Gene

KWMTBOMO10983

Pre Gene Modal

BGIBMGA008511

Annotation

PREDICTED:_semaphorin-2A-like_[Amyelois_transitella]

Location

Bomo_Chr18(+):8822591-8855739      View in EpiBrowser

Full name

Semaphorin-2A      

Alternative Name

Sema II
Semaphorin-II

Location in the cell

Mitochondrial   Reliability : 1.11 PlasmaMembrane   Reliability : 1.18

CDS

ATGAAAAGAATTCCACGTGAACAGTCGCAGTTCGACGCTTCACTAAGCTTTGCCTTTTATGAACGTCGTGTTCTGAAGAATGTTAATGGTGTTTTTATAAAGATTGCGAATTCGGAATCTAGCTCGATTAAGATTAAGCAAATTTCAAGTGAACTGAGATTTAAATGTACAAAAACCAAGATCCACCAAGATCTAAAGGCAATTTCCTTCTTTACAGATCATGTACGGGAATTTTCCTGTGGCGCCTTGTACTACAGGACCTTCTTTGTTGACTCGAAAAGGGATGCACTCTATGTTGGCGCTATGGATCGGTTATATCGGCTGAATATGAATAACATTAGTGCGTCGCATTGCGAAAGAGATTCAATTAACCTAGAGCCTAGCAACGTGGCCCAATGCGTATCCAAAGGAAAATCAGAGCATTTCGACTGTCGAAACCACATCCGTGTAATTCAACCTATGGGCGACGGATCACGCCTGTATGTCTGCGGTACCAATGCTCACAGCCCGAAGGATTGGGTCTTATATTCGAACTTGACGCACCTGCCTCGTTACGAGTACGTGCCGGGCATAGGGATGGGGGTTGCAAAATGCCCGTATGATCCAGCGGACAACTCTACTGCTTTGTGGGTGGAGAAGGGCAACCCTGGCAACCTGCCCGCACTGTACTCGGGAACTAACGCCGAATTCACCAAAGCCGATACGGTGATCTTCAGAACGGATTTGCATAACTTGACGACGGGACGACAAGAGTTTTCCTTCAAGAGAACTCTGAAATACGACTCGAAGTGGCTCGACAAGCCTAACTTCGTTGGATCATTTGATGTTGGTGAATACGTTCTATTTTTCTATCGCGAAACGGCTGTGGAGTACATTAATTGCGGCAAAGCTGTGTATTCGAGGGTGGCCAGAGTCTGTAAGAGGGACACAGGAGGCAAGAACATTTTGAGCCAAAACTGGGCAACTTACTTGAAAGCCAGACTAAACTGCAGCATACCCGGAGAATTTCCATTTTATTTTAATGAAATACAGAGCATTTATAAAATTCCCGGCGACGACAGCAAATTCTATGGTGTTTTCACAACAGCTTCGACTGGTCTCATGGGATCTGCGATTTGCACCTTCACTATCGGAGATATCCAGAAGGCTTTCGAAGGGAAATTCAAAGAGCAGGCTTCCTCCAGCTCTGCTTGGCTTCCGGTCATCACCAGCAAAGTACCGGAACCTAGACCGGGGACTTGTGTGAATGATACGGCATCTCTGCCAGACACAGTTCTGAATTTTATTCGGTCACATCCCCTTATGGACAGTGCCGTTTCCCATGAACATGAAAAACCGATTTATTACAAAAGGGACTTGTTCTTCACGAGACTTGTGGTAGACAGAGTGAAGGTCGACATGATGGGACACCAGCTGGACTACACCGTGTATTATGCTGGAACAAGTAAGTGTTTTAATGTTAATTGCGTGCAGTTAAAATCTTAA

Protein

MKRIPREQSQFDASLSFAFYERRVLKNVNGVFIKIANSESSSIKIKQISSELRFKCTKTKIHQDLKAISFFTDHVREFSCGALYYRTFFVDSKRDALYVGAMDRLYRLNMNNISASHCERDSINLEPSNVAQCVSKGKSEHFDCRNHIRVIQPMGDGSRLYVCGTNAHSPKDWVLYSNLTHLPRYEYVPGIGMGVAKCPYDPADNSTALWVEKGNPGNLPALYSGTNAEFTKADTVIFRTDLHNLTTGRQEFSFKRTLKYDSKWLDKPNFVGSFDVGEYVLFFYRETAVEYINCGKAVYSRVARVCKRDTGGKNILSQNWATYLKARLNCSIPGEFPFYFNEIQSIYKIPGDDSKFYGVFTTASTGLMGSAICTFTIGDIQKAFEGKFKEQASSSSAWLPVITSKVPEPRPGTCVNDTASLPDTVLNFIRSHPLMDSAVSHEHEKPIYYKRDLFFTRLVVDRVKVDMMGHQLDYTVYYAGTSKCFNVNCVQLKS

Description

Plays a role in growth cones guidance. Required for both proper adult behavior and survival. Can function in vivo as a selective target-derived signal that inhibits the formation of specific synaptic terminal arbors.

Subunit

Interacts with PlexB.

Similarity

Belongs to the semaphorin family.

Keywords

Developmental protein   Differentiation   Disulfide bond   Glycoprotein   Immunoglobulin domain   Neurogenesis   Secreted   Signal   Alternative splicing   Complete proteome   Reference proteome  

Feature

chain  Semaphorin-2A
splice variant  In isoform C.

Uniprot

A0A3S2LY87   A0A212ERV2   A0A194RRL5   A0A139WNC0   A0A158NY55   A0A026WKJ4   + More
D6BK68   A0A139WNB6   A0A1Y1N840   A0A1Y1NCB7   A0A088A483   A0A1Y1NE22   A0A154NWA1   A0MT98   K7J7T3   A0A1Y1N8R5   A0A195EDQ7   A0A1B6FNE2   A0A1B6LQ10   A0A0C9RMB0   A0A194PN26   A0A1B6C5M3   A0A0A9Y8U9   E0VMC9   A0A023F5G6   Q9XZC8   A0A2H8TGV7   A0A2S2PAN5   A0A0P6I923   J9K5D2   A0A0P5YB13   A0A0N8D296   A0A0P5A215   A0A0P5UPR1   A0A0P4Z9Q7   A0A0P5X8F5   A0A0P5G8G5   A0A0P5ESR9   A0A0P5BDT7   A0A1W7R6R0   A0A0P5EVZ2   E2A5X9   A0A0P5ZW11   A0A0P5DMX6   A0A0N8BQ25   A0A0P6K0S6   A0A1Q3FWP5   Q177X8   Q7Q552   A0A023EW03   A0A195B0N5   A0A0P5EKF9   A0A3S2NF77   A0A0M4ECX6   A0A151IJF0   B4J7G7   A0A151WPV4   A0A0N8CJF1   A0A0P5TW35   B4LME9   A0A0Q9XIE5   A0A0R3NLI8   A0A0A1WSG7   W8BL50   B4KSI2   A0A3B0IZ98   B4MPH4   A0A0Q9WG98   A0A3B0JJQ7   A0A0P9C0E2   B5DZT9   B4GA96   A0A1J1INU3   W8BB33   B3MFQ2   A0A0K8W563   A0A1W4UYA5   B4QI01   B4HSZ1   Q24323-2   A0A0J9U3N0   A0A1W4UL16   Q24323   C0PTV9   B3NPH7   B4P659   A0A0P5P7H7   A0A0P5P7F9   A0A0Q5VN12   A0A0R1DSV2   A0A0P6GQ47   A0A2P2HZ25   E9GIV0   A0A1I8P3Q1   A0A194QAG8   A0A084WMF0   A0A212ELY0   A0A194RH66   A0A1I8NGM9   Q7PP64  

Pubmed

22118469    26354079    18362917    19820115    21347285    24508170    + More
28004739    20075255    25401762    20566863    25474469    10101134    20798317    26999592    17510324    12364791    24945155    17994087    15632085    25830018    24495485    18057021    22936249    8269517    10731132    12537572    12537569    16672342    19349973    17550304    21292972    24438588    25315136   

EMBL

RSAL01000119    RVE46737.1    AGBW02012905    OWR44236.1    KQ459765    KPJ20039.1    + More
KQ971312    KYB29357.1    ADTU01003207    ADTU01003208    ADTU01003209    ADTU01003210    ADTU01003211    ADTU01003212    KK107168    EZA56161.1    EU836737    ACJ23177.1    KYB29356.1    GEZM01010724    JAV93879.1    GEZM01010727    JAV93876.1    GEZM01010726    JAV93877.1    KQ434772    KZC03927.1    EF036538    ABK35089.3    AAZX01003580    AAZX01006728    AAZX01007460    AAZX01008558    AAZX01009344    AAZX01009609    AAZX01020005    GEZM01010725    JAV93878.1    KQ979074    KYN22979.1    GECZ01020839    GECZ01018246    JAS48930.1    JAS51523.1    GEBQ01014268    JAT25709.1    GBYB01009445    JAG79212.1    KQ459604    KPI92525.1    GEDC01028490    JAS08808.1    GBHO01015025    GBRD01015533    JAG28579.1    JAG50293.1    DS235306    EEB14535.1    GBBI01002318    JAC16394.1    AF134904    GFXV01001551    MBW13356.1    GGMR01013377    MBY25996.1    GDIQ01024602    JAN70135.1    ABLF02036314    ABLF02036316    ABLF02036319    ABLF02036320    ABLF02036322    ABLF02036323    ABLF02047241    ABLF02047629    ABLF02048663    ABLF02066977    GDIP01062188    JAM41527.1    GDIP01075879    JAM27836.1    GDIP01217514    JAJ05888.1    GDIP01111340    JAL92374.1    GDIP01217515    JAJ05887.1    GDIP01075878    JAM27837.1    GDIQ01266421    JAJ85303.1    GDIP01174818    GDIQ01268439    GDIQ01106037    GDIQ01059404    GDIQ01049163    LRGB01002993    JAJ48584.1    JAJ83285.1    KZS05205.1    GDIP01186221    GDIQ01116330    GDIQ01059403    JAJ37181.1    JAL35396.1    GEHC01000845    JAV46800.1    GDIQ01266422    JAJ85302.1    GL437072    EFN71160.1    GDIP01042284    JAM61431.1    GDIP01171022    JAJ52380.1    GDIQ01156059    JAK95666.1    GDUN01000846    JAN95073.1    GFDL01003077    JAV31968.1    CH477369    EAT42479.1    AAAB01008960    EAA11400.4    GAPW01000322    JAC13276.1    KQ976692    KYM77764.1    GDIQ01268438    JAJ83286.1    RSAL01000144    RVE45961.1    CP012524    ALC41677.1    KQ977355    KYN03331.1    CH916367    EDW01091.1    KQ982851    KYQ49896.1    GDIP01125839    JAL77875.1    GDIP01125889    JAL77825.1    CH940648    EDW62044.2    CH933808    KRG04686.1    CM000071    KRT01800.1    GBXI01012515    JAD01777.1    GAMC01016191    JAB90364.1    EDW09487.1    OUUW01000001    SPP73455.1    CH963849    EDW74013.1    KRF80399.1    KRF80400.1    SPP73456.1    CH902619    KPU77008.1    EDY68862.1    CH479181    EDW31848.1    CVRI01000054    CRL00153.1    GAMC01016189    GAMC01016188    JAB90366.1    EDV37742.1    KPU77009.1    KPU77010.1    GDHF01034064    GDHF01027113    GDHF01019851    GDHF01006112    GDHF01002618    JAI18250.1    JAI25201.1    JAI32463.1    JAI46202.1    JAI49696.1    CM000362    CM002911    EDX07372.1    KMY94279.1    CH480816    EDW48155.1    L26083    AE013599    AY095026    AY128437    BT011447    KMY94280.1    KMY94281.1    KMY94282.1    BT071804    ACN43740.1    CH954179    EDV55744.1    CM000158    EDW91909.1    GDIQ01132581    JAL19145.1    GDIQ01132582    JAL19144.1    KQS62451.1    KQS62452.1    KRK00203.1    KRK00204.1    KRK00205.1    GDIQ01040643    JAN54094.1    IACF01001160    LAB66876.1    GL732547    EFX80330.1    KQ459299    KPJ01990.1    ATLV01024426    ATLV01024427    KE525352    KFB51394.1    AGBW02013971    OWR42495.1    KQ460205    KPJ16922.1    EAA11003.5   

Proteomes

UP000283053    UP000007151    UP000053240    UP000007266    UP000005205    UP000053097    + More
UP000005203    UP000076502    UP000002358    UP000078492    UP000053268    UP000009046    UP000007819    UP000076858    UP000000311    UP000008820    UP000007062    UP000078540    UP000092553    UP000078542    UP000001070    UP000075809    UP000008792    UP000009192    UP000001819    UP000268350    UP000007798    UP000007801    UP000008744    UP000183832    UP000192221    UP000000304    UP000001292    UP000000803    UP000008711    UP000002282    UP000000305    UP000095300    UP000030765    UP000095301   

PRIDE

Q9XZC8    Q24323    C0PTV9   

Pfam

PF01403   Sema        + More
PF00078   RVT_1
PF01437   PSI

Interpro

IPR001627   Semap_dom        + More
IPR036352   Semap_dom_sf       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR027231   Semaphorin       
IPR036179   Ig-like_dom_sf       
IPR013783   Ig-like_fold       
IPR007110   Ig-like_dom       
IPR003599   Ig_sub       
IPR000477   RT_dom       
IPR002165   Plexin_repeat       

SUPFAM

SSF48726   SSF48726        + More
SSF101912   SSF101912       

Gene 3D

2.130.10.10     2.60.40.10    

ProteinModelPortal

A0A3S2LY87   A0A212ERV2   A0A194RRL5   A0A139WNC0   A0A158NY55   A0A026WKJ4   + More
D6BK68   A0A139WNB6   A0A1Y1N840   A0A1Y1NCB7   A0A088A483   A0A1Y1NE22   A0A154NWA1   A0MT98   K7J7T3   A0A1Y1N8R5   A0A195EDQ7   A0A1B6FNE2   A0A1B6LQ10   A0A0C9RMB0   A0A194PN26   A0A1B6C5M3   A0A0A9Y8U9   E0VMC9   A0A023F5G6   Q9XZC8   A0A2H8TGV7   A0A2S2PAN5   A0A0P6I923   J9K5D2   A0A0P5YB13   A0A0N8D296   A0A0P5A215   A0A0P5UPR1   A0A0P4Z9Q7   A0A0P5X8F5   A0A0P5G8G5   A0A0P5ESR9   A0A0P5BDT7   A0A1W7R6R0   A0A0P5EVZ2   E2A5X9   A0A0P5ZW11   A0A0P5DMX6   A0A0N8BQ25   A0A0P6K0S6   A0A1Q3FWP5   Q177X8   Q7Q552   A0A023EW03   A0A195B0N5   A0A0P5EKF9   A0A3S2NF77   A0A0M4ECX6   A0A151IJF0   B4J7G7   A0A151WPV4   A0A0N8CJF1   A0A0P5TW35   B4LME9   A0A0Q9XIE5   A0A0R3NLI8   A0A0A1WSG7   W8BL50   B4KSI2   A0A3B0IZ98   B4MPH4   A0A0Q9WG98   A0A3B0JJQ7   A0A0P9C0E2   B5DZT9   B4GA96   A0A1J1INU3   W8BB33   B3MFQ2   A0A0K8W563   A0A1W4UYA5   B4QI01   B4HSZ1   Q24323-2   A0A0J9U3N0   A0A1W4UL16   Q24323   C0PTV9   B3NPH7   B4P659   A0A0P5P7H7   A0A0P5P7F9   A0A0Q5VN12   A0A0R1DSV2   A0A0P6GQ47   A0A2P2HZ25   E9GIV0   A0A1I8P3Q1   A0A194QAG8   A0A084WMF0   A0A212ELY0   A0A194RH66   A0A1I8NGM9   Q7PP64  

PDB

6FKN     E-value=4.20281e-73,     Score=699

KEGG

101740012    no KO assigned | (RefSeq) semaphorin-2A

GO

GO:0050919   GO:0071526   GO:0030335   GO:0045499   GO:0005615   GO:0007411   GO:0001755   GO:0048843   GO:0030215   GO:0016020   GO:0007399   GO:0030154   GO:0005576   GO:0016021   GO:0071678   GO:0042756   GO:0097374   GO:0016201   GO:0007629   GO:0007632   GO:0070983   GO:0030534   GO:0012505   GO:0005829   GO:0005515   GO:0008270   GO:0016787   GO:0030163   GO:0015935   GO:0051603   GO:0051028   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR11036  

Subcellular location

Secreted  

Length:

494

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

5.72845

Exp number, first 60 AAs:

0.00032

Total prob of N-in:

0.19776

outside

1  -  494

 

 

Pi

212.270667

Theta

186.802819

Tajima's D

0.836888

CLR

0.52675

CSRT

0.615619219039048

Interpretation

Uncertain