Gene

KWMTBOMO10958  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008336

Annotation

PREDICTED:_glycogen_synthase_kinase-3_beta_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr18(-):8217367-8246546      View in EpiBrowser

Location in the cell

Cytoplasmic   Reliability : 1.218 Mitochondrial   Reliability : 1.204 Nuclear   Reliability : 1.574

CDS

ATGAGCGGACGCCCTAGGACCACGTCATTCGCCGAGGGCAGCAAATCCGTTCGAAAGACTTTCGACAATCAACCTCCAAAACCACCTCTCGGAGGCGTAAAAATTAGCAGCAAGGACGGCTCAAAGGTGACGACTGTGGTAGCGACGCCGGGGCAGGGCCCTGACCGGCCTCAGGAAGTGAGCTATGCTGACATGAAATTGATCGGCAACGGCAGCTTCGGCGTCGTCTATCAAGCCAAACTATGTGACACCGGCGAGCTCATTGCCATCAAGAAGGTGCTCCAGGACAAGAGGTTTAAGAACCGAGAACTTCAAATCATGCGACGGCTGGAGCATTGCAACATTGTGAAACTGAAGTATTTCTTTTATTCCAGTGGCGAAAAGAAAGACGAAGTGTACCTGAATTTGGTGCTGGAGTACATACCCGAGACCGTGTACAAAGTGGCGCGTCATTACTCCAAAGACGAACAAACCATACCCATTAGTTTTATAAAGCTGTACATGTACCAGCTGTTCAGAAGTCTGGCGTACATTCATTCTTTGGGCATCTGTCACCGAGATATCAAGCCGCAGAACCTATTGCTTGACCCCAAGACTGGAGTGTTGAAGCTGTGCGACTTTGGCTCGGCGAAGCACCTCGTTCGCGGAGAACCAAACGTTTCCTACATATGTTCGCGTTATTACCGCGCTCCGGAGCTCATCTTTGGCGCCACCGACTACACCACGAAAATTGACGTGTGGAGCGCGGGATGCGTTGTCGCTGAGCTGTTGTTGGGTCAACCGATATTCCCAGGAGATTCCGGGGTTGACCAATTGGTTGAAATTATCAAGGTTTTAGGGACACCGACAAGAGAACAAATCCGAGAGATGAATCCAAATTATACAGAATTTAAGTTTCCGCAAATCAAGAGTCACCCTTGGGCGAAGGTGTTCCGCGCGTGCACGCCCCCGGACGCCATCTCGCTGGTGTCGCGGCTGCTGGAGTACACGCCGGGCGCGCGCCTGTCGCCGCTGCAGGCCTGCGTGCACAGCTTCTTCGACGAGCTGCGCGAGCCCACCGCCCGCCTGCCCAACGGCCGCCCGCTGCCGCCGCTCTTCAACTTCACCGAGTACGAGCTCGGCATCCAGCCCTCGCTCAACGAGTTCCTGAAGCCGCGCAGCGCCGCGCAGTCCGAGCCGGCCGCCGCCTCCTCTGCGCCCGACCACGACGCGCCAGGCGAGGCGGCATCGGGCGGCGCGACGGCCGACGCTTCCTAG

Protein

MSGRPRTTSFAEGSKSVRKTFDNQPPKPPLGGVKISSKDGSKVTTVVATPGQGPDRPQEVSYADMKLIGNGSFGVVYQAKLCDTGELIAIKKVLQDKRFKNRELQIMRRLEHCNIVKLKYFFYSSGEKKDEVYLNLVLEYIPETVYKVARHYSKDEQTIPISFIKLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPKTGVLKLCDFGSAKHLVRGEPNVSYICSRYYRAPELIFGATDYTTKIDVWSAGCVVAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWAKVFRACTPPDAISLVSRLLEYTPGARLSPLQACVHSFFDELREPTARLPNGRPLPPLFNFTEYELGIQPSLNEFLKPRSAAQSEPAAASSAPDHDAPGEAASGGATADAS

Similarity

Belongs to the protein kinase superfamily.

Uniprot

A0A3S2NX33   A0A2A4JYU5   A0A0N7B1F3   S4P264   B0LBZ5   A0A2H1VZH2   + More
A0A1B6C0U9   A0A1B6F6J0   T1H8J1   A0A194RV56   A0A0V0G765   A0A023F639   A0A1Y1KDH6   A0A0K8S854   A0A1L5YQK4   A0A0M4N2C8   A0A1B6GHH2   G3M3K4   A0A1Y1KKT3   A0A336KSE0   A0A1L8DIV1   A0A1L8DKQ2   A0A0C9R1V4   A0A1B6D5Y6   A0A2R5L9D4   U5EWA5   A0A2M4A5A8   A0A1S6LQ19   Q1HRP9   A0A1Q3G2A6   A0A1Q3G280   T1DE55   A0A1B6FQA7   V5HHR9   A0A0C9QU91   A0A286RXX4   A0A2I6BQ08   F5HLN9   V9IA57   A0A1B6E4X9   A0A087UXA8   A0A1B6EFD5   A0A0A9X6R6   A0A2J7R578   A9P773   A0A1E1X322   A0A023GMQ4   A0A1E1XS44   A0A023FX91   A0A023FIX7   A0A2L2YB23   T1IIH7   L7M8D6   A0A224YNQ5   A0A131Z5I0   A0A0P6C028   A0A067RL75   A0A0K8TM77   A0A069DSV4   A0A131XBN5   A0A0P5KKG9   A0A1B6FDU2   V9ICE0   A0A0P5ZK17   A0A034VLD1   A0A0P5I123   A0A0P5TXZ5   A0A2H8U153   A0A2S2PQD5   B5THN8   A0A0P4YJ16   E9H6Q6   B4JNN7   A0A0A9XG80   A0A1B6MI16   A0A034VMD5   A0A2P2I2X3   C3Y0G1   A0A1I9P1M5   W8C918   A0A0K8S849   A0A0K8VES1   A0A087UB97   A0A1I9WLM5   A0A1Y1KGF5   A0A2M4CZ54   B4M217   T1PFF3   A0A218VDR1   A0A1V4JB40   A0A3Q2TVV5   A0A2I0MLE2   H0ZT29   A0A0Q9WLE3   A0A0Q9XGA1   W5MJG8   A0A0P6IRZ3   A0A026WZI6   A0A2U9C9M7   A0A151MD28  

Pubmed

23622113    18184036    18183285    26354079    25474469    28004739    + More
26823975    18362917    19820115    17204158    24330624    25765539    29255161    12364791    14747013    17210077    25401762    19285806    28503490    29209593    26561354    25576852    28797301    26830274    24845553    26369729    26334808    28049606    25348373    21292972    17994087    18563158    24495485    27538518    15592404    23371554    20360741    24508170    22293439   

EMBL

RSAL01000119    RVE46742.1    NWSH01000347    PCG77187.1    KM233161    AKC42322.1    + More
GAIX01012175    JAA80385.1    EF554581    ABU49716.1    ODYU01005418    SOQ46230.1    GEDC01030304    GEDC01010866    JAS06994.1    JAS26432.1    GECZ01023949    JAS45820.1    ACPB03010082    KQ459765    KPJ20051.1    GECL01002323    JAP03801.1    GBBI01002044    JAC16668.1    GEZM01086439    GEZM01086438    JAV59444.1    GBRD01016483    GBRD01016482    GDHC01012482    JAG49344.1    JAQ06147.1    KX602320    APP94029.1    KR075840    ALE20559.1    GECZ01007892    JAS61877.1    JN602375    KQ971338    AEO44887.1    KYB27979.1    GEZM01086441    GEZM01086437    JAV59437.1    UFQS01000789    UFQT01000789    SSX06891.1    SSX27235.1    GFDF01007701    JAV06383.1    GFDF01007164    JAV06920.1    GBYB01000831    JAG70598.1    GEDC01016201    JAS21097.1    GGLE01001962    MBY06088.1    GANO01003038    JAB56833.1    GGFK01002589    MBW35910.1    KU641425    MG680178    AQT40602.1    AWG41959.1    DQ440045    ABF18078.1    GFDL01001112    JAV33933.1    GFDL01001118    JAV33927.1    GALA01001182    JAA93670.1    GECZ01017425    JAS52344.1    GANP01011440    JAB73028.1    GBYB01007299    JAG77066.1    KY974307    ASW35107.1    KY923001    AUI80372.1    AAAB01008898    EGK97172.1    JR037830    AEY57993.1    GEDC01004317    JAS32981.1    KK122137    KFM81997.1    GEDC01019129    GEDC01000724    JAS18169.1    JAS36574.1    GBHO01029101    GBHO01025784    GBHO01017337    GBRD01016489    GBRD01016486    JAG14503.1    JAG17820.1    JAG26267.1    JAG49337.1    NEVH01007393    PNF35983.1    EF142066    ABO61882.1    GFAC01005508    JAT93680.1    GBBM01001268    JAC34150.1    GFAA01001287    JAU02148.1    GBBL01001221    JAC26099.1    GBBK01002606    JAC21876.1    IAAA01011464    LAA05187.1    AFFK01014267    GACK01004729    JAA60305.1    GFPF01008092    MAA19238.1    GEDV01001980    JAP86577.1    GDIP01007833    JAM95882.1    KK852559    KDR21360.1    GDAI01002144    JAI15459.1    GBGD01001716    JAC87173.1    GEFH01004028    JAP64553.1    GDIQ01184278    JAK67447.1    GECZ01021409    JAS48360.1    JR037831    AEY57994.1    GDIP01043960    JAM59755.1    GAKP01015698    JAC43254.1    GDIQ01225908    GDIP01112240    JAK25817.1    JAL91474.1    GDIP01120453    JAL83261.1    GFXV01007333    MBW19138.1    GGMR01018437    MBY31056.1    EU939764    ACH73246.1    GDIP01226788    JAI96613.1    GL732598    EFX72595.1    CH916371    EDV92330.1    GBHO01035195    GBHO01025781    GBHO01018235    GBRD01016485    GBRD01007877    JAG08409.1    JAG17823.1    JAG25369.1    JAG49341.1    GEBQ01004458    JAT35519.1    GAKP01015695    JAC43257.1    IACF01002588    LAB68236.1    GG666478    EEN66234.1    KT336322    ANZ22981.1    GAMC01007026    GAMC01007025    JAB99529.1    GBRD01016487    GBRD01007876    GDHC01015893    JAG49339.1    JAQ02736.1    GDHF01015274    JAI37040.1    KK119083    KFM74636.1    KU932409    APA34045.1    GEZM01086440    GEZM01086436    JAV59451.1    GGFL01006367    MBW70545.1    CH940651    EDW65721.1    KA646638    AFP61267.1    MUZQ01000007    OWK63988.1    LSYS01008075    OPJ69398.1    AADN05000813    AKCR02000007    PKK30500.1    ABQF01034770    ABQF01034771    ABQF01034772    ABQF01034773    KRF82353.1    CH933815    KRG07531.1    AHAT01020299    AHAT01020300    GDIQ01006531    JAN88206.1    KK107063    EZA61243.1    CP026256    AWP13254.1    AKHW03006231    KYO22436.1   

Proteomes

UP000283053    UP000218220    UP000015103    UP000053240    UP000007266    UP000007062    + More
UP000054359    UP000235965    UP000027135    UP000000305    UP000001070    UP000001554    UP000008792    UP000197619    UP000190648    UP000000539    UP000053872    UP000007754    UP000009192    UP000018468    UP000053097    UP000246464    UP000050525   

Pfam

PF00069   Pkinase

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR039192   STKc_GSK3       
IPR000719   Prot_kinase_dom       
IPR033573   GSK3B       

SUPFAM

SSF56112   SSF56112       

CDD

cd14137  STKc_GSK3

ProteinModelPortal

A0A3S2NX33   A0A2A4JYU5   A0A0N7B1F3   S4P264   B0LBZ5   A0A2H1VZH2   + More
A0A1B6C0U9   A0A1B6F6J0   T1H8J1   A0A194RV56   A0A0V0G765   A0A023F639   A0A1Y1KDH6   A0A0K8S854   A0A1L5YQK4   A0A0M4N2C8   A0A1B6GHH2   G3M3K4   A0A1Y1KKT3   A0A336KSE0   A0A1L8DIV1   A0A1L8DKQ2   A0A0C9R1V4   A0A1B6D5Y6   A0A2R5L9D4   U5EWA5   A0A2M4A5A8   A0A1S6LQ19   Q1HRP9   A0A1Q3G2A6   A0A1Q3G280   T1DE55   A0A1B6FQA7   V5HHR9   A0A0C9QU91   A0A286RXX4   A0A2I6BQ08   F5HLN9   V9IA57   A0A1B6E4X9   A0A087UXA8   A0A1B6EFD5   A0A0A9X6R6   A0A2J7R578   A9P773   A0A1E1X322   A0A023GMQ4   A0A1E1XS44   A0A023FX91   A0A023FIX7   A0A2L2YB23   T1IIH7   L7M8D6   A0A224YNQ5   A0A131Z5I0   A0A0P6C028   A0A067RL75   A0A0K8TM77   A0A069DSV4   A0A131XBN5   A0A0P5KKG9   A0A1B6FDU2   V9ICE0   A0A0P5ZK17   A0A034VLD1   A0A0P5I123   A0A0P5TXZ5   A0A2H8U153   A0A2S2PQD5   B5THN8   A0A0P4YJ16   E9H6Q6   B4JNN7   A0A0A9XG80   A0A1B6MI16   A0A034VMD5   A0A2P2I2X3   C3Y0G1   A0A1I9P1M5   W8C918   A0A0K8S849   A0A0K8VES1   A0A087UB97   A0A1I9WLM5   A0A1Y1KGF5   A0A2M4CZ54   B4M217   T1PFF3   A0A218VDR1   A0A1V4JB40   A0A3Q2TVV5   A0A2I0MLE2   H0ZT29   A0A0Q9WLE3   A0A0Q9XGA1   W5MJG8   A0A0P6IRZ3   A0A026WZI6   A0A2U9C9M7   A0A151MD28  

PDB

4PTG     E-value=0,     Score=1653

KEGG

100862751    K03083 glycogen synthase kinase 3 beta [EC:2.7.11.26] | (RefSeq) glycogen synthase kinase-3 beta

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04341    Hedgehog signaling pathway - fly - Bombyx mori (domestic silkworm)
04711    Circadian rhythm - fly - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0004674   GO:0004672   GO:1904781   GO:0001933   GO:0001954   GO:0031333   GO:0005886   GO:2000300   GO:0005813   GO:0043547   GO:0006983   GO:0001085   GO:0001837   GO:0071109   GO:0035176   GO:0032436   GO:0008285   GO:0098978   GO:0071625   GO:0002039   GO:0050321   GO:0030877   GO:0010822   GO:0002020   GO:0034452   GO:0008013   GO:0005634   GO:0070507   GO:0043066   GO:0021766   GO:0046827   GO:0008284   GO:1901215   GO:0031175   GO:0032091   GO:0018107   GO:0031334   GO:0046777   GO:0031625   GO:0070885   GO:0035556   GO:1901216   GO:0018105   GO:0034236   GO:0005977   GO:0051059   GO:0006468   GO:0016192   GO:0005839   GO:0051603   GO:0051028   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR24057:SF8  

Length:

418

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02619

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00841

outside

1  -  418

 

 

Pi

201.14805

Theta

171.021835

Tajima's D

0.67611

CLR

0.210568

CSRT

0.567871606419679

Interpretation

Possibly Positive selection