Silkworm Genome Informatics Database

Gene

KWMTBOMO11013

Pre Gene Modal

BGIBMGA008529

Annotation

PREDICTED:_galactosylgalactosylxylosylprotein_3-beta-glucuronosyltransferase_I_[Papilio_machaon]

Location

Bomo_Chr18(+):9675519-9686353 View in EpiBrowser

Full name

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase + More
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I

Alternative Name

Beta-1,3-glucuronyltransferase I
Glucuronosyltransferase I
UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase

Location in the cell

Mitochondrial Reliability : 1.45

CDS

ATGCCTTTTGTAAACATTAAGAAGCATTATATAGCATTCGGGATGTTACTTTTTGTTTTGTTATTCTTATTTAATAGCAAGCCGGCGTTTCAGTGTCAGTTTAGCCAAGAGCCCCCTGCGTACTTGCCCACGATTTATGGGATCACACCGACATACTCAAGATTAGCCCAAAAAGCTGATCTCACAAGGCTGTCACAAACATTGATGCTCGTAAAGAATTTCCATTGGATCATCATAGAGGATTCAGAAACAAAAACTAAATTGGTTGAGAATTTATTGAAAGAATCAGGTCTGAAATACACTCATTTAAATGTGAAAACCCATAAGGCAAAACATTCAACAGCGAGCGGCGTTGAGCAGAGAAACGCTGCGTTGGACTGGTTGAAGGGGCATTTAAATCAAATTGAAGACAAAAAAGGCGTAGTTTACTTCATGGATGACGACAATACATATTCATTGAAAGTTTTTGATGAGATGCGAAAGATAAAAAGAGTTGGCGTATGGCCGGTCGGCATCGTGGGTGGGATGAGAGTGGAGATGCCCCTAGTCACAGATGGAAAGATAAGCGGCTTCAACGCGGTCTGGAAACCGTTCAGACCTTTCCCTATCGATATGGCAGGATTCGCCATCAACTCAACTCTGTTCCTGGATTATCCAGAAGCTAAGTTCTCGAGGAAGGTTCAGTCTGGATTTCAGGAAAGCGAGATATTAAAGTATTTTACGACGAAAGAAGCAATGGAGCCGCTAGCCGAGTTCTGTACTAAAGTTTACGTTTGGCACACGAGAACGCAGCACCCATCAATACTCAACGTTAAGAAATTAAAACATCCACCGGTACCAGACGATCATATTGAAGTTTGA

Protein

MPFVNIKKHYIAFGMLLFVLLFLFNSKPAFQCQFSQEPPAYLPTIYGITPTYSRLAQKADLTRLSQTLMLVKNFHWIIIEDSETKTKLVENLLKESGLKYTHLNVKTHKAKHSTASGVEQRNAALDWLKGHLNQIEDKKGVVYFMDDDNTYSLKVFDEMRKIKRVGVWPVGIVGGMRVEMPLVTDGKISGFNAVWKPFRPFPIDMAGFAINSTLFLDYPEAKFSRKVQSGFQESEILKYFTTKEAMEPLAEFCTKVYVWHTRTQHPSILNVKKLKHPPVPDDHIEV

Description

Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates.

Catalytic Activity

3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP

Cofactor

Mn(2+)

Similarity

Belongs to the glycosyltransferase 43 family.

Keywords

Complete proteome Glycoprotein Golgi apparatus Manganese Membrane Metal-binding Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix

Feature

chain Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

Uniprot

A0A212EWN3 A0A0N1IIR2 A0A2A4JQT8 A0A3S2L438 A0A194PMZ0 H9JG82 + More
A0A0L7L7J4 A0A1S3IRF9 A0A1S3ITE2 A0A232F966 D2A2P0 A0A2S2N9M5 A0A067R8M4 A0A1B6ES19 A0A0T6B7Q0 E9IXQ4 A0A0N0U6V8 A0A1B6H6B8 A0A087T797 A0A0L7QT39 J9JL59 A0A151X7G3 A0A158NA63 F4X1I4 A0A2H8TCZ5 T1PBR6 H3ALB0 A0A1D2N145 A0A195CUZ4 A0A195FRA9 E9GYK1 A0A026VZC6 A0A195BJ65 A0A310S907 K7GGW8 A0A1B6LH87 A0A195DLV6 B4L6N5 A0A0M3QYX7 A0A1Y1JXM6 V4B895 A0A2R7W130 A0A154PHM1 A0A2A3EAK8 A0A088A512 N6SZS9 A0A1I8NYW1 B4M7M8 A0A0L0BT89 R7UMF9 A0A1B6D806 B4JNG3 A0A0N8D105 V9L0F8 A0A0P6DM17 A0A0P5IIT0 A0A0P5V879 C3Y0J0 E2BH40 W8BQG1 E2ATZ4 T1DBR3 A0A0N8CZH3 A0A0P5B0I5 A0A0K8SVG4 H9G8F2 A0A0A9VZB6 A0A1W4WEK0 A0A336MD60 A0A146MC75 A0A0A9W6K2 T1HLC9 A0A336L8K9 A0A0K8SWD8 A0A0K8V5G6 B3MSL0 Q599K4 Q5CAS5 A0A0P5B7G8 A0A0L8H2S1 F6WKR0 Q0VA80 B5RJ22 O97422 A0A034W377 W4XBK7 Q5CAS6 A0A1W4V1H6 A0A3Q2ZZH6 M7BMM6 B3NSU9 B4NPA6 B4R4F3 Q7ZZM8 A0A3Q2CN62 E0VR40 A0A0B7B9P1 A0A3B0KYG9 A0A3B3QXH0

EC Number

2.4.1.135

Pubmed

22118469 26354079 19121390 26227816 28648823 18362917 + More
19820115 24845553 21282665 21347285 21719571 25315136 9215903 27289101 21292972 24508170 30249741 17381049 17994087 28004739 23254933 23537049 26108605 24402279 18563158 20798317 24495485 23758969 25727380 21881562 25401762 26823975 17550304 20431018 12511570 10731132 12537572 10731137 12537569 25348373 23624526 27762356 20566863 29240929

EMBL

AGBW02011933 OWR45895.1 KQ459718 KPJ20233.1 NWSH01000862 PCG73813.1 + More
RSAL01000170 RVE45192.1 KQ459604 KPI92490.1 BABH01002172 JTDY01002407 KOB71472.1 NNAY01000709 OXU26857.1 KQ971338 EFA01477.1 GGMR01001236 MBY13855.1 KK852624 KDR19937.1 GECZ01029030 JAS40739.1 LJIG01009288 KRT83379.1 GL766762 EFZ14643.1 KQ435727 KOX78102.1 GECU01037526 JAS70180.1 KK113765 KFM60986.1 KQ414755 KOC61719.1 ABLF02013400 KQ982446 KYQ56311.1 ADTU01010044 GL888529 EGI59712.1 GFXV01000160 MBW11965.1 KA646119 AFP60748.1 AFYH01015715 LJIJ01000307 ODM98958.1 KQ977276 KYN04496.1 KQ981305 KYN42966.1 GL732575 EFX75410.1 KK107538 QOIP01000005 EZA49128.1 RLU22713.1 KQ976455 KYM85141.1 KQ769211 OAD52891.1 AGCU01052699 AGCU01052700 AGCU01052701 GEBQ01016979 JAT22998.1 KQ980734 KYN13826.1 CH933812 EDW06031.1 CP012528 ALC48389.1 GEZM01100239 GEZM01100238 JAV52961.1 KB200330 ESP01922.1 KK854230 PTY13443.1 KQ434908 KZC11323.1 KZ288303 PBC28803.1 APGK01057945 KB741283 ENN70773.1 CH940653 EDW62795.1 JRES01001388 KNC23208.1 AMQN01006953 KB299620 ELU07724.1 GEDC01015479 JAS21819.1 CH916371 EDV92256.1 GDIP01079407 JAM24308.1 JW872227 AFP04745.1 GDIQ01085013 JAN09724.1 GDIQ01214167 JAK37558.1 GDIP01103008 JAM00707.1 GG666478 EEN66263.1 GL448268 EFN84961.1 GAMC01003090 JAC03466.1 GL442749 EFN63091.1 GAAZ01000974 GBKC01001449 JAA96969.1 JAG44621.1 GDIP01085306 GDIP01083663 JAM20052.1 GDIP01191550 GDIP01151508 GDIQ01054284 LRGB01002813 JAJ31852.1 JAN40453.1 KZS06248.1 GBRD01008612 JAG57209.1 AAWZ02036177 GBHO01043103 GDHC01017598 JAG00501.1 JAQ01031.1 UFQS01000889 UFQT01000889 SSX07510.1 SSX27850.1 GDHC01001251 JAQ17378.1 GBHO01043104 JAG00500.1 ACPB03017676 UFQS01002306 UFQT01002306 SSX13759.1 SSX33180.1 GBRD01008611 JAG57210.1 GDHF01018193 JAI34121.1 CH902622 EDV34765.1 AJ890837 CAI68023.1 AJ889608 CM000162 CAI63866.1 EDX01233.1 GDIP01189000 JAJ34402.1 KQ419458 KOF83507.1 AAMC01131587 AAMC01131588 BC121200 AAI21201.1 BT044296 ACH92361.1 AB080695 AE014298 AL033125 AY060634 GAKP01009788 GAKP01009784 GAKP01009780 JAC49164.1 AAGJ04167922 AJ889607 CAI63865.1 KB519582 EMP38489.1 CH954180 EDV45779.1 CH964291 EDW86346.1 CM000366 EDX17043.1 BC169407 BC169433 AJ557582 CM004472 AAI69407.1 CAD89797.1 OCT84115.1 DS235451 EEB15846.1 HACG01042131 CEK88996.1 OUUW01000018 SPP89148.1

Proteomes

UP000007151 UP000053240 UP000218220 UP000283053 UP000053268 UP000005204 + More
UP000037510 UP000085678 UP000215335 UP000007266 UP000027135 UP000053105 UP000054359 UP000053825 UP000007819 UP000075809 UP000005205 UP000007755 UP000095301 UP000008672 UP000094527 UP000078542 UP000078541 UP000000305 UP000053097 UP000279307 UP000078540 UP000007267 UP000078492 UP000009192 UP000092553 UP000030746 UP000076502 UP000242457 UP000005203 UP000019118 UP000095300 UP000008792 UP000037069 UP000014760 UP000001070 UP000001554 UP000008237 UP000000311 UP000076858 UP000001646 UP000192223 UP000015103 UP000007801 UP000002282 UP000053454 UP000008143 UP000000803 UP000007110 UP000192221 UP000264800 UP000031443 UP000008711 UP000007798 UP000000304 UP000186698 UP000265020 UP000009046 UP000268350 UP000261540

PRIDE

H9JG82 B5RJ22 O97422

Pfam

PF03360 Glyco_transf_43

Interpro

IPR029044 Nucleotide-diphossugar_trans + More
IPR005027 Glyco_trans_43

SUPFAM

SSF53448 SSF53448

Gene 3D

3.90.550.10

CDD

cd00218 GlcAT-I

ProteinModelPortal

A0A212EWN3 A0A0N1IIR2 A0A2A4JQT8 A0A3S2L438 A0A194PMZ0 H9JG82 + More
A0A0L7L7J4 A0A1S3IRF9 A0A1S3ITE2 A0A232F966 D2A2P0 A0A2S2N9M5 A0A067R8M4 A0A1B6ES19 A0A0T6B7Q0 E9IXQ4 A0A0N0U6V8 A0A1B6H6B8 A0A087T797 A0A0L7QT39 J9JL59 A0A151X7G3 A0A158NA63 F4X1I4 A0A2H8TCZ5 T1PBR6 H3ALB0 A0A1D2N145 A0A195CUZ4 A0A195FRA9 E9GYK1 A0A026VZC6 A0A195BJ65 A0A310S907 K7GGW8 A0A1B6LH87 A0A195DLV6 B4L6N5 A0A0M3QYX7 A0A1Y1JXM6 V4B895 A0A2R7W130 A0A154PHM1 A0A2A3EAK8 A0A088A512 N6SZS9 A0A1I8NYW1 B4M7M8 A0A0L0BT89 R7UMF9 A0A1B6D806 B4JNG3 A0A0N8D105 V9L0F8 A0A0P6DM17 A0A0P5IIT0 A0A0P5V879 C3Y0J0 E2BH40 W8BQG1 E2ATZ4 T1DBR3 A0A0N8CZH3 A0A0P5B0I5 A0A0K8SVG4 H9G8F2 A0A0A9VZB6 A0A1W4WEK0 A0A336MD60 A0A146MC75 A0A0A9W6K2 T1HLC9 A0A336L8K9 A0A0K8SWD8 A0A0K8V5G6 B3MSL0 Q599K4 Q5CAS5 A0A0P5B7G8 A0A0L8H2S1 F6WKR0 Q0VA80 B5RJ22 O97422 A0A034W377 W4XBK7 Q5CAS6 A0A1W4V1H6 A0A3Q2ZZH6 M7BMM6 B3NSU9 B4NPA6 B4R4F3 Q7ZZM8 A0A3Q2CN62 E0VR40 A0A0B7B9P1 A0A3B0KYG9 A0A3B3QXH0

PDB

3CU0 E-value=2.45758e-64, Score=621

KEGG

101743406 K10158 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 [EC:2.4.1.135] | (RefSeq)

PATHWAY

00532    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Bombyx mori (domestic silk
00534    Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0046872 GO:0015018 GO:0000139 GO:0006486 GO:0016021 GO:0050650 GO:0030198 GO:0015012 GO:0051216 GO:0090316 GO:0072542 GO:0005801 GO:0006024 GO:0050651 GO:0015020 GO:0030206 GO:0030166 GO:0016020 GO:0015074 GO:0006810 GO:0042626 GO:0016887 GO:0005622 GO:0003824

PANTHER

PTHR10896

Subcellular location

Golgi apparatus membrane

SignalP

Position: 1 - 31, Likelihood: 0.568031

Length:

286

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

17.3943

Exp number, first 60 AAs:

16.78044

Total prob of N-in:

0.61792

POSSIBLE N-term signal

sequence

inside

1 - 8

TMhelix

9 - 26

outside

27 - 286

Pi

251.340048

Theta

162.599964

Tajima's D

1.74148

CLR

0

CSRT

0.832008399580021

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics