Gene

KWMTBOMO11008  Validated by peptides from experiments

Annotation

PREDICTED:_alpha-actinin?_sarcomeric_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr18(-):9286104-9331592      View in EpiBrowser

Full name

Alpha-actinin, sarcomeric      

Alternative Name

F-actin cross-linking protein

Location in the cell

Cytoplasmic   Reliability : 2.8

CDS

ATGCTGCTGCTGGAGGTCATCTCCGGCGAGACTCTGCCCAAGCCCGACCGTGGCAAAATGCGATTCCACAAAATCGCTAACGTCAACAAGGCACTCGACTTCATCGCCTCCAAAGGTGTGAAGCTTGTGTCAATTGGTGCCGAAGAAATCGTCGATGGTAACCTTAAGATGACTCTTGGTATGATTTGGACCATTATTCTCCGTTTCGCCATCCAAGACATCTCAGTTGAAGAAATGACCGCAAAGGAAGGTCTGTTGCTCTGGTGTCAACGTAAGACAGCGCCGTACAAGAATGTCAATGTCCAGAACTTCCACCTGTCGTTCAAGGACGGTCTGGCCTTCTGTGCCCTCATTCACAGGCACAGGCCAGACCTCATCGACTACAGTAAACTCTCCAAGGACAATCCCCTCGAGAACTTGAACACCGCTTTCGACGTAGCCGAGAAATATCTCGACATCCCCCGCATGTTAGACCCTGACGACCTAATAAACACGCCCAAGCCGGACGAGCGCGCCATTATGACCTATGTGTCGTGTTACTACCACGCCTTCCAAGGCGCGCAACAGGCTGAAACGGCCGCGAACCGTATTTGCAAAGTTCTCAAAGTCAACCAGGAGAACGAACGCCTAATGGAAGAGTACGAACGTCTTGCCAGTGACCTCTTGGACTGGATCCGTCGCACCATGCCATGGCTGAACAGCCGTCAGACCGACAACTCTCTTGCCGGGTGCCAAAAAAAACTGGAAGACTACCGTACTTACAGGCGTAAGCACAAGCCACCACGTGTAGAACAGAAGGCCAAACTGGAGACCAACTTCAACACCCTTCAGACCAAGCTTAGGTTGAGCAACCGTCCTGCGTACATGCCCACCGAAGGCAAAATGGTTTCTGACATCGCTCAAGCATGGAAGGGCCTAGAGATCGCCGAGAAGGCATTCGAAGAGTGGCTTCTCAGTGAAATGATGCGTCTCGAGCGACTCGAATACCTCGCTCAGAAGTTCAAGCACAAGGCCGACATCCACGAAGACTGGACTAGAGGCAAGGAAGAGATGCTACAGTCCCAGGACTTCCGTCAATGTAAGCTCAACGACATCAAAGCTCTCAAGAAGAAGCACGAGGCCTTCGAATCCGACCTGGCCGCCCACCAAGATCGTGTCGAGCAAATCGCGGCCATCGCCCAGGAACTCAACACCCTGGAGTACCACGAGGTTGCGAGCGTGAACGCGCGTTGCCAGCGCATCTGCTCGCAGTGGGACCGGCTCGGCGCGCTCACGCAGCGCCGCCGGCACGCACTCGACGACGCCGAGCGCGTGCTCGAGCAGATCGACCTGCTGCATCTCGAATTCGCCAAACGCGCTGCACCATTCAACAACTGGTTGGACGGAACTCGCGAAGATCTCGTGGATATGTTCATCGTTCATACCATCGAAGAAATCTCAGGTCTCATGGACGCTCACGCTCGCTTCAAGGCAACCCTCGGCGAGGCTGACAAAGAATACCAGGCTATCGTCAACCTGGTACATCAAGTCGAATCTATTGTCAAGCAGCACCAGATCCCCGGCGGTTTGGAGAACCCATACACCACTCTCACAGCTCATGAGTTGAACCGCAAGTGGTCGGACGTGAGGCAGCTGGTGCCGCAGCGCGACGCGACGCTGGCCGCAGAGCTTCGCAAGCAACAGAACAACGAGAACCTGCGAAGGCAGTTCGCAGAAAAGGCCAACGCAGTCGGACCTTGGATCGAGAGGCAGATGGACGCCGTCACCGCTATCGGAATGGGCCTGCAGGGCTCTCTGGAAGACCAGCTGCGCAGACTTAAAGAATACGAAGCTGGAGTGTACGCTTACAAGCCACACATTGAGGAACTCGAACGCATCCACCAGGCTGTCCAGGAAGGCATGATCTTCGAAAACAGATATTCACAATACACAATGGAGACTCTGCGCGTCGGCTGGGAACAGCTCCTGACCTCGATCAACCGCACCATCAACGAAGTGGAGAACCAGATCCTCACCCGCGACTCAAAGGGTATCACTCAGGAGCAACTGACAGAGTTCCGCGCCTCATTCAACCACTTCGACAAGAACCGCACAGGCCGTCTGCTGCCAGAGGAGTTGAAATCGTGCTTAGTCTCCCTGGGTTACAGCATCGGCAAGGACAGGCAAGGAGAACTCGACTTCCAACGTATTCTTGCTGTTGTCGATCCCAACAATACCGGCTACGTGTCATTCGATTCGTTCCTGGACTTTATGACCAGAGAGTCGACAGATACCGACACCGCCGAACAAGTCATTGACAGCTTCAGGATCTTAGCTGGTGACAAGCCGTACATAACGGCGGAGGAGTTGCGCCGCGAGCTGCCGCCCGACCAGGCGGAGTACTGCGTGGCGCGCATGCCGCCGTACCGCGGGCCCGGCGCGCCGCCCGGCTCACTCGACTACATGGCCTTCTCCACCGCACTCTACGGCGAAACCGACCTCTAG

Protein

MLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYSKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLINTPKPDERAIMTYVSCYYHAFQGAQQAETAANRICKVLKVNQENERLMEEYERLASDLLDWIRRTMPWLNSRQTDNSLAGCQKKLEDYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYMPTEGKMVSDIAQAWKGLEIAEKAFEEWLLSEMMRLERLEYLAQKFKHKADIHEDWTRGKEEMLQSQDFRQCKLNDIKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHEVASVNARCQRICSQWDRLGALTQRRRHALDDAERVLEQIDLLHLEFAKRAAPFNNWLDGTREDLVDMFIVHTIEEISGLMDAHARFKATLGEADKEYQAIVNLVHQVESIVKQHQIPGGLENPYTTLTAHELNRKWSDVRQLVPQRDATLAAELRKQQNNENLRRQFAEKANAVGPWIERQMDAVTAIGMGLQGSLEDQLRRLKEYEAGVYAYKPHIEELERIHQAVQEGMIFENRYSQYTMETLRVGWEQLLTSINRTINEVENQILTRDSKGITQEQLTEFRASFNHFDKNRTGRLLPEELKSCLVSLGYSIGKDRQGELDFQRILAVVDPNNTGYVSFDSFLDFMTRESTDTDTAEQVIDSFRILAGDKPYITAEELRRELPPDQAEYCVARMPPYRGPGAPPGSLDYMAFSTALYGETDL

Description

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

Subunit

Homodimer; antiparallel. Interacts with Smn; the interaction occurs in adult thoracic tissues.

Similarity

Belongs to the alpha-actinin family.

Keywords

Actin-binding   Alternative splicing   Calcium   Complete proteome   Cytoplasm   Metal-binding   Reference proteome   Repeat  

Feature

chain  Alpha-actinin, sarcomeric
splice variant  In isoform Non-muscle.

Uniprot

A0A2A4J6U3   A0A2A4J7H8   A0A212EUA9   S4PGX9   A0A194PHG6   A0A3G2M391   + More
A0A2J7RAV9   A0A1W4W9Y3   D2A2X1   V5G2Q8   P18091-4   B3P8U6   M9MS06   A0A0Q9WZJ5   A0A0A1X2E2   A0A1W4VRB2   A0A0R3P3P8   A0A2J7RAW2   A0A0K8VXD6   A0A034VRI7   A0A0P8Y4Z7   A0A0K8TNG3   W8BQJ8   A0A0K8WEA9   A0A067R9E8   A0A1B6CVZ8   B4M7S8   A0A154PSJ3   A0A1W4WK35   A0A1B6D5Q4   A0A1Y1KQ58   A0A1W4WL95   A0A139WIX0   A0A3L8DYN3   U4UUX3   E2C444   N6UDM8   A0A158NJ83   A0A1A9W9F6   P18091-3   A0A0L7QV59   A0A0Q5SY78   M9PGA7   A0A1I8Q6C8   Q29J93   A0A1W4VEA9   W8BK39   B4L2K7   A0A0A1XKV1   T1PEU3   A0A0Q9WTS6   P18091   A0A0Q9WHM2   B3MYQ6   A0A1A9Z1N2   A0A1L8E5E7   E0VM19   A0A0M4EIB6   B4NBX2   A0A0Q9W7E7   A0A0Q9WMT3   A0A0Q9WG66   P18091-5   A0A3B0J7L4   A0A0Q5T4X4   A0A0R3NY48   A0A1B6LAJ9   A0A0C9R6F9   A0A1W4VS21   A0A0P9BQT6   B4JM22   A0A1L8E5J5   A0A0Q9W868   F0JAG6   A0A0Q9WTR0   A0A023EWA2   A0A182UKZ0   A0A182NQC2   A0A182PGZ0   A0A1I8Q6G8   A0A026WHE0   A0A1I8M2T6   Q172T4   A0A1Q3G3W7   A0A182R500   A0A158NJ82   A0A2M4AHE6   A0A182FRR1   A0A182VPH1   A0A182WS69   F5HMN8   A0A182HL18   A0A182Q0K6   A0A182VWE6   P18091-2   A0A182YB86   A0A182L9E1   A0A182LTI8   T1DG57   A0A0A9Z8X1  

Pubmed

22118469    23622113    26354079    25628762    18362917    19820115    + More
2112549    10731132    12537572    10731137    12537569    1734023    17353360    17994087    18057021    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25830018    15632085    25348373    26369729    24495485    24845553    28004739    30249741    23537049    20798317    21347285    25315136    20566863    24945155    24508170    17510324    12364791    14747013    17210077    25244985    20966253    25401762   

EMBL

NWSH01002874    PCG67398.1    PCG67400.1    AGBW02012451    OWR45047.1    GAIX01003462    + More
JAA89098.1    KQ459604    KPI92493.1    MH818215    MH818216    AYN80724.1    NEVH01006564    PNF37964.1    KQ971338    EFA02232.2    GALX01004166    JAB64300.1    X51753    AE014298    AL009192    AL031765    AY069615    X64419    CH954183    EDV45551.2    KQS26015.1    ADV37616.1    ADV37617.1    CH933810    KRF93861.1    GBXI01009020    JAD05272.1    CH379063    KRT05984.1    PNF37965.1    GDHF01008768    GDHF01005691    GDHF01003330    JAI43546.1    JAI46623.1    JAI48984.1    GAKP01013027    GAKP01013026    JAC45926.1    CH902632    KPU74118.1    GDAI01001930    JAI15673.1    GAMC01007472    JAB99083.1    GDHF01002887    JAI49427.1    KK852804    KDR16234.1    GEDC01019925    JAS17373.1    CH940653    EDW62845.2    KQ435127    KZC14843.1    GEDC01016279    JAS21019.1    GEZM01076923    JAV63542.1    KYB27862.1    QOIP01000002    RLU25580.1    KB632375    ERL93980.1    GL452396    EFN77273.1    APGK01032464    APGK01032465    APGK01032466    KB740842    ENN78731.1    ADTU01017556    ADTU01017557    KQ414727    KOC62528.1    KQS26013.1    KQS26016.1    KQS26017.1    KQS26018.1    AGB95011.1    AGB95012.1    AGB95013.1    EAL32408.3    GAMC01007468    JAB99087.1    EDW06883.2    KRF93860.1    KRF93862.1    KRF93864.1    GBXI01010286    GBXI01002715    JAD04006.1    JAD11577.1    KA647307    KA647308    AFP61936.1    CH964239    KRF99599.1    KRF80820.1    EDV32750.2    GFDF01000161    JAV13923.1    DS235286    EEB14425.1    CP012528    ALC48604.1    EDW82331.2    KRF80816.1    KRF80819.1    KRF93863.1    KRF80817.1    OUUW01000003    SPP78254.1    KQS26014.1    KRT05985.1    GEBQ01019302    JAT20675.1    GBYB01002346    JAG72113.1    KPU74119.1    CH916371    EDV91783.1    GFDF01000160    JAV13924.1    KRF80818.1    BT126008    ADX64768.1    AGB95010.1    KRF99598.1    GAPW01000166    JAC13432.1    KK107207    EZA55445.1    CH477432    EAT41013.1    GFDL01000586    JAV34459.1    GGFK01006895    MBW40216.1    AAAB01008987    EGK97560.1    APCN01000879    AXCN02001524    AXCN02001525    AXCM01001640    GAMD01002891    JAA98699.1    GBHO01003806    GBRD01010314    JAG39798.1    JAG55510.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000235965    UP000192223    UP000007266    + More
UP000000803    UP000008711    UP000009192    UP000192221    UP000001819    UP000007801    UP000027135    UP000008792    UP000076502    UP000279307    UP000030742    UP000008237    UP000019118    UP000005205    UP000091820    UP000053825    UP000095300    UP000095301    UP000007798    UP000092445    UP000009046    UP000092553    UP000268350    UP000001070    UP000075902    UP000075884    UP000075885    UP000053097    UP000008820    UP000075900    UP000069272    UP000075903    UP000076407    UP000007062    UP000075840    UP000075886    UP000075920    UP000076408    UP000075882    UP000075883   

PRIDE

P18091    M9MS06    M9PGA7    F0JAG6   

Pfam

PF08726   EFhand_Ca_insen        + More
PF00307   CH
PF00435   Spectrin
PF13405   EF-hand_6

Interpro

IPR002017   Spectrin_repeat        + More
IPR001589   Actinin_actin-bd_CS       
IPR011992   EF-hand-dom_pair       
IPR002048   EF_hand_dom       
IPR001715   CH-domain       
IPR018159   Spectrin/alpha-actinin       
IPR036872   CH_dom_sf       
IPR014837   EF-hand_Ca_insen       
IPR018247   EF_Hand_1_Ca_BS       
IPR026921   Alpha-actinin_1       

SUPFAM

SSF47576   SSF47576        + More
SSF47473   SSF47473       

Gene 3D

1.10.418.10    

CDD

cd00051  EFh
cd00014  CH

ProteinModelPortal

A0A2A4J6U3   A0A2A4J7H8   A0A212EUA9   S4PGX9   A0A194PHG6   A0A3G2M391   + More
A0A2J7RAV9   A0A1W4W9Y3   D2A2X1   V5G2Q8   P18091-4   B3P8U6   M9MS06   A0A0Q9WZJ5   A0A0A1X2E2   A0A1W4VRB2   A0A0R3P3P8   A0A2J7RAW2   A0A0K8VXD6   A0A034VRI7   A0A0P8Y4Z7   A0A0K8TNG3   W8BQJ8   A0A0K8WEA9   A0A067R9E8   A0A1B6CVZ8   B4M7S8   A0A154PSJ3   A0A1W4WK35   A0A1B6D5Q4   A0A1Y1KQ58   A0A1W4WL95   A0A139WIX0   A0A3L8DYN3   U4UUX3   E2C444   N6UDM8   A0A158NJ83   A0A1A9W9F6   P18091-3   A0A0L7QV59   A0A0Q5SY78   M9PGA7   A0A1I8Q6C8   Q29J93   A0A1W4VEA9   W8BK39   B4L2K7   A0A0A1XKV1   T1PEU3   A0A0Q9WTS6   P18091   A0A0Q9WHM2   B3MYQ6   A0A1A9Z1N2   A0A1L8E5E7   E0VM19   A0A0M4EIB6   B4NBX2   A0A0Q9W7E7   A0A0Q9WMT3   A0A0Q9WG66   P18091-5   A0A3B0J7L4   A0A0Q5T4X4   A0A0R3NY48   A0A1B6LAJ9   A0A0C9R6F9   A0A1W4VS21   A0A0P9BQT6   B4JM22   A0A1L8E5J5   A0A0Q9W868   F0JAG6   A0A0Q9WTR0   A0A023EWA2   A0A182UKZ0   A0A182NQC2   A0A182PGZ0   A0A1I8Q6G8   A0A026WHE0   A0A1I8M2T6   Q172T4   A0A1Q3G3W7   A0A182R500   A0A158NJ82   A0A2M4AHE6   A0A182FRR1   A0A182VPH1   A0A182WS69   F5HMN8   A0A182HL18   A0A182Q0K6   A0A182VWE6   P18091-2   A0A182YB86   A0A182L9E1   A0A182LTI8   T1DG57   A0A0A9Z8X1  

PDB

1SJJ     E-value=0,     Score=2934

KEGG

101742794    K05699 actinin alpha 1/4 | (RefSeq) alpha-actinin, sarcomeric

GO

GO:0005509   GO:0003779   GO:0007016   GO:0051015   GO:0045214   GO:0051017   GO:0031532   GO:0030018   GO:0005925   GO:0004725   GO:0005515   GO:0045454   GO:0006810   GO:0016021   GO:0042626   GO:0016887   GO:0005622   GO:0003824  

PANTHER

PTHR11915:SF434  

Subcellular location

  

Length:

827

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00535999999999999

Exp number, first 60 AAs:

0.00176

Total prob of N-in:

0.00023

outside

1  -  827

 

 

Pi

230.668058

Theta

182.769507

Tajima's D

0.89136

CLR

0.247536

CSRT

0.629618519074046

Interpretation

Uncertain