Gene

KWMTBOMO11077  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008304

Annotation

PREDICTED:_RAC_serine/threonine-protein_kinase_[Bombyx_mori]

Location

Bomo_Chr18(-):12313004-12316856      View in EpiBrowser

Full name

Non-specific serine/threonine protein kinase       + More
RAC serine/threonine-protein kinase      

Alternative Name

Akt
Protein kinase B

Location in the cell

Cytoplasmic   Reliability : 1.239 Nuclear   Reliability : 1.455

CDS

ATGGCGTGCGGCCGGCTGCCCTTCTACAACCGGGACCACGACGTGCTGTTCGGGCTCATCATCAACGAGGAGGTCCGGTTCCCCCGCAGCGTGTCGGCCGCGTGTCGCTCGCTGCTGGACGGGTTGCTGACCAAGGACCCTCGCGCGCGGCTGGGCGCCGGGCCGGACGACGCGCACGAGATCATGAACCACCCCTTCTTCGCGTCGATCAACTGGAACGACCTCGTGGCCAAGAAGATCCCGCCCCCGTTCAAGCCTCAAGTGGAATCCGACATCGACACCCGGTACTTCGACTCTGAGTTCACCGGGGAGAGCGTCGAGCTCACGCCGCCAGAGAATGAGAACAGCCTCGCCTTTATACAGGAGGAGAGCTTCCCTCAGTTCTCCTATCAGGATATATGTTCATCAGCGCATTCAGCCCTCTCTCACATGTCGCATCACTCCGCGCTGACCGACAAACGGCACTAG

Protein

MACGRLPFYNRDHDVLFGLIINEEVRFPRSVSAACRSLLDGLLTKDPRARLGAGPDDAHEIMNHPFFASINWNDLVAKKIPPPFKPQVESDIDTRYFDSEFTGESVELTPPENENSLAFIQEESFPQFSYQDICSSAHSALSHMSHHSALTDKRH

Description

Serine/threonine kinase involved in various developmental processes (PubMed:9601646, PubMed:10587646, PubMed:10962553, PubMed:11740943, PubMed:12172554, PubMed:11872800, PubMed:14525946, PubMed:12893776, PubMed:15466161, PubMed:15712201). During early embryogenesis, acts as a survival protein (PubMed:9601646, PubMed:10962553). During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination (PubMed:11740943). Also regulates tracheal cell migration (PubMed:11740943, PubMed:14525946). Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor (PubMed:10587646, PubMed:10962553, PubMed:11752451, PubMed:12893776, PubMed:25329475, PubMed:29025897, PubMed:24603715). Controls follicle cell size during oogenesis (PubMed:15712201). May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex (PubMed:12172554, PubMed:15466161). Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth (PubMed:10962553).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Interacts with trbl.

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

Keywords

Alternative initiation   Apoptosis   ATP-binding   Cell membrane   Complete proteome   Cytoplasm   Developmental protein   Growth regulation   Kinase   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  RAC serine/threonine-protein kinase
splice variant  In isoform A.

Uniprot

H9JFK7   B0FC95   G3LIS8   A0A2A4J8L6   A0A385KNU3   A0A194QIC0   + More
A0A212EWQ2   A0A194RMU6   A0A0L7LP67   A0A182G722   Q16XQ9   A0A1Y1LC46   A0A182TGK4   A0A182WNJ4   Q868D7   T1DIP8   A0A2S2PB94   A0A2M4AHT7   A0A182MDR8   A0A1L8DM53   A0A1L8DLW5   A0A0M3TCD7   A0A2J7PG41   A0A182NY76   A0A084WSB1   A0A2M4BM98   A0A182JAD8   D3TNA8   A0A1A9VQL9   A0A1A9ZY90   A0A1A9W8B8   A0A1Q3EWZ4   A0A1I8PVS7   A0A182Q166   A0A067QWC1   A0A1W4VVH5   U5ESE8   A0A1A9XWB4   A0A1B0BL57   Q7QK56   A0A3F2YSG6   B0WKM3   A0A182XT68   A0A182VCH1   W8BSF8   A0A1B0A8N4   D2A1F0   A0A2M4BHQ6   A0A2M4BHK8   A0A2H8TGM0   J9JPP1   A0A2M4BHC8   A0A2M4BHE8   A0A2M4BGN9   A0A151JR19   A0A1W4X247   W5JVM4   T1P884   A0A2M4A1A7   A0A0A1WMJ5   A0A2M3YYW6   A0A0A9WDP1   A0A0V0GAY2   A0A034VRF0   A0A0K8UFB8   A0A2M3YYS8   B4QXQ5   B4HLD8   Q8INB9-2   A0A0B4LIA3   A0A2M4CGK2   A0A0M3MAL4   A0A3B0JN69   A0A2S2Q587   A0A0K8TS07   Q294V1   B4NL10   H1ZY64   H1ZY63   Q8INB9   A0A0A1WFT7   B4PR40   A0A224XEX3   A0A069DVH6   B3LZY7   A0A0T6AVT9   E0VM17   A0A026WVT4   A0A1B6HD11   A0A0Q9WEG2   A0A158NSC5   A0A151X6Y9   B3P0Y2   B4LY08   E2BHF8   B4JG98   A0A151I2J8   E2AEF1   B4GMK7   F4W5K6  

EC Number

2.7.11.1

Pubmed

19121390    20197069    26354079    22118469    26227816    26483478    + More
17510324    28004739    12752655    24438588    20353571    24845553    12364791    14747013    17210077    24495485    18362917    19820115    20920257    23761445    25315136    25830018    25401762    25348373    26701614    17994087    8302573    7876156    10731132    12537572    12537569    9601646    10587646    10962553    11740943    11344272    11752451    12172554    11872800    14525946    12893776    15466161    15712201    15808505    15718470    18327897    22493059    24786828    24603715    25329475    29025897    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26369729    15632085    17550304    26334808    20566863    24508170    30249741    18057021    21347285    20798317    21719571   

EMBL

BABH01002405    BABH01002406    BABH01002407    EU305740    ABY50539.1    JN399217    + More
AEM63703.1    NWSH01002510    PCG68106.1    MG657021    AXZ96481.1    KQ458880    KPJ04675.1    AGBW02011923    OWR45915.1    KQ460154    KPJ17321.1    JTDY01000430    KOB77215.1    JXUM01040821    JXUM01040822    JXUM01040823    JXUM01045953    JXUM01045954    JXUM01045955    JXUM01045956    JXUM01045957    JXUM01045958    JXUM01045959    JXUM01045960    KQ561456    KQ561260    KXJ78517.1    KXJ79179.1    CH477534    EAT39383.1    GEZM01060190    JAV71204.1    AF532204    AAP37655.1    GAMD01001821    JAA99769.1    GGMR01014091    MBY26710.1    GGFK01007035    MBW40356.1    AXCM01005381    GFDF01006637    JAV07447.1    GFDF01006636    JAV07448.1    KR075834    ALE20553.1    NEVH01025635    PNF15294.1    ATLV01026430    ATLV01026431    KE525413    KFB53105.1    GGFJ01004942    MBW54083.1    EZ422910    ADD19186.1    GFDL01015327    JAV19718.1    AXCN02001547    KK853289    KDR08900.1    GANO01003277    JAB56594.1    JXJN01016217    AAAB01008799    EAA03708.5    APCN01001995    APCN01001996    APCN01001997    DS231974    EDS29954.1    GAMC01010339    JAB96216.1    KQ971338    EFA02105.1    GGFJ01003382    MBW52523.1    GGFJ01003381    MBW52522.1    GFXV01001386    MBW13191.1    ABLF02033919    GGFJ01003067    MBW52208.1    GGFJ01003087    MBW52228.1    GGFJ01003066    MBW52207.1    KQ978642    KYN29496.1    ADMH02000189    ETN67433.1    KA644799    AFP59428.1    GGFK01001189    MBW34510.1    GBXI01014649    JAC99642.1    GGFM01000711    MBW21462.1    GBHO01037043    GBHO01037042    GBRD01005526    JAG06561.1    JAG06562.1    JAG60295.1    GECL01001027    JAP05097.1    KJ011125    GAKP01013076    GAKP01013075    GAKP01013074    GAKP01013073    AIC77786.1    JAC45876.1    GDHF01029189    GDHF01027048    GDHF01009039    GDHF01007074    GDHF01005983    JAI23125.1    JAI25266.1    JAI43275.1    JAI45240.1    JAI46331.1    GGFM01000665    MBW21416.1    CM000364    EDX12729.1    CH480815    EDW41958.1    Z26242    X83510    AE014297    AY069856    AHN57352.1    GGFL01000187    MBW64365.1    KM250121    AKE33866.1    OUUW01000008    SPP83664.1    GGMS01003557    MBY72760.1    GDAI01000662    JAI16941.1    CM000070    EAL28863.3    CH964272    EDW84213.2    FR870081    FR870083    FR870086    FR870087    FR870088    FR870089    FR870091    FR870093    CCB63039.1    CCB63041.1    CCB63044.1    CCB63045.1    CCB63046.1    CCB63047.1    CCB63049.1    CCB63051.1    FR870082    FR870084    FR870085    FR870090    FR870092    CCB63040.1    CCB63042.1    CCB63043.1    CCB63048.1    CCB63050.1    GBXI01017024    GBXI01007662    JAC97267.1    JAD06630.1    CM000160    EDW97362.2    GFTR01006862    JAW09564.1    GBGD01001177    JAC87712.1    CH902617    EDV44177.2    LJIG01022700    KRT79174.1    DS235286    EEB14423.1    KK107079    QOIP01000010    EZA60145.1    RLU17369.1    GECU01035119    JAS72587.1    CH940650    KRF82952.1    ADTU01024816    KQ982459    KYQ56142.1    CH954181    EDV49101.1    EDW66874.2    GL448287    EFN84927.1    CH916369    EDV92567.1    KQ976543    KYM80981.1    GL438828    EFN68203.1    CH479185    EDW38081.1    GL887655    EGI70503.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000053240    UP000037510    + More
UP000069940    UP000249989    UP000008820    UP000075902    UP000075920    UP000075883    UP000235965    UP000075884    UP000030765    UP000075880    UP000078200    UP000092445    UP000091820    UP000095300    UP000075886    UP000027135    UP000192221    UP000092443    UP000092460    UP000007062    UP000075840    UP000002320    UP000076407    UP000075903    UP000007266    UP000007819    UP000078492    UP000192223    UP000000673    UP000095301    UP000000304    UP000001292    UP000000803    UP000268350    UP000001819    UP000007798    UP000002282    UP000007801    UP000009046    UP000053097    UP000279307    UP000008792    UP000005205    UP000075809    UP000008711    UP000008237    UP000001070    UP000078540    UP000000311    UP000008744    UP000007755   

PRIDE

H9JFK7    B0FC95    Q8INB9    H1ZY63   

Pfam

PF00069   Pkinase        + More
PF00433   Pkinase_C
PF00169   PH

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR001849   PH_domain       
IPR008271   Ser/Thr_kinase_AS       
IPR017892   Pkinase_C       
IPR000719   Prot_kinase_dom       
IPR039026   PH_PKB       
IPR000961   AGC-kinase_C       
IPR017441   Protein_kinase_ATP_BS       
IPR011993   PH-like_dom_sf       
IPR039029   RAC_gamma-like       

SUPFAM

SSF56112   SSF56112       

Gene 3D

2.30.29.30    

CDD

cd01241  PH_PKB

ProteinModelPortal

H9JFK7   B0FC95   G3LIS8   A0A2A4J8L6   A0A385KNU3   A0A194QIC0   + More
A0A212EWQ2   A0A194RMU6   A0A0L7LP67   A0A182G722   Q16XQ9   A0A1Y1LC46   A0A182TGK4   A0A182WNJ4   Q868D7   T1DIP8   A0A2S2PB94   A0A2M4AHT7   A0A182MDR8   A0A1L8DM53   A0A1L8DLW5   A0A0M3TCD7   A0A2J7PG41   A0A182NY76   A0A084WSB1   A0A2M4BM98   A0A182JAD8   D3TNA8   A0A1A9VQL9   A0A1A9ZY90   A0A1A9W8B8   A0A1Q3EWZ4   A0A1I8PVS7   A0A182Q166   A0A067QWC1   A0A1W4VVH5   U5ESE8   A0A1A9XWB4   A0A1B0BL57   Q7QK56   A0A3F2YSG6   B0WKM3   A0A182XT68   A0A182VCH1   W8BSF8   A0A1B0A8N4   D2A1F0   A0A2M4BHQ6   A0A2M4BHK8   A0A2H8TGM0   J9JPP1   A0A2M4BHC8   A0A2M4BHE8   A0A2M4BGN9   A0A151JR19   A0A1W4X247   W5JVM4   T1P884   A0A2M4A1A7   A0A0A1WMJ5   A0A2M3YYW6   A0A0A9WDP1   A0A0V0GAY2   A0A034VRF0   A0A0K8UFB8   A0A2M3YYS8   B4QXQ5   B4HLD8   Q8INB9-2   A0A0B4LIA3   A0A2M4CGK2   A0A0M3MAL4   A0A3B0JN69   A0A2S2Q587   A0A0K8TS07   Q294V1   B4NL10   H1ZY64   H1ZY63   Q8INB9   A0A0A1WFT7   B4PR40   A0A224XEX3   A0A069DVH6   B3LZY7   A0A0T6AVT9   E0VM17   A0A026WVT4   A0A1B6HD11   A0A0Q9WEG2   A0A158NSC5   A0A151X6Y9   B3P0Y2   B4LY08   E2BHF8   B4JG98   A0A151I2J8   E2AEF1   B4GMK7   F4W5K6  

PDB

1GZN     E-value=5.65254e-46,     Score=459

KEGG

100141438    K04456 RAC serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) Akt; serine/threonine protein ki

GO

GO:0005524   GO:0004674   GO:0035556   GO:0043491   GO:0018105   GO:0006468   GO:0005737   GO:0005634   GO:0032869   GO:0031104   GO:0007424   GO:0045793   GO:0007623   GO:0007525   GO:0008284   GO:1901215   GO:0043066   GO:1904263   GO:0043025   GO:0050773   GO:0005829   GO:0042632   GO:0035206   GO:0045886   GO:0005938   GO:0006629   GO:0090278   GO:0040014   GO:0048010   GO:0040018   GO:0007520   GO:0060292   GO:0010884   GO:0007427   GO:0008362   GO:0006915   GO:0005886   GO:0046622   GO:0035264   GO:0048477   GO:0030307   GO:0010897   GO:0048680   GO:0008286   GO:0006979   GO:0035091   GO:1904262   GO:0000155   GO:0000160   GO:0005216   GO:0006811   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR24351:SF199  

Subcellular location

Cytoplasm  
Cytosol  
Cell membrane  

Length:

155

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.10763

outside

1  -  155

 

 

Pi

222.846444

Theta

169.355258

Tajima's D

0.993489

CLR

0.000042

CSRT

0.662616869156542

Interpretation

Uncertain