Gene

KWMTBOMO11025  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008532

Annotation

N-acetyltransferase_[Bombyx_mori]

Location

Bomo_Chr18(+):10138429-10139490      View in EpiBrowser

Full name

Probable N-acetyltransferase san      

Alternative Name

N-epsilon-acetyltransferase san
Protein atado
Protein separation anxiety

Location in the cell

Cytoplasmic   Reliability : 1.942

CDS

ATGACTAGAGCTAAAATAGAACTCGGCGACGTGACGCCGCATAATATAAAGCAGTTGAAAAAATTGAACACAGTTGTATTTCCAGTGTCATATAATGATAAGTTTTACAAAGATGTTCTGGAGGCTGGTGAACTCGCAAAATTAGCTTATTATAATGACATAGTGGTGGGAGCCGTGTGCTGCAGGATAGACACATCGGAGAACTCTCGGCGGCTTTACATTATGACACTGGGATGCTTGTATCCATATAGAAGACTTGGTATTGGTTCAATGATGGTTAAGCATGTGCTCAATTATGTGAAACAGGATGGAAATTTTGACAGTATTTTTTTACACGTACAAGTGAATAATGAAGGTGCAATAGACTTTTACAAGAAATTCGGCTTTGAAATTGTTGAAACAAAAGAACGTTACTATAAGAGAATAGAACCAGCAGACGCTCATGTCTTACAAAAGACCATAAGACTACCGAGCACACCTTTGGTCAACGGGTCAGTATCACACACAAAGACAAACGGCTATGATGCAGGCTCACAACAAAACAACATAATGTTTTATTTGTAA

Protein

MTRAKIELGDVTPHNIKQLKKLNTVVFPVSYNDKFYKDVLEAGELAKLAYYNDIVVGAVCCRIDTSENSRRLYIMTLGCLYPYRRLGIGSMMVKHVLNYVKQDGNFDSIFLHVQVNNEGAIDFYKKFGFEIVETKERYYKRIEPADAHVLQKTIRLPSTPLVNGSVSHTKTNGYDAGSQQNNIMFYL

Description

N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides (By similarity). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates (PubMed:14653991). Required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together (PubMed:14653991, PubMed:18801358, PubMed:27996020). Required for the interaction between Scc1/vtd and SMC3, possibly by mediating N-terminal acetylation of Scc1/vtd (PubMed:27996020).
(Microbial infection) Required for optimal replication of E.chaffeensis in the immune tissues, hemocytes, and fat body.

Catalytic Activity

acetyl-CoA + N-terminal L-methionyl-L-alanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein]
acetyl-CoA + N-terminal L-methionyl-L-seryl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein]
acetyl-CoA + N-terminal L-methionyl-L-valyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein]
acetyl-CoA + N-terminal L-methionyl-L-threonyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein]
acetyl-CoA + N-terminal L-methionyl-L-lysyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein]
acetyl-CoA + N-terminal L-methionyl-L-leucyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein]
acetyl-CoA + N-terminal L-methionyl-L-phenylalanyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein]
acetyl-CoA + N-terminal L-methionyl-L-tyrosyl-[protein] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein]

Subunit

Component of an acetyltransferase complex, at least composed of san, Ard1 and Nat1.

Similarity

Belongs to the acetyltransferase family.

Keywords

Acetylation   Acyltransferase   Cell cycle   Complete proteome   Cytoplasm   Reference proteome   Transferase  

Feature

chain  Probable N-acetyltransferase san

Uniprot

H9JG85   Q1HQ22   A0A2H1WZ80   A0A0N1PIG5   A0A2A4JT86   S4P9N5   + More
A0A212F9D7   A0A194PGQ5   A0A0L7L5F4   A0A2P8Z3L4   V5I7T4   A0A0L0C4K5   A0A1W4WS08   A0A1Y1MKE1   A0A067RF13   A0A195B5Q8   A0A158NQJ1   A0A026VW07   J3JUI8   A0A0J7NR31   E2A6I6   E2C1H1   A0A2A3E3L4   A0A0M9AC75   A0A088AAB4   A0A232EZQ4   A0A154NZT4   A0A151XBE4   E9IUW0   A0A195ETR2   F4WCJ1   A0A224YUC3   A0A131XPZ4   K7IV35   A0A1I8NP51   A0A131YZP1   A0A1L8EDK5   A0A195EL83   T1P9T9   V5HCY4   A0A1B0GL00   A0A1A9X4Z0   E0VLH5   B4J8Y5   A0A023GIM2   G3MPN3   A0A1E1XUU7   A0A0C9SCU2   A0A023FHH9   A0A2J7RCF9   B4NSE1   B4P6I0   B7PB60   B3NSH0   A0A1E1WZA2   A0A0L7QNX6   A0A1B0FDG1   A0A1A9Y441   A0A1A9VU33   A0A1B0BTS3   A0A1B0AF17   Q9NHD5   A0A1L8DBB5   A0A0K8TRH2   B4KRG5   T1II22   B4LQ58   A0A293MGS5   B3MFA8   A0A1W4UI72   A0A1B6ESD5   A0A1B6HV29   A0A023FTR2   A0A3B0JKV2   A0A0A9XXE9   A0A2R5LL25   Q28Y94   A0A0K8RL29   A0A0P4VQ56   A0A1B6HY40   B4NME4   B4GCV7   W8BXR8   A0A0K8UK57   A0A034V173   A0A0V0GBK8   A0A069DQ76   A0A336L500   R4G5E0   A0A0M5J2I1   A0A1Q3F196   B0X936   L7LS72   Q178Z8   A0A182HF31   A0A1S4FBD7   T1HI27   A0A1S3D554   U5EWV7   A0A1Q3F1D9  

EC Number

2.3.1.258

Pubmed

19121390    26354079    23622113    22118469    26227816    29403074    + More
26108605    28004739    24845553    21347285    24508170    30249741    22516182    23537049    20798317    28648823    21282665    21719571    28797301    28049606    20075255    26830274    25315136    25765539    20566863    17994087    22216098    29209593    26131772    22936249    17550304    28503490    14653991    10731132    12537572    12537569    18801358    22851751    23306065    27996020    26369729    25401762    15632085    27129103    24495485    25348373    26334808    25576852    17510324    26483478   

EMBL

BABH01002213    DQ443230    ABF51319.1    ODYU01012207    SOQ58389.1    KQ459718    + More
KPJ20240.1    NWSH01000670    PCG74908.1    GAIX01003694    JAA88866.1    AGBW02009596    OWR50352.1    KQ459604    KPI92482.1    JTDY01002811    KOB70677.1    PYGN01000212    PSN51085.1    GALX01005880    JAB62586.1    JRES01000930    KNC27220.1    GEZM01028902    JAV86201.1    KK852506    KDR22471.1    KQ976582    KYM79853.1    ADTU01001826    KK107796    QOIP01000013    EZA47676.1    RLU15348.1    APGK01053114    BT126902    KB741221    KB632081    AEE61864.1    ENN72420.1    ERL88582.1    LBMM01002362    KMQ94920.1    GL437132    EFN70943.1    GL451937    EFN78147.1    KZ288392    PBC26343.1    KQ435695    KOX80856.1    NNAY01001470    OXU23855.1    KQ434786    KZC05121.1    KQ982327    KYQ57706.1    GL766058    EFZ15645.1    KQ981979    KYN31269.1    GL888070    EGI68171.1    GFPF01010062    MAA21208.1    GEFH01000306    JAP68275.1    AAZX01001194    GEDV01005186    JAP83371.1    GFDG01002136    JAV16663.1    KQ978739    KYN28891.1    KA645482    AFP60111.1    GANP01009199    JAB75269.1    AJWK01033992    DS235271    EEB14231.1    CH916367    EDW01334.1    GBBM01002808    JAC32610.1    JO843834    AEO35451.1    GFAA01000605    JAU02830.1    GBZX01002227    JAG90513.1    GBBK01003988    JAC20494.1    NEVH01005885    PNF38518.1    CH982175    CM002911    EDX15519.1    KMY92988.1    CM000158    EDW90932.1    ABJB010501136    ABJB010881781    DS674641    EEC03832.1    CH954179    EDV56472.1    GFAC01006838    JAT92350.1    KQ414843    KOC60328.1    CCAG010003082    JXJN01020338    AF225902    AE013599    AY070826    GFDF01010328    JAV03756.1    GDAI01001083    JAI16520.1    CH933808    EDW10391.1    JH430078    CH940648    EDW61343.1    GFWV01020169    MAA44897.1    CH902619    EDV35582.1    GECZ01028903    JAS40866.1    GECU01029193    JAS78513.1    GBBL01002099    JAC25221.1    OUUW01000001    SPP73866.1    GBHO01021639    GBRD01009923    JAG21965.1    JAG55901.1    GGLE01006063    MBY10189.1    CM000071    EAL26071.2    GADI01002006    JAA71802.1    GDKW01001994    JAI54601.1    GECU01028119    JAS79587.1    CH964282    EDW85533.2    CH479181    EDW32520.1    GAMC01000365    JAC06191.1    GDHF01025378    JAI26936.1    GAKP01022718    JAC36234.1    GECL01000864    JAP05260.1    GBGD01002869    JAC86020.1    UFQS01001615    UFQS01002921    UFQT01001615    UFQT01002921    SSX11609.1    SSX14894.1    SSX31176.1    GAHY01000051    JAA77459.1    CP012524    ALC41281.1    GFDL01013719    JAV21326.1    DS232517    EDS42942.1    GACK01010622    JAA54412.1    CH477355    EAT42821.1    JXUM01133374    KQ567972    KXJ69210.1    ACPB03012932    GANO01000378    JAB59493.1    GFDL01013673    JAV21372.1   

Proteomes

UP000005204    UP000053240    UP000218220    UP000007151    UP000053268    UP000037510    + More
UP000245037    UP000037069    UP000192223    UP000027135    UP000078540    UP000005205    UP000053097    UP000279307    UP000019118    UP000030742    UP000036403    UP000000311    UP000008237    UP000242457    UP000053105    UP000005203    UP000215335    UP000076502    UP000075809    UP000078541    UP000007755    UP000002358    UP000095300    UP000078492    UP000095301    UP000092461    UP000091820    UP000009046    UP000001070    UP000235965    UP000000304    UP000002282    UP000001555    UP000008711    UP000053825    UP000092444    UP000092443    UP000078200    UP000092460    UP000092445    UP000000803    UP000009192    UP000008792    UP000007801    UP000192221    UP000268350    UP000001819    UP000007798    UP000008744    UP000092553    UP000002320    UP000008820    UP000069940    UP000249989    UP000015103    UP000079169   

PRIDE

H9JG85    Q1HQ22    Q9NHD5   

Pfam

PF00583   Acetyltransf_1

Interpro

IPR000182   GNAT_dom        + More
IPR016181   Acyl_CoA_acyltransferase       

SUPFAM

SSF55729   SSF55729       

ProteinModelPortal

H9JG85   Q1HQ22   A0A2H1WZ80   A0A0N1PIG5   A0A2A4JT86   S4P9N5   + More
A0A212F9D7   A0A194PGQ5   A0A0L7L5F4   A0A2P8Z3L4   V5I7T4   A0A0L0C4K5   A0A1W4WS08   A0A1Y1MKE1   A0A067RF13   A0A195B5Q8   A0A158NQJ1   A0A026VW07   J3JUI8   A0A0J7NR31   E2A6I6   E2C1H1   A0A2A3E3L4   A0A0M9AC75   A0A088AAB4   A0A232EZQ4   A0A154NZT4   A0A151XBE4   E9IUW0   A0A195ETR2   F4WCJ1   A0A224YUC3   A0A131XPZ4   K7IV35   A0A1I8NP51   A0A131YZP1   A0A1L8EDK5   A0A195EL83   T1P9T9   V5HCY4   A0A1B0GL00   A0A1A9X4Z0   E0VLH5   B4J8Y5   A0A023GIM2   G3MPN3   A0A1E1XUU7   A0A0C9SCU2   A0A023FHH9   A0A2J7RCF9   B4NSE1   B4P6I0   B7PB60   B3NSH0   A0A1E1WZA2   A0A0L7QNX6   A0A1B0FDG1   A0A1A9Y441   A0A1A9VU33   A0A1B0BTS3   A0A1B0AF17   Q9NHD5   A0A1L8DBB5   A0A0K8TRH2   B4KRG5   T1II22   B4LQ58   A0A293MGS5   B3MFA8   A0A1W4UI72   A0A1B6ESD5   A0A1B6HV29   A0A023FTR2   A0A3B0JKV2   A0A0A9XXE9   A0A2R5LL25   Q28Y94   A0A0K8RL29   A0A0P4VQ56   A0A1B6HY40   B4NME4   B4GCV7   W8BXR8   A0A0K8UK57   A0A034V173   A0A0V0GBK8   A0A069DQ76   A0A336L500   R4G5E0   A0A0M5J2I1   A0A1Q3F196   B0X936   L7LS72   Q178Z8   A0A182HF31   A0A1S4FBD7   T1HI27   A0A1S3D554   U5EWV7   A0A1Q3F1D9  

PDB

4X5K     E-value=4.21375e-70,     Score=668

KEGG

732937    K20793 N-alpha-acetyltransferase 50 [EC:2.3.1.258] | (RefSeq) N-acetyltransferase

GO

GO:0016740   GO:0004596   GO:0016573   GO:0007064   GO:0031415   GO:0005829   GO:0006474   GO:0008999   GO:0008080   GO:0005737   GO:0000278   GO:0031248   GO:0016021   GO:0016705   GO:0020037   GO:0005622   GO:0042626   GO:0016887   GO:0006810   GO:0003824  

Subcellular location

Cytoplasm   During interphase, it localizes to the cytoplasm. During the entry into mitosis, it becomes distributed throughout the entire cell in a punctate pattern. From metaphase through telophase, it is distributed uniformly throughout the cell.   With evidence from 3 publications.

Length:

187

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.10797

Exp number, first 60 AAs:

0.0037

Total prob of N-in:

0.16487

outside

1  -  187

 

 

Pi

168.721121

Theta

173.529637

Tajima's D

-0.273523

CLR

1.106529

CSRT

0.289585520723964

Interpretation

Uncertain