Gene

KWMTBOMO11069  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008554

Annotation

PREDICTED:_mitochondrial_genome_maintenance_exonuclease_1-like_[Amyelois_transitella]

Location

Bomo_Chr18(+):12095957-12104081      View in EpiBrowser

Full name

Mitochondrial genome maintenance exonuclease 1      

Location in the cell

Mitochondrial   Reliability : 1.943

CDS

ATGTGGCAAAATACAAGGCACTGTTTGAATATTTTTGGAGTTCTTTTAAATAACACAGCTATACGTGGCTTAAAAACATCTGTAGTATGTGGTACAGCCAAAAGTTCACCAGCGCAACCTGGATATCCCAGTGAAGATAAAATCTTGCAGATAAAACACCACAGAAATGATTATGCTGAACAATACCCATCGGTGACACTAATATTAAATAAAACAATGACTGAAGAGTCTAGGTTGGCTTTGGAGAAGTGGAAACAAGAGAGGATTGCCGAAATGGGAGTTGAAGAATTTAATAGATTTTACCAAGCTCAAATGGCAGTCGGTACCAAGTTTCACAACACTTTAAAGGATTACTTCACTCAACCTCGTAGCCAGCTTCGTATAGAGAAGGAAGTGGAGGGTGTATGGGTGTCTGTAGCAGATGTGTTGAAAAGTATATCTTCTCCAAAAGCCATAGAATCGAATGTTGTACACCCCGTACTGAAGTATAGGGGAATTTTTGATGCCATTGCTGATTATGAAGACAAACCGACTTTAATCGAGTGGAAGAAGTCTGATAAGCCGAGGAAGTCGATAGCCCTGACCTACGACAACCCGGTACAGCTGGCCGCTTACTTCGGTGCGGTCTGCAACGACCTCAACTACAAGCACATGAAGGTCCGCGACGCGCTGCTCGTCATAGCGTACACGGACGGCTCGAAGGCGGACGTCTTCCACCTGTCCACCGACAAGCTGAGGGAGCACTGGGCGCAGTGGCTGATCCGACTCGAGGAATACATAAACAAGCACGGCAAAGATTCCGAGAAGTTCCTGAAAGGCGGTAAAAGGTTGTTTGAGGTGGAAATCGGAAATCTCCAGTAA

Protein

MWQNTRHCLNIFGVLLNNTAIRGLKTSVVCGTAKSSPAQPGYPSEDKILQIKHHRNDYAEQYPSVTLILNKTMTEESRLALEKWKQERIAEMGVEEFNRFYQAQMAVGTKFHNTLKDYFTQPRSQLRIEKEVEGVWVSVADVLKSISSPKAIESNVVHPVLKYRGIFDAIADYEDKPTLIEWKKSDKPRKSIALTYDNPVQLAAYFGAVCNDLNYKHMKVRDALLVIAYTDGSKADVFHLSTDKLREHWAQWLIRLEEYINKHGKDSEKFLKGGKRLFEVEIGNLQ

Description

Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair.
Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.

Similarity

Belongs to the MGME1 family.

Feature

chain  Mitochondrial genome maintenance exonuclease 1

Uniprot

H9JGA7   A0A212ELA2   A0A194QM96   A0A1E1WAI0   A0A1E1WG20   A0A194RIH7   + More
A0A3S2LY56   A0A0L7LAH9   A0A067RLA5   A0A0V0GCJ9   A0A2P8YGF1   A0A3B1JXT4   A0A224YNK8   A0A023G7P1   T1JCQ7   A0A2I4B122   A0A131XJL8   A0A1A7X9A2   A0A2U3YX08   A0A3P8UAN4   A0A0C9SC69   A0A3Q3CCN1   A0A3P8R923   A0A3P9BQB3   A0A3Q1EY05   A0A3B4GTB3   A0A3P9NJL6   A0A3Q1EA08   B7Q3F6   A0A315VR18   A0A131YR72   A0A3Q3IW50   I3JUQ2   A0A3Q3G760   A0A3M0J414   A0A3Q0RI01   A0A0S7HKA3   G1LF86   A0A3B4CKU8   A0A3L8SR64   D2HRE0   A0A131XVZ4   A0A3Q7PFV5   M3WRB4   A0A3B3YJN8   A0A2U3W7L1   H0Z676   A0A3Q7TSF4   G3NLE2   G3NLE4   V5HWA4   Q2WBW2   A0A3N0YVD1   A0A3Q3VVV1   E0VLE6   A0A087YGY6   A0A3B3TUG2   A0A3B5LRB9   A0A218V7F6   A0A3Q1AR02   A0A1A8JSV9   F4X1J1   G3GVW8   A0A1A8F434   W5Q9V5   K9IRU0   A0A384DML2   A0A3Q7WX20   A0A3Q3NA22   A0A2U9CCB9   U3JYR3   L8I3R8   B8A4D5   A0A3Q2HH00   Q1LZC4   A0A3B5R240   A0A2Y9IVI3   A0A1W4Z4I0   A0A1A8BCG0   G9L2D3   F6Q6G1   G3X2I1   A0A3B5A2M4   A0A1A8V9R6   A0A1A6HEX0  

EC Number

3.1.-.-

Pubmed

19121390    22118469    26354079    26227816    24845553    29403074    + More
25329095    28797301    28049606    26131772    25186727    29703783    26830274    20010809    30282656    17975172    20360741    25765539    16311335    20566863    21719571    21804562    20809919    24813606    22751099    23594743    19892987    19393038    23542700    23236062    21709235   

EMBL

BABH01002387    AGBW02014086    OWR42280.1    KQ458880    KPJ04596.1    GDQN01007127    + More
GDQN01003913    JAT83927.1    JAT87141.1    GDQN01005198    GDQN01004787    GDQN01004453    JAT85856.1    JAT86267.1    JAT86601.1    KQ460154    KPJ17244.1    RSAL01000117    RVE46834.1    JTDY01001979    KOB72415.1    KK852559    KDR21395.1    GECL01000283    JAP05841.1    PYGN01000614    PSN43329.1    GFPF01004418    MAA15564.1    GBBM01005207    JAC30211.1    JH432074    GEFH01000827    JAP67754.1    HADW01013118    HADX01008222    SBP14518.1    GBZX01001508    JAG91232.1    ABJB010921702    DS849458    EEC13378.1    NHOQ01001229    PWA25621.1    GEDV01007512    JAP81045.1    AERX01006458    QRBI01000208    RMB93643.1    GBYX01439831    JAO41527.1    ACTA01153874    ACTA01161873    QUSF01000008    RLW07020.1    GL193216    EFB28263.1    GEFM01006035    JAP69761.1    AANG04003379    ABQF01122982    GANP01005755    JAB78713.1    AM114790    CAJ38815.1    RJVU01026577    ROL49668.1    DS235271    EEB14202.1    AYCK01002128    MUZQ01000035    OWK61849.1    HAED01016181    HAEE01002957    SBR22977.1    GL888529    EGI59719.1    JH000044    EGV95405.1    HAEB01006994    HAEC01016191    SBQ53521.1    AMGL01024928    GABZ01002102    JAA51423.1    CP026257    AWP14215.1    AGTO01022007    JH882323    ELR49917.1    BX005372    BC116086    AAI16087.1    HADZ01000662    SBP64603.1    AEYP01035840    AEYP01035841    JP022714    AES11312.1    AEFK01029543    AEFK01029544    HAEJ01016648    SBS57105.1    LZPO01034865    OBS76796.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000283053    UP000037510    + More
UP000027135    UP000245037    UP000018467    UP000192220    UP000245341    UP000265080    UP000264840    UP000265100    UP000265160    UP000257200    UP000261460    UP000242638    UP000001555    UP000261600    UP000005207    UP000264800    UP000269221    UP000261340    UP000008912    UP000261440    UP000276834    UP000286641    UP000011712    UP000261480    UP000245340    UP000007754    UP000286640    UP000007635    UP000261620    UP000009046    UP000028760    UP000261500    UP000261380    UP000197619    UP000257160    UP000007755    UP000001075    UP000002356    UP000261680    UP000291021    UP000286642    UP000261640    UP000246464    UP000016665    UP000000437    UP000002281    UP000009136    UP000002852    UP000248482    UP000192224    UP000000715    UP000007648    UP000261400    UP000092124   

PRIDE

H9JGA7    G3GVW8   

Pfam

PF12705   PDDEXK_1        + More
PF07648   Kazal_2

Interpro

IPR026970   MGME1        + More
IPR038726   PDDEXK_AddAB-type       
IPR011335   Restrct_endonuc-II-like       
IPR036058   Kazal_dom_sf       
IPR002350   Kazal_dom       

SUPFAM

SSF52980   SSF52980        + More
SSF100895   SSF100895       

ProteinModelPortal

H9JGA7   A0A212ELA2   A0A194QM96   A0A1E1WAI0   A0A1E1WG20   A0A194RIH7   + More
A0A3S2LY56   A0A0L7LAH9   A0A067RLA5   A0A0V0GCJ9   A0A2P8YGF1   A0A3B1JXT4   A0A224YNK8   A0A023G7P1   T1JCQ7   A0A2I4B122   A0A131XJL8   A0A1A7X9A2   A0A2U3YX08   A0A3P8UAN4   A0A0C9SC69   A0A3Q3CCN1   A0A3P8R923   A0A3P9BQB3   A0A3Q1EY05   A0A3B4GTB3   A0A3P9NJL6   A0A3Q1EA08   B7Q3F6   A0A315VR18   A0A131YR72   A0A3Q3IW50   I3JUQ2   A0A3Q3G760   A0A3M0J414   A0A3Q0RI01   A0A0S7HKA3   G1LF86   A0A3B4CKU8   A0A3L8SR64   D2HRE0   A0A131XVZ4   A0A3Q7PFV5   M3WRB4   A0A3B3YJN8   A0A2U3W7L1   H0Z676   A0A3Q7TSF4   G3NLE2   G3NLE4   V5HWA4   Q2WBW2   A0A3N0YVD1   A0A3Q3VVV1   E0VLE6   A0A087YGY6   A0A3B3TUG2   A0A3B5LRB9   A0A218V7F6   A0A3Q1AR02   A0A1A8JSV9   F4X1J1   G3GVW8   A0A1A8F434   W5Q9V5   K9IRU0   A0A384DML2   A0A3Q7WX20   A0A3Q3NA22   A0A2U9CCB9   U3JYR3   L8I3R8   B8A4D5   A0A3Q2HH00   Q1LZC4   A0A3B5R240   A0A2Y9IVI3   A0A1W4Z4I0   A0A1A8BCG0   G9L2D3   F6Q6G1   G3X2I1   A0A3B5A2M4   A0A1A8V9R6   A0A1A6HEX0  

PDB

5ZYT     E-value=8.30734e-36,     Score=375

KEGG

101746665    K19465 mitochondrial genome maintenance exonuclease 1 [EC:3.1.-.-] | (RefSeq) mitochondrial genome m

GO

GO:0043504   GO:0008297   GO:0005739   GO:0004527   GO:0006264   GO:0043565   GO:0003676   GO:0005543   GO:0042626   GO:0016887   GO:0005622   GO:0006810   GO:0003824  

Subcellular location

Mitochondrion  

Length:

286

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.16961

Exp number, first 60 AAs:

0.14945

Total prob of N-in:

0.13751

outside

1  -  286

 

 

Pi

236.087312

Theta

173.103833

Tajima's D

-1.259136

CLR

101.284193

CSRT

0.0918954052297385

Interpretation

Uncertain