Gene

KWMTBOMO11076

Pre Gene Modal

BGIBMGA008560

Annotation

PREDICTED:_potassium_voltage-gated_channel_protein_eag_[Bombyx_mori]

Location

Bomo_Chr18(+):12264317-12304538      View in EpiBrowser

Full name

Potassium voltage-gated channel protein eag      

Alternative Name

Ether-a-go-go protein

Location in the cell

PlasmaMembrane   Reliability : 3.008

CDS

ATGCCGGGCGGCCGCCGGGGGCTGGTGGCCCCGCAGAACACCTTCCTCGAGAACATCATCCGCCGCTCCTCATCGCAGCCAGACAGCAGCTTCCTGCTGGCGAACGCGCAGATCGTGGACTATCCGATCGTGTACTGCAACGAAACCTTCTGCAAGATGAGCGGCTACAATCGGGCCGAGGTCATGCAAAAGTCCTGCAGATGCACGTGGATGTACGGCGAGCTAACGGAAAAAGAAGCTATAGAGCGAATCGACCGAGCTCTGGACCACCACCTGGCGGATCAGTTTGAGATACTACTGTACAAGAAGAACAGAACACCACTATGGCTGCTCGTTCACGTGGCCCCGATACGGAACGAGAGGGAGCTGGTCGTACTCTTCCTGCTCACCTTCAGAGACATCACTGCCCTGAAGCAACCTATCGATGCAGACGACCCCAAAGGAGGTCTGTCGAAATTCGCGAAGTTAGCCCGCAGCGTTACAAGGTCTAGGTCGGTGCTGGTCTCCGCGCTGCCGGCCCTCAAGGAGCCGCAGCGACAGAGTCACCTGGCGCATGTGATGTCCTTATCGGGGGACGTTTTGCCGCAATACAGACAAGAAGCACCGAAGACGCCGCCCCATATCCTACTCCACTACTGCGCGTTTAAAGCCATCTGGGACTGGATTATCCTCTGCTTGACCTTCTACACAGCCATCATGGTGCCCTACAACGTGGCCTTCAAGAACAAAACGAGCGAAGACGTGTCCCTCCTTGTGATAGACTCCATTGTGGACGTGGTGTTTTTCATCGATATAGTGCTGAATTTTCACACGACCTTCGTGGGTCCCGGCGGAGAAGTTGTCAGTGATCCAAAGGTTATAAGGAAGAATTACTTCAAGTCGTGGTTCCTCATAGACTTGCTCTCCTGCCTGCCGTATGATGTGTTCAATGCCTTCGATCACGACGAAGATGGAATCGGAAGTCTGTTTAGTGCGCTCAAAGTCGTGAGATTACTCCGGCTGGGTCGTGTAGTTCGTAAGCTAGATCGATACCTTGAGTATGGGGCGGCGATGCTGATCCTTCTGCTCTGCTTCTACATGCTGGTGGCGCACTGGTTGGCCTGCGTCTGGTACAGCATCGGCCGCTCGGACGCCGACTCCGGCCTCCAATACTCATGGTTATGGAAACTGGCCAACGTGACCCAGTCCCCATATTCCTACGTCTGGTCCAACGAGTCTGACGGGCCCGAGCTAGTTAACGGGCCCTCGCGCAAGACCATGTACGTGACGGCGCTGTACTTCACCATGACCTGCATGACCTCCGTGGGCTTCGGCAATGTCGCCGCCGAGACCGATAACGAGAAGATCTTCACCATCTGCATGATGATCGTGGCAGCTCTGCTGTACGCGACTATATTTGGCCACGTCACGACAATCATCCAACAAATGACATCAGCAACGGCGAAGTATCACGACATGCTGAACAACGTTAGAGAGTTCATGAAACTACACGAGGTGCCTAAAGCTTTAAGCGAAAGAGTCATGGACTACGTGGTTTCCACTTGGGCCATGACTAAGGGCATCGACACGGATAAGGTGCTAAATTACTGTCCGAAAGACATGAAGGCCGATATCTGCGTCCACTTGAACCGGAAAGTCTTCAACGAGCACCCGGCGTTCAGACTGGCATCCGACGGCTGTCTGCGAGCCCTCGCGATGCACTTCCAAATGTCGCACTCCGCGCCCGGAGACCTGCTGTACCACACGGGAGAGTCCATAGATTCGTTGTGTTTCATCGTTACCGGCAGTCTAGAAGTAATACAGGACGATGAAGTTGTCGCTATATTGGGTAAAGGAGACGTCTTCGGAGATTCGTTCTGGAAGGACAGTGCCGTCGGTCAGTCGGCCGCGAACGTTAGGGCGCTCACGTACTGCGACCTGCACACCATCAAGCGAGACCGTCTGCTGGAAGTCCTGGACTTTTATCAAGCGTTCGCGAACAGTTTCGCCAGAAATCTAACCCTCACTTATAATTTAAGACATCGACTAATATTTCGCAAGGTAGCAGACGTCCGTCGCGAGCGAGAGCTAATGGAGAGACGGAAGCGGGAACCTCAACTCGAACAAGCACAAGACCATCTCGTCCGCAAGATATTCTCTCGCTTCCGCCGTGAGAGGAGCGTCGCGGCCGCACCCGCTCCCGCCCCCGCTCGCGCGACCCCCGCCCTCGCCACGACCGCGGCTCAACCCACTGACGCAGAGCGCGGTGAAGCCACACAAGCGACTTCCGCATCGACGACCACAACGACGACGGCCGCTCGTGGGAAGTGGGGGCGGCTGCTGGCGGGCGGGTCGCTGGACGCGCCCTCCGGGGAACCGCCGCGGAGCGCCTTCGCCCGCAGTCTGAGCACCCGTGACCGACCCACGCCGCCCGCCATCACGGAGACCACGACTGCCACTCCTGCGCCCATCTCCACTCTATCCATTAAGGCGTCATTCGCAAAAGGTCGTTCAGCCGGTGCATTGGGCGGGAGCGGAGGCTCGACAAGGCAGGACACTATAGAGGAAGAATTAGAAGAGAAGCGTGCCCCCGCGGCGGCCCCCTCGGCGGCTCCCGCAGCGCCATCCGCTGTGTCGCATGACGCGGCCTTGGCGGAGCTGCGACGCGATGTGCGCAATGAAGTTCAAAGGCTGCAGCAGAAATTGGGTCGCGTCGAAGAGCTGCTAACGATGCTAGCCGCCCGTCTTGGGGCCGACCCCGCGGAGACGGCGGCGGCCGGTGCGGGGGCTGAGCCCGACCCTCCGCGCGCGCCCCCCACCGACCTAGCGGCACTCACTAGGAAACGACGCTCGAAGGCTCGCAGTAAAGGCGCAGCCCCACAAGCGCCGACGCCGACGACTCCCACGGAGACCCCGTCGAGTCCGGGGGCCACGAGCGGCGCGTCAAGCGGAGCGTCGAGCGGGGCGGCGCAGCGGCGGAGGGACTTCGTGTAG

Protein

MPGGRRGLVAPQNTFLENIIRRSSSQPDSSFLLANAQIVDYPIVYCNETFCKMSGYNRAEVMQKSCRCTWMYGELTEKEAIERIDRALDHHLADQFEILLYKKNRTPLWLLVHVAPIRNERELVVLFLLTFRDITALKQPIDADDPKGGLSKFAKLARSVTRSRSVLVSALPALKEPQRQSHLAHVMSLSGDVLPQYRQEAPKTPPHILLHYCAFKAIWDWIILCLTFYTAIMVPYNVAFKNKTSEDVSLLVIDSIVDVVFFIDIVLNFHTTFVGPGGEVVSDPKVIRKNYFKSWFLIDLLSCLPYDVFNAFDHDEDGIGSLFSALKVVRLLRLGRVVRKLDRYLEYGAAMLILLLCFYMLVAHWLACVWYSIGRSDADSGLQYSWLWKLANVTQSPYSYVWSNESDGPELVNGPSRKTMYVTALYFTMTCMTSVGFGNVAAETDNEKIFTICMMIVAALLYATIFGHVTTIIQQMTSATAKYHDMLNNVREFMKLHEVPKALSERVMDYVVSTWAMTKGIDTDKVLNYCPKDMKADICVHLNRKVFNEHPAFRLASDGCLRALAMHFQMSHSAPGDLLYHTGESIDSLCFIVTGSLEVIQDDEVVAILGKGDVFGDSFWKDSAVGQSAANVRALTYCDLHTIKRDRLLEVLDFYQAFANSFARNLTLTYNLRHRLIFRKVADVRRERELMERRKREPQLEQAQDHLVRKIFSRFRRERSVAAAPAPAPARATPALATTAAQPTDAERGEATQATSASTTTTTTAARGKWGRLLAGGSLDAPSGEPPRSAFARSLSTRDRPTPPAITETTTATPAPISTLSIKASFAKGRSAGALGGSGGSTRQDTIEEELEEKRAPAAAPSAAPAAPSAVSHDAALAELRRDVRNEVQRLQQKLGRVEELLTMLAARLGADPAETAAAGAGAEPDPPRAPPTDLAALTRKRRSKARSKGAAPQAPTPTTPTETPSSPGATSGASSGASSGAAQRRRDFV

Description

Structural component of a potassium channel. Mediates the potassium permeability of membranes; potassium current is regulated by CaMKII and CASK. Has a role in growth of the perineurial glial layer of the larval peripheral nerve.

Subunit

The voltage-dependent potassium channel is a heterotetramer of potassium channel proteins (By similarity). Interaction with CASK.

Miscellaneous

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
The segment H5 is thought to line the channel pore.

Similarity

Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Eag sub-subfamily.

Keywords

3D-structure   Complete proteome   Developmental protein   Differentiation   Glycoprotein   Ion channel   Ion transport   Membrane   Neurogenesis   Phosphoprotein   Potassium   Potassium channel   Potassium transport   Reference proteome   Repeat   Transmembrane   Transmembrane helix   Transport   Voltage-gated channel  

Feature

chain  Potassium voltage-gated channel protein eag

Uniprot

Q7YW98   A0A194QMH4   A0A212EWU4   D2A144   A0A182QA24   A0A182MFB9   + More
A0A182Y401   A0A2A3ELH7   T1UL18   A0A067RA94   A0A2U8JGI2   A0A158NDT5   E0VIQ8   A0A1Y9J0N8   A0A195C544   A0A154PT84   T1ULL2   A0A0M4EUP2   A0A1W4VFC7   K7IUF0   A0A1W4VFD2   A0A336LSJ2   A0A1W4V3J7   A0A0R1EBX2   M9PHM3   A0A0R1EA59   A0A0Q5TJL1   B4MTB1   A0A0R3P4T6   Q17P69   A0A1W4V336   A0A1W4VGP6   A0A0R3NYL0   A0A0R1EA65   A0A158NDT4   A0A1W4VFV6   A0A1W4VFW1   A0A0R3NZ14   M9MSA6   A0A0R1EAH1   B4IJ85   B3NUW4   B4PW93   A0A0R3P437   A0A0R3NYM1   Q0KHS8   A0A3L8DIY6   A0A0R3P3M8   A0A0R1EAT7   A0A1W4V3K2   A0A0R1EGI0   A0A0Q5T4V1   B5DLA7   A0A0R3NYW1   W8AKR4   A0A3B0J9Q6   A0A182NR49   Q02280   A0A0R3NYK0   A0A0R3P469   A0A0R3P3E3   A0A0R1EFW3   A0A0L0CHK3   A0A0Q5TFL1   A0A0R3NYI8   A0A0R3NYH3   A0A195BQL1   A0A2S2QFH8   A0A0R3P337   A0A2H8TG26   W8ASU3   A0A0P6HSW8   A0A0P6ACN3   E2C8H5   B4M8E5   A0A1J1IF70   E9GYK5   A0A026WN14   A0A0P6GAH2   B7QJV6   T1IIG6   A0A139WJM3   A0A1A9W8S6   T1HRP1  

Pubmed

26354079    22118469    18362917    19820115    25244985    24845553    + More
21347285    20566863    20075255    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    15632085    17510324    30249741    24495485    1840699    11517334    11980904    15901771    26108605    20798317    21292972    24508170   

EMBL

AF528521    AAQ09035.1    KQ458880    KPJ04676.1    AGBW02011923    OWR45917.1    + More
KQ971338    EFA02607.1    AXCN02001476    AXCM01000144    KZ288215    PBC32567.1    KF010814    AGT78115.1    KK852783    KDR16607.1    MF360101    AWK67799.1    ADTU01012959    ADTU01012960    ADTU01012961    ADTU01012962    ADTU01012963    ADTU01012964    ADTU01012965    ADTU01012966    DS235201    EEB13264.1    KQ978251    KYM95987.1    KQ435078    KZC14488.1    KF010813    AGT78114.1    CP012528    ALC48835.1    AAZX01005844    AAZX01006174    UFQS01000095    UFQT01000095    SSW99303.1    SSX19683.1    CM000162    KRK06318.1    AE014298    AGB95400.1    KRK06320.1    CH954180    KQS30324.1    CH963851    EDW75350.2    CH379063    KRT06134.1    CH477193    EAT48564.1    KRT06136.1    KRK06316.1    KRT06140.1    ADV37674.1    KRK06317.1    CH480847    EDW51064.1    EDV47062.2    EDX01724.2    KRT06144.1    KRT06145.1    ABI30980.1    QOIP01000007    RLU20172.1    KRT06133.1    KRK06315.1    KRK06319.1    KRK06322.1    KQS30323.1    EDY72306.2    KRT06137.1    GAMC01017305    JAB89250.1    OUUW01000003    SPP78665.1    M61157    KRT06130.1    KRT06131.1    KRT06141.1    KRK06321.1    JRES01000394    KNC31697.1    KQS30325.1    KRT06142.1    KRT06135.1    KQ976424    KYM88423.1    GGMS01007240    MBY76443.1    KRT06143.1    GFXV01001261    MBW13066.1    GAMC01017303    JAB89252.1    GDIQ01022614    JAN72123.1    GDIP01032489    JAM71226.1    GL453666    EFN75705.1    CH940653    EDW62421.2    CVRI01000047    CRK97638.1    GL732575    EFX75411.1    KK107152    EZA57036.1    GDIQ01036297    JAN58440.1    ABJB010089629    ABJB010192172    ABJB010252095    ABJB010271157    ABJB010790026    ABJB010841397    DS954789    EEC19128.1    AFFK01014262    KYB28116.1    ACPB03018640   

Proteomes

UP000053268    UP000007151    UP000007266    UP000075886    UP000075883    UP000076408    + More
UP000242457    UP000027135    UP000005205    UP000009046    UP000076407    UP000078542    UP000076502    UP000092553    UP000192221    UP000002358    UP000002282    UP000000803    UP000008711    UP000007798    UP000001819    UP000008820    UP000001292    UP000279307    UP000268350    UP000075884    UP000037069    UP000078540    UP000008237    UP000008792    UP000183832    UP000000305    UP000053097    UP000001555    UP000091820    UP000015103   

PRIDE

Q0KHS8    Q02280   

Pfam

PF00520   Ion_trans        + More
PF00027   cNMP_binding
PF13426   PAS_9

Interpro

IPR035965   PAS-like_dom_sf        + More
IPR001610   PAC       
IPR014710   RmlC-like_jellyroll       
IPR030171   EAG2       
IPR000700   PAS-assoc_C       
IPR005821   Ion_trans_dom       
IPR003949   K_chnl_volt-dep_EAG       
IPR018490   cNMP-bd-like       
IPR000595   cNMP-bd_dom       
IPR003938   K_chnl_volt-dep_EAG/ELK/ERG       
IPR000014   PAS       
IPR027359   Volt_channel_dom_sf       

SUPFAM

SSF51206   SSF51206        + More
SSF55785   SSF55785       

Gene 3D

1.20.120.350     2.60.120.10    

CDD

cd00038  CAP_ED
cd00130  PAS

ProteinModelPortal

Q7YW98   A0A194QMH4   A0A212EWU4   D2A144   A0A182QA24   A0A182MFB9   + More
A0A182Y401   A0A2A3ELH7   T1UL18   A0A067RA94   A0A2U8JGI2   A0A158NDT5   E0VIQ8   A0A1Y9J0N8   A0A195C544   A0A154PT84   T1ULL2   A0A0M4EUP2   A0A1W4VFC7   K7IUF0   A0A1W4VFD2   A0A336LSJ2   A0A1W4V3J7   A0A0R1EBX2   M9PHM3   A0A0R1EA59   A0A0Q5TJL1   B4MTB1   A0A0R3P4T6   Q17P69   A0A1W4V336   A0A1W4VGP6   A0A0R3NYL0   A0A0R1EA65   A0A158NDT4   A0A1W4VFV6   A0A1W4VFW1   A0A0R3NZ14   M9MSA6   A0A0R1EAH1   B4IJ85   B3NUW4   B4PW93   A0A0R3P437   A0A0R3NYM1   Q0KHS8   A0A3L8DIY6   A0A0R3P3M8   A0A0R1EAT7   A0A1W4V3K2   A0A0R1EGI0   A0A0Q5T4V1   B5DLA7   A0A0R3NYW1   W8AKR4   A0A3B0J9Q6   A0A182NR49   Q02280   A0A0R3NYK0   A0A0R3P469   A0A0R3P3E3   A0A0R1EFW3   A0A0L0CHK3   A0A0Q5TFL1   A0A0R3NYI8   A0A0R3NYH3   A0A195BQL1   A0A2S2QFH8   A0A0R3P337   A0A2H8TG26   W8ASU3   A0A0P6HSW8   A0A0P6ACN3   E2C8H5   B4M8E5   A0A1J1IF70   E9GYK5   A0A026WN14   A0A0P6GAH2   B7QJV6   T1IIG6   A0A139WJM3   A0A1A9W8S6   T1HRP1  

PDB

5K7L     E-value=0,     Score=2350

KEGG

101735517    K04908 potassium voltage-gated channel Eag-related subfamily H member 5 | (RefSeq) potassium voltage

GO

GO:0034765   GO:0016021   GO:0005249   GO:0042391   GO:0071805   GO:0005887   GO:0016740   GO:0005244   GO:0005267   GO:0007612   GO:0051259   GO:0008016   GO:0007619   GO:0022843   GO:0007608   GO:0048150   GO:0006813   GO:0042066   GO:0005886   GO:0008076   GO:0007611   GO:0016020   GO:0000155   GO:0000160   GO:0005216   GO:0006811   GO:0005622   GO:0006810   GO:0003824   GO:0055085  

PANTHER

PTHR10217:SF533  

Subcellular location

Membrane  

Length:

990

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

95.3798600000002

Exp number, first 60 AAs:

0.00405

Total prob of N-in:

0.06889

outside

1  -  217

TMhelix

218  -  240

inside

241  -  351

TMhelix

352  -  374

outside

375  -  419

TMhelix

420  -  442

inside

443  -  448

TMhelix

449  -  471

outside

472  -  990

 

 

Pi

239.183265

Theta

169.308639

Tajima's D

1.395617

CLR

0.580536

CSRT

0.76261186940653

Interpretation

Uncertain