Gene

KWMTBOMO11038  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008538

Annotation

arylalkylamine_N-acetyltransferase_[Bombyx_mori]

Location

Bomo_Chr18(+):10670414-10689604      View in EpiBrowser

Full name

Dopamine N-acetyltransferase      

Alternative Name

Arylalkylamine N-acetyltransferase

Location in the cell

Cytoplasmic   Reliability : 2.091

CDS

ATGCTCGGAGACGAACTGCCGGCGCAGCTTTCGAGCTTGGAGATCCGGCCTCGCAAAATGTCCGTTCCAGCTTACACCATACAGAGGCTCACGTACAACGATCGGGACCTAGTACTGAAATTCCTCAGAAGATTCTTCTTTCGCGATGAGCCAATGAATCTCGCCGTCAATCTGCTTGAAACACCAGAGTCAAGATGCACTGAGCTCGATGACTATGCGGCAGCTACCTTGAGCGATGGAGTTTCAGTCGCCGCTGTTGATGAGAACGGCGACTACGTAGGAGTCATCATTAACGGGATTGTGAGGAGAGAGGAAGTAGACTACACGGACAAGTCTGAAGACTGCCCCAATCCAAAATTCCGACGGATCCTGAAAGTACTGGGTCACTTGGACCGCGAAGCTCGCATCTGGGACAAACTGCCGGAGACTTGTGACTCTGTTCTCGAGATCAGGATAGCGTCTACACACTCGTCTTGGCGCGGCAGAGGACTGATGAGGGTGCTGTGTGAGGAAGCGGAACGTCTGGCCAAAGCCATGGGAGCCGGAGCTCTTAGAATGGATACAACGTCAGCTTTCTCTGCGGCCGCTGCGGAGAGGCTCAATTACAAGATGGCGTTTGGGGTTCGGTATGCTGATTTGCCGTACGCACCTCAACCTGAAGCACCACACCTTGAAGCCAGGGTCTACATTAAGGAGCTGTAA

Protein

MLGDELPAQLSSLEIRPRKMSVPAYTIQRLTYNDRDLVLKFLRRFFFRDEPMNLAVNLLETPESRCTELDDYAAATLSDGVSVAAVDENGDYVGVIINGIVRREEVDYTDKSEDCPNPKFRRILKVLGHLDREARIWDKLPETCDSVLEIRIASTHSSWRGRGLMRVLCEEAERLAKAMGAGALRMDTTSAFSAAAAERLNYKMAFGVRYADLPYAPQPEAPHLEARVYIKEL

Description

Catalyzes N-acetylation of tryptamine, tyramine, dopamine, serotonin and octopamine. Is not essential for sclerotization.

Catalytic Activity

2-arylethylamine + acetyl-CoA = CoA + H(+) + N-acetyl-2-arylethylamine

Biophysicochemical Properties

0.19 mM for tryptamine (in transfected COS-7 cell extracts)
0.89 mM for tryptamine (using purified enzyme from flies after hydroxylapatite chromatography)
1.15 mM for dopamine (in transfected COS-7 cell extracts)
0.97 mM for dopamine (using purified enzyme from flies after hydroxylapatite chromatography)
1.62 mM for serotonin (in transfected COS-7 cell extracts)
0.91 mM for serotonin (using purified enzyme from flies after hydroxylapatite chromatography)

Keywords

3D-structure   Acyltransferase   Alternative splicing   Complete proteome   Direct protein sequencing   Melatonin biosynthesis   Reference proteome   Transferase  

Feature

chain  Dopamine N-acetyltransferase
splice variant  In isoform A.

Uniprot

A0EM56   H9JG91   A2SZ52   D5LPS6   A0A194PIC1   A0A0N1PG91   + More
A0A0G3VGS2   A0A1E1VZG3   A0A2A4JDQ1   A0A3S2M5D3   A0A2H1VQT5   A0A2H1VQM5   A0A1B6HCH3   A0A1B6G7D1   A0A1B6FNE4   A0A2J7PVW3   A0A194PHE6   A0A0N1I6F1   A0A1Y1K969   A0A1B6EAE7   A0A067RIR6   Q76EI8   A0A0F6PL61   A0A067RHB4   H9JG92   R4UKH6   A0A146LGW6   A0A0A9ZC44   A0A146KRC8   A0A0V0G2Q8   A0A195DYD3   A0A224XX80   A0A0P4VME3   R4FQP0   A0A195B6S7   T1IG91   A0A195FFY7   A0A151XCX3   A0A158NGU6   F4WZQ5   A0A146B0I0   U4U4U9   A0A1Y1K9F0   A0A1Y1K8M0   E0VM27   A0A026W9X1   A0A2R7WYS7   A0A1Y1L7Z9   E2AL26   A0A1Y1L398   A0A1Y1L2X8   V9IEZ0   E2BVK3   A0A0J7L9R0   A0A2A3EEC9   V9IDN1   D2A0F0   A0A0L7RID8   A0A1J0AHX8   A0A139WJ51   A0A0Q9W5M3   A0A088AHR1   B4LJV2   A0A0Q9X7Z8   A0A0Q9X6F7   A0A1B0A475   T1PBJ7   B4NMS2   B4KNV5   A0A0M3QUJ6   D3TLI5   A0A023F7Y2   A0A1I8NFY9   A0A1W4UM97   A0A1B0FG71   A0A2S2QUJ8   A0A1W4V1A5   A0A3B0JNQ8   Q94521-2   B3MDN7   A0A3B0JVX0   Q94521   R4V140   A0A154NZL6   R4V906   C4WSQ4   A0A1B0AWQ3   A0A0Q5VPC8  

EC Number

2.3.1.87

Pubmed

17449311    19121390    26354079    28004739    24845553    16034984    + More
25712907    26823975    25401762    27129103    21347285    21719571    26984060    23537049    20566863    24508170    30249741    20798317    18362917    19820115    17994087    20353571    25474469    25315136    8901578    9703021    10731132    12537572    12537569    7498465    23919438   

EMBL

DQ256382    ABB70231.1    BABH01002257    BABH01002258    DQ372910    ABD17803.1    + More
GU953216    ADF43200.1    KQ459604    KPI92474.1    KQ460813    KPJ12134.1    KP657626    AKL78851.1    GDQN01010919    JAT80135.1    NWSH01001851    PCG69916.1    RSAL01000035    RVE51340.1    ODYU01003860    SOQ43146.1    SOQ43145.1    GECU01035326    GECU01017712    JAS72380.1    JAS89994.1    GECZ01011536    JAS58233.1    GECZ01018069    JAS51700.1    NEVH01020940    PNF20477.1    KPI92473.1    KPJ12135.1    GEZM01094047    JAV55976.1    GEDC01028707    GEDC01002464    JAS08591.1    JAS34834.1    KK852446    KDR23746.1    AB106562    BAC87874.1    KJ865242    AJS19086.1    KK852473    KDR23147.1    BABH01002260    KC740795    AGM32619.1    GDHC01012427    GDHC01005399    JAQ06202.1    JAQ13230.1    GBHO01004224    JAG39380.1    GDHC01020837    JAP97791.1    GECL01003704    JAP02420.1    KQ980107    KYN17712.1    GFTR01003767    JAW12659.1    GDKW01003121    JAI53474.1    GAHY01000294    JAA77216.1    KQ976574    KYM80218.1    ACPB03006810    KQ981625    KYN39137.1    KQ982294    KYQ58226.1    ADTU01015227    ADTU01015228    GL888480    EGI60330.1    KX023898    AMW91815.1    KB631647    ERL84995.1    GEZM01093935    JAV56066.1    GEZM01093936    JAV56065.1    DS235286    EEB14433.1    KK107314    QOIP01000012    EZA52845.1    RLU16273.1    KK856027    PTY24677.1    GEZM01066220    GEZM01066217    JAV68055.1    GL440430    EFN65864.1    GEZM01066218    JAV68054.1    GEZM01066219    JAV68053.1    JR040667    AEY59232.1    GL450875    EFN80273.1    LBMM01000179    KMR04593.1    KZ288282    PBC29526.1    JR040668    AEY59233.1    KQ971338    EFA02503.2    KQ414584    KOC70563.1    KX812753    APB53910.1    KYB28020.1    CH940648    KRF80098.1    EDW61606.1    CH933808    KRG04412.1    CH964282    KRG00263.1    KA646044    KA647918    AFP60673.1    EDW85661.1    EDW09000.2    CP012524    ALC40789.1    EZ422287    ADD18563.1    GBBI01001364    JAC17348.1    CCAG010011116    GGMS01012191    MBY81394.1    OUUW01000001    SPP75219.1    Y07964    AE013599    AY118780    AAF47172.1    AAM50640.1    CAA69262.1    CH902619    EDV37500.1    SPP75218.1    KC626025    KC626027    KC626028    AGM38188.1    AGM38190.1    AGM38191.1    KQ434786    KZC05043.1    KC626026    AGM38189.1    ABLF02035746    AK340292    BAH70924.1    JXJN01004888    CH954179    KQS63110.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000218220    UP000283053    UP000235965    + More
UP000027135    UP000078492    UP000078540    UP000015103    UP000078541    UP000075809    UP000005205    UP000007755    UP000030742    UP000009046    UP000053097    UP000279307    UP000000311    UP000008237    UP000036403    UP000242457    UP000007266    UP000053825    UP000008792    UP000005203    UP000009192    UP000007798    UP000092445    UP000092553    UP000095301    UP000192221    UP000092444    UP000268350    UP000000803    UP000007801    UP000076502    UP000007819    UP000092460    UP000008711   

PRIDE

A0EM56    H9JG91    H9JG92    Q94521   

Pfam

PF00583   Acetyltransf_1        + More
PF13673   Acetyltransf_10

Interpro

IPR000182   GNAT_dom        + More
IPR016181   Acyl_CoA_acyltransferase       

SUPFAM

SSF55729   SSF55729       

ProteinModelPortal

A0EM56   H9JG91   A2SZ52   D5LPS6   A0A194PIC1   A0A0N1PG91   + More
A0A0G3VGS2   A0A1E1VZG3   A0A2A4JDQ1   A0A3S2M5D3   A0A2H1VQT5   A0A2H1VQM5   A0A1B6HCH3   A0A1B6G7D1   A0A1B6FNE4   A0A2J7PVW3   A0A194PHE6   A0A0N1I6F1   A0A1Y1K969   A0A1B6EAE7   A0A067RIR6   Q76EI8   A0A0F6PL61   A0A067RHB4   H9JG92   R4UKH6   A0A146LGW6   A0A0A9ZC44   A0A146KRC8   A0A0V0G2Q8   A0A195DYD3   A0A224XX80   A0A0P4VME3   R4FQP0   A0A195B6S7   T1IG91   A0A195FFY7   A0A151XCX3   A0A158NGU6   F4WZQ5   A0A146B0I0   U4U4U9   A0A1Y1K9F0   A0A1Y1K8M0   E0VM27   A0A026W9X1   A0A2R7WYS7   A0A1Y1L7Z9   E2AL26   A0A1Y1L398   A0A1Y1L2X8   V9IEZ0   E2BVK3   A0A0J7L9R0   A0A2A3EEC9   V9IDN1   D2A0F0   A0A0L7RID8   A0A1J0AHX8   A0A139WJ51   A0A0Q9W5M3   A0A088AHR1   B4LJV2   A0A0Q9X7Z8   A0A0Q9X6F7   A0A1B0A475   T1PBJ7   B4NMS2   B4KNV5   A0A0M3QUJ6   D3TLI5   A0A023F7Y2   A0A1I8NFY9   A0A1W4UM97   A0A1B0FG71   A0A2S2QUJ8   A0A1W4V1A5   A0A3B0JNQ8   Q94521-2   B3MDN7   A0A3B0JVX0   Q94521   R4V140   A0A154NZL6   R4V906   C4WSQ4   A0A1B0AWQ3   A0A0Q5VPC8  

PDB

5GI9     E-value=6.30678e-21,     Score=246

KEGG

780849    no KO assigned | (RefSeq) Aanat; arylalkylamine N-acetyltransferase

GO

GO:0016740   GO:0004059   GO:0005737   GO:0008080   GO:0016746   GO:0004060   GO:0006584   GO:0048066   GO:0042429   GO:0045187   GO:0042420   GO:0030187   GO:0046334   GO:0030431   GO:0003678   GO:0006281   GO:0008152   GO:0016787   GO:0042626   GO:0016887   GO:0005622   GO:0006810   GO:0003824  

Length:

233

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00171

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00740

outside

1  -  233

 

 

Pi

158.110198

Theta

151.420941

Tajima's D

0.503983

CLR

0.023357

CSRT

0.52122393880306

Interpretation

Possibly Positive selection