Gene

KWMTBOMO10985

Pre Gene Modal

BGIBMGA008512

Annotation

Semaphorin-2A_[Papilio_xuthus]

Location

Bomo_Chr18(+):8880791-8885689      View in EpiBrowser

Full name

Semaphorin-2A      

Alternative Name

Semaphorin-II
Sema II

Location in the cell

Extracellular   Reliability : 3.324

CDS

ATGGCTATTTCGCGTATCCACGGCTCGTTGTATGCAGCATCTGATAGAAGAGTGCTACAACTCCGTTTGGCTTTGTGTGCGAGACGGTATGATGCTTGCGTAAGGTGTGCAAGAGATCCGTACTGCGGATGGGACAGAGATGCTAGCGTCTGTCGCGAGTATATACCTGGACTGATTCAAGATGTAGCCAATGAGACAGCCGATATCTGTGATTCATCAATTTCTCGGAAGAGCGTGTCGGCTACGTGGGGCCAAAGCCTCCACTTAGGAAGCTTTGTGAAGATGCCAGAAGTACTCCAACCTAGGGCTGTCACTTGGTTTCACTATTCAAGGGAAAAGGGTCGTCACCCGATTACATTTAATAAACCAGAAAAGTATATCGAGACCTCAGAGCATGGACTACTGATAATCGCTGTGAATGAAGCGGACGCTGGAAGATATGATTGCTGGCTAGGAGGCTCTTTGTTGTGCTCATATAACATCACCGTTGACACACATAGGTGTTCGCCGCCGGAGAAAAGCAATGAATATCAAAAGATATATTCAAATTGGTGTCACGAGTTCGAAAAGTACAAAACTGCCATGAAGACGTGGGAAAGAAAGCAAGAGCAATGCGCTCGGCAAAATGATTCGAATCAGAACACGCATCCGAACGAAATAGTGTGA

Protein

MAISRIHGSLYAASDRRVLQLRLALCARRYDACVRCARDPYCGWDRDASVCREYIPGLIQDVANETADICDSSISRKSVSATWGQSLHLGSFVKMPEVLQPRAVTWFHYSREKGRHPITFNKPEKYIETSEHGLLIIAVNEADAGRYDCWLGGSLLCSYNITVDTHRCSPPEKSNEYQKIYSNWCHEFEKYKTAMKTWERKQEQCARQNDSNQNTHPNEIV

Description

Plays a role in growth cones guidance. Required for both proper adult behavior and survival. Can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors.

Subunit

Interacts with PlexB.

Similarity

Belongs to the semaphorin family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Differentiation   Disulfide bond   Glycoprotein   Immunoglobulin domain   Neurogenesis   Reference proteome   Secreted   Signal  

Feature

chain  Semaphorin-2A
splice variant  In isoform C.

Uniprot

H9JG65   A0A2A4K0A3   A0A2H1VW33   A0A194PN26   A0A194RRL5   A0A3S2LY87   + More
A0A0L7LUF7   A0A0T6BC85   A0A2J7RIM7   V5GWN2   A0A2P8Z2C6   N6T3H6   A0A139WNC0   V9IM36   A0A139WNB6   A0A182PDL1   U4UDG0   A0A182X4L6   A0A1B6IML8   A0A1W4XRB0   A0MT98   A0A1Y1N8R5   A0A195EUY7   A0A1Y1N840   A0A1Y1NCB7   A0A1Y1NE22   A0A0L7QK86   A0A182NI73   T1HS95   A0A023F5G6   F4WPL7   A0A0J7P2N7   A0A182Y2H3   Q16IP8   E2C7X7   A0A182J8B8   A0A1B6C5M3   E2A5X9   A0A151IJF0   A0A195EDQ7   A0A182MC94   D6BK68   W5J6H7   A0A182R981   A0A088A483   A0A158NY55   A0A182SAC6   A0A1A9WR72   A0A1B6FNE2   A0A0A9Y8U9   K7J7T3   A0A195B0N5   Q7Q552   A0A3L8E448   A0A034VT40   A0A0C9RMB0   A0A1W7R6R0   A0A1I8P3Q1   A0A151WPV4   B0XD36   A0A0P6K0S6   A0A1I8NGM9   A0A023EW03   A0A1A9VSN3   W8BL50   B3NPH7   A0A182I4L3   A0A0R3NLI8   A0A1W4UYA5   A0A1B0AB24   A0A0P9C0E2   B4P659   A0A3B0IZ98   A0A0A1WSG7   A0A182WBN3   B4HSZ1   W8ANI8   Q24323-2   B4J7G7   A0A1Q3FWP5   B4QI01   Q24323-3   Q24323-4   Q24323   C0PTV9   A0A1W4UL16   A0A3B0JJQ7   A0A0R1DSV2   B5DZT9   A0A0J9U3N0   A0A0Q5VN12   W8BB33   A0A0P6GQ47   B3MFQ2   A0A0P6IH40   Q9XZC8   A0A0Q9XIE5   B4LME9   A0A0K8W563   B4MPH4  

Pubmed

19121390    26354079    26227816    29403074    23537049    18362917    + More
19820115    28004739    25474469    21719571    25244985    17510324    20798317    20920257    23761445    21347285    25401762    20075255    12364791    30249741    25348373    26999592    25315136    24945155    24495485    17994087    15632085    17550304    25830018    8269517    10731132    12537572    12537569    16672342    19349973    22936249    18057021    10101134   

EMBL

BABH01002096    NWSH01000291    PCG77691.1    ODYU01004792    SOQ45040.1    KQ459604    + More
KPI92525.1    KQ459765    KPJ20039.1    RSAL01000119    RVE46737.1    JTDY01000073    KOB79019.1    LJIG01001993    KRT84947.1    NEVH01003495    PNF40689.1    GALX01002344    JAB66122.1    PYGN01000228    PSN50647.1    APGK01053912    KB741239    ENN72123.1    KQ971312    KYB29357.1    JR052803    AEY61792.1    KYB29356.1    KB632275    ERL91097.1    GECU01019551    JAS88155.1    EF036538    ABK35089.3    GEZM01010725    JAV93878.1    KQ981958    KYN31966.1    GEZM01010724    JAV93879.1    GEZM01010727    JAV93876.1    GEZM01010726    JAV93877.1    KQ414965    KOC59032.1    ACPB03019078    ACPB03019079    ACPB03019080    ACPB03019081    ACPB03019082    ACPB03019083    ACPB03019084    GBBI01002318    JAC16394.1    GL888250    EGI63859.1    LBMM01000276    KMR01956.1    CH478062    EAT34141.1    GL453503    EFN75947.1    GEDC01028490    JAS08808.1    GL437072    EFN71160.1    KQ977355    KYN03331.1    KQ979074    KYN22979.1    AXCM01012059    EU836737    ACJ23177.1    ADMH02001991    ETN60057.1    ADTU01003207    ADTU01003208    ADTU01003209    ADTU01003210    ADTU01003211    ADTU01003212    GECZ01020839    GECZ01018246    JAS48930.1    JAS51523.1    GBHO01015025    GBRD01015533    JAG28579.1    JAG50293.1    AAZX01003580    AAZX01006728    AAZX01007460    AAZX01008558    AAZX01009344    AAZX01009609    AAZX01020005    KQ976692    KYM77764.1    AAAB01008960    EAA11400.4    QOIP01000001    RLU27461.1    GAKP01013685    JAC45267.1    GBYB01009445    JAG79212.1    GEHC01000845    JAV46800.1    KQ982851    KYQ49896.1    DS232737    EDS45271.1    GDUN01000846    JAN95073.1    GAPW01000322    JAC13276.1    GAMC01016191    JAB90364.1    CH954179    EDV55744.1    APCN01002317    CM000071    KRT01800.1    CH902619    KPU77008.1    CM000158    EDW91909.1    OUUW01000001    SPP73455.1    GBXI01012515    JAD01777.1    CH480816    EDW48155.1    GAMC01016190    JAB90365.1    L26083    AE013599    AY095026    AY128437    BT011447    CH916367    EDW01091.1    GFDL01003077    JAV31968.1    CM000362    CM002911    EDX07372.1    KMY94279.1    BT071804    ACN43740.1    SPP73456.1    KRK00203.1    KRK00204.1    KRK00205.1    EDY68862.1    KMY94280.1    KMY94281.1    KMY94282.1    KQS62451.1    KQS62452.1    GAMC01016189    GAMC01016188    JAB90366.1    GDIQ01040643    JAN54094.1    EDV37742.1    KPU77009.1    KPU77010.1    GDIQ01004618    JAN90119.1    AF134904    CH933808    KRG04686.1    CH940648    EDW62044.2    GDHF01034064    GDHF01027113    GDHF01019851    GDHF01006112    GDHF01002618    JAI18250.1    JAI25201.1    JAI32463.1    JAI46202.1    JAI49696.1    CH963849    EDW74013.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000283053    UP000037510    + More
UP000235965    UP000245037    UP000019118    UP000007266    UP000075885    UP000030742    UP000076407    UP000192223    UP000078541    UP000053825    UP000075884    UP000015103    UP000007755    UP000036403    UP000076408    UP000008820    UP000008237    UP000075880    UP000000311    UP000078542    UP000078492    UP000075883    UP000000673    UP000075900    UP000005203    UP000005205    UP000075901    UP000091820    UP000002358    UP000078540    UP000007062    UP000279307    UP000095300    UP000075809    UP000002320    UP000095301    UP000078200    UP000008711    UP000075840    UP000001819    UP000192221    UP000092445    UP000007801    UP000002282    UP000268350    UP000075920    UP000001292    UP000000803    UP000001070    UP000000304    UP000009192    UP000008792    UP000007798   

PRIDE

H9JG65    Q24323    C0PTV9    Q9XZC8   

Pfam

PF01437   PSI        + More
PF01403   Sema
PF00078   RVT_1

Interpro

IPR036179   Ig-like_dom_sf        + More
IPR027231   Semaphorin       
IPR002165   Plexin_repeat       
IPR013783   Ig-like_fold       
IPR036352   Semap_dom_sf       
IPR001627   Semap_dom       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR000477   RT_dom       

SUPFAM

SSF48726   SSF48726        + More
SSF101912   SSF101912       

Gene 3D

2.130.10.10     2.60.40.10    

ProteinModelPortal

H9JG65   A0A2A4K0A3   A0A2H1VW33   A0A194PN26   A0A194RRL5   A0A3S2LY87   + More
A0A0L7LUF7   A0A0T6BC85   A0A2J7RIM7   V5GWN2   A0A2P8Z2C6   N6T3H6   A0A139WNC0   V9IM36   A0A139WNB6   A0A182PDL1   U4UDG0   A0A182X4L6   A0A1B6IML8   A0A1W4XRB0   A0MT98   A0A1Y1N8R5   A0A195EUY7   A0A1Y1N840   A0A1Y1NCB7   A0A1Y1NE22   A0A0L7QK86   A0A182NI73   T1HS95   A0A023F5G6   F4WPL7   A0A0J7P2N7   A0A182Y2H3   Q16IP8   E2C7X7   A0A182J8B8   A0A1B6C5M3   E2A5X9   A0A151IJF0   A0A195EDQ7   A0A182MC94   D6BK68   W5J6H7   A0A182R981   A0A088A483   A0A158NY55   A0A182SAC6   A0A1A9WR72   A0A1B6FNE2   A0A0A9Y8U9   K7J7T3   A0A195B0N5   Q7Q552   A0A3L8E448   A0A034VT40   A0A0C9RMB0   A0A1W7R6R0   A0A1I8P3Q1   A0A151WPV4   B0XD36   A0A0P6K0S6   A0A1I8NGM9   A0A023EW03   A0A1A9VSN3   W8BL50   B3NPH7   A0A182I4L3   A0A0R3NLI8   A0A1W4UYA5   A0A1B0AB24   A0A0P9C0E2   B4P659   A0A3B0IZ98   A0A0A1WSG7   A0A182WBN3   B4HSZ1   W8ANI8   Q24323-2   B4J7G7   A0A1Q3FWP5   B4QI01   Q24323-3   Q24323-4   Q24323   C0PTV9   A0A1W4UL16   A0A3B0JJQ7   A0A0R1DSV2   B5DZT9   A0A0J9U3N0   A0A0Q5VN12   W8BB33   A0A0P6GQ47   B3MFQ2   A0A0P6IH40   Q9XZC8   A0A0Q9XIE5   B4LME9   A0A0K8W563   B4MPH4  

PDB

3OKY     E-value=0.000236881,     Score=102

KEGG

101740012    no KO assigned | (RefSeq) semaphorin-2A

GO

GO:0050919   GO:0071526   GO:0030335   GO:0045499   GO:0005615   GO:0007411   GO:0001755   GO:0048843   GO:0030215   GO:0016020   GO:0016021   GO:0097374   GO:0071678   GO:0042756   GO:0007629   GO:0016201   GO:0070983   GO:0007632   GO:0030534   GO:0012505   GO:0005829   GO:0005576   GO:0007399   GO:0030154   GO:0005515   GO:0008270   GO:0016787   GO:0030163   GO:0015935   GO:0051603   GO:0051028   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR11036  

Subcellular location

Secreted  

Length:

221

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00036

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03953

outside

1  -  221

 

 

Pi

303.474009

Theta

209.535472

Tajima's D

1.352597

CLR

0.06515

CSRT

0.755362231888406

Interpretation

Uncertain