Gene

KWMTBOMO10997  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008521

Annotation

PREDICTED:_xaa-Pro_dipeptidase_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr18(+):9186723-9188535      View in EpiBrowser

Full name

Xaa-Pro dipeptidase      

Alternative Name

Imidodipeptidase
Peptidase D
Proline dipeptidase

Location in the cell

Cytoplasmic   Reliability : 1.583

CDS

ATGGCAGCGACGTGGTCTATGGGCCCTGGCACTCTTGAAGTGCCGTTATCTTTGTTCGCAACAAACCGACGAAGATTAGCAAATAAACTCAAAAGTGGACAAATAGTGGTTTTGCAAGGAGGTGAAGATGTGAACCACTATGATACTGATGTACAATATGTATTTAGACAGGAAGCCTATTTTACATGGGTTTGTGGCGTTAGAGAACCCGGTTGTTATTTTGCCCTAGATGTTAGTACAGGCAAGTCTTACCTCTTTGTGCCCAGACTTCCTGAGGAGTATGAAGTCTGGATGGGCAAACTCCATGCCTGTAGTGACTTCAAAAACATATATGCAGTTGATGAAGTCTATTATGTTGATGAGATAAAAGATGTACTCAAAAGTTTGATGCCGGAAACATTGCTGACATTGTCTGGCCCAAACACAGACAGTGGCTTGACGGCCCGAGAAGCCATTTTTAATGGAATTGATGAGTTCAATGTGGATAATGAATCCTTATTTCCCATTATCGCAGAATTGTAA

Protein

MAATWSMGPGTLEVPLSLFATNRRRLANKLKSGQIVVLQGGEDVNHYDTDVQYVFRQEAYFTWVCGVREPGCYFALDVSTGKSYLFVPRLPEEYEVWMGKLHACSDFKNIYAVDEVYYVDEIKDVLKSLMPETLLTLSGPNTDSGLTAREAIFNGIDEFNVDNESLFPIIAEL

Catalytic Activity

Hydrolysis of Xaa-|-Pro dipeptides. Also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro.

Cofactor

Mn(2+)

Subunit

Homodimer.

Similarity

Belongs to the peptidase M24B family.
Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.

Keywords

3D-structure   Acetylation   Alternative splicing   Collagen degradation   Complete proteome   Dipeptidase   Direct protein sequencing   Disease mutation   Hydrolase   Manganese   Metal-binding   Metalloprotease   Phosphoprotein   Polymorphism   Protease   Reference proteome  

Feature

chain  Xaa-Pro dipeptidase
splice variant  In isoform 3.
sequence variant  In PD; dbSNP:rs121917722.

Uniprot

H9JG74   A0A2A4JXP1   A0A2A4JVW9   A0A194PIF1   A0A194RRJ5   A0A2H1VH66   + More
A0A212FGA3   A0A1I9WLD4   V5H133   A0A0L7LBM2   A0A2A3EBH4   T1DP25   A0A2I0M7X1   A0A2M4CTM5   J3JUK6   A0A1B6MCZ8   A0A2J8QGT9   A0A2Y9I4E4   A0A2M4CTQ3   A0A2M4CTP3   A0A091GZU2   A0A2M4AEE3   Q16XF1   A0A1S4FKR6   A0A0P6JU66   A0A2M4AE57   G5BXM2   A0A139WNR5   A0A151N708   A0A1L8DQK8   A0A1L8DQT9   A0A2J8RL00   D2I4G0   G1LCC7   A0A091DD12   U4UG94   N6TDH5   L5JMG2   A0A093HVV7   A0A093D0S0   K7FLR7   A0A023EVA5   E2BCC7   A0A1U7QVI0   A0A1V4K0N9   A0A091NIJ0   Q5ZKL3   A0A091GJ56   I3MA31   A0A091V531   A0A087R8U6   B1PMA7   A0A091WT01   A0A1B0FV12   A0A026W6M7   A0A1U7RLW2   A0A0A0ABK4   H0ZGS5   A0A158NBP2   U5EJJ7   G1N2P4   A0A094L6I4   A0A2R9A450   A0A023ESZ2   P12955-2   A0A2J8QH08   A0A1Q3FH32   A0A087V907   A0A093II33   A0A2I3RB40   A0A218UIL1   A0A1Q3FHW7   A0A140VJR2   P12955   J3K000   A0A2R8ZZT3   A0A2R9A0Z7   A0A2K6DUR6   A0A2R9A5F1   G2HFR0   A0A2I3S7Z0   A0A2R8ZZV1   U3ILP7   A0A034VC08   A0A2I3TWC3   A0A2I3RNM8   A0A2R8ZZU5   A0A3Q7UV47   R0L601   A0A093QN59   A0A2K6DUN1   A0A2Y9PFW1   A0A2K6DUQ2   A0A2K6DUP6   M3W8R0   A0A2K6DUQ3   A0A2I2V3Z9   A0A1I8G1B6   A0A3Q7VQ27   A0A091JPD1  

EC Number

3.4.13.9

Pubmed

19121390    26354079    22118469    27538518    26227816    23371554    + More
22516182    17510324    21993625    18362917    19820115    22293439    20010809    23537049    23258410    17381049    24945155    20798317    15642098    24508170    20360741    21347285    20838655    22722832    2925654    14702039    15057824    15489334    11840567    19413330    21269460    22223895    24275569    2365824    8198124    8900231    12384772    16136131    21484476    23749191    25348373    17975172    26392545   

EMBL

BABH01002123    BABH01002124    BABH01002125    NWSH01000474    PCG76152.1    PCG76151.1    + More
KQ459604    KPI92504.1    KQ459765    KPJ20019.1    ODYU01002540    SOQ40166.1    AGBW02008690    OWR52762.1    KU932318    APA33954.1    GALX01001918    JAB66548.1    JTDY01001819    KOB72794.1    KZ288311    PBC28536.1    GAMD01002330    JAA99260.1    AKCR02000031    PKK25775.1    GGFL01004528    MBW68706.1    BT126921    AEE61883.1    GEBQ01006169    JAT33808.1    NBAG03000037    PNI95505.1    GGFL01004554    MBW68732.1    GGFL01004529    MBW68707.1    KL515729    KFO87935.1    GGFK01005799    MBW39120.1    CH477540    EAT39285.1    GEBF01005959    JAN97673.1    GGFK01005754    MBW39075.1    JH172334    EHB14033.1    KQ971307    KYB29640.1    AKHW03003905    KYO32612.1    GFDF01005341    JAV08743.1    GFDF01005340    JAV08744.1    NDHI03003675    PNJ09202.1    GL194465    EFB25831.1    ACTA01068868    KN122516    KFO30034.1    KB632309    ERL92052.1    APGK01042262    APGK01042263    KB741002    ENN75793.1    KB031158    ELK00530.1    KL206526    KFV83137.1    KL470553    KFV18704.1    AGCU01024232    AGCU01024233    AGCU01024234    AGCU01024235    AGCU01024236    AGCU01024237    AGCU01024238    AGCU01024239    AGCU01024240    AGCU01024241    GAPW01001184    JAC12414.1    GL447257    EFN86663.1    LSYS01005191    OPJ77943.1    KL383988    KFP89281.1    AJ720071    CAG31730.1    KL448230    KFO81341.1    AGTP01062927    AGTP01062928    AGTP01062929    KL410586    KFQ97482.1    KL226217    KFM09900.1    EU477530    ACA48584.1    KK734143    KFR04606.1    AJWK01006525    AJWK01006526    AJWK01006527    AJWK01006528    AJWK01006529    KK107453    EZA50679.1    KL871093    KGL90360.1    ABQF01043613    ABQF01043614    ABQF01043615    ABQF01043616    ABQF01043617    ABQF01043618    ABQF01043619    ABQF01043620    ABQF01043621    ABQF01043622    ADTU01011261    ADTU01011262    ADTU01011263    ADTU01011264    GANO01002212    JAB57659.1    KL360427    KFZ65087.1    AJFE02054631    AJFE02054632    AJFE02054633    AJFE02054634    AJFE02054635    AJFE02054636    AJFE02054637    AJFE02054638    AJFE02054639    GAPW01001185    JAC12413.1    J04605    BT006692    AK290756    AK290781    AK291561    AK293126    AK294619    AC008744    AC010485    BC004305    BC015027    BC028295    PNI95501.1    GFDL01008165    JAV26880.1    KL484381    KFO09099.1    KK594629    KFW02380.1    AACZ04019762    AACZ04019763    MUZQ01000278    OWK53627.1    GFDL01007898    JAV27147.1    HM005451    AEE61049.1    CR541669    CAG46470.1    AK305574    GABC01008843    GABF01009690    GABD01006559    GABE01010860    BAK62568.1    JAA02495.1    JAA12455.1    JAA26541.1    JAA33879.1    PNI95500.1    ADON01076040    ADON01076041    ADON01076042    ADON01076043    GAKP01019316    GAKP01019315    JAC39637.1    KB743139    EOB01044.1    KL672275    KFW85417.1    AANG04004361    NIVC01003675    PAA50308.1    KK501247    KFP13531.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    + More
UP000242457    UP000053872    UP000248481    UP000008820    UP000006813    UP000007266    UP000050525    UP000008912    UP000028990    UP000030742    UP000019118    UP000010552    UP000053584    UP000007267    UP000008237    UP000189706    UP000190648    UP000053760    UP000005215    UP000053283    UP000053286    UP000053605    UP000092461    UP000053097    UP000189705    UP000053858    UP000007754    UP000005205    UP000001645    UP000240080    UP000005640    UP000002277    UP000197619    UP000233120    UP000016666    UP000286642    UP000053258    UP000248483    UP000011712    UP000095280    UP000215902    UP000053119   

PRIDE

H9JG74    P12955    A0A140VJR2    J3K000   

Pfam

PF05195   AMP_N        + More
PF00557   Peptidase_M24
PF14687   DUF4460
PF14688   DUF4461

Interpro

IPR001131   Peptidase_M24B_aminopep-P_CS        + More
IPR029149   Creatin/AminoP/Spt16_NTD       
IPR007865   Aminopep_P_N       
IPR036005   Creatinase/aminopeptidase-like       
IPR000994   Pept_M24       
IPR028031   DUF4460       
IPR027989   DUF4461       

SUPFAM

SSF55920   SSF55920        + More
SSF53092   SSF53092       

Gene 3D

3.40.350.10    

ProteinModelPortal

H9JG74   A0A2A4JXP1   A0A2A4JVW9   A0A194PIF1   A0A194RRJ5   A0A2H1VH66   + More
A0A212FGA3   A0A1I9WLD4   V5H133   A0A0L7LBM2   A0A2A3EBH4   T1DP25   A0A2I0M7X1   A0A2M4CTM5   J3JUK6   A0A1B6MCZ8   A0A2J8QGT9   A0A2Y9I4E4   A0A2M4CTQ3   A0A2M4CTP3   A0A091GZU2   A0A2M4AEE3   Q16XF1   A0A1S4FKR6   A0A0P6JU66   A0A2M4AE57   G5BXM2   A0A139WNR5   A0A151N708   A0A1L8DQK8   A0A1L8DQT9   A0A2J8RL00   D2I4G0   G1LCC7   A0A091DD12   U4UG94   N6TDH5   L5JMG2   A0A093HVV7   A0A093D0S0   K7FLR7   A0A023EVA5   E2BCC7   A0A1U7QVI0   A0A1V4K0N9   A0A091NIJ0   Q5ZKL3   A0A091GJ56   I3MA31   A0A091V531   A0A087R8U6   B1PMA7   A0A091WT01   A0A1B0FV12   A0A026W6M7   A0A1U7RLW2   A0A0A0ABK4   H0ZGS5   A0A158NBP2   U5EJJ7   G1N2P4   A0A094L6I4   A0A2R9A450   A0A023ESZ2   P12955-2   A0A2J8QH08   A0A1Q3FH32   A0A087V907   A0A093II33   A0A2I3RB40   A0A218UIL1   A0A1Q3FHW7   A0A140VJR2   P12955   J3K000   A0A2R8ZZT3   A0A2R9A0Z7   A0A2K6DUR6   A0A2R9A5F1   G2HFR0   A0A2I3S7Z0   A0A2R8ZZV1   U3ILP7   A0A034VC08   A0A2I3TWC3   A0A2I3RNM8   A0A2R8ZZU5   A0A3Q7UV47   R0L601   A0A093QN59   A0A2K6DUN1   A0A2Y9PFW1   A0A2K6DUQ2   A0A2K6DUP6   M3W8R0   A0A2K6DUQ3   A0A2I2V3Z9   A0A1I8G1B6   A0A3Q7VQ27   A0A091JPD1  

PDB

5MC5     E-value=8.11885e-50,     Score=493

KEGG

101741579    K14213 Xaa-Pro dipeptidase [EC:3.4.13.9] | (RefSeq) xaa-Pro dipeptidase

GO

GO:0030145   GO:0004177   GO:0005654   GO:0004181   GO:0102009   GO:0006520   GO:0070062   GO:0006508   GO:0005634   GO:0030574   GO:0046872   GO:0016787   GO:0046975   GO:0005515   GO:0006357   GO:0051603   GO:0051028   GO:0005622   GO:0006810   GO:0003824  

Length:

173

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06532

Exp number, first 60 AAs:

0.06241

Total prob of N-in:

0.05833

outside

1  -  173

 

 

Pi

262.340002

Theta

208.046834

Tajima's D

0.410349

CLR

0.001955

CSRT

0.488025598720064

Interpretation

Uncertain