Gene

KWMTBOMO11084  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008563

Annotation

calcineurin_B_[Bombyx_mori]

Location

Bomo_Chr18(+):12392017-12407260      View in EpiBrowser

Full name

Calcineurin subunit B type 2       + More
Calcineurin subunit B type 1      

Alternative Name

Protein phosphatase 2B regulatory subunit 2
dCNB2
Protein phosphatase 2B regulatory subunit 1

Location in the cell

Nuclear   Reliability : 3.301

CDS

ATGGGTAACGAAAACTCTATTCCCATGGAACTATGTTCAAACTTCGATGCGGATGAGATCCGTCGTCTCGGCAAGCGTTTCCGGAAACTGGACTTGGACAATTCCGGGGCGCTGTCCATCGATGAGTTCATGTCTCTACCTGAGCTGCAGCAAAATCCACTTGTCCAACGCGTCATCGATATATTCGACGCAGACGGGAACGGAGAGGTCGACTTCAAGGAGTTCATCCAGGGCGTGTCTCAGTTTAGTGTGAAAGGGGATAAACTGTCCAAATTACGATTCGCTTTCCGCATATACGACATGGACAACGATGGGTTCATATCCAACGGCGAATTGTTTCAGGTACTCAAAATGATGGTAGGCAACAATCTAAAGGACACACAGCTCCAGCAGATCGTCGATAAGACGATACTTTTCGCCGACAAGGACGAGGACGGGAAAATATCATTCGAGGAGTTTTGCAATGTGGTTGGCAACACTGACATTCATAAGAAAATGGTCGTTGACGTTTAA

Protein

MGNENSIPMELCSNFDADEIRRLGKRFRKLDLDNSGALSIDEFMSLPELQQNPLVQRVIDIFDADGNGEVDFKEFIQGVSQFSVKGDKLSKLRFAFRIYDMDNDGFISNGELFQVLKMMVGNNLKDTQLQQIVDKTILFADKDEDGKISFEEFCNVVGNTDIHKKMVVDV

Description

Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase.

Subunit

Composed of a catalytic subunit (A) and a regulatory subunit (B) (By similarity). Interacts with sra.
Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

Miscellaneous

This protein has four functional calcium-binding sites.

Similarity

Belongs to the calcineurin regulatory subunit family.

Keywords

Calcium   Complete proteome   Metal-binding   Phosphoprotein   Reference proteome   Repeat  

Feature

chain  Calcineurin subunit B type 2

Uniprot

A0A3G2LEE2   A0A159D821   Q95P81   C5HW10   D2A3E7   V5G234   + More
A0A1W4WHP7   N6TU92   A0A1Y1L1B0   B0X5C6   A0A1L8DM94   A0A1B0F072   A0A1B0GJ55   A0A1Q3F985   A0A182XWQ9   A0A2M3Z5F8   A0A2M4AEY9   W5JG79   Q16SV8   A0A182IWC0   A0A182F9K4   A0A023EHZ1   D3TPF2   A0A1B0BYF8   A0A1I8PTT0   A0A0L0BPQ6   A0A0A1XAE2   A0A1A9WNJ5   A0A0K8VQT8   W8AEY7   T1PAZ7   A0A034VKT8   A0A0A9XTX6   A0A182PRH5   A0A182MMQ3   A0A182QQA4   A0A182VBP1   A0A182NCB4   A0A182VY50   A0A182X8U8   A0A182L6W7   F5HLK4   A0A182R5M5   A0A182ID30   A0A2A3EMY3   V9IJA5   A0A336M1B3   B4LMJ8   A0A1W4WB64   B4KSY0   A0A3B0J4H4   A0A0B4K833   B4GDK8   B4P234   A0A0M4ETG9   B3MHU2   B4MPK4   B4HR72   B3N9T9   B4NS61   Q24214   A0A0N7Z9G5   A0A023FB92   A0A1B6MEK0   A0A1B6HCB3   A0A069DNK6   R4G4G1   A0A1B6FMH4   A0A1B6DIW0   A0A2J7RKZ5   A0A0K8TPL8   A0A2S2PX83   C4WVG3   B4MEG6   A0A3B0K081   M9NFW6   B4GVM5   B4PZR0   B4NCK1   B4I0Q3   B4JMB8   B3NV37   A0A1W4VJB9   B4L7T7   Q29GB9   P48451   A0A2R7WB91   A0A212EWQ5   A0A0V0G4P3   A0A0A1XB79   A0A195BQI9   A0A1B6DX16   A0A195CH79   A0A195F4B1   U5EWP2   E9GYL6   A0A0P5U8S7   T1DTZ7   A0A0B4UGQ8   A0A0P4WLX9  

Pubmed

11886782    19442669    18362917    19820115    23537049    28004739    + More
25244985    20920257    23761445    17510324    24945155    20353571    26108605    25830018    24495485    25315136    25348373    25401762    26823975    20966253    12364791    14747013    17210077    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17550304    22936249    8921860    12537569    18327897    22421435    27129103    25474469    26334808    26369729    18057021    15632085    23185243    1331060    22118469    21292972    25541080   

EMBL

MH108091    AYN70621.1    KR260841    ALS92680.1    AF287251    AAK83039.1    + More
FJ555522    NWSH01002437    ACR78448.1    PCG68301.1    KQ971338    EFA01924.1    GALX01004406    JAB64060.1    APGK01052113    APGK01052114    KB741209    KB632081    ENN72845.1    ERL88597.1    GEZM01067672    JAV67453.1    DS232374    EDS40811.1    GFDF01006553    JAV07531.1    AJVK01007409    AJVK01007410    AJWK01019315    GFDL01010910    JAV24135.1    GGFM01002999    MBW23750.1    GGFK01006024    MBW39345.1    ADMH02001608    ETN61819.1    CH477664    EAT37561.1    AXCP01001778    GAPW01005098    GEHC01000775    JAC08500.1    JAV46870.1    EZ423304    ADD19580.1    JXJN01022630    JRES01001567    KNC21991.1    GBXI01006421    JAD07871.1    GDHF01011073    GDHF01002195    JAI41241.1    JAI50119.1    GAMC01019766    GAMC01019765    JAB86790.1    KA645118    AFP59747.1    GAKP01016267    GAKP01016265    JAC42687.1    GBHO01021271    GBRD01002316    GDHC01002523    JAG22333.1    JAG63505.1    JAQ16106.1    AXCM01014138    AXCN02001188    AAAB01008898    EAA09157.6    EGK97136.1    EGK97137.1    APCN01004984    KZ288215    PBC32622.1    JR047449    AEY60419.1    UFQS01000315    UFQT01000315    SSX02749.1    SSX23121.1    CH940648    EDW59985.2    CH933808    EDW08477.2    OUUW01000001    SPP74352.1    AE013599    AFH07947.1    CH479181    EDW31665.1    CM000157    EDW89235.1    CP012524    ALC40812.1    CH902619    EDV36929.1    CH963849    EDW74043.1    CH480816    EDW46815.1    CH954177    EDV59635.1    CM000362    CH981913    CM002911    EDX06071.1    EDX15439.1    KMY92089.1    U56245    AY089602    BT003768    GDKW01000611    JAI55984.1    GBBI01000524    JAC18188.1    GEBQ01005672    JAT34305.1    GECU01035369    JAS72337.1    GBGD01003236    JAC85653.1    ACPB03018626    GAHY01000801    JAA76709.1    GECZ01029262    GECZ01018363    GECZ01014700    JAS40507.1    JAS51406.1    JAS55069.1    GEDC01011748    JAS25550.1    NEVH01002706    PNF41469.1    GDAI01001261    JAI16342.1    GGMS01000767    MBY69970.1    ABLF02029770    AK341502    BAH71883.1    CH940664    EDW62941.1    OUUW01000003    SPP78411.1    AE014298    AFH07245.1    CH479193    EDW26720.1    CM000162    EDX01127.1    CH964239    EDW82560.1    CH480819    EDW53084.1    CH916371    EDV91879.1    CH954180    EDV45885.1    CH933814    EDW05512.1    KRG07410.1    KRG07411.1    CH379064    EAL32191.1    KRT07035.1    KRT07036.1    M97215    AY070642    KK854569    PTY16964.1    AGBW02011923    OWR45919.1    GECL01003115    JAP03009.1    GBXI01006031    JAD08261.1    KQ976424    KYM88231.1    GEDC01007076    JAS30222.1    KQ977827    KYM99438.1    KQ981820    KYN35221.1    GANO01001328    JAB58543.1    GL732575    EFX75418.1    GDIP01116464    LRGB01000024    JAL87250.1    KZS21505.1    GAMD01000604    JAB00987.1    KM658167    AJD07837.1    GDRN01031763    JAI67510.1   

Proteomes

UP000218220    UP000007266    UP000192223    UP000019118    UP000030742    UP000002320    + More
UP000092462    UP000092461    UP000076408    UP000000673    UP000008820    UP000075880    UP000069272    UP000092460    UP000095300    UP000037069    UP000091820    UP000095301    UP000075885    UP000075883    UP000075886    UP000075903    UP000075884    UP000075920    UP000076407    UP000075882    UP000007062    UP000075900    UP000075840    UP000242457    UP000008792    UP000192221    UP000009192    UP000268350    UP000000803    UP000008744    UP000002282    UP000092553    UP000007801    UP000007798    UP000001292    UP000008711    UP000000304    UP000015103    UP000235965    UP000007819    UP000001070    UP000001819    UP000007151    UP000078540    UP000078542    UP000078541    UP000000305    UP000076858   

PRIDE

Q95P81    Q24214    M9NFW6    P48451   

Pfam

PF13499   EF-hand_7

Interpro

IPR002048   EF_hand_dom        + More
IPR011992   EF-hand-dom_pair       
IPR018247   EF_Hand_1_Ca_BS       

SUPFAM

SSF47473   SSF47473       

CDD

cd00051  EFh

ProteinModelPortal

A0A3G2LEE2   A0A159D821   Q95P81   C5HW10   D2A3E7   V5G234   + More
A0A1W4WHP7   N6TU92   A0A1Y1L1B0   B0X5C6   A0A1L8DM94   A0A1B0F072   A0A1B0GJ55   A0A1Q3F985   A0A182XWQ9   A0A2M3Z5F8   A0A2M4AEY9   W5JG79   Q16SV8   A0A182IWC0   A0A182F9K4   A0A023EHZ1   D3TPF2   A0A1B0BYF8   A0A1I8PTT0   A0A0L0BPQ6   A0A0A1XAE2   A0A1A9WNJ5   A0A0K8VQT8   W8AEY7   T1PAZ7   A0A034VKT8   A0A0A9XTX6   A0A182PRH5   A0A182MMQ3   A0A182QQA4   A0A182VBP1   A0A182NCB4   A0A182VY50   A0A182X8U8   A0A182L6W7   F5HLK4   A0A182R5M5   A0A182ID30   A0A2A3EMY3   V9IJA5   A0A336M1B3   B4LMJ8   A0A1W4WB64   B4KSY0   A0A3B0J4H4   A0A0B4K833   B4GDK8   B4P234   A0A0M4ETG9   B3MHU2   B4MPK4   B4HR72   B3N9T9   B4NS61   Q24214   A0A0N7Z9G5   A0A023FB92   A0A1B6MEK0   A0A1B6HCB3   A0A069DNK6   R4G4G1   A0A1B6FMH4   A0A1B6DIW0   A0A2J7RKZ5   A0A0K8TPL8   A0A2S2PX83   C4WVG3   B4MEG6   A0A3B0K081   M9NFW6   B4GVM5   B4PZR0   B4NCK1   B4I0Q3   B4JMB8   B3NV37   A0A1W4VJB9   B4L7T7   Q29GB9   P48451   A0A2R7WB91   A0A212EWQ5   A0A0V0G4P3   A0A0A1XB79   A0A195BQI9   A0A1B6DX16   A0A195CH79   A0A195F4B1   U5EWP2   E9GYL6   A0A0P5U8S7   T1DTZ7   A0A0B4UGQ8   A0A0P4WLX9  

PDB

4IL1     E-value=2.37917e-79,     Score=747

KEGG

692578    K06268 serine/threonine-protein phosphatase 2B regulatory subunit | (RefSeq) Cnb; calcineurin B

PATHWAY

04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005509   GO:0030431   GO:0030241   GO:0051321   GO:0045214   GO:0004721   GO:0005955   GO:0008021   GO:0006470   GO:0008597   GO:0016192   GO:0005516   GO:0007269   GO:0006414   GO:0005515   GO:0000155   GO:0000160   GO:0005216   GO:0006811   GO:0005622   GO:0006810   GO:0003824  

Length:

170

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00071

Exp number, first 60 AAs:

0

Total prob of N-in:

0.07879

outside

1  -  170

 

 

Pi

193.304854

Theta

167.03162

Tajima's D

0.461581

CLR

1.378618

CSRT

0.504574771261437

Interpretation

Uncertain