Gene

KWMTBOMO10999

Pre Gene Modal

BGIBMGA008328

Annotation

PREDICTED:_ankyrin_repeat_and_SOCS_box_protein_3-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr18(-):9201665-9203902      View in EpiBrowser

Full name

Ankyrin repeat and SOCS box protein 3      

Location in the cell

Cytoplasmic   Reliability : 1.293 PlasmaMembrane   Reliability : 1.496

CDS

ATGGATTTCAGTTCTCATAATCCGGAAACGTCTAATCCATTAAACTTAGCCGCAAGGAATAACGACGCACTATTAGTGCAACAGCTTTTGAAAAAAATTAATCCGAACATTGCCGACAACAGAGGATGGACTTGTTTGCATGAAGCTGCTTTTCATGATTGCTATGAAAGCTTACAGGTTATTCTTAAAAACCCAGAGTGTCGTCCTCTTATCGAAACCCATGAAGGCCACACTGCCCTTTACTTAGCTTGCCGCAATCAAGCCTCCCCACAAACAGTGAAGTATCTGTTAGAAAATGTTGAAGATATAGCTAATTATGGAAGTACAGAGTCTGTGACTCCATTGCACGTTGTCAGCGGTCAAGGAAATCTTGAAATAATGCAGTTGCTTATTGAACATGGGGCACTAATTGATGTGCAAGATTATGATGGAGATACACCATTGCATGATGCTGTATTAGAAACAAAATTTGAGGCTGTATCTCTGTTATTACATGCAGGTGCTAGTCCTGAAATACCAAATGAACCAGGATCATTCACACCATTCCATTTAGCTTGTTCTAAAGGTTGTTTTGAAACGATGAAAGCAATATATCCTTTTGTCACTGATATTAATCAAGTGACATCATCTGGTAAGACTGCATTAATGTTGGCACTGACAGGGGCGAATGAAGAAATAGTTGACTTCTTATTAGAAAATGGTATAGATCCTCACATACGGGACATAAATGGAGACTTGGCATTAGATATTGCATTAACTGATGGTTACCACGCACATTACAAAAAAATATTTAATGTTACAAAACTGCATCAAATTAGTCTCAATACTATATTAAAAGCTTGCAAACCACATTATTGTAAAATGGATATATTAGAAATTTTACTGAGTAGCGATCTTGGTCCAGAATACTTTGACTTTATTGAAATATTTCATGTAATGTTAGAAAAAATAGGTGACATAAGACCATATTATCGCACGAATGCAGTACTGAACTCATATTTGAACATATGTGAGTACATCTATAATAGATCTCGAGAGAAATTTTATGAGTTCTTCTACTTGTTTTTAATGCGTGGAGTATCAGTAAATGCATTAGAATTTTATGAGTGTCCTCCCCTTGTTTACATACACTACTGTTTACATATTAATTCTTTTAGTGAAGCATTCCAAATAATGATTGACCATGGCTGTAATGTTGATTACTGCAGTGTTCCAGAATGTTATTACAAAGATAAGTGTATACCTGATGCTTTTATTGCATCATTGACATCTGATGCTCTAACACTTCCATATATGATTCCTTATAGTCTACATGTTGATCCTGACAGTATATTACAGTTTGCAGAAGACAGTGGTGTTTCAGGACGGATTAACTCACAAGTGCAAATAACATTAGTTACCATGGCAGGCTATGATCCCAGTGTAACATCAGAAACTTTGGCCTTCCATGTTGCACCATTAAAGCACATAACTAGATGCAGAATTCGCAGTCTGATTAGAAATAGGAAAGGTGGTGTAAAGTCAACGAAAGAGTTTTTTAAGATTTTAGAAGCTATGCCTTTACCTACATCAATGAAAAACTATTTAAGCTATCATTAA

Protein

MDFSSHNPETSNPLNLAARNNDALLVQQLLKKINPNIADNRGWTCLHEAAFHDCYESLQVILKNPECRPLIETHEGHTALYLACRNQASPQTVKYLLENVEDIANYGSTESVTPLHVVSGQGNLEIMQLLIEHGALIDVQDYDGDTPLHDAVLETKFEAVSLLLHAGASPEIPNEPGSFTPFHLACSKGCFETMKAIYPFVTDINQVTSSGKTALMLALTGANEEIVDFLLENGIDPHIRDINGDLALDIALTDGYHAHYKKIFNVTKLHQISLNTILKACKPHYCKMDILEILLSSDLGPEYFDFIEIFHVMLEKIGDIRPYYRTNAVLNSYLNICEYIYNRSREKFYEFFYLFLMRGVSVNALEFYECPPLVYIHYCLHINSFSEAFQIMIDHGCNVDYCSVPECYYKDKCIPDAFIASLTSDALTLPYMIPYSLHVDPDSILQFAEDSGVSGRINSQVQITLVTMAGYDPSVTSETLAFHVAPLKHITRCRIRSLIRNRKGGVKSTKEFFKILEAMPLPTSMKNYLSYH

Description

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B.

Subunit

Interacts with ELOB and TNFRSF1B.

Similarity

Belongs to the ankyrin SOCS box (ASB) family.

Keywords

Alternative splicing   ANK repeat   Complete proteome   Reference proteome   Repeat   Ubl conjugation pathway  

Feature

chain  Ankyrin repeat and SOCS box protein 3
splice variant  In isoform 2.

Uniprot

H9JFN1   A0A3S2NT47   A0A2A4JXC8   A0A194PHH5   A0A212FGD1   A0A2H1VH69   + More
A0A194RQ74   A0A2J7PLA3   A0A067R8K4   A0A2J7PL79   A0A0D9RMP9   A0A2K6RR63   A0A2K6MP28   A0A2K6RR51   G7NA20   A0A2K5V5R5   Q4R791   A0A2K6DUH2   A0A2K6DUF4   F7BJ78   A0A2K5ZZ48   A0A2K5F1K9   A0A2K5ZZ73   A0A2I3LLP9   A0A096NGW2   A0A2K5P0Z5   A0A2K5SIR9   A0A2K5P0Y3   A0A1S3A1V9   H2P682   G1T5R9   A0A2I2Z799   Q53HI5   G3QE45   Q9Y575   F7BYA5   A0A2I2YJ15   Q9Y575-3   A0A0A6YYF3   Q53H66   A0A2Y9R654   A0A2R9BJ86   A0A2Y9D7Q8   A0A2Y9RH87   H2QHW7   A0A2I3SXH5   G1RC83   A0A2I3HLT6   A0A2Y9JK50   A0A2K5V5S6   A0A0P6I544   F7BJ60   A0A2Y9HZG3   L5KTA9   A0A2Y9JG36   A0A355KRR0   A0A2K5J4K5   A0A2U3ZIZ1   A0A0P6AA48   A0A2U3ZK08   A0A2K5J4B6   A0A3Q7NTL2   A0A2U3X842   M3YH49   E2R235   G3T5S0   G3U3D1   I3MBP2   A0A2Y9SEY1  

Pubmed

19121390    26354079    22118469    24845553    25362486    22002653    + More
25319552    15944441    17431167    21993624    8125298    9373149    11111040    14702039    15815621    15489334    15899873    22814378    22722832    16136131    23258410    30148503    16341006   

EMBL

BABH01002125    RSAL01000229    RVE43903.1    NWSH01000474    PCG76153.1    KQ459604    + More
KPI92503.1    AGBW02008690    OWR52763.1    ODYU01002540    SOQ40167.1    KQ459765    KPJ20018.1    NEVH01024428    PNF17089.1    KK852811    KDR15919.1    PNF17090.1    AQIB01040315    AQIB01040316    AQIB01040317    AQIB01040318    AQIB01040319    AQIB01040320    AQIB01040321    AQIB01040322    AQIB01040323    AQIB01040324    JU322595    CM001265    AFE66351.1    EHH22117.1    AQIA01018066    AQIA01018067    AQIA01018068    AQIA01018069    AQIA01018070    AQIA01018071    AQIA01018072    AQIA01018073    AQIA01018074    AQIA01018075    AB168930    BAE01031.1    JSUE03010880    JSUE03010881    JSUE03010882    JSUE03010883    AHZZ02005400    AHZZ02005401    AHZZ02005402    AHZZ02005403    AHZZ02005404    ABGA01330928    ABGA01330929    ABGA01330930    ABGA01330931    ABGA01330932    ABGA01330933    ABGA01330934    ABGA01330935    ABGA01330936    ABGA01330937    NDHI03003368    PNJ79876.1    AAGW02006409    AAGW02006410    CABD030012811    CABD030012812    CABD030012813    AK222595    BAD96315.1    AF156778    AK000985    AK001283    AK056069    AC007883    AC008064    AC008068    AC069157    CH471053    BC006488    BC009569    BC110915    AK222715    BAD96435.1    AJFE02079181    AJFE02079182    AJFE02079183    AJFE02079184    AJFE02079185    AJFE02079186    AACZ04001898    AACZ04001899    AACZ04001900    NBAG03000238    PNI66210.1    ADFV01009613    ADFV01009614    ADFV01009615    ADFV01009616    ADFV01009617    ADFV01009618    ADFV01009619    ADFV01009620    GDIQ01009235    JAN85502.1    KB030567    ELK14709.1    DOAP01000002    HBL98362.1    GDIP01032688    JAM71027.1    AEYP01087353    AEYP01087354    AEYP01087355    AEYP01087356    AEYP01087357    AEYP01087358    AEYP01087359    AAEX03007517    AGTP01023553    AGTP01023554    AGTP01023555    AGTP01023556   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000007151    UP000053240    + More
UP000235965    UP000027135    UP000029965    UP000233200    UP000233180    UP000233100    UP000233120    UP000006718    UP000233140    UP000233020    UP000028761    UP000233060    UP000233040    UP000079721    UP000001595    UP000001811    UP000001519    UP000005640    UP000008225    UP000248480    UP000240080    UP000002277    UP000001073    UP000248482    UP000248481    UP000010552    UP000233080    UP000245340    UP000286641    UP000245341    UP000000715    UP000002254    UP000007646    UP000005215    UP000248484   

PRIDE

H9JFN1    Q53HI5    Q9Y575    A0A0A6YYF3    Q53H66   

Pfam

PF12796   Ank_2        + More
PF07525   SOCS_box
PF00023   Ank
PF13606   Ank_3

Interpro

IPR036770   Ankyrin_rpt-contain_sf        + More
IPR020683   Ankyrin_rpt-contain_dom       
IPR002110   Ankyrin_rpt       
IPR036036   SOCS_box-like_dom_sf       
IPR001496   SOCS_box       
IPR037329   ASB3_SOCS       

SUPFAM

SSF48403   SSF48403        + More
SSF158235   SSF158235       

Gene 3D

1.25.40.20    

CDD

cd00204  ANK
cd03722  SOCS_ASB3

ProteinModelPortal

H9JFN1   A0A3S2NT47   A0A2A4JXC8   A0A194PHH5   A0A212FGD1   A0A2H1VH69   + More
A0A194RQ74   A0A2J7PLA3   A0A067R8K4   A0A2J7PL79   A0A0D9RMP9   A0A2K6RR63   A0A2K6MP28   A0A2K6RR51   G7NA20   A0A2K5V5R5   Q4R791   A0A2K6DUH2   A0A2K6DUF4   F7BJ78   A0A2K5ZZ48   A0A2K5F1K9   A0A2K5ZZ73   A0A2I3LLP9   A0A096NGW2   A0A2K5P0Z5   A0A2K5SIR9   A0A2K5P0Y3   A0A1S3A1V9   H2P682   G1T5R9   A0A2I2Z799   Q53HI5   G3QE45   Q9Y575   F7BYA5   A0A2I2YJ15   Q9Y575-3   A0A0A6YYF3   Q53H66   A0A2Y9R654   A0A2R9BJ86   A0A2Y9D7Q8   A0A2Y9RH87   H2QHW7   A0A2I3SXH5   G1RC83   A0A2I3HLT6   A0A2Y9JK50   A0A2K5V5S6   A0A0P6I544   F7BJ60   A0A2Y9HZG3   L5KTA9   A0A2Y9JG36   A0A355KRR0   A0A2K5J4K5   A0A2U3ZIZ1   A0A0P6AA48   A0A2U3ZK08   A0A2K5J4B6   A0A3Q7NTL2   A0A2U3X842   M3YH49   E2R235   G3T5S0   G3U3D1   I3MBP2   A0A2Y9SEY1  

PDB

5Y4D     E-value=8.83339e-21,     Score=248

KEGG

101741439    no KO assigned | (RefSeq) ankyrin repeat and SOCS box protein 3-like

GO

GO:0016021   GO:0035556   GO:0016567   GO:0005829   GO:0043687   GO:0005515   GO:0030145   GO:0046975   GO:0006357   GO:0051603   GO:0051028   GO:0005622   GO:0006810   GO:0003824  

Length:

532

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0327500000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00142

outside

1  -  532

 

 

Pi

232.401079

Theta

203.392612

Tajima's D

0.636248

CLR

0.244452

CSRT

0.554172291385431

Interpretation

Uncertain