Gene

KWMTBOMO11029

Annotation

PREDICTED:_elongation_of_very_long_chain_fatty_acids_protein_AAEL008004_[Microplitis_demolitor]

Location

Bomo_Chr18(-):10206712-10212938      View in EpiBrowser

Full name

Elongation of very long chain fatty acids protein       + More
Elongation of very long chain fatty acids protein 7      
Elongation of very long chain fatty acids protein 4      

Alternative Name

Very-long-chain 3-oxoacyl-CoA synthase
3-keto acyl-CoA synthase ELOVL7
ELOVL fatty acid elongase 7
Very long chain 3-ketoacyl-CoA synthase 7
Very long chain 3-oxoacyl-CoA synthase 7
3-keto acyl-CoA synthase ELOVL4
ELOVL fatty acid elongase 4
Very long chain 3-ketoacyl-CoA synthase 4
Very long chain 3-oxoacyl-CoA synthase 4

Location in the cell

PlasmaMembrane   Reliability : 4.919

CDS

ATGGCGTTCCTTTTGGCAATATATTTGGCGTTTATATTGAAAATAGGTCCAATGGTTATGGAGCACTTCAATGCTATACAAATGAGAACAATCTTGACAGTCTACAATGCAATTAAAGTTGCCAATTCGACAATGTTAACGTTTCAGGGTTCGAGATTTATTGAAGATCTCAATGTATCTAGCACTAGCATAAAGAATATTACGTTCCAGACAATCGCCGCTCTATACTGGAAGTACATGGTGACGAAAGTTCTAGACCTCTTCGATACGGTTTTCTTCGTACTCCGTAAGAAGTACAGTCAAATAACGTTTCTACACGTTTATCACCACGTGTTCATGGTAATGATTACTTGGTCCAGTTTGAAATACGACCCGTCGGACCACTGGGCGTTTATGGCCGTGTTAAATTGCACTATTCACGTTTTCATGTACGTGTATTATGGGATAGCGTCTTTTGGGCTGAAATACAGAAAGTACTTGTGGTGGAAAAAGTACTTGACTATAATGCAGTTGATCCAATTTCTCTTGATAATGATTCACGTAATGATTCAGACGCACATAACGGACTGTCCTATGCACGCTGGTACCTATTGGTTGGGTTTATCCAACATTGTTCTCTTCATATTTCTCTTCATGGATTTCTATAATAAGAAATATCGAACAGGTACACCTGTGGACAACTTAAAAATTGTATGTGGTAAGCACCAGTAA

Protein

MAFLLAIYLAFILKIGPMVMEHFNAIQMRTILTVYNAIKVANSTMLTFQGSRFIEDLNVSSTSIKNITFQTIAALYWKYMVTKVLDLFDTVFFVLRKKYSQITFLHVYHHVFMVMITWSSLKYDPSDHWAFMAVLNCTIHVFMYVYYGIASFGLKYRKYLWWKKYLTIMQLIQFLLIMIHVMIQTHITDCPMHAGTYWLGLSNIVLFIFLFMDFYNKKYRTGTPVDNLKIVCGKHQ

Description

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.

Catalytic Activity

a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA

Subunit

Oligomer.

Similarity

Belongs to the ELO family.
Belongs to the ELO family. ELOVL7 subfamily.
Belongs to the ELO family. ELOVL4 subfamily.

Uniprot

A0A212EWL1   A0A182SH20   A0A182TTW7   H9JN19   A0A154PBW3   A0A182NB62   + More
A0A182VI27   A0A182Q5E2   A0A182LJY2   Q7Q862   A0A182IB51   A0A182K6I2   A0A336K2J4   A0A2H1VZH1   A0A182RA83   A0A182Y8H9   A0A182IU15   A0A194PYL9   A0A182VTN1   A0A2A4JNZ7   A0A182MR22   W5J2I2   A0A194RDG5   A0A1S3D216   A0A2H1X1Z6   A0A0T6AXI8   A0A1A9V746   A0A182X628   A0A182F0V8   A0A084VMT0   B4NJS5   A0A1W4X4I5   A0A2A4J2V1   A0A0K8S4K6   A0A2A4IT40   T1PEI5   A0A336M748   A0A1W4WV07   A0A336L063   H9JN18   A0A1I8NVN9   A0A3L8DHE2   A0A026VWZ7   A0A336KLJ3   B4JF47   A0A1A9XJ23   A0A2A4IXM4   A0A194RE66   B0X9D9   Q9VCY7   C6SV14   B4HEP6   A0A232FLJ0   B4R0M2   A0A023F182   Q29BK4   B3P8N4   B4PMB5   A0A3Q3MU99   A0A194Q3Y8   A0A3B5KEL0   B4GP37   A0A1Y1LS48   A0A194REJ3   A0A1Y1KWU6   A0A1A9V750   A0A1A9Z486   B3M000   A0A2P8XLH7   A0A194PZF1   B4K959   A0A3B0JF55   A0A069DYC2   B4M164   A0A1E1WEQ6   A0A0P5JDW1   A0A0M4F374   A0A1A9XJ22   A0A1B0BXZ2   A0A1W4VR29   A0A3B0JEF4   A0A1A9W5Z6   A0A3P9J5F1   A0A1B0AU16   F1RQL1   A0A287A8V2   A0A094ZDS4   A0A2H1X1Z5   A0A212C5T5   I3LVJ0   A0A182GG17   A0A2A3EJY7   A0A1A9W5Z7  

EC Number

2.3.1.199

Pubmed

22118469    19121390    20966253    12364791    14747013    17210077    + More
25244985    26354079    20920257    23761445    24438588    17994087    25315136    30249741    24508170    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28648823    25474469    15632085    23185243    17550304    21551351    28004739    18057021    29403074    26334808    17554307    22246508    26483478   

EMBL

AGBW02011990    OWR45834.1    BABH01030562    KQ434856    KZC08758.1    AXCN02000640    + More
AAAB01008944    EAA10201.4    APCN01000639    UFQS01000065    UFQT01000065    SSW98909.1    SSX19295.1    ODYU01005098    SOQ45634.1    KQ459586    KPI98123.1    NWSH01000869    PCG73785.1    AXCM01003970    ADMH02002132    ETN58472.1    KQ460323    KPJ15883.1    ODYU01012860    SOQ59370.1    LJIG01022581    KRT79814.1    ATLV01014624    KE524975    KFB39274.1    CH964272    EDW85037.1    NWSH01003488    PCG66199.1    GBRD01017654    JAG48173.1    NWSH01008171    PCG62666.1    KA647151    AFP61780.1    UFQT01000651    SSX26132.1    UFQS01000742    UFQT01000742    SSX06530.1    SSX26879.1    BABH01030564    QOIP01000008    RLU19339.1    KK107672    EZA48150.1    UFQS01000651    SSX05774.1    SSX26133.1    CH916369    EDV93328.1    NWSH01004932    PCG64575.1    KPJ15887.1    DS232533    EDS43108.1    AE014297    AY061182    AAF56018.1    AAL28730.1    BT089006    ACT88147.1    CH480815    EDW43207.1    NNAY01000044    OXU31604.1    CM000364    EDX13945.1    GBBI01003435    JAC15277.1    CM000070    EAL26992.1    CH954182    EDV54129.1    CM000160    EDW98020.1    KPI98125.1    CH479186    EDW38920.1    GEZM01052596    JAV74396.1    KPJ15884.1    GEZM01077270    GEZM01077269    GEZM01077268    GEZM01077267    JAV63347.1    CH902617    EDV44190.1    KPU80676.1    PYGN01001778    PSN32848.1    KPI98119.1    CH933806    EDW14472.1    KRG01026.1    OUUW01000005    SPP80765.1    GBGD01002495    JAC86394.1    CH940650    EDW67475.1    KRF83305.1    GDQN01005618    JAT85436.1    GDIQ01226210    JAK25515.1    CP012526    ALC45632.1    JXJN01022417    SPP80764.1    JXJN01003500    AEMK02000001    KL250505    KGB32480.1    ODYU01012850    SOQ59355.1    MKHE01000028    OWK01340.1    JXUM01010795    KQ560317    KXJ83083.1    KZ288222    PBC32085.1   

Proteomes

UP000007151    UP000075901    UP000075902    UP000005204    UP000076502    UP000075884    + More
UP000075903    UP000075886    UP000075882    UP000007062    UP000075840    UP000075881    UP000075900    UP000076408    UP000075880    UP000053268    UP000075920    UP000218220    UP000075883    UP000000673    UP000053240    UP000079169    UP000078200    UP000076407    UP000069272    UP000030765    UP000007798    UP000192223    UP000095301    UP000095300    UP000279307    UP000053097    UP000001070    UP000092443    UP000002320    UP000000803    UP000001292    UP000215335    UP000000304    UP000001819    UP000008711    UP000002282    UP000261640    UP000005226    UP000008744    UP000092445    UP000007801    UP000245037    UP000009192    UP000268350    UP000008792    UP000092553    UP000092460    UP000192221    UP000091820    UP000265200    UP000008227    UP000069940    UP000249989    UP000242457   

PRIDE

H9JN19    H9JN18    Q9VCY7    C6SV14    F1RQL1    I3LVJ0    + More

Pfam

PF01151   ELO

Interpro

IPR002076   ELO_fam        + More
IPR030457   ELO_CS       
IPR033670   ELOVL7       
IPR033678   ELOVL4       

ProteinModelPortal

A0A212EWL1   A0A182SH20   A0A182TTW7   H9JN19   A0A154PBW3   A0A182NB62   + More
A0A182VI27   A0A182Q5E2   A0A182LJY2   Q7Q862   A0A182IB51   A0A182K6I2   A0A336K2J4   A0A2H1VZH1   A0A182RA83   A0A182Y8H9   A0A182IU15   A0A194PYL9   A0A182VTN1   A0A2A4JNZ7   A0A182MR22   W5J2I2   A0A194RDG5   A0A1S3D216   A0A2H1X1Z6   A0A0T6AXI8   A0A1A9V746   A0A182X628   A0A182F0V8   A0A084VMT0   B4NJS5   A0A1W4X4I5   A0A2A4J2V1   A0A0K8S4K6   A0A2A4IT40   T1PEI5   A0A336M748   A0A1W4WV07   A0A336L063   H9JN18   A0A1I8NVN9   A0A3L8DHE2   A0A026VWZ7   A0A336KLJ3   B4JF47   A0A1A9XJ23   A0A2A4IXM4   A0A194RE66   B0X9D9   Q9VCY7   C6SV14   B4HEP6   A0A232FLJ0   B4R0M2   A0A023F182   Q29BK4   B3P8N4   B4PMB5   A0A3Q3MU99   A0A194Q3Y8   A0A3B5KEL0   B4GP37   A0A1Y1LS48   A0A194REJ3   A0A1Y1KWU6   A0A1A9V750   A0A1A9Z486   B3M000   A0A2P8XLH7   A0A194PZF1   B4K959   A0A3B0JF55   A0A069DYC2   B4M164   A0A1E1WEQ6   A0A0P5JDW1   A0A0M4F374   A0A1A9XJ22   A0A1B0BXZ2   A0A1W4VR29   A0A3B0JEF4   A0A1A9W5Z6   A0A3P9J5F1   A0A1B0AU16   F1RQL1   A0A287A8V2   A0A094ZDS4   A0A2H1X1Z5   A0A212C5T5   I3LVJ0   A0A182GG17   A0A2A3EJY7   A0A1A9W5Z7  

KEGG

101744268    K10249 elongation of very long chain fatty acids protein 4 [EC:2.3.1.199] | (RefSeq) elongation of v

PATHWAY

00062    Fatty acid elongation - Bombyx mori (domestic silkworm)
01040    Biosynthesis of unsaturated fatty acids - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01212    Fatty acid metabolism - Bombyx mori (domestic silkworm)

GO

GO:0102756   GO:0016021   GO:0102338   GO:0102336   GO:0006633   GO:0102337   GO:0030176   GO:0034625   GO:0034626   GO:0009922   GO:0042761   GO:0030148   GO:0019367   GO:0000915   GO:0042811   GO:0007111   GO:0007112   GO:0007110   GO:0000212   GO:0051225   GO:0030497   GO:0005789   GO:0035338   GO:0006636   GO:0016042   GO:0016298   GO:0008152   GO:0016787   GO:0042626   GO:0016887   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR11157   PTHR11157:SF118  

Subcellular location

Endoplasmic reticulum membrane  

Length:

236

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

108.6669

Exp number, first 60 AAs:

22.94115

Total prob of N-in:

0.09346

POSSIBLE N-term signal

sequence

outside

1  -  3

TMhelix

4  -  26

inside

27  -  101

TMhelix

102  -  121

outside

122  -  130

TMhelix

131  -  153

inside

154  -  164

TMhelix

165  -  184

outside

185  -  193

TMhelix

194  -  211

inside

212  -  236

 

 

Pi

258.355954

Theta

172.544436

Tajima's D

2.223691

CLR

0.242794

CSRT

0.915304234788261

Interpretation

Uncertain