Gene

KWMTBOMO10968

Pre Gene Modal

BGIBMGA008508

Annotation

UDP-glycosyltransferase_UGT43B1_precursor_[Bombyx_mori]

Location

Bomo_Chr18(+):8309707-8313918      View in EpiBrowser

Full name

UDP-glucuronosyltransferase      

Location in the cell

PlasmaMembrane   Reliability : 2.113

CDS

ATGAAAAACATATCGAAATTAAGACAAATACCACTCGAGTACAAAGTGAGCGGAAGCGATGTTGTTGATATAGACGATACTCTAAAAAACCTTCCTGGTATATTGGTTAATTTTCATAAAGCTTTGGACACAGCGAGAGCTTTCAAGAATTTAGCTAACTCAAATTGTAATAAATTGATGTCCAACAAAGAAATACAAGGAATAATATCGTCGAAGACTAAATTTGATTTAGTGATAGTTGAGCAATTTGTGACGGACTGCGGTCTTGCTGTTGCCTTTAAGTTGAATGCACCCATTGTCGGTATAACTGCTCATATTTTGATGCCGTGGACTTATTCAAGGTTGGGTGCGCTCAATCACCCGGCATACGTTCCGAATCATTTCATTGGTAGCGGAACCAAGCCTGGCTTTTGGGATAAGATACAAAGTGCACTAATTAATATCGCTTTCAACATTTACTTTAAGTATGTAATTCAAAAAAGCGACCAAATGATAATCAATAGTGTTTTTGAAGATGTACCGGACTTGGATGAGATCGGAAAGAATATTTCATTGATTTTATTGAATCAGTATTTTCCTTTGACTGGATCTCGGTTATATGGAGCGAATGTTATTGAAGTTGGTGGTTTACATATCAAAGAAAATACAACTATAGATGATGAGGAAATTAAAAGCTTCATTGACAAGGCAGAAAGCGACGTCATTTACATTAGTTTTGGAACTGTTGCATCTAATTTTCCGGATAGAATAATTAAAGAAATAATAAATTTTATCACGAAAAGTTCCGTAAAGGTTCTATGGAAAATTGACAATGTTGGTAATTTGAATTTGCCGAAGAATGTTTTAATAAGAAAATGGTTTCCGCAGACTGCTGTTTTGTGTCATCCAAAAGTGAAAGCATTTATCACACATTCTGGAATGTTAAGTTCAATTGAAGCTATGCATTGTGGGGTGCCAGTCATAAGCGTTCCGTTGTTCGGAGACCAATTCGCGAACGCAGCGGCAGCTACTGAAATTGGCTTGGGAGTTACCATTGATGTTTCCACAATGAATGAAAGAAAAATCAATCAAGCCCTAAAAACTGTGATGCAAGATTCTTATCAGATAAGGGCTCAAAATTTGTCTGCTTTGTGGAGAGATAGGCCCGTGTCACCTCTGAATTTAGCTATATTTTGGATTGAATACGTGATTCGGCACAAAGAAGACGACATATAA

Protein

MKNISKLRQIPLEYKVSGSDVVDIDDTLKNLPGILVNFHKALDTARAFKNLANSNCNKLMSNKEIQGIISSKTKFDLVIVEQFVTDCGLAVAFKLNAPIVGITAHILMPWTYSRLGALNHPAYVPNHFIGSGTKPGFWDKIQSALINIAFNIYFKYVIQKSDQMIINSVFEDVPDLDEIGKNISLILLNQYFPLTGSRLYGANVIEVGGLHIKENTTIDDEEIKSFIDKAESDVIYISFGTVASNFPDRIIKEIINFITKSSVKVLWKIDNVGNLNLPKNVLIRKWFPQTAVLCHPKVKAFITHSGMLSSIEAMHCGVPVISVPLFGDQFANAAAATEIGLGVTIDVSTMNERKINQALKTVMQDSYQIRAQNLSALWRDRPVSPLNLAIFWIEYVIRHKEDDI

Catalytic Activity

glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP

Similarity

Belongs to the UDP-glycosyltransferase family.

Feature

chain  UDP-glucuronosyltransferase

Uniprot

G9LPV8   H9JG61   A0A2A4JYW3   A0A191T1N2   A0A2H1VZI1   A0A2A4JZH0   + More
G9LPR4   A0A0L7LQI5   A0A191T2H3   A0A2H4WB66   A0A1L8D6L6   A0A3S2LHF3   A0A2A4JZV9   A0A024AHN3   A0A2H4WB56   A0A212EWE0   G9LPR2   A0A2H1W091   G9LPV6   A0A191T1P6   A0A286MXP4   A0A194PHJ2   A0A1L8D6F4   A0A2H4WB57   G9LPV7   I4DM95   G9LPR3   G9LPV5   A0A212EWH2   A0A194RRD0   H9JYK2   A0A194PIG8   A0A194RRL0   A0A0C9RNU1   D2A2V5   A0A194Q839   A0A194RQ88   A0A182NE44   A0A2P8ZG78   A0A1L8E1G2   A0A182PJ64   A0A2M3Z1Z8   A0A084VP43   A0A1J1HE03   A0A2M3Z1Z1   A0A182GI26   A0A3S2PBM0   V5H2B2   A0A1S4F2K0   Q17HG0   A0A1I8N2C0   A0A336LZ19   A0A182V6Z3   A0A336KDN1   A0A336LVC8   A0A1Y1LIT5   T1PFI1   A0A182IX39   A0A182W9Q0   A0A2P8ZG70   B0WBP4   A0A182F4M1   A0A2A4JHL4   A0A182SC34   A0A1Q3FPW9   A0A182UEM4   A0A3Q0JH20   A0A182RBM8   A0A1Q3FPY1   A0A182YGV2   A0A139WIW7   A0A3Q0JLK0   Q17NF9   G9LPR5   A0A1W7R8J2   A0A182WT93   A0A1S4GXF8   W5J9T2   A0A212EWF8   A0A2J7R4V3   A0A182F4L8   A0A1I8NWG2   A0A182HV86   A0A1W4WYE4   A0A2J7R4V1   A0A286MXP5   B3NL93   W8AR85   S4PCR1   A0A067QGQ4   A0A1W4WMF1   A0A1I8NWF4   A0A2J7R4S8   A0A1S4EWK0   A0A2H4WB74   A0A1B6DGT0   A0A0K8UGE5   A0A0K8UM10   A0A2J7QFA8   A0A2J7R4W8  

EC Number

2.4.1.17

Pubmed

22155036    19121390    26227816    29027758    24698447    22118469    + More
19954531    25299618    26354079    22651552    18362917    19820115    29403074    24438588    26483478    17510324    25315136    28004739    25244985    12364791    20920257    23761445    17994087    24495485    23622113    24845553   

EMBL

JQ070265    AEW43181.1    BABH01002044    NWSH01000347    PCG77205.1    KU680307    + More
ANI22013.1    ODYU01005418    SOQ46241.1    PCG77209.1    JQ070221    AEW43137.1    JTDY01000310    KOB77758.1    KU680305    ANI22011.1    KY202934    AUC64278.1    GEYN01000094    JAV02035.1    RSAL01000119    RVE46732.1    PCG77184.1    KF777118    AHY99689.1    KY202929    AUC64273.1    AGBW02012000    OWR45818.1    JQ070219    AEW43135.1    SOQ46242.1    JQ070263    AEW43179.1    KU680306    ANI22012.1    MF684362    ASX93996.1    KQ459604    KPI92518.1    GEYN01000096    JAV02033.1    KY202930    AUC64274.1    JQ070264    AEW43180.1    AK402413    BAM19035.1    JQ070220    AEW43136.1    JQ070262    AEW43178.1    OWR45817.1    KQ459765    KPJ20032.1    BABH01043998    KPI92519.1    KPJ20034.1    GBYB01008756    JAG78523.1    KQ971338    EFA02977.2    KQ459302    KPJ01707.1    KPJ20033.1    PYGN01000068    PSN55501.1    GFDF01001547    JAV12537.1    GGFM01001806    MBW22557.1    ATLV01014974    KE524999    KFB39737.1    CVRI01000001    CRK86175.1    GGFM01001770    MBW22521.1    JXUM01065169    KQ562333    KXJ76125.1    RVE46733.1    GALX01001513    JAB66953.1    CH477249    EAT46102.1    UFQS01000219    UFQT01000219    SSX01523.1    SSX21903.1    SSX01525.1    SSX21905.1    SSX01524.1    SSX21904.1    GEZM01054555    JAV73559.1    KA647552    AFP62181.1    PSN55494.1    DS231880    EDS42579.1    NWSH01001552    PCG70882.1    GFDL01005396    JAV29649.1    GFDL01005384    JAV29661.1    KYB27856.1    CH477199    EAT48259.1    JQ070222    AEW43138.1    GEHC01000181    JAV47464.1    AAAB01008964    ADMH02001962    ETN60168.1    OWR45816.1    NEVH01007402    PNF35864.1    APCN01002501    PNF35863.1    MF684363    ASX93997.1    CH954179    EDV54743.1    GAMC01019493    GAMC01019492    GAMC01019491    JAB87063.1    GAIX01004036    JAA88524.1    KK853490    KDR07235.1    PNF35836.1    KY202936    AUC64280.1    GEDC01012446    JAS24852.1    GDHF01026592    JAI25722.1    GDHF01024708    JAI27606.1    NEVH01015300    PNF27276.1    PNF35870.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000283053    UP000007151    UP000053268    + More
UP000053240    UP000007266    UP000075884    UP000245037    UP000075885    UP000030765    UP000183832    UP000069940    UP000249989    UP000008820    UP000095301    UP000075903    UP000075880    UP000075920    UP000002320    UP000069272    UP000075901    UP000075902    UP000079169    UP000075900    UP000076408    UP000076407    UP000000673    UP000235965    UP000095300    UP000075840    UP000192223    UP000008711    UP000027135   

PRIDE

G9LPV8    H9JG61    G9LPV6    G9LPV7    G9LPV5    H9JYK2    + More

Pfam

PF00201   UDPGT        + More
PF12597   DUF3767
PF00003   7tm_3
PF00941   FAD_binding_5
PF01799   Fer2_2
PF02738   Ald_Xan_dh_C2
PF01315   Ald_Xan_dh_C
PF00111   Fer2
PF03450   CO_deh_flav_C

Interpro

IPR002213   UDP_glucos_trans        + More
IPR035595   UDP_glycos_trans_CS       
IPR001041   2Fe-2S_ferredoxin-type       
IPR036010   2Fe-2S_ferredoxin-like_sf       
IPR022533   Cox20       
IPR036683   CO_DH_flav_C_dom_sf       
IPR036856   Ald_Oxase/Xan_DH_a/b_sf       
IPR006058   2Fe2S_fd_BS       
IPR016166   FAD-bd_PCMH       
IPR002346   Mopterin_DH_FAD-bd       
IPR037165   AldOxase/xan_DH_Mopterin-bd_sf       
IPR000674   Ald_Oxase/Xan_DH_a/b       
IPR002888   2Fe-2S-bd       
IPR014307   Xanthine_DH_ssu       
IPR036884   2Fe-2S-bd_dom_sf       
IPR005107   CO_DH_flav_C       
IPR008274   AldOxase/xan_DH_Mopterin-bd       
IPR017978   GPCR_3_C       
IPR036318   FAD-bd_PCMH-like_sf       

SUPFAM

SSF47741   SSF47741        + More
SSF55447   SSF55447       
SSF56176   SSF56176       
SSF56003   SSF56003       
SSF54292   SSF54292       
SSF54665   SSF54665       

CDD

cd00207  fer2

ProteinModelPortal

G9LPV8   H9JG61   A0A2A4JYW3   A0A191T1N2   A0A2H1VZI1   A0A2A4JZH0   + More
G9LPR4   A0A0L7LQI5   A0A191T2H3   A0A2H4WB66   A0A1L8D6L6   A0A3S2LHF3   A0A2A4JZV9   A0A024AHN3   A0A2H4WB56   A0A212EWE0   G9LPR2   A0A2H1W091   G9LPV6   A0A191T1P6   A0A286MXP4   A0A194PHJ2   A0A1L8D6F4   A0A2H4WB57   G9LPV7   I4DM95   G9LPR3   G9LPV5   A0A212EWH2   A0A194RRD0   H9JYK2   A0A194PIG8   A0A194RRL0   A0A0C9RNU1   D2A2V5   A0A194Q839   A0A194RQ88   A0A182NE44   A0A2P8ZG78   A0A1L8E1G2   A0A182PJ64   A0A2M3Z1Z8   A0A084VP43   A0A1J1HE03   A0A2M3Z1Z1   A0A182GI26   A0A3S2PBM0   V5H2B2   A0A1S4F2K0   Q17HG0   A0A1I8N2C0   A0A336LZ19   A0A182V6Z3   A0A336KDN1   A0A336LVC8   A0A1Y1LIT5   T1PFI1   A0A182IX39   A0A182W9Q0   A0A2P8ZG70   B0WBP4   A0A182F4M1   A0A2A4JHL4   A0A182SC34   A0A1Q3FPW9   A0A182UEM4   A0A3Q0JH20   A0A182RBM8   A0A1Q3FPY1   A0A182YGV2   A0A139WIW7   A0A3Q0JLK0   Q17NF9   G9LPR5   A0A1W7R8J2   A0A182WT93   A0A1S4GXF8   W5J9T2   A0A212EWF8   A0A2J7R4V3   A0A182F4L8   A0A1I8NWG2   A0A182HV86   A0A1W4WYE4   A0A2J7R4V1   A0A286MXP5   B3NL93   W8AR85   S4PCR1   A0A067QGQ4   A0A1W4WMF1   A0A1I8NWF4   A0A2J7R4S8   A0A1S4EWK0   A0A2H4WB74   A0A1B6DGT0   A0A0K8UGE5   A0A0K8UM10   A0A2J7QFA8   A0A2J7R4W8  

PDB

2O6L     E-value=5.26078e-20,     Score=241

KEGG

100862819    K00699 glucuronosyltransferase [EC:2.4.1.17] | (RefSeq) UGT43B1; UDP-glycosyltransferase UGT43B1

PATHWAY

00040    Pentose and glucuronate interconversions - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
00830    Retinol metabolism - Bombyx mori (domestic silkworm)
00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
00980    Metabolism of xenobiotics by cytochrome P450 - Bombyx mori (domestic silkworm)
00982    Drug metabolism - cytochrome P450 - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0015020   GO:0016758   GO:0016740   GO:0033617   GO:0009055   GO:0071949   GO:0009060   GO:0004855   GO:0004930   GO:0004854   GO:0051537   GO:0005743   GO:0046872   GO:0008194   GO:0043231   GO:0008152   GO:0016787   GO:0030163   GO:0015935   GO:0051603   GO:0051028   GO:0005622   GO:0006810   GO:0003824  

Subcellular location

Membrane  

Length:

404

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.27128

Exp number, first 60 AAs:

0

Total prob of N-in:

0.14939

outside

1  -  404

 

 

Pi

219.683867

Theta

128.578852

Tajima's D

2.424756

CLR

0.166154

CSRT

0.935453227338633

Interpretation

Uncertain