Gene

KWMTBOMO11033

Pre Gene Modal

BGIBMGA008534

Annotation

PREDICTED:_G-protein_coupled_receptor_moody_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr18(+):10515994-10566288      View in EpiBrowser

Full name

G-protein coupled receptor moody      

Location in the cell

PlasmaMembrane   Reliability : 4.991

CDS

ATGTCTGAAAACAATATAAACTTCACAGACGACGTCACGACCAGCGCGGAGCCCAGCGAACTATCCAAATTTTCACCCGGCTTATTGACGTTTGCAGCTATAGCGACTGGCATCATTATGCTTATCGGCTTATTTGGTAACCTGCTCACCGTGGTCGCGCTGCTCAAATGCCCTAAAGTAAGAAATGTGGCAGCAGCCTTTATTATAAGTTTATGTATAGCTGACTTCTTGTTCTGCGCCATGGTATTACCGTTCGCCATATCCGGGTTCTGGACTAGAACCTGGTCTCATGGGGTCGCCCTCTGCAAGCTAGTACCGTTTCTCCGATACGGAAACGTCGGCGTATCCTTATTAAGCATAGCGCTTATAACTGTCAACAGGTACATTATGATAGCTCACCACAGTTGGTACGGCCGCGTTTACAGAAAACACAACATAGCCTTGATGATCCTGTTCTCGTGGATGTTCTCGTATGGAATGCAGATACCTACTCTCATTGGAATTTGGGGTCAGTTCGACTACGACCCCGAATTGGGAACTTGCTCAATAGTTCCAGACGAATTTGGACGTTCTTCAAAAACAGCACTCTTCGTGATCGCGTTCATAGTTCCCGCTTTGCTAATCTTGATATGCTACGCTAGAATATTCTGGGTCGTACACAGCTCAGAGCAAAGAATGCGTGAACATCAAAGATCCCAACACAGCAATCCGGGAACATTAAACAACAGCACCGTAGACAAAAGATCCACGATCAAAGACAACAGAGAGACTAAGGCGAGACGAAATGAATGGAGGATCACAAAGATGGTCTTAGCTATATTCCTGTCTTTTATTGTTTGCTATTTGCCTATTACTATTGCAAAGGTCACTGATGCTCACGTACATTATCCAGTATTCCACGTAGCGGGCTACTTGCTACTGTACGCAAGCGCATGCGTGAACCCGATCATCTACGTGATAATGAACGCGCAGTACCGCGCGGCGTACGCGGCTGCCCTGTGCTGCCCTCTGTCCCGGCTCTCGGGCCTCACCAGCGAGAAATGGAACGAGCGTCACGGGTACAGCTTCAGCAACACACGAACGGCGCTCAGCCAAGTGTCACTGGGCGAGTCGAGAGCAGACCCTCGACCGGCCCCGGACACGTCCGTCCGTGGCTCAAGTTTTAGTTGTGCGTAA

Protein

MSENNINFTDDVTTSAEPSELSKFSPGLLTFAAIATGIIMLIGLFGNLLTVVALLKCPKVRNVAAAFIISLCIADFLFCAMVLPFAISGFWTRTWSHGVALCKLVPFLRYGNVGVSLLSIALITVNRYIMIAHHSWYGRVYRKHNIALMILFSWMFSYGMQIPTLIGIWGQFDYDPELGTCSIVPDEFGRSSKTALFVIAFIVPALLILICYARIFWVVHSSEQRMREHQRSQHSNPGTLNNSTVDKRSTIKDNRETKARRNEWRITKMVLAIFLSFIVCYLPITIAKVTDAHVHYPVFHVAGYLLLYASACVNPIIYVIMNAQYRAAYAAALCCPLSRLSGLTSEKWNERHGYSFSNTRTALSQVSLGESRADPRPAPDTSVRGSSFSCA

Description

Isoform A and isoform B are required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors. Galphai and Galphao, and the regulator of G protein signaling, loco, are required in the surface glia to achieve effective insulation. The components function by regulating the cortical actin and thereby stabilizing the extended morphology of the surface glia, which in turn is necessary for the formation of septate junctions of sufficient length to achieve proper sealing of the nerve cord.
Required in glia to regulate the acute sensitivity to cocaine and to continuously maintain the proper blood-brain barrier (BBB) function. A moody-mediated signaling pathway functions in glia to regulate nervous system insulation and drug-related behaviors (By similarity).

Similarity

Belongs to the G-protein coupled receptor 1 family.
Belongs to the BolA/IbaG family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Membrane   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  G-protein coupled receptor moody
splice variant  In isoform B.

Uniprot

A0A2A4K1C9   A0A0N0PBS8   A0A194PGF9   A0A3S2LPU3   H9JG87   A0A2A4K1R8   + More
A0A336MKP8   A0A336MMQ3   A0A336MHX8   A0A336L7J0   A0A1Y9G768   A0A1Y9G764   A0A0K8V2F7   A0A0A1WYP2   A0A0A9VU90   A0A1A9ZQI2   A0A1A9YJ85   A0A1A9USV4   A0A336M990   A0A1B0BCU0   A0A1A9X5L1   A0A0K8V0E3   A0A1I8Q593   A0A0A9X0P7   A0A182PGY8   A0A0A1X356   A0A034W324   A0A0A9W657   B4Q1C5   B4NBW9   T1I4P9   B3P8U9   A0A0L0CB57   A0A0A1WR06   T1P8N5   A0A0L7KTY4   A0A0K8V414   A0A146KR09   A0A1W4VEL6   A0A1I8M5H3   A0A146L4M5   A0A0A9X653   M9PDK4   Q9W534   A0A2M4A3E3   A0A2M4A3C9   A0A2R7X1S7   A0A1Y9G885   B4I9N0   Q9W534-2   A0A182FRQ9   W8B2I3   A0A2M4CMA4   W5JA65   A0A2M4CLL5   A0A0K8VJ00   A0A0M4F907   A0A182JTL8   M9MS14   A0A2M4CMF3   A0A182WS71   A0A182V9A5   A0A182L9D6   B4M7T1   A0A182HL21   A0A2M4BPA7   A0A2M4BPB7   A0A2M4BNG5   B4JM25   A0A0R3NY35   Q29J90   B4H3X4   B4L2K4   A0A3B0JZT1   A0A0Q9WMD7   A0A0L7QNS7   A0A2M4BRM8   A0A182QGJ7   A0A232F8Q8   A0A0N9JS05   A0A1B0C8F2   A0A182NQC4   A0A2M3ZBB6   A0A182YB84   K7IMB7   A0A2P8XU17   A0A0C9R1U9   A0A088AAC4   A0A2A3E4N0   A0A0I9QPZ7   A0A182R4Z8   B3MYQ9   A0A1B0FI59   A0A084W547   A0A151IHF4   A0A067QKZ9   A0A1J1HQP6   A0A182UCS9  

Pubmed

26354079    19121390    25830018    25401762    25348373    17994087    + More
17550304    18057021    26108605    26227816    26823975    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    10731137    12537569    16213218    16213219    24495485    20920257    23761445    20966253    15632085    28648823    26164593    25244985    20075255    29403074    24952173    24438588    24845553   

EMBL

NWSH01000269    PCG77869.1    KQ460813    KPJ12132.1    KQ459604    KPI92476.1    + More
RSAL01000035    RVE51342.1    BABH01002247    BABH01002248    PCG77868.1    UFQS01001227    UFQT01001227    SSX09836.1    SSX29559.1    SSX09834.1    SSX29557.1    SSX09837.1    SSX29560.1    SSX09835.1    SSX29558.1    GDHF01019579    JAI32735.1    GBXI01010764    JAD03528.1    GBHO01044831    GBHO01044825    GBHO01044823    GBHO01029305    JAF98772.1    JAF98778.1    JAF98780.1    JAG14299.1    UFQT01000746    SSX26914.1    JXJN01012114    GDHF01019993    JAI32321.1    GBHO01040331    GBHO01039592    GBHO01029307    GBHO01029306    GBRD01017549    JAG03273.1    JAG04012.1    JAG14297.1    JAG14298.1    JAG48278.1    GBXI01009174    JAD05118.1    GAKP01009838    JAC49114.1    GBHO01044826    GBHO01040330    GBHO01040326    GBHO01029303    JAF98777.1    JAG03274.1    JAG03278.1    JAG14301.1    CM000162    EDX01432.1    KRK06151.1    CH964239    EDW82328.1    ACPB03006985    CH954183    EDV45554.1    KQS26020.1    JRES01000663    KNC29455.1    GBXI01012803    JAD01489.1    KA645022    AFP59651.1    JTDY01005888    KOB66511.1    GDHF01018647    JAI33667.1    GDHC01020524    JAP98104.1    GDHC01015158    JAQ03471.1    GBHO01044830    GBHO01044829    GBHO01029304    GBHO01029301    GBRD01017552    JAF98773.1    JAF98774.1    JAG14300.1    JAG14303.1    JAG48275.1    AE014298    ADV37618.1    AGB95016.1    AGB95017.1    AL031765    AY121660    AAF45709.2    AAM51987.1    CAA21123.1    GGFK01001986    MBW35307.1    GGFK01001992    MBW35313.1    KK856420    PTY25716.1    CH480825    EDW43911.1    GAMC01015309    GAMC01015307    JAB91248.1    GGFL01002266    MBW66444.1    ADMH02001952    ETN60303.1    GGFL01002048    MBW66226.1    GDHF01013477    JAI38837.1    CP012528    ALC48607.1    ADV37619.1    ADV37620.1    GGFL01002267    MBW66445.1    CH940653    EDW62848.1    KRF80822.1    APCN01000879    GGFJ01005775    MBW54916.1    GGFJ01005776    MBW54917.1    GGFJ01005454    MBW54595.1    CH916371    EDV91786.1    CH379063    KRT05986.1    CH479207    EDW31075.1    CH933810    EDW06880.2    KRF93853.1    KRF93854.1    KRF93856.1    KRF93857.1    KRF93858.1    OUUW01000003    SPP78251.1    KRF93855.1    KQ414843    KOC60278.1    GGFJ01006492    MBW55633.1    AXCN02001525    NNAY01000709    OXU26858.1    KP963677    ALG36125.1    AJWK01000535    AJWK01000536    GGFM01005009    MBW25760.1    PYGN01001348    PSN35490.1    GBYB01001970    GBYB01011724    JAG71737.1    JAG81491.1    KZ288377    PBC26648.1    BK008818    DAA64807.1    CH902632    EDV32753.1    KPU74120.1    CCAG010004713    CCAG010004714    ATLV01020482    ATLV01020483    ATLV01020484    KE525302    KFB45341.1    KQ977613    KYN01393.1    KK853229    KDR09651.1    CVRI01000010    CRK88798.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000283053    UP000005204    UP000069272    + More
UP000092445    UP000092443    UP000078200    UP000092460    UP000091820    UP000095300    UP000075885    UP000002282    UP000007798    UP000015103    UP000008711    UP000037069    UP000037510    UP000192221    UP000095301    UP000000803    UP000001292    UP000000673    UP000092553    UP000075881    UP000076407    UP000075903    UP000075882    UP000008792    UP000075840    UP000001070    UP000001819    UP000008744    UP000009192    UP000268350    UP000053825    UP000075886    UP000215335    UP000092461    UP000075884    UP000076408    UP000002358    UP000245037    UP000005203    UP000242457    UP000075900    UP000007801    UP000092444    UP000030765    UP000078542    UP000027135    UP000183832    UP000075902   

PRIDE

H9JG87    M9PDK4    Q9W534    M9MS14   

Pfam

PF00001   7tm_1        + More
PF01722   BolA

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR017452   GPCR_Rhodpsn_7TM       
IPR029071   Ubiquitin-like_domsf       
IPR002634   BolA       
IPR036065   BolA-like_sf       

SUPFAM

SSF82657   SSF82657        + More
SSF54236   SSF54236       

ProteinModelPortal

A0A2A4K1C9   A0A0N0PBS8   A0A194PGF9   A0A3S2LPU3   H9JG87   A0A2A4K1R8   + More
A0A336MKP8   A0A336MMQ3   A0A336MHX8   A0A336L7J0   A0A1Y9G768   A0A1Y9G764   A0A0K8V2F7   A0A0A1WYP2   A0A0A9VU90   A0A1A9ZQI2   A0A1A9YJ85   A0A1A9USV4   A0A336M990   A0A1B0BCU0   A0A1A9X5L1   A0A0K8V0E3   A0A1I8Q593   A0A0A9X0P7   A0A182PGY8   A0A0A1X356   A0A034W324   A0A0A9W657   B4Q1C5   B4NBW9   T1I4P9   B3P8U9   A0A0L0CB57   A0A0A1WR06   T1P8N5   A0A0L7KTY4   A0A0K8V414   A0A146KR09   A0A1W4VEL6   A0A1I8M5H3   A0A146L4M5   A0A0A9X653   M9PDK4   Q9W534   A0A2M4A3E3   A0A2M4A3C9   A0A2R7X1S7   A0A1Y9G885   B4I9N0   Q9W534-2   A0A182FRQ9   W8B2I3   A0A2M4CMA4   W5JA65   A0A2M4CLL5   A0A0K8VJ00   A0A0M4F907   A0A182JTL8   M9MS14   A0A2M4CMF3   A0A182WS71   A0A182V9A5   A0A182L9D6   B4M7T1   A0A182HL21   A0A2M4BPA7   A0A2M4BPB7   A0A2M4BNG5   B4JM25   A0A0R3NY35   Q29J90   B4H3X4   B4L2K4   A0A3B0JZT1   A0A0Q9WMD7   A0A0L7QNS7   A0A2M4BRM8   A0A182QGJ7   A0A232F8Q8   A0A0N9JS05   A0A1B0C8F2   A0A182NQC4   A0A2M3ZBB6   A0A182YB84   K7IMB7   A0A2P8XU17   A0A0C9R1U9   A0A088AAC4   A0A2A3E4N0   A0A0I9QPZ7   A0A182R4Z8   B3MYQ9   A0A1B0FI59   A0A084W547   A0A151IHF4   A0A067QKZ9   A0A1J1HQP6   A0A182UCS9  

PDB

6ME7     E-value=2.35694e-22,     Score=261

KEGG

101744412    no KO assigned | (RefSeq) G-protein coupled receptor moody

GO

GO:0004930   GO:0016021   GO:0048149   GO:0030866   GO:0005919   GO:0060857   GO:0048148   GO:0007419   GO:0035095   GO:0019991   GO:0005886   GO:0007186   GO:0008366   GO:0008152   GO:0016787   GO:0042626   GO:0016887   GO:0005622   GO:0006810   GO:0003824  

Subcellular location

Cell membrane  

Length:

391

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

156.73821

Exp number, first 60 AAs:

23.08872

Total prob of N-in:

0.00004

POSSIBLE N-term signal

sequence

outside

1  -  30

TMhelix

31  -  53

inside

54  -  64

TMhelix

65  -  87

outside

88  -  106

TMhelix

107  -  129

inside

130  -  149

TMhelix

150  -  172

outside

173  -  195

TMhelix

196  -  218

inside

219  -  269

TMhelix

270  -  287

outside

288  -  296

TMhelix

297  -  319

inside

320  -  391

 

 

Pi

276.033784

Theta

170.568398

Tajima's D

2.346675

CLR

0.237775

CSRT

0.927903604819759

Interpretation

Uncertain