Gene

KWMTBOMO11115  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008221

Annotation

promoting_protein_precursor_[Bombyx_mori]

Location

Bomo_Chr18(-):13315360-13322285      View in EpiBrowser

Full name

MD-2-related lipid-recognition protein      

Location in the cell

Extracellular   Reliability : 3.78

CDS

ATGGCTCTCTACTCTTCGCTGTTATTCGCTGCATTCCTCGGCTGTGGTCTAGCTGAATTCAACGTCGTCACCACAAGGCTATGCCGGGAAGTGGACGCCAGCGCGTGTACTGTGAACGAGGTCCGAATTGACCCCTGTGTTAACAGTCGACTGTGCCACCTCAAGAAAGGGAAAAACGCGAAGGTTTCTTTCGACTTTACACCACAATTCTCCACAACTAAACTCAAGACCGGCCTCTTTGGGTTGAAGAATGGCGCTGAAATTCCTTTTGATGCTCTCTACAATGCTGACGCTTGCACACTCACGTCATGTCCCACCGAAGCTGGCAAAACTCAAACCTTAGACTTTAGTTTGCATATTGGAAAAAAACTGCCTACGGGAAACTTTGAATTCAAATGGAAGCTTTGGAATGAAGACAATGAGAGCCAGATGTGCTGCTACAGAACGAATGTCAGGCTTGTTTAG

Protein

MALYSSLLFAAFLGCGLAEFNVVTTRLCREVDASACTVNEVRIDPCVNSRLCHLKKGKNAKVSFDFTPQFSTTKLKTGLFGLKNGAEIPFDALYNADACTLTSCPTEAGKTQTLDFSLHIGKKLPTGNFEFKWKLWNEDNESQMCCYRTNVRLV

Description

Binds to lipopolysaccharide from a variety of Gram-negative bacteria and to lipid A.

Similarity

Belongs to the NPC2 family.

Keywords

Direct protein sequencing   Disulfide bond   Glycoprotein   Lipid-binding   Secreted   Signal  

Feature

chain  MD-2-related lipid-recognition protein

Uniprot

Q69FX2   Q9U5E1   A0A194QMD5   B0FHH8   A0A194RMQ6   I4DJ01   + More
A0A2A4K8D6   A0A2H1VQ20   A0A1E1WBL4   A0A1B6FIF8   A0A1B6EXE9   A0A1B6F3J1   A0A1B6LQS7   A0A1B6K3N1   F4WT68   E9IGX8   A0A195FNF4   A0A2P8XTA6   A0A195BJ96   A0A1B6MNU6   E2BVP4   A0A195CUE1   A0A158NQ68   A0A026WLK4   A0A195DEP2   A0A336MCY1   A0A336MF43   A0A0J7L5K5   A0A1B6HHP2   A0A087ZRW9   A0A151XFX7   A0A0L7QRS9   A0A2H1VQ41   V9IHT6   A0A1W6EWD0   I4DKA2   A0A0M9ADU4   A0A194RI95   A0A023EGU1   A0A310SNK0   A0A023EHB9   A0A182JL51   A0A2A3E5R2   A0A2A4KA03   B0WEN9   A0A084VI82   Q17DQ0   U5EWD5   D2A0I8   A0A1Q3FPN8   A0A1L8DQG5   A0A182MYQ4   A0A182SFU5   A0A182Y1M5   D3KAS0   A0A034VFC7   A0A182P6K2   A0A0A1XHF5   E0VLE3   W8BXI8   I4DRU5   A0A0C9REG8   D3KAR8   D3KAM3   D3KAR6   A0A182JTI9   D3KAP4   A0A182WZN8   Q7Q0A4   A0A182HQ84   A0A1A9W6L0   D3KAR0   D3KAN6   D3KAP7   D3KAM7   D3KAL0   D3KAP2   D3KAP6   A0A0K8W6Y5   A0A182KSG2   A0A1Q3EV83   D3KAS1   D3KAN2   D3KAM4   D3KAQ6   D3KAN1   D3KAK5   D3KAN9   A0A182UVA1   D3KAS2   D3KAM8   D3KAK7   B4K9G6   D3KAK6   D3KAP9  

Pubmed

16233927    19121390    10725443    26354079    18343500    22651552    + More
21719571    21282665    29403074    20798317    21347285    24508170    30249741    24945155    24438588    17510324    18362917    19820115    25244985    20126662    25348373    25830018    20566863    24495485    12364791    14747013    17210077    20966253    17994087   

EMBL

BABH01038277    AY338398    AAQ01563.1    AB030701    BAA89306.1    KQ458880    + More
KPJ04631.1    EU329722    ABY55152.1    KQ460154    KPJ17281.1    AK401269    BAM17891.1    NWSH01000032    PCG80481.1    ODYU01003754    SOQ42919.1    GDQN01006715    JAT84339.1    GECZ01019802    JAS49967.1    GECZ01027085    JAS42684.1    GECZ01024940    JAS44829.1    GEBQ01013881    JAT26096.1    GECU01001658    JAT06049.1    GL888332    EGI62597.1    GL763074    EFZ20175.1    KQ981382    KYN42100.1    PYGN01001381    PSN35232.1    KQ976464    KYM84467.1    GEBQ01002351    JAT37626.1    GL450924    EFN80227.1    KQ977279    KYN04301.1    ADTU01022872    ADTU01022873    ADTU01022874    ADTU01022875    KK107154    QOIP01000001    EZA56925.1    RLU27056.1    KQ980934    KYN11307.1    UFQT01000719    SSX26759.1    UFQS01001079    UFQT01001079    SSX08875.1    SSX28786.1    LBMM01000477    KMQ98252.1    GECU01033585    JAS74121.1    KQ982182    KYQ59257.1    KQ414771    KOC61332.1    SOQ42918.1    JR048187    AEY60595.1    KY563621    ARK20030.1    AK401720    BAM18342.1    KPJ04632.1    KQ435692    KOX81109.1    KPJ17282.1    GAPW01005548    JAC08050.1    KQ762692    OAD55535.1    GAPW01005313    JAC08285.1    KZ288358    PBC27040.1    PCG80482.1    DS231910    EDS45755.1    ATLV01013330    KE524853    KFB37676.1    CH477292    EAT44525.1    GANO01002997    JAB56874.1    KQ971338    EFA02815.1    GFDL01005490    JAV29555.1    GFDF01005489    JAV08595.1    GU432989    ADC29993.1    GAKP01018709    GAKP01018708    JAC40243.1    GBXI01004349    JAD09943.1    DS235271    EEB14199.1    GAMC01002568    GAMC01002567    JAC03988.1    AK405273    BAM20635.1    GBYB01005361    JAG75128.1    GU432987    ADC29991.1    GU432942    ADC29946.1    GU432985    ADC29989.1    GU432963    GU432964    ADC29967.1    ADC29968.1    AAAB01008986    EAA00385.4    APCN01003297    GU432979    ADC29983.1    GU432955    ADC29959.1    GU432966    ADC29970.1    GU432946    ADC29950.1    GU432929    ADC29933.1    GU432961    ADC29965.1    GU432965    ADC29969.1    GDHF01005492    JAI46822.1    GFDL01015826    JAV19219.1    GU432990    ADC29994.1    GU432951    ADC29955.1    GU432943    ADC29947.1    GU432975    GU432978    ADC29979.1    ADC29982.1    GU432950    GU432953    GU432954    ADC29954.1    ADC29957.1    ADC29958.1    GU432924    GU432930    GU432931    GU432980    ADC29928.1    ADC29934.1    ADC29935.1    ADC29984.1    GU432958    GU432959    GU432960    ADC29962.1    ADC29963.1    ADC29964.1    GU432991    ADC29995.1    GU432947    GU432948    GU432949    GU432952    ADC29951.1    ADC29952.1    ADC29953.1    ADC29956.1    GU432926    GU432927    GU432928    ADC29930.1    ADC29931.1    ADC29932.1    CH933806    EDW16626.2    GU432925    ADC29929.1    GU432968    GU432969    GU432970    GU432972    GU432973    ADC29972.1    ADC29973.1    ADC29974.1    ADC29976.1    ADC29977.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000007755    UP000078541    + More
UP000245037    UP000078540    UP000008237    UP000078542    UP000005205    UP000053097    UP000279307    UP000078492    UP000036403    UP000005203    UP000075809    UP000053825    UP000053105    UP000075880    UP000242457    UP000002320    UP000030765    UP000008820    UP000007266    UP000075884    UP000075901    UP000076408    UP000075885    UP000009046    UP000075881    UP000076407    UP000007062    UP000075840    UP000091820    UP000075882    UP000075903    UP000009192   

PRIDE

Q69FX2    Q9U5E1   

Pfam

PF02221   E1_DerP2_DerF2        + More
PF00536   SAM_1

Interpro

IPR039670   NPC2-like        + More
IPR014756   Ig_E-set       
IPR003172   ML_dom       
IPR033916   ML_Npc2-like       
IPR013087   Znf_C2H2_type       
IPR036236   Znf_C2H2_sf       
IPR001660   SAM       
IPR013761   SAM/pointed_sf       

SUPFAM

SSF81296   SSF81296        + More
SSF57667   SSF57667       
SSF47769   SSF47769       

Gene 3D

1.10.150.50    

CDD

cd00916  Npc2_like

ProteinModelPortal

Q69FX2   Q9U5E1   A0A194QMD5   B0FHH8   A0A194RMQ6   I4DJ01   + More
A0A2A4K8D6   A0A2H1VQ20   A0A1E1WBL4   A0A1B6FIF8   A0A1B6EXE9   A0A1B6F3J1   A0A1B6LQS7   A0A1B6K3N1   F4WT68   E9IGX8   A0A195FNF4   A0A2P8XTA6   A0A195BJ96   A0A1B6MNU6   E2BVP4   A0A195CUE1   A0A158NQ68   A0A026WLK4   A0A195DEP2   A0A336MCY1   A0A336MF43   A0A0J7L5K5   A0A1B6HHP2   A0A087ZRW9   A0A151XFX7   A0A0L7QRS9   A0A2H1VQ41   V9IHT6   A0A1W6EWD0   I4DKA2   A0A0M9ADU4   A0A194RI95   A0A023EGU1   A0A310SNK0   A0A023EHB9   A0A182JL51   A0A2A3E5R2   A0A2A4KA03   B0WEN9   A0A084VI82   Q17DQ0   U5EWD5   D2A0I8   A0A1Q3FPN8   A0A1L8DQG5   A0A182MYQ4   A0A182SFU5   A0A182Y1M5   D3KAS0   A0A034VFC7   A0A182P6K2   A0A0A1XHF5   E0VLE3   W8BXI8   I4DRU5   A0A0C9REG8   D3KAR8   D3KAM3   D3KAR6   A0A182JTI9   D3KAP4   A0A182WZN8   Q7Q0A4   A0A182HQ84   A0A1A9W6L0   D3KAR0   D3KAN6   D3KAP7   D3KAM7   D3KAL0   D3KAP2   D3KAP6   A0A0K8W6Y5   A0A182KSG2   A0A1Q3EV83   D3KAS1   D3KAN2   D3KAM4   D3KAQ6   D3KAN1   D3KAK5   D3KAN9   A0A182UVA1   D3KAS2   D3KAM8   D3KAK7   B4K9G6   D3KAK6   D3KAP9  

PDB

5KWY     E-value=8.45059e-07,     Score=121

KEGG

692685    K13443 Niemann-Pick C2 protein | (RefSeq) pp; promoting protein

PATHWAY

04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0032367   GO:0005623   GO:0005576   GO:0008289   GO:0016021   GO:0003676   GO:0032934   GO:0015918   GO:0051087   GO:0005488   GO:0005515   GO:0015992   GO:0005524   GO:0006811   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR11306  

Subcellular location

Secreted  

SignalP

Position:   1 - 18,         Likelihood:  0.978853

 

 

Length:

154

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

4.85927

Exp number, first 60 AAs:

4.8592

Total prob of N-in:

0.09623

outside

1  -  154

 

 

Pi

230.085569

Theta

161.222842

Tajima's D

1.234639

CLR

0.002153

CSRT

0.72376381180941

Interpretation

Uncertain