Gene

KWMTBOMO10969

Annotation

UDP-glucuronosyltransferase_2B14-like_precursor_[Bombyx_mori]

Location

Bomo_Chr18(-):8314534-8322486      View in EpiBrowser

Full name

UDP-glucuronosyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 2.084

CDS

ATGTTAGCTAATAAACAAGTGCAAGAACTGATCAAAAGTAAGCAAAAGTTTGATGTGGTTGTTGTCGAACAGTTCAACAGTGATTGTGCGTTAGGTGTAGCTTATAAACTAGGTGCTCCAGCGATCGGAATGTCCTCACACACACTAATGCCTTATCACTATAAGAGATTAGGCATCCCCTACAACCCATCATACGTGCCCTTTCATTTCCTGGAGGGGGGAACTAAGCCATCTCTCTTTCACCGAGTCGAGAGATTGTTTTTTGACTTCTTCTTTAGAACGTTTTATTACTTTGTAAGCCAGCGGAGTGATCAAAACACACTGGCTGAATATTTTGATGACATCCCTCCGCTAGAAGAACTGGCTAGGAACATGAAATTTCATCTATTGTATCACAACTTCATTTTAACCGGGTCAAGGCTGTTCCCATCCAATGTGATTGAAGTCGGCGGCTATCACGTTAGCAACGCCAATCCTTTAACTAGTGATTTGAAAAAATTCGTTGATGAAGCTGAACATGGAATTATATTCATAAGTTTTGGTTCTGTTATCAAGAGCTCAACTATGACAACGGATAAAGTAGAAGCTATTTTGGAAGTTATGAAAAGAATGCCGCAGAGATTCATATGGAAATGGGAAGACAAATCATTAATAGTTGATAAAAACAAATTATATGTGTCTCATTGGCTGCCGCAAGTTGATATTTTAGGACACCCGAAAACTTTGGCGTTTCTCTCACATGCGGGAATGGGTGGAATTACCGAGGCCATTCATTTTGGAGTACCAGTAGTGGCCATGCCTTTCTTGGGCGATCAGCCTGCTAATGCTGCGGACGTCGAAGAGAGCGGTCTAGGAATTCAATTGCAATTCAGAGATTTAACAACTGAGAGCTTATTGAATGCGTTCCAAACTGTTTTGAACACCACATTCCGTGAGAAGGTAAAAAAAGTCTCGAAAGCATGGCACGACCGACCAATGCCCCCTTTAGAAACAGCAATCTACTGGACCGAGTTTGTTGCCAGGAATCCAGATTTGAATTTTAGAACGGCTGCAGCCGACACTCCTCTATACCAATATATTCTGCTTGATGTAATAGCAGTGCTATTAACACCACTTATTATTATATTCGTCGCATTGAAACGTACAAGAAAATCTTCCGCGCCAATTGTAAAAAAAACGAACGGTAAAAAGAAATCAAAGAAAACTTGA

Protein

MLANKQVQELIKSKQKFDVVVVEQFNSDCALGVAYKLGAPAIGMSSHTLMPYHYKRLGIPYNPSYVPFHFLEGGTKPSLFHRVERLFFDFFFRTFYYFVSQRSDQNTLAEYFDDIPPLEELARNMKFHLLYHNFILTGSRLFPSNVIEVGGYHVSNANPLTSDLKKFVDEAEHGIIFISFGSVIKSSTMTTDKVEAILEVMKRMPQRFIWKWEDKSLIVDKNKLYVSHWLPQVDILGHPKTLAFLSHAGMGGITEAIHFGVPVVAMPFLGDQPANAADVEESGLGIQLQFRDLTTESLLNAFQTVLNTTFREKVKKVSKAWHDRPMPPLETAIYWTEFVARNPDLNFRTAAADTPLYQYILLDVIAVLLTPLIIIFVALKRTRKSSAPIVKKTNGKKKSKKT

Catalytic Activity

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP

Similarity

Belongs to the UDP-glycosyltransferase family.

Feature

chain  UDP-glucuronosyltransferase

Uniprot

G9LPV7   A0A2H1W091   A0A191T2H3   A0A2A4JZV9   A0A024AHN3   G9LPR2   + More
A0A194PHJ2   A0A194RRD0   A0A212EWE0   A0A286MXP4   A0A2H4WB66   A0A1L8D6L6   G9LPV5   A0A3S2LHF3   A0A191T1P6   I4DM95   G9LPV6   A0A2H4WB56   A0A1L8D6F4   A0A194RQ88   A0A2H4WB57   G9LPR3   A0A194RRL0   A0A194PIG8   A0A212EWH2   A0A0L7LRH5   H9JYK2   A0A191T1N2   A0A2A4JYW3   A0A2H1VZI1   G9LPR4   A0A2J7R4W8   A0A2A4JZH0   A0A2P8ZG70   A0A2P8ZG78   A0A2P8ZG71   D2A2V5   A0A2J7R4W4   A0A1B6E1B5   A0A1B6C1J3   G9LPV8   A0A2J7R4W2   V5H2B2   A0A3Q0JH20   A0A3Q0JLK0   A0A2A4JHL4   A0A2P8ZG63   A0A1W4WYE4   A0A1I8N2C0   A0A3S2PBM0   T1PFI1   A0A194Q839   A0A182PJ64   G9LPR5   A0A2J7R4T0   A0A1B6FAC1   E2B0N7   A0A286MXP5   A0A182UEM4   A0A1Y1LIT5   A0A182V6Z3   S4PCR1   A0A182WT93   A0A182HV86   A0A1S4GXF8   A0A1W4WMF1   A0A2J7R4V4   W8AR85   A0A1B6K0J6   A0A182NE44   B4MWT7   A0A182W9Q0   A0A0C9RNU1   A0A0L0C9T9   A0A1I8NWG2   G9LPV9   A0A182YGV2   A0A182RBM8   A0A0A1WW96   A0A084VP43   A0A1W4WMC9   A0A1B6K3R7   A0A182IX39   A0A0K8UM10   A0A0K8UGE5   A0A034V788   A0A139WIW7   A0A191T1N3   A0A182SC34   A0A1S4F2K0   B3NL93   Q17HG0   A0A1I8NWF4   A0A1B6DPF5   A0A067RAP7   Q7Q3K2   B4P9Y7   A0A336KCF6   A0A067RAD1   A0A1L8D6F8  

EC Number

2.4.1.17

Pubmed

22155036    24698447    26354079    22118469    19954531    25299618    + More
29027758    22651552    26227816    19121390    29403074    18362917    19820115    25315136    20798317    28004739    23622113    12364791    24495485    17994087    26108605    25244985    25830018    24438588    25348373    17510324    24845553    17550304   

EMBL

JQ070264    AEW43180.1    ODYU01005418    SOQ46242.1    KU680305    ANI22011.1    + More
NWSH01000347    PCG77184.1    KF777118    AHY99689.1    JQ070219    AEW43135.1    KQ459604    KPI92518.1    KQ459765    KPJ20032.1    AGBW02012000    OWR45818.1    MF684362    ASX93996.1    KY202934    AUC64278.1    GEYN01000094    JAV02035.1    JQ070262    AEW43178.1    RSAL01000119    RVE46732.1    KU680306    ANI22012.1    AK402413    BAM19035.1    JQ070263    AEW43179.1    KY202929    AUC64273.1    GEYN01000096    JAV02033.1    KPJ20033.1    KY202930    AUC64274.1    JQ070220    AEW43136.1    KPJ20034.1    KPI92519.1    OWR45817.1    JTDY01000310    KOB77761.1    BABH01043998    KU680307    ANI22013.1    PCG77205.1    SOQ46241.1    JQ070221    AEW43137.1    NEVH01007402    PNF35870.1    PCG77209.1    PYGN01000068    PSN55494.1    PSN55501.1    PSN55491.1    KQ971338    EFA02977.2    PNF35869.1    GEDC01005597    JAS31701.1    GEDC01030149    GEDC01014244    JAS07149.1    JAS23054.1    JQ070265    AEW43181.1    PNF35872.1    GALX01001513    JAB66953.1    NWSH01001552    PCG70882.1    PSN55493.1    RVE46733.1    KA647552    AFP62181.1    KQ459302    KPJ01707.1    JQ070222    AEW43138.1    PNF35837.1    GECZ01022678    JAS47091.1    GL444666    EFN60709.1    MF684363    ASX93997.1    GEZM01054555    JAV73559.1    GAIX01004036    JAA88524.1    APCN01002501    AAAB01008964    PNF35866.1    GAMC01019493    GAMC01019492    GAMC01019491    JAB87063.1    GECU01002730    JAT04977.1    CH963857    EDW76576.1    GBYB01008756    JAG78523.1    JRES01000714    KNC29017.1    JQ070266    AEW43182.1    GBXI01011391    JAD02901.1    ATLV01014974    KE524999    KFB39737.1    GECU01001605    JAT06102.1    GDHF01024708    JAI27606.1    GDHF01026592    JAI25722.1    GAKP01020965    JAC37987.1    KYB27856.1    KU680308    ANI22014.1    CH954179    EDV54743.1    CH477249    EAT46102.1    GEDC01009759    JAS27539.1    KK852590    KDR20745.1    EAA12774.4    CM000158    EDW90328.1    UFQS01000219    UFQT01000219    SSX01542.1    SSX21922.1    KDR20744.1    GEYN01000098    JAV02031.1   

Proteomes

UP000218220    UP000053268    UP000053240    UP000007151    UP000283053    UP000037510    + More
UP000005204    UP000235965    UP000245037    UP000007266    UP000079169    UP000192223    UP000095301    UP000075885    UP000000311    UP000075902    UP000075903    UP000076407    UP000075840    UP000075884    UP000007798    UP000075920    UP000037069    UP000095300    UP000076408    UP000075900    UP000030765    UP000075880    UP000075901    UP000008711    UP000008820    UP000027135    UP000007062    UP000002282   

PRIDE

G9LPV7    G9LPV5    G9LPV6    H9JYK2    G9LPV8    G9LPV9    + More

Pfam

PF00201   UDPGT        + More
PF00108   Thiolase_N
PF02803   Thiolase_C
PF02036   SCP2

Interpro

IPR035595   UDP_glycos_trans_CS        + More
IPR002213   UDP_glucos_trans       
IPR020613   Thiolase_CS       
IPR020617   Thiolase_C       
IPR016039   Thiolase-like       
IPR003033   SCP2_sterol-bd_dom       
IPR020615   Thiolase_acyl_enz_int_AS       
IPR020616   Thiolase_N       
IPR036527   SCP2_sterol-bd_dom_sf       

SUPFAM

SSF53901   SSF53901        + More
SSF55718   SSF55718       

Gene 3D

3.30.1050.10     3.40.47.10    

ProteinModelPortal

G9LPV7   A0A2H1W091   A0A191T2H3   A0A2A4JZV9   A0A024AHN3   G9LPR2   + More
A0A194PHJ2   A0A194RRD0   A0A212EWE0   A0A286MXP4   A0A2H4WB66   A0A1L8D6L6   G9LPV5   A0A3S2LHF3   A0A191T1P6   I4DM95   G9LPV6   A0A2H4WB56   A0A1L8D6F4   A0A194RQ88   A0A2H4WB57   G9LPR3   A0A194RRL0   A0A194PIG8   A0A212EWH2   A0A0L7LRH5   H9JYK2   A0A191T1N2   A0A2A4JYW3   A0A2H1VZI1   G9LPR4   A0A2J7R4W8   A0A2A4JZH0   A0A2P8ZG70   A0A2P8ZG78   A0A2P8ZG71   D2A2V5   A0A2J7R4W4   A0A1B6E1B5   A0A1B6C1J3   G9LPV8   A0A2J7R4W2   V5H2B2   A0A3Q0JH20   A0A3Q0JLK0   A0A2A4JHL4   A0A2P8ZG63   A0A1W4WYE4   A0A1I8N2C0   A0A3S2PBM0   T1PFI1   A0A194Q839   A0A182PJ64   G9LPR5   A0A2J7R4T0   A0A1B6FAC1   E2B0N7   A0A286MXP5   A0A182UEM4   A0A1Y1LIT5   A0A182V6Z3   S4PCR1   A0A182WT93   A0A182HV86   A0A1S4GXF8   A0A1W4WMF1   A0A2J7R4V4   W8AR85   A0A1B6K0J6   A0A182NE44   B4MWT7   A0A182W9Q0   A0A0C9RNU1   A0A0L0C9T9   A0A1I8NWG2   G9LPV9   A0A182YGV2   A0A182RBM8   A0A0A1WW96   A0A084VP43   A0A1W4WMC9   A0A1B6K3R7   A0A182IX39   A0A0K8UM10   A0A0K8UGE5   A0A034V788   A0A139WIW7   A0A191T1N3   A0A182SC34   A0A1S4F2K0   B3NL93   Q17HG0   A0A1I8NWF4   A0A1B6DPF5   A0A067RAP7   Q7Q3K2   B4P9Y7   A0A336KCF6   A0A067RAD1   A0A1L8D6F8  

PDB

2O6L     E-value=1.62091e-28,     Score=314

KEGG

101739741    K00699 glucuronosyltransferase [EC:2.4.1.17] | (RefSeq) UGT42B1; UDP-glucuronosyltransferase 2B14-li

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00830    Retinol metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0015020   GO:0016021   GO:0016758   GO:0016740   GO:0016747   GO:0008194   GO:0043231   GO:0008152   GO:0016787   GO:0030163   GO:0015935   GO:0051603   GO:0051028   GO:0005622   GO:0006810   GO:0003824  

Subcellular location

Membrane  

Length:

402

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.51763

Exp number, first 60 AAs:

0.10385

Total prob of N-in:

0.04554

outside

1  -  356

TMhelix

357  -  379

inside

380  -  402

 

 

Pi

17.114561

Theta

24.02756

Tajima's D

1.615511

CLR

0.191073

CSRT

0.816409179541023

Interpretation

Uncertain