Gene

KWMTBOMO11140

Annotation

p260_[Bombyx_mori]

Location

Bomo_Chr18(-):14576700-14579433      View in EpiBrowser

Full name

Fatty acid synthase      

Location in the cell

Nuclear   Reliability : 1.146 PlasmaMembrane   Reliability : 1.46

CDS

ATGAGCTTTTTGTTTACATCCGGGAGCTATGTATCAACACAATTTTCTTCGATCTTCAAAACTGAAGGACTAAACGAGAAAAAGTTGCTGCACAAATTGATTAGCGAAGGTATAGCAAGTGGAGTGGTGAGGCCCCTCAGTCGGATGGTGTATTCTCCAGCGAATGTATCCAGAGCGTTCCGTCTCCTGGCCTCCAGTAAGCACCGAGGCAAGGTTTTGATTAAAATGAGGGACTCCAACACGAATCACGACTTGAAGGTTCATCCAAGATTGACCTGTACATCGAGGGGAAGCTATATCGTTGTCTGTGATGAAAGCGCTCTAAGCTTGGAACTGATTGATCGCTTAGTGAAACGTGGTGCCAGAAATCTGTTTATCCACATCAAGCCTAATTCTATCGCCGGATATTGTTTCACTAAAATTTTCAAGTGGAAAAAACTGAACGTGACAATCAAGATCTCGTCAGAAAACTTACAAACAGAGAACGGATGCACAAACATGATCAGAGAAGCGACTAAAACTGGACCAGTTTGTGGTATCTTCATAGTACAAAACTACAGTTCTGATGCCCAAGAAGATCAGTTCAGAGCTAATGAACATTTGTAA

Protein

MSFLFTSGSYVSTQFSSIFKTEGLNEKKLLHKLISEGIASGVVRPLSRMVYSPANVSRAFRLLASSKHRGKVLIKMRDSNTNHDLKVHPRLTCTSRGSYIVVCDESALSLELIDRLVKRGARNLFIHIKPNSIAGYCFTKIFKWKKLNVTIKISSENLQTENGCTNMIREATKTGPVCGIFIVQNYSSDAQEDQFRANEHL

Catalytic Activity

acetyl-CoA + 2n H(+) + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP(+)
acetyl-CoA + holo-[ACP] = acetyl-[ACP] + CoA
holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]
a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]
a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH
a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O
a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + H(+) + NADPH
(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP]

Subunit

Homodimer which is arranged in a head to tail fashion.

Keywords

Acetylation   Alternative splicing   Complete proteome   Direct protein sequencing   Fatty acid biosynthesis   Fatty acid metabolism   Hydrolase   Lipid biosynthesis   Lipid metabolism   Lyase   Multifunctional enzyme   NAD   NADP   Oxidoreductase   Phosphopantetheine   Phosphoprotein   Pyridoxal phosphate   Reference proteome   Transferase  

Feature

chain  Fatty acid synthase
splice variant  In isoform 1.

Uniprot

O01677   H9JGF5   A0A2H1WZR1   A0A2A4IY92   A0A2A4JTZ4   A0A2H1V933   + More
A0A3S2NJM7   A0A2A4JVR3   A0A2A4K3Y5   A0A2A4K4K9   H9JGD5   A0A2A4IZ90   A0A2H1VPQ1   A0A0N1I4Z6   A0A2H1VBX5   A0A0L7L2W8   A0A0L7L1N0   A0A2A4K3Y0   A0A194PKD7   A0A3S2NT94   A0A3S2M8J0   A0A1L8D6D5   A0A2A4K5B4   A0A1B6CGM1   A0A194QVD5   A0A1B6KCK1   A0A212EN78   A0A182YSB5   A0A182SG92   A0A182MEL3   A0A172GY34   A0A1L8D6P2   A0A1B6IHH2   A0A1B6JP24   A0A182G1R8   A0A091V5Y9   A0A182GNP7   A0A2P8XAG4   A0A182GVQ5   D2A4M7   A0A182WHF5   A0A1S4F133   Q17IW6   A0A1S3HXN4   A0A1S3I0B3   A0A087ZKN3   A0A226N0S9   U4UDB2   T1E9A6   A0A182M3X3   D2A4M5   V5GRN6   A0A182I0F0   Q7PYE4   A0A182V5F6   A0A182XBL3   A0A1W4XV87   E0W0Z3   A0A182KM38   Q16ZI9   A0A1S4FIT0   A0A226PNW4   A0A182P667   N6TW05   A0A067RHL3   A0A182JQR8   A0A1J1I2M2   A0A1D5P6Q5   A0A1S4GYC7   P12276-2   A0A182VQY2   P12276   A0A1L1RKS2   A0A3Q0IWX7   Q7Q4L2   A0A2C9GS69   A0A2J7RA25   D2A4P4   A0A093G8C4   A0A344X1T4   A0A182TPE9   A0A091ET99   A0A1S4HE27   A0A1B6GY38   A0A1J1IGX7   A0A182R1J1   N6TYU8   U4UFT3   A0A182YJT7   A0A1J1IKA4   D2A4M4   G1KJG9   A0A093S8M7   A0A182FQK1   A0A182N5X9   A0A2H1W5A9  

EC Number

2.3.1.85

Pubmed

19121390    26354079    26227816    22118469    25244985    27180724    + More
26483478    29403074    18362917    19820115    17510324    20920257    23537049    12364791    14747013    17210077    20566863    20966253    24621616    24845553    15592404    7944406    2734291    2917973    2842766    3207710    2648999    3207709    2751995   

EMBL

U67866    AAB53257.1    BABH01033637    ODYU01012325    SOQ58579.1    NWSH01005646    + More
PCG64083.1    NWSH01000591    PCG75471.1    ODYU01001294    SOQ37311.1    RSAL01000068    RVE49259.1    PCG75472.1    NWSH01000156    PCG78967.1    PCG78966.1    BABH01033612    BABH01033613    NWSH01005017    PCG64490.1    ODYU01003708    SOQ42815.1    KQ461178    KPJ07769.1    ODYU01001484    SOQ37744.1    JTDY01003263    KOB69848.1    JTDY01003650    KOB69211.1    PCG78965.1    KQ459602    KPI93194.1    RSAL01000223    RVE44006.1    RSAL01000013    RVE53445.1    GEYN01000117    JAV02012.1    PCG78963.1    GEDC01024813    JAS12485.1    KQ461073    KPJ09498.1    GEBQ01031053    JAT08924.1    AGBW02013713    OWR42929.1    AXCM01003979    KU516006    AMK38868.1    GEYN01000115    JAV02014.1    GECU01021338    JAS86368.1    GECU01006695    JAT01012.1    JXUM01038912    KQ561184    KXJ79436.1    KL410718    KFQ98751.1    JXUM01076840    KQ562972    KXJ74732.1    PYGN01016841    PSN28987.1    JXUM01091581    JXUM01091582    KQ971344    EFA05201.1    CH477236    EAT46627.1    MCFN01000295    OXB61122.1    KB632003    ERL87905.1    GAMD01002013    JAA99577.1    AXCM01001692    EFA05203.2    GALX01004174    JAB64292.1    APCN01002072    AAAB01008987    EAA01044.4    DS235863    EEB19298.1    CH477489    EAT40085.1    AWGT02000039    OXB81109.1    APGK01052936    APGK01052937    KB741216    ENN72556.1    KK852680    KDR18643.1    CVRI01000038    CRK94451.1    AADN05000628    AAAB01008964    J03860    J04485    J02839    EAA12911.4    APCN01000761    NEVH01006580    PNF37676.1    EFA05248.1    KL215558    KFV65378.1    MF817713    AXE71619.1    KK717885    KFO52920.1    GECZ01002433    JAS67336.1    CVRI01000051    CRK99509.1    APGK01049539    APGK01049540    KB741156    ENN73526.1    KB632169    ERL89446.1    CRK99510.1    EFA05204.2    KL670490    KFW79189.1    ODYU01006431    SOQ48269.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000037510    UP000053268    + More
UP000007151    UP000076408    UP000075901    UP000075883    UP000069940    UP000249989    UP000053283    UP000245037    UP000007266    UP000075920    UP000008820    UP000085678    UP000198323    UP000030742    UP000075840    UP000007062    UP000075903    UP000076407    UP000192223    UP000009046    UP000075882    UP000198419    UP000075885    UP000019118    UP000027135    UP000075881    UP000183832    UP000000539    UP000079169    UP000235965    UP000053875    UP000075902    UP000052976    UP000075900    UP000001646    UP000053258    UP000069272    UP000075884   

PRIDE

O01677    H9JGF5    H9JGD5    A0A1D5P6Q5    P12276   

Pfam

PF14765   PS-DH        + More
PF02801   Ketoacyl-synt_C
PF00698   Acyl_transf_1
PF16197   KAsynt_C_assoc
PF00975   Thioesterase
PF00109   ketoacyl-synt
PF08659   KR
PF00107   ADH_zinc_N
PF00550   PP-binding

Interpro

IPR018201   Ketoacyl_synth_AS        + More
IPR001031   Thioesterase       
IPR014043   Acyl_transferase       
IPR036291   NAD(P)-bd_dom_sf       
IPR032821   KAsynt_C_assoc       
IPR042104   PKS_dehydratase_sf       
IPR011032   GroES-like_sf       
IPR014031   Ketoacyl_synth_C       
IPR023102   Fatty_acid_synthase_dom_2       
IPR016035   Acyl_Trfase/lysoPLipase       
IPR016036   Malonyl_transacylase_ACP-bd       
IPR020807   PKS_dehydratase       
IPR001227   Ac_transferase_dom_sf       
IPR029058   AB_hydrolase       
IPR020841   PKS_Beta-ketoAc_synthase_dom       
IPR020801   PKS_acyl_transferase       
IPR016039   Thiolase-like       
IPR014030   Ketoacyl_synth_N       
IPR020843   PKS_ER       
IPR013968   PKS_KR       
IPR013149   ADH_C       
IPR036736   ACP-like_sf       
IPR009081   PP-bd_ACP       
IPR020806   PKS_PP-bd       
IPR029063   SAM-dependent_MTases       
IPR006162   Ppantetheine_attach_site       

SUPFAM

SSF50129   SSF50129        + More
SSF55048   SSF55048       
SSF53901   SSF53901       
SSF53474   SSF53474       
SSF52151   SSF52151       
SSF51735   SSF51735       
SSF47336   SSF47336       
SSF53335   SSF53335       

Gene 3D

1.10.1470.20     3.10.129.110     3.40.366.10     3.40.47.10     3.40.50.1820     1.10.1200.10    

ProteinModelPortal

O01677   H9JGF5   A0A2H1WZR1   A0A2A4IY92   A0A2A4JTZ4   A0A2H1V933   + More
A0A3S2NJM7   A0A2A4JVR3   A0A2A4K3Y5   A0A2A4K4K9   H9JGD5   A0A2A4IZ90   A0A2H1VPQ1   A0A0N1I4Z6   A0A2H1VBX5   A0A0L7L2W8   A0A0L7L1N0   A0A2A4K3Y0   A0A194PKD7   A0A3S2NT94   A0A3S2M8J0   A0A1L8D6D5   A0A2A4K5B4   A0A1B6CGM1   A0A194QVD5   A0A1B6KCK1   A0A212EN78   A0A182YSB5   A0A182SG92   A0A182MEL3   A0A172GY34   A0A1L8D6P2   A0A1B6IHH2   A0A1B6JP24   A0A182G1R8   A0A091V5Y9   A0A182GNP7   A0A2P8XAG4   A0A182GVQ5   D2A4M7   A0A182WHF5   A0A1S4F133   Q17IW6   A0A1S3HXN4   A0A1S3I0B3   A0A087ZKN3   A0A226N0S9   U4UDB2   T1E9A6   A0A182M3X3   D2A4M5   V5GRN6   A0A182I0F0   Q7PYE4   A0A182V5F6   A0A182XBL3   A0A1W4XV87   E0W0Z3   A0A182KM38   Q16ZI9   A0A1S4FIT0   A0A226PNW4   A0A182P667   N6TW05   A0A067RHL3   A0A182JQR8   A0A1J1I2M2   A0A1D5P6Q5   A0A1S4GYC7   P12276-2   A0A182VQY2   P12276   A0A1L1RKS2   A0A3Q0IWX7   Q7Q4L2   A0A2C9GS69   A0A2J7RA25   D2A4P4   A0A093G8C4   A0A344X1T4   A0A182TPE9   A0A091ET99   A0A1S4HE27   A0A1B6GY38   A0A1J1IGX7   A0A182R1J1   N6TYU8   U4UFT3   A0A182YJT7   A0A1J1IKA4   D2A4M4   G1KJG9   A0A093S8M7   A0A182FQK1   A0A182N5X9   A0A2H1W5A9  

PDB

6FN6     E-value=1.22731e-15,     Score=199

KEGG

693037    K00665 fatty acid synthase, animal type [EC:2.3.1.85] | (RefSeq) p260

GO

GO:0004312   GO:0009058   GO:0016788   GO:0016491   GO:0016740   GO:0031177   GO:0016021   GO:0004316   GO:0102131   GO:0102132   GO:0004313   GO:0003960   GO:0016296   GO:0004320   GO:0004317   GO:0016295   GO:0004319   GO:0030223   GO:0008611   GO:0005886   GO:0006633   GO:0032100   GO:0006089   GO:0090557   GO:0005829   GO:0071353   GO:0042587   GO:0005623   GO:0005794   GO:0030224   GO:0047117   GO:0003697   GO:0004314   GO:0008659   GO:0004315   GO:0047451  

Length:

201

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01807

Exp number, first 60 AAs:

0.00251

Total prob of N-in:

0.01731

outside

1  -  201

 

 

Pi

7.260173

Theta

15.608615

Tajima's D

-1.412545

CLR

0.722325

CSRT

0.0667966601669917

Interpretation

Uncertain