Gene

KWMTBOMO11114  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008222

Annotation

PREDICTED:_MD-2-related_lipid-recognition_protein-like_[Papilio_machaon]

Location

Bomo_Chr18(-):13307749-13312345      View in EpiBrowser

Full name

MD-2-related lipid-recognition protein      

Location in the cell

Extracellular   Reliability : 2.63

CDS

ATGTACGCCGTATTTTGTCTTATTTTGATTTCGAATTACGCTTTTGTTCAGGGCGAGTTTGTATTCAAGAAAAAATGTAGAGATGTGGACACTTCATTGTGTACCGTTCATAACGTGATGGTTGAACCTTGTGGCGAAGGCCCGATCTTCTGCGCTCTCAAGAAGAATAAGCCTTACAGCATAAGCTTAGACGTTACTCCACACTTTTCTGCGAATAAATTGCACGCAGTCATAAAGGGAGACGTCCAAAACCAAAACACTTTCTCGACTACCTTCACGAGATCAGCAGAGTACAATGACCTACTGGACAATACTTTATCGGAAGGGAAGCGAACACACATACAACTCCAGTTGGCTGTGGACAAACGCGCCTCTGGCAAATTCCCATTGGAAGTTCGCGTTTGGGACGAGGATGATACGTCTCATGTTTGTTGCTCAATATTTACGGTTAAAATCAGATAA

Protein

MYAVFCLILISNYAFVQGEFVFKKKCRDVDTSLCTVHNVMVEPCGEGPIFCALKKNKPYSISLDVTPHFSANKLHAVIKGDVQNQNTFSTTFTRSAEYNDLLDNTLSEGKRTHIQLQLAVDKRASGKFPLEVRVWDEDDTSHVCCSIFTVKIR

Description

Binds to lipopolysaccharide from a variety of Gram-negative bacteria and to lipid A.

Similarity

Belongs to the NPC2 family.

Keywords

Direct protein sequencing   Disulfide bond   Glycoprotein   Lipid-binding   Secreted   Signal  

Feature

chain  MD-2-related lipid-recognition protein

Uniprot

H9JFC5   A0A2H1VQ41   A0A2A4KA03   A0A194RI95   I4DKA2   I4DRU5   + More
A0A212FIA0   A0A3S2LS99   A0A194QMD5   Q69FX2   I4DJ01   Q9U5E1   A0A1A9W6L0   A0A194RMQ6   A0A1B0BF04   A0A2H1VQ20   D3TR84   A0A1E1WBL4   W8BXI8   B0FHH8   A0A0M9ADU4   A0A1B0FR67   A0A195CUE1   A0A2A4K8D6   E2BVP4   A0A182QW33   A0A1A9VVQ8   A0A195BJ96   A0A026WLK4   A0A034VFC7   A0A310SNK0   Q29CB5   B4GNB9   A0A0C9REG8   F4WT68   A0A0K8W6Y5   B4LW70   A0A131YR94   A0A0L7QRS9   A0A195DEP2   A0A0A1XHF5   D2A0I8   A0A0J7L5K5   E9IGX8   A0A1W4U6E5   A0A195FNF4   B4LW71   A0A158NQ68   A0A151XFX7   A0A1Y1KP13  

Pubmed

19121390    26354079    22651552    22118469    16233927    10725443    + More
20353571    24495485    18343500    20798317    24508170    30249741    25348373    15632085    17994087    21719571    26830274    25830018    18362917    19820115    21282665    21347285    28004739   

EMBL

BABH01038277    ODYU01003754    SOQ42918.1    NWSH01000032    PCG80482.1    KQ460154    + More
KPJ17282.1    AK401720    KQ458880    BAM18342.1    KPJ04632.1    AK405273    BAM20635.1    AGBW02008411    OWR53463.1    RSAL01000264    RVE43288.1    KPJ04631.1    AY338398    AAQ01563.1    AK401269    BAM17891.1    AB030701    BAA89306.1    KPJ17281.1    JXJN01013235    SOQ42919.1    EZ423936    ADD20212.1    GDQN01006715    JAT84339.1    GAMC01002568    GAMC01002567    JAC03988.1    EU329722    ABY55152.1    KQ435692    KOX81109.1    CCAG010021984    KQ977279    KYN04301.1    PCG80481.1    GL450924    EFN80227.1    AXCN02001032    KQ976464    KYM84467.1    KK107154    QOIP01000001    EZA56925.1    RLU27056.1    GAKP01018709    GAKP01018708    JAC40243.1    KQ762692    OAD55535.1    CM000070    EAL26731.1    CH479186    EDW39245.1    GBYB01005361    JAG75128.1    GL888332    EGI62597.1    GDHF01005492    JAI46822.1    CH940650    EDW67604.1    GEDV01008146    JAP80411.1    KQ414771    KOC61332.1    KQ980934    KYN11307.1    GBXI01004349    JAD09943.1    KQ971338    EFA02815.1    LBMM01000477    KMQ98252.1    GL763074    EFZ20175.1    KQ981382    KYN42100.1    EDW67605.1    ADTU01022872    ADTU01022873    ADTU01022874    ADTU01022875    KQ982182    KYQ59257.1    GEZM01080352    JAV62201.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000283053    + More
UP000091820    UP000092460    UP000053105    UP000092444    UP000078542    UP000008237    UP000075886    UP000078200    UP000078540    UP000053097    UP000279307    UP000001819    UP000008744    UP000007755    UP000008792    UP000053825    UP000078492    UP000007266    UP000036403    UP000192221    UP000078541    UP000005205    UP000075809   

PRIDE

H9JFC5    Q69FX2    Q9U5E1   

Pfam

PF02221   E1_DerP2_DerF2        + More
PF00536   SAM_1

Interpro

IPR014756   Ig_E-set        + More
IPR039670   NPC2-like       
IPR003172   ML_dom       
IPR033916   ML_Npc2-like       
IPR001660   SAM       
IPR013761   SAM/pointed_sf       
IPR013087   Znf_C2H2_type       
IPR036236   Znf_C2H2_sf       

SUPFAM

SSF81296   SSF81296        + More
SSF47769   SSF47769       
SSF57667   SSF57667       

Gene 3D

1.10.150.50    

CDD

cd00916  Npc2_like

ProteinModelPortal

H9JFC5   A0A2H1VQ41   A0A2A4KA03   A0A194RI95   I4DKA2   I4DRU5   + More
A0A212FIA0   A0A3S2LS99   A0A194QMD5   Q69FX2   I4DJ01   Q9U5E1   A0A1A9W6L0   A0A194RMQ6   A0A1B0BF04   A0A2H1VQ20   D3TR84   A0A1E1WBL4   W8BXI8   B0FHH8   A0A0M9ADU4   A0A1B0FR67   A0A195CUE1   A0A2A4K8D6   E2BVP4   A0A182QW33   A0A1A9VVQ8   A0A195BJ96   A0A026WLK4   A0A034VFC7   A0A310SNK0   Q29CB5   B4GNB9   A0A0C9REG8   F4WT68   A0A0K8W6Y5   B4LW70   A0A131YR94   A0A0L7QRS9   A0A195DEP2   A0A0A1XHF5   D2A0I8   A0A0J7L5K5   E9IGX8   A0A1W4U6E5   A0A195FNF4   B4LW71   A0A158NQ68   A0A151XFX7   A0A1Y1KP13  

KEGG

101744032    K13443 Niemann-Pick C2 protein | (RefSeq) uncharacterized LOC101744032

PATHWAY

04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0032367   GO:0005623   GO:0005576   GO:0008289   GO:0016021   GO:0032934   GO:0015918   GO:0003676  

PANTHER

PTHR11306  

Subcellular location

Secreted  

SignalP

Position:   1 - 18,         Likelihood:  0.961229

 

 

Length:

153

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.01228

Exp number, first 60 AAs:

1.01228

Total prob of N-in:

0.07832

outside

1  -  153

 

 

Pi

342.725514

Theta

29.311906

Tajima's D

0.081883

CLR

0.082834

CSRT

0.393830308484576

Interpretation

Uncertain