRACFNSSCSRSTKSIVRTLRAFNHVDVPRETVATIKDSRIVVSWKPPEITNGPILAYTVELLPKIEQTSYLIPQSWCVMGNITSFEIVNLVASTNKVRVCSKTLASLNTCNEWILVTFSKPVLRSWAWWSLLFGFMLYGLSLLVGSLWRQREDRSDTVSLVEWTNN

Description

This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity.

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Cofactor

Mn(2+)

Subunit

Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain (By similarity).

Similarity

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Belongs to the protein kinase superfamily. Tyr protein kinase family.

Keywords

ATP-binding   Cleavage on pair of basic residues   Complete proteome   Disulfide bond   Glycoprotein   Kinase   Manganese   Membrane   Metal-binding   Nucleotide-binding   Phosphoprotein   Receptor   Reference proteome   Repeat   Signal   Transferase   Transmembrane   Transmembrane helix   Tyrosine-protein kinase  

Feature

chain  Tyrosine-protein kinase receptor

Uniprot

H9JGF0   A0A194RI75   A0A2A4J6M5   A0A2H1WC37   A0A194QGF1   A0A212FHM5   + More
A0A0L7L922   A0A1Y1KTZ9   A0A1S4FB83   A0A067QUW8   K9M126   A0A154PNN8   A0A2R4G8S9   A0A1B6FCK7   A0A1Y1JWT1   A0A2P8YHI3   A0A0L7QP05   A0A1W4X1J6   A0A158NGH6   A0A182HGH6   A0A2R4G8T0   A0A2J7R3R6   A0A088AP10   J9K8T8   A0A182UZL2   E2A530   A0A195BXX3   A0A2S2NHA9   A0A158NFV3   A0A182PE85   A0A195BAD2   A0A151X1W0   A0A1B6KAQ3   A0A151IYJ9   A0A182TM38   A0A1S4H0M5   A0A0G4DDB6   A0A182WW35   F4WZG2   A0A1V0JFF9   A0A182QRS4   A0A2S2N7Z7   A0A151IIN9   A0A151JYW9   Q7Q0F6   A0A2H8TMN4   A0A146KY69   A0A182JT77   A0A151X3W9   G3ER33   A0A0N0BDV4   A0A2P8YXX9   A0A1S4F1J9   A0A1B6DYS9   A0A310SXM6   Q93105   T1HQC7   A0A0A9XLS6   A0A026W008   A0A0A9YBQ5   A0A1L8DJW7   A0A2J7RD67   A0A0C4UQS4   A0A1W4XBR9   A0A182WEW1   A0A182J7Y1   A0A1B1UZE9   A0A067RC78   A0A195CNS3   T1JFU0   A0A0C9RT38   A0A182Y1F3   A0A067RBV2   A0A2R7WTX2   A0A087TYT4   A0A336LVG6   A0A1J1J845   A0A088AUM7   A0A182MYU2   G2J5R2   A0A182MVW1  

EC Number

2.7.10.1

Pubmed

19121390    26354079    22118469    26227816    28004739    24845553    + More
23136112    29403074    21347285    20798317    12364791    24657890    21719571    28230772    26823975    21797944    9099579    17510324    25401762    24508170    30249741    25799997    25244985   

EMBL

BABH01033569    KQ460154    KPJ17262.1    NWSH01002879    PCG67386.1    ODYU01007358    + More
SOQ50054.1    KQ458880    KPJ04613.1    AGBW02008501    OWR53216.1    JTDY01002276    KOB71751.1    GEZM01078176    GEZM01078174    JAV62886.1    KK852921    KDR13786.1    JN711464    AFQ20827.1    KQ435007    KZC13496.1    MF620042    AVT56264.1    GECZ01022086    JAS47683.1    GEZM01098738    JAV53779.1    PYGN01000591    PSN43728.1    KQ414842    KOC60353.1    ADTU01001599    ADTU01001600    ADTU01001601    APCN01004232    APCN01004233    MF620044    AVT56266.1    NEVH01007818    PNF35477.1    ABLF02025445    ABLF02025449    GL436794    EFN71461.1    KQ976398    KYM92793.1    GGMR01003889    MBY16508.1    ADTU01000013    ADTU01000014    ADTU01000015    KQ976532    KYM81501.1    KQ982585    KYQ54358.1    GEBQ01031456    JAT08521.1    KQ980763    KYN13503.1    AAAB01008984    HG518668    CDI30232.1    GL888479    EGI60406.1    KX507134    ARD07921.1    AXCN02001027    GGMR01000678    MBY13297.1    KQ977474    KYN02510.1    KQ981463    KYN41515.1    AAAB01008986    EAA00322.3    GFXV01003618    MBW15423.1    GDHC01018543    GDHC01006354    JAQ00086.1    JAQ12275.1    KQ982557    KYQ55071.1    JF304722    ADZ56366.1    KQ435850    KOX70962.1    PYGN01000294    PSN49099.1    GEDC01006489    JAS30809.1    KQ759862    OAD62524.1    U72939    CH477238    ACPB03020572    GBHO01022675    GDHC01001418    JAG20929.1    JAQ17211.1    KK107519    QOIP01000009    EZA49388.1    RLU18570.1    GBHO01041436    GBHO01014558    GBRD01008020    JAG02168.1    JAG29046.1    JAG57801.1    GFDF01007444    JAV06640.1    NEVH01005295    PNF38775.1    KF974333    AIY24638.1    KX428482    ANW09593.1    KK852559    KDR21367.1    KQ977481    KYN02366.1    JH432185    GBYB01011835    JAG81602.1    KDR21366.1    KK855531    PTY22998.1    KK117368    KFM70273.1    UFQS01000225    UFQT01000225    SSX01656.1    SSX22036.1    CVRI01000074    CRL08130.1    BK008012    DAA34971.1    AXCM01007680   

Proteomes

UP000005204    UP000053240    UP000218220    UP000053268    UP000007151    UP000037510    + More
UP000027135    UP000076502    UP000245037    UP000053825    UP000192223    UP000005205    UP000075840    UP000235965    UP000005203    UP000007819    UP000075903    UP000000311    UP000078540    UP000075885    UP000075809    UP000078492    UP000075902    UP000076407    UP000007755    UP000075886    UP000078542    UP000078541    UP000007062    UP000075881    UP000053105    UP000008820    UP000015103    UP000053097    UP000279307    UP000075920    UP000075880    UP000076408    UP000054359    UP000183832    UP000075884    UP000075883   

PRIDE

H9JGF0   

Pfam

PF01030   Recep_L_domain        + More
PF00757   Furin-like
PF07714   Pkinase_Tyr
PF00041   fn3
PF00595   PDZ
PF03453   MoeA_N
PF00994   MoCF_biosynth

Interpro

IPR000494   Rcpt_L-dom        + More
IPR036941   Rcpt_L-dom_sf       
IPR036116   FN3_sf       
IPR013783   Ig-like_fold       
IPR003961   FN3_dom       
IPR006212   Furin_repeat       
IPR017900   4Fe4S_Fe_S_CS       
IPR006211   Furin-like_Cys-rich_dom       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR020635   Tyr_kinase_cat_dom       
IPR008266   Tyr_kinase_AS       
IPR002011   Tyr_kinase_rcpt_2_CS       
IPR000719   Prot_kinase_dom       
IPR011009   Kinase-like_dom_sf       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR017441   Protein_kinase_ATP_BS       
IPR036034   PDZ_sf       
IPR001478   PDZ       
IPR017896   4Fe4S_Fe-S-bd       
IPR001453   MoaB/Mog_dom       
IPR008284   MoCF_biosynth_CS       
IPR005110   MoeA_linker/N       
IPR038987   MoeA-like       
IPR036425   MoaB/Mog-like_dom_sf       
IPR036135   MoeA_linker/N_sf       
IPR016246   Tyr_kinase_insulin-like_rcpt       
IPR028792   INSRR       

SUPFAM

SSF49265   SSF49265        + More
SSF57184   SSF57184       
SSF56112   SSF56112       
SSF50156   SSF50156       
SSF53218   SSF53218       
SSF63882   SSF63882       

Gene 3D

2.60.40.10     3.80.20.20     3.40.980.10    

CDD

cd00063  FN3
cd00064  FU
cd00887  MoeA
cd00886  MogA_MoaB

ProteinModelPortal

H9JGF0   A0A194RI75   A0A2A4J6M5   A0A2H1WC37   A0A194QGF1   A0A212FHM5   + More
A0A0L7L922   A0A1Y1KTZ9   A0A1S4FB83   A0A067QUW8   K9M126   A0A154PNN8   A0A2R4G8S9   A0A1B6FCK7   A0A1Y1JWT1   A0A2P8YHI3   A0A0L7QP05   A0A1W4X1J6   A0A158NGH6   A0A182HGH6   A0A2R4G8T0   A0A2J7R3R6   A0A088AP10   J9K8T8   A0A182UZL2   E2A530   A0A195BXX3   A0A2S2NHA9   A0A158NFV3   A0A182PE85   A0A195BAD2   A0A151X1W0   A0A1B6KAQ3   A0A151IYJ9   A0A182TM38   A0A1S4H0M5   A0A0G4DDB6   A0A182WW35   F4WZG2   A0A1V0JFF9   A0A182QRS4   A0A2S2N7Z7   A0A151IIN9   A0A151JYW9   Q7Q0F6   A0A2H8TMN4   A0A146KY69   A0A182JT77   A0A151X3W9   G3ER33   A0A0N0BDV4   A0A2P8YXX9   A0A1S4F1J9   A0A1B6DYS9   A0A310SXM6   Q93105   T1HQC7   A0A0A9XLS6   A0A026W008   A0A0A9YBQ5   A0A1L8DJW7   A0A2J7RD67   A0A0C4UQS4   A0A1W4XBR9   A0A182WEW1   A0A182J7Y1   A0A1B1UZE9   A0A067RC78   A0A195CNS3   T1JFU0   A0A0C9RT38   A0A182Y1F3   A0A067RBV2   A0A2R7WTX2   A0A087TYT4   A0A336LVG6   A0A1J1J845   A0A088AUM7   A0A182MYU2   G2J5R2   A0A182MVW1  

PDB

5U8R     E-value=3.69628e-53,     Score=530

KEGG

101738080    no KO assigned | (RefSeq) insulin-like receptor

GO

GO:0016021   GO:0007169   GO:0004714   GO:0005524   GO:0071469   GO:0005887   GO:0016020   GO:0005009   GO:0043560   GO:0051897   GO:0014068   GO:0043410   GO:0042593   GO:0030424   GO:0005899   GO:0043235   GO:0006777   GO:0032324   GO:0043548   GO:0046777   GO:0046872   GO:0051290   GO:0008286   GO:0043559   GO:0042802   GO:0006468   GO:0005515   GO:0006811   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR10192   PTHR24416:SF338  

Subcellular location

Membrane  

Length:

833

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

22.81321

Exp number, first 60 AAs:

0.02381

Total prob of N-in:

0.00166

outside

1  -  792

TMhelix

793  -  815

inside

816  -  833

 

 

Pi

13.74372

Theta

15.026074

Tajima's D

0

CLR

12.806123

CSRT

0.382280885955702

Interpretation

Uncertain