Gene

KWMTBOMO11078  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008304

Annotation

PREDICTED:_RAC_serine/threonine-protein_kinase_[Bombyx_mori]

Location

Bomo_Chr18(-):12317708-12331786      View in EpiBrowser

Full name

Non-specific serine/threonine protein kinase       + More
RAC serine/threonine-protein kinase      

Alternative Name

Akt
Protein kinase B

Location in the cell

Cytoplasmic   Reliability : 2.236

CDS

ATGGCGGCGCCCGGGATCATCGTGAAGGAAGGATGGCTGCAGAAACGTGGTGAACACATCCGGAATTGGCGAGATCGGTACTTCATATTGTTCGACACGGGGGACCTGGTGGGCTTCAAGACCCAGCCGGAGCGGAACAACTACAGGGACCCTCTCAACAAGTTCACCGTACGCGACTGCCAGATCATGGCTGTGGACAAACCTCGCCCCTACACTTTTACCATACGTGGCCTGCAGTGGACCACTGTTATTGAAAGGAACTTCTCAGTTGACAACGAAAAAGAAAGAGAAGAATGGGTGAAGGCCATCCGAGAAGTTGCCTCGCAACTGAGCACCGGAGGGCCCAGTTCAGCATCGATGTCCGATGCTGACGATCGCGACATGGCACAGCTCGGCACCAGCTTCCGTGACCCCCGCCGCATCACCTTAGAAAAATTCGAATTCGTGAAGGTGCTAGGCAAGGGTACGTTTGGGAAGGTGGTTCTGAGCCGTGAGAAGGGAACGGGAAAGCTGTACGCTATGAAGATATTGAAGAAACACCTCATTATACAGAAGGATGAGGTCGCGCACACCATCACCGAGAACCGAGTGCTCAAGAAGACCAAGCATCCATTTTTGACGGCTCTCCGCTATTCCTTCCAAACGGCAGACCGTGTCTGCTTCGTAATGGAATACGCTAATGGCGGTGAATTGTTCTTTCATTTGTCCCGCGAGCGTTCGTTCACCGAGGACCGCACCAGGTTCTACGGAGCCGAGATAGTATCTGCTCTCGGGTACCTCCACTCCGAGGGCATTATATATCGGGATTTGAAACTCGAGAATTTGCTGCTAGACAAAGACGGACACATCAAGATTGCAGACTTCGGACTATGCAAGGTGAATATAACGTATGGACGCACGACCAAGACGTTCTGTGGCACCCCCGAGTACCTCGCCCCTGAGGTCATAGAGGACTCCGATTATGGTCCCGCCGTAGATTGGTTAGTTGCTAACTAA

Protein

MAAPGIIVKEGWLQKRGEHIRNWRDRYFILFDTGDLVGFKTQPERNNYRDPLNKFTVRDCQIMAVDKPRPYTFTIRGLQWTTVIERNFSVDNEKEREEWVKAIREVASQLSTGGPSSASMSDADDRDMAQLGTSFRDPRRITLEKFEFVKVLGKGTFGKVVLSREKGTGKLYAMKILKKHLIIQKDEVAHTITENRVLKKTKHPFLTALRYSFQTADRVCFVMEYANGGELFFHLSRERSFTEDRTRFYGAEIVSALGYLHSEGIIYRDLKLENLLLDKDGHIKIADFGLCKVNITYGRTTKTFCGTPEYLAPEVIEDSDYGPAVDWLVAN

Description

Serine/threonine kinase involved in various developmental processes (PubMed:9601646, PubMed:10587646, PubMed:10962553, PubMed:11740943, PubMed:12172554, PubMed:11872800, PubMed:14525946, PubMed:12893776, PubMed:15466161, PubMed:15712201). During early embryogenesis, acts as a survival protein (PubMed:9601646, PubMed:10962553). During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination (PubMed:11740943). Also regulates tracheal cell migration (PubMed:11740943, PubMed:14525946). Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor (PubMed:10587646, PubMed:10962553, PubMed:11752451, PubMed:12893776, PubMed:25329475, PubMed:29025897, PubMed:24603715). Controls follicle cell size during oogenesis (PubMed:15712201). May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex (PubMed:12172554, PubMed:15466161). Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth (PubMed:10962553).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Interacts with trbl.

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
Belongs to the membrane-bound acyltransferase family.

Keywords

Alternative initiation   Apoptosis   ATP-binding   Cell membrane   Complete proteome   Cytoplasm   Developmental protein   Growth regulation   Kinase   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  RAC serine/threonine-protein kinase
splice variant  In isoform A.

Uniprot

B0FC95   A0A2A4J8L6   G3LIS8   A0A385KNU3   A0A194QGX8   A0A194RMU6   + More
S4PL92   A0A212EWQ2   H9JFK7   A0A0L7LP67   A0A087TFB1   E0VM17   A0A0K8UFB8   A0A034VRF0   A0A2H8TGM0   A0A0M3TCD7   A0A067QWC1   D2A1F0   U5ESE8   A0A2S2Q587   J9JPP1   A0A1Y1LC46   A0A2L2Y9W6   W8BSF8   A0A0T6AVT9   A0A131Y2G3   A0A147BUH3   T1P884   A0A182WNJ4   A0A1S3DA70   A0A1I8PVS7   A0A2M3YYS8   A0A2M3YYW6   A0A1B6GA14   V5H036   A0A182NY76   A0A2R5LBS4   Q7QK56   A0A3F2YSG6   A0A182XT68   A0A182VCH1   A0A182MDR8   Q8INB9-2   A0A0B4LIA3   B4QXQ5   B4HLD8   A0A293M499   B3P0Y2   H1ZY63   H1ZY64   Q8INB9   T1JL53   A0A0V1LT75   A0A0V0X785   A0A0V1PFC8   A0A1Y3EJB3   A0A0V0SNC6   A0A023GNP7   A0A1E1X356   A0A131YY67   A0A0V1C341   A0A224YYY4   L7MAG4   L7RA14   A0A1E1XRF4   A0A0V1N108   F5HR84   A0A0V1C2F7   A0A131XFF7   A0A0V1C2D6   A0A0V1FWK3   A0A0V1JFA2   A0A0V1AG58   A0A077YWW3   A0A0V0VUE6   A0A3Q0J4F5   A0A1D1VR66   A0A210Q3T4   A0A159ZKT0   A0A0V0UG04   A0A0V0UHG7   A0A0V1N1E2   A0A085NKI5   V9KNB7   A0A1S3JCH1   B5THM6   A0A0N5DJ40   A0A0S2GL00   W5K6L6   A0A2D0Q8N4   A0A3B4DV68   A0A0S7KZT5   E7EXT6   A0A2Z2U8A4   A0A3Q3KIW6   A0A3Q3BT62   A0A0F8APH6   A0A1A7Y5C8   A0A147A0Y3   A0A1A8EWH3  

EC Number

2.7.11.1

Pubmed

20197069    26354079    23622113    22118469    19121390    26227816    + More
20566863    25348373    26701614    24845553    18362917    19820115    28004739    26561354    24495485    29652888    25315136    12364791    14747013    17210077    8302573    7876156    10731132    12537572    12537569    9601646    10587646    10962553    11740943    11344272    11752451    12172554    11872800    14525946    12893776    15466161    15712201    15808505    15718470    18327897    22493059    24786828    24603715    25329475    29025897    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17994087    28503490    26830274    28797301    25576852    23274741    29209593    22193391    28049606    27649274    28812685    25158315    24929829    24402279    26549179    25329095    23594743    25835551   

EMBL

EU305740    ABY50539.1    NWSH01002510    PCG68106.1    JN399217    AEM63703.1    + More
MG657021    AXZ96481.1    KQ458880    KPJ04674.1    KQ460154    KPJ17321.1    GAIX01004160    JAA88400.1    AGBW02011923    OWR45915.1    BABH01002405    BABH01002406    BABH01002407    JTDY01000430    KOB77215.1    KK114965    KFM63800.1    DS235286    EEB14423.1    GDHF01029189    GDHF01027048    GDHF01009039    GDHF01007074    GDHF01005983    JAI23125.1    JAI25266.1    JAI43275.1    JAI45240.1    JAI46331.1    KJ011125    GAKP01013076    GAKP01013075    GAKP01013074    GAKP01013073    AIC77786.1    JAC45876.1    GFXV01001386    MBW13191.1    KR075834    ALE20553.1    KK853289    KDR08900.1    KQ971338    EFA02105.1    GANO01003277    JAB56594.1    GGMS01003557    MBY72760.1    ABLF02033919    GEZM01060190    JAV71204.1    IAAA01011346    IAAA01011347    LAA04941.1    GAMC01010339    JAB96216.1    LJIG01022700    KRT79174.1    GEFM01002729    JAP73067.1    GEGO01000991    JAR94413.1    KA644799    AFP59428.1    GGFM01000665    MBW21416.1    GGFM01000711    MBW21462.1    GECZ01030783    GECZ01021084    GECZ01010492    GECZ01004955    JAS38986.1    JAS48685.1    JAS59277.1    JAS64814.1    GALX01000899    JAB67567.1    GGLE01002780    MBY06906.1    AAAB01008799    EAA03708.5    APCN01001995    APCN01001996    APCN01001997    AXCM01005381    Z26242    X83510    AE014297    AY069856    AHN57352.1    CM000364    EDX12729.1    CH480815    EDW41958.1    GFWV01010192    MAA34921.1    CH954181    EDV49101.1    FR870082    FR870084    FR870085    FR870090    FR870092    CCB63040.1    CCB63042.1    CCB63043.1    CCB63048.1    CCB63050.1    FR870081    FR870083    FR870086    FR870087    FR870088    FR870089    FR870091    FR870093    CCB63039.1    CCB63041.1    CCB63044.1    CCB63045.1    CCB63046.1    CCB63047.1    CCB63049.1    CCB63051.1    JH431868    JYDW01000006    KRZ62719.1    JYDK01000011    KRX83768.1    JYDM01000015    KRZ94928.1    LVZM01010870    OUC45065.1    JYDL01000001    KRX28218.1    GBBM01000838    JAC34580.1    GFAC01005505    JAT93683.1    GEDV01005065    JAP83492.1    JYDH01000001    KRY43484.1    GFPF01011670    MAA22816.1    GACK01004940    JAA60094.1    JX648548    AGC00787.1    GFAA01001539    JAU01896.1    JYDO01000018    KRZ77583.1    AB601888    BAK26531.1    KRY43482.1    GEFH01004205    JAP64376.1    KRY43481.1    JYDT01000023    KRY90257.1    JYDU01000020    JYDS01000008    KRX98585.1    KRZ33625.1    JYDQ01000003    KRY23530.1    HG805825    CDW52527.1    JYDN01000008    KRX66993.1    BDGG01000008    GAV02683.1    NEDP02005114    OWF43362.1    KX056492    AMY95372.1    JYDJ01000006    KRX50398.1    KRX50397.1    KRZ77582.1    KL363228    KL367491    KFD52402.1    KFD69981.1    JW867172    AFO99689.1    EU939752    ACH73234.1    KT362182    ALN96976.1    GBYX01191286    GBYX01191285    GBYX01191282    JAO82760.1    CU928197    KX966254    ATO58448.1    KQ041256    KKF28993.1    HADW01014163    HADX01003261    SBP25493.1    GCES01014100    JAR72223.1    HAEB01004958    SBQ51485.1   

Proteomes

UP000218220    UP000053268    UP000053240    UP000007151    UP000005204    UP000037510    + More
UP000054359    UP000009046    UP000027135    UP000007266    UP000007819    UP000095301    UP000075920    UP000079169    UP000095300    UP000075884    UP000007062    UP000075840    UP000076407    UP000075903    UP000075883    UP000000803    UP000000304    UP000001292    UP000008711    UP000054721    UP000054673    UP000054924    UP000243006    UP000054630    UP000054776    UP000054843    UP000054995    UP000054805    UP000054815    UP000054783    UP000030665    UP000054681    UP000186922    UP000242188    UP000055048    UP000085678    UP000046395    UP000018467    UP000221080    UP000261440    UP000000437    UP000261640    UP000264840    UP000265000   

PRIDE

B0FC95    H9JFK7    Q8INB9    H1ZY63    L7MAG4    L7RA14    + More
F5HR84   

Pfam

PF00169   PH        + More
PF00433   Pkinase_C
PF00069   Pkinase
PF08389   Xpo1
PF03062   MBOAT

Interpro

IPR000961   AGC-kinase_C        + More
IPR000719   Prot_kinase_dom       
IPR017892   Pkinase_C       
IPR011993   PH-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR039026   PH_PKB       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR001849   PH_domain       
IPR039029   RAC_gamma-like       
IPR016024   ARM-type_fold       
IPR013598   Exportin-1/Importin-b-like       
IPR004299   MBOAT_fam       

SUPFAM

SSF56112   SSF56112        + More
SSF48371   SSF48371       

Gene 3D

2.30.29.30    

CDD

cd01241  PH_PKB

ProteinModelPortal

B0FC95   A0A2A4J8L6   G3LIS8   A0A385KNU3   A0A194QGX8   A0A194RMU6   + More
S4PL92   A0A212EWQ2   H9JFK7   A0A0L7LP67   A0A087TFB1   E0VM17   A0A0K8UFB8   A0A034VRF0   A0A2H8TGM0   A0A0M3TCD7   A0A067QWC1   D2A1F0   U5ESE8   A0A2S2Q587   J9JPP1   A0A1Y1LC46   A0A2L2Y9W6   W8BSF8   A0A0T6AVT9   A0A131Y2G3   A0A147BUH3   T1P884   A0A182WNJ4   A0A1S3DA70   A0A1I8PVS7   A0A2M3YYS8   A0A2M3YYW6   A0A1B6GA14   V5H036   A0A182NY76   A0A2R5LBS4   Q7QK56   A0A3F2YSG6   A0A182XT68   A0A182VCH1   A0A182MDR8   Q8INB9-2   A0A0B4LIA3   B4QXQ5   B4HLD8   A0A293M499   B3P0Y2   H1ZY63   H1ZY64   Q8INB9   T1JL53   A0A0V1LT75   A0A0V0X785   A0A0V1PFC8   A0A1Y3EJB3   A0A0V0SNC6   A0A023GNP7   A0A1E1X356   A0A131YY67   A0A0V1C341   A0A224YYY4   L7MAG4   L7RA14   A0A1E1XRF4   A0A0V1N108   F5HR84   A0A0V1C2F7   A0A131XFF7   A0A0V1C2D6   A0A0V1FWK3   A0A0V1JFA2   A0A0V1AG58   A0A077YWW3   A0A0V0VUE6   A0A3Q0J4F5   A0A1D1VR66   A0A210Q3T4   A0A159ZKT0   A0A0V0UG04   A0A0V0UHG7   A0A0V1N1E2   A0A085NKI5   V9KNB7   A0A1S3JCH1   B5THM6   A0A0N5DJ40   A0A0S2GL00   W5K6L6   A0A2D0Q8N4   A0A3B4DV68   A0A0S7KZT5   E7EXT6   A0A2Z2U8A4   A0A3Q3KIW6   A0A3Q3BT62   A0A0F8APH6   A0A1A7Y5C8   A0A147A0Y3   A0A1A8EWH3  

PDB

3O96     E-value=1.14566e-110,     Score=1021

KEGG

100141438    K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) Akt; serine/threonine protein ki

PATHWAY

04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)
04933    AGE-RAGE signaling pathway in diabetic complications - Bombyx mori (domestic silkworm)

GO

GO:0004674   GO:0005524   GO:0043491   GO:0035556   GO:0006468   GO:0005737   GO:0005634   GO:0018105   GO:0032869   GO:0031104   GO:0007424   GO:0045793   GO:0007623   GO:0007525   GO:0008284   GO:1901215   GO:0043066   GO:1904263   GO:0043025   GO:0050773   GO:0005829   GO:0042632   GO:0035206   GO:0045886   GO:0005938   GO:0006629   GO:0090278   GO:0040014   GO:0048010   GO:0040018   GO:0007520   GO:0060292   GO:0010884   GO:0007427   GO:0008362   GO:0006915   GO:0005886   GO:0046622   GO:0035264   GO:0048477   GO:0030307   GO:0010897   GO:0048680   GO:0008286   GO:0006979   GO:0035091   GO:1904262   GO:0016021   GO:0004672   GO:0000155   GO:0000160   GO:0005216   GO:0006811   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR24351:SF199  

Subcellular location

Cytoplasm  
Cytosol  
Cell membrane  
Nucleus  

Length:

331

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01458

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01072

outside

1  -  331

 

 

Pi

242.73269

Theta

197.764145

Tajima's D

0.735846

CLR

0.302281

CSRT

0.586870656467177

Interpretation

Uncertain