Gene

KWMTBOMO10951  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008501

Annotation

PREDICTED:_serine/threonine-protein_phosphatase_PP1-beta_catalytic_subunit_[Papilio_polytes]

Location

Bomo_Chr18(+):8071907-8078095      View in EpiBrowser

Full name

Serine/threonine-protein phosphatase       + More
Serine/threonine-protein phosphatase PP1-beta catalytic subunit      

Location in the cell

Cytoplasmic   Reliability : 2.612

CDS

ATGGCTGACGAACTAAATGTTGACAGTCTAATTCACAGACTTTTGGAAGTTCGAGGATGCAGGCCTGGCAAGACTGTGCAAATGTCGGAGGCAGAGGTACGTGGGCTCTGCACAAAGTCCAGAGAAATATTCCTGCAGCAGCCCATATTACTGGAGTTGGAGGCACCACTCAAAATTTGTGGTGATATACATGGTCAGTACACAGATTTGCTACGTCTCTTTGAATATGGAGGATTTCCGCCAGAAGCCAATTACTTATTCCTTGGTGACTATGTAGATCGTGGTAAACAGTCACTGGAGACTATCTGTCTCCTATTGGCTTACAAAATAAAGTACCCTGAGAATTTCTTCCTACTCAGAGGCAATCATGAGTGTGCTAGCATAAACCGCATTTATGGTTTTTATGACGAGTGCAAACGCCGATACAATATAAAACTGTGGAAGACTTTCACGGATTGCTTTAACTGCTTGCCAATTGCTGCTATAATTGATGAGAAGATTTTCTGTTGCCATGGTGGTTTGTCTCCAGATTTACAGGGAATGGAACAGATCAGAAGAATAATGCGACCCACTGATGTTCCAGATACAGGATTGCTTTGTGACTTGCTGTGGTCAGATCCCGATAAGGATGTTCAAGGTTGGGGGGAAAACGATCGCGGCGTCTCGTTTACTTTCGGACCCGACGTCGTCAGTAAATTCCTCAACAGGCATGATTTAGATTTGATTTGCCGTGCTCACCAGGTGGTGGAAGATGGATATGAATTTTTCGCCAAACGAATGTTGGTTACTTTGTTCTCTGCACCCAACTACTGTGGAGAATTTGATAATGCTGGTGGAATGATGTCTGTTGATGAAACTCTAATGTGCTCCTTCCAGATTCTTAAACCATCTGAAAAAAAAGCAAAATACCAGTACAATGGTATAAACAGTGGAAGGCCAGCTACTCCTCAAAGGTCACCACCTAAGAAAAAATAA

Protein

MADELNVDSLIHRLLEVRGCRPGKTVQMSEAEVRGLCTKSREIFLQQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCCHGGLSPDLQGMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGPDVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRMLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYNGINSGRPATPQRSPPKKK

Description

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity (By similarity).

Catalytic Activity

H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate
H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate

Cofactor

Mn(2+)

Similarity

Belongs to the PPP phosphatase family.
Belongs to the PPP phosphatase family. PP-1 subfamily.

Keywords

Acetylation   Carbohydrate metabolism   Cell cycle   Cell division   Complete proteome   Cytoplasm   Glycogen metabolism   Hydrolase   Manganese   Metal-binding   Nucleus   Protein phosphatase   Reference proteome  

Feature

chain  Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Uniprot

A0A194RQB4   A0A2H1WFH0   A0A194PN42   A0A212EZH9   A0A2W1BHD6   A0A067RHV6   + More
A0A1B6H380   D2A1L2   A0A1B6LLR6   A0A1W4X671   A0A1B2M4Z2   E9IB51   A0A3M0KGY3   A0A0F8C489   A0A151WXC7   R4WDK9   E2C580   A0A0P4VMT2   K7INQ5   T1HE80   A0A158NB15   A0A026X1J8   A0A2J7RS99   A0A1B6EE98   A0A0A9X5V2   G1SEK1   A0A2K5CNF7   A0A224XJX0   A0A0V0G580   A0A087UKD3   A0A2K6QEJ2   A0A023FIW7   T1K2I3   A0A1B6DJX4   A0A210R013   A0A023GLJ1   A0A2R5LKD5   A0A224Z8Q5   A0A0K8RLZ2   A0A131YYT9   L7MB61   A0A023FWJ6   A0A293M3P6   A0A1Z5KWW7   A0A131XDT1   A0A2U9CUF0   A0A1L8G146   A0A3Q2HV97   A0A2I2V0N2   A0A1S3HZC0   A0A1E1XEM8   Q5I085   Q6GQL2   A0A2I0US19   A0A218UW58   A0A0S7KRU2   G1KIW6   A0A0B8RQ66   A0A1W7RDE9   T1E4U8   J3S0H7   U3FW09   A0A3Q0CW64   A0A250YFL0   A0A1J0N213   A0A1S3EYZ1   H0VAY6   A0A2K6C145   A0A2K6KHF2   L5KTG1   A0A2K5VEA0   K9IJA5   G1LET8   G1RZE5   A0A0D9RE27   G3SW90   A0A3Q2HEA5   A0A2U3V6V6   A0A340YHP4   A0A096P0A8   F7AJD1   A0A2Y9SAP0   A0A2K6QEJ4   A0A2U3YDE7   A0A2K5MSN5   A0A2Y9IEY6   A0A3Q7T4E9   F7BDA3   A0A1S2ZSM5   A0A3P4M0G5   M3Z2R4   A0A2K5RMM3   A0A2K6S1I8   A0A2Y9R8S4   A0A2J8VNA3   A0A2U3VJ48   A0A2Y9HP77   M3XDH6   A0A341A9E4   A0A3Q7U171  

EC Number

3.1.3.16

Pubmed

26354079    22118469    28756777    24845553    18362917    19820115    + More
21282665    25835551    23691247    20798317    27129103    20075255    21347285    24508170    30249741    25401762    26823975    21993624    25362486    28812685    28797301    26830274    25576852    28528879    28049606    27762356    19892987    17975172    28503490    25476704    26358130    23758969    23025625    23915248    26319212    28087693    23258410    20010809    17495919    18464734   

EMBL

KQ459765    KPJ20058.1    ODYU01008324    SOQ51813.1    KQ459604    KPI92540.1    + More
AGBW02011299    OWR46861.1    KZ150127    PZC73104.1    KK852624    KDR19936.1    GECZ01000625    JAS69144.1    KQ971338    EFA02685.2    GEBQ01015468    JAT24509.1    KX467781    AOA60277.1    GL762111    EFZ22160.1    QRBI01000106    RMC12509.1    KQ042798    KKF10562.1    KQ982665    KYQ52564.1    AK417788    BAN21003.1    GL452767    EFN76901.1    GDKW01000725    JAI55870.1    ACPB03013340    ADTU01010746    KK107039    QOIP01000006    EZA61891.1    RLU21750.1    NEVH01000267    PNF43716.1    GEDC01018405    GEDC01001055    JAS18893.1    JAS36243.1    GBHO01028578    GBHO01028577    GBRD01014960    GDHC01000279    JAG15026.1    JAG15027.1    JAG50866.1    JAQ18350.1    AAGW02005738    AAGW02005739    AAGW02005740    GFTR01005082    JAW11344.1    GECL01003284    JAP02840.1    KK120226    KFM77822.1    GBBK01002930    JAC21552.1    CAEY01001363    GEDC01011304    GEDC01008183    JAS25994.1    JAS29115.1    NEDP02001069    OWF54353.1    GBBM01001733    JAC33685.1    GGLE01005858    MBY09984.1    GFPF01011726    MAA22872.1    GADI01001701    JAA72107.1    GEDV01004214    JAP84343.1    GACK01004611    JAA60423.1    GBBL01001446    JAC25874.1    GFWV01008876    MAA33605.1    GFJQ02007512    JAV99457.1    GEFH01003188    JAP65393.1    CP026262    AWP20257.1    CM004475    CM004474    OCT77504.1    OCT79525.1    AANG04003329    GFAC01001466    JAT97722.1    CR760533    BC088594    BC072730    KZ505646    PKU48820.1    MUZQ01000117    OWK57761.1    GBYX01200363    JAO79661.1    GBSH01002506    JAG66520.1    GDAY02002267    JAV49165.1    GAAZ01002311    JAA95632.1    JU175400    GBEX01003142    AFJ50924.1    JAI11418.1    GAEP01001490    GBEW01000949    JAB53331.1    JAI09416.1    GFFW01002361    JAV42427.1    KU871095    APD32937.1    AAKN02023477    AAKN02023478    KB030580    ELK14088.1    AQIA01018690    GABZ01006993    JAA46532.1    ACTA01012251    ACTA01020251    ADFV01011382    ADFV01011383    ADFV01011384    AQIB01033937    AQIB01033938    AQIB01033939    AQIB01033940    AQIB01033941    AQIB01033942    AQIB01033943    AQIB01033944    AHZZ02005103    AHZZ02005104    AHZZ02005105    CYRY02004269    VCW68787.1    AEYP01091144    AEYP01091145    AEYP01091146    AEYP01091147    NDHI03003415    PNJ59007.1   

Proteomes

UP000053240    UP000053268    UP000007151    UP000027135    UP000007266    UP000192223    + More
UP000269221    UP000075809    UP000008237    UP000002358    UP000015103    UP000005205    UP000053097    UP000279307    UP000235965    UP000001811    UP000233020    UP000054359    UP000233200    UP000015104    UP000242188    UP000246464    UP000186698    UP000002281    UP000011712    UP000085678    UP000008143    UP000197619    UP000001646    UP000189706    UP000081671    UP000005447    UP000233120    UP000233180    UP000010552    UP000233100    UP000008912    UP000001073    UP000029965    UP000007646    UP000245320    UP000265300    UP000028761    UP000002280    UP000248484    UP000245341    UP000233060    UP000248482    UP000286640    UP000002279    UP000079721    UP000000715    UP000233040    UP000233220    UP000248480    UP000245340    UP000248481    UP000252040    UP000286642   

PRIDE

Q5I085    Q6GQL2   

Pfam

PF16891   STPPase_N        + More
PF00149   Metallophos
PF13499   EF-hand_7
PF00657   Lipase_GDSL

Interpro

IPR006186   Ser/Thr-sp_prot-phosphatase        + More
IPR004843   Calcineurin-like_PHP_ApaH       
IPR031675   STPPase_N       
IPR029052   Metallo-depent_PP-like       
IPR002048   EF_hand_dom       
IPR011992   EF-hand-dom_pair       
IPR018247   EF_Hand_1_Ca_BS       
IPR036514   SGNH_hydro_sf       
IPR038885   PLB1       
IPR001087   GDSL       
IPR035547   Phospholipase_B       

SUPFAM

SSF47473   SSF47473       

Gene 3D

3.60.21.10     3.40.50.1110    

CDD

cd00051  EFh
cd01824  Phospholipase_B_like

ProteinModelPortal

A0A194RQB4   A0A2H1WFH0   A0A194PN42   A0A212EZH9   A0A2W1BHD6   A0A067RHV6   + More
A0A1B6H380   D2A1L2   A0A1B6LLR6   A0A1W4X671   A0A1B2M4Z2   E9IB51   A0A3M0KGY3   A0A0F8C489   A0A151WXC7   R4WDK9   E2C580   A0A0P4VMT2   K7INQ5   T1HE80   A0A158NB15   A0A026X1J8   A0A2J7RS99   A0A1B6EE98   A0A0A9X5V2   G1SEK1   A0A2K5CNF7   A0A224XJX0   A0A0V0G580   A0A087UKD3   A0A2K6QEJ2   A0A023FIW7   T1K2I3   A0A1B6DJX4   A0A210R013   A0A023GLJ1   A0A2R5LKD5   A0A224Z8Q5   A0A0K8RLZ2   A0A131YYT9   L7MB61   A0A023FWJ6   A0A293M3P6   A0A1Z5KWW7   A0A131XDT1   A0A2U9CUF0   A0A1L8G146   A0A3Q2HV97   A0A2I2V0N2   A0A1S3HZC0   A0A1E1XEM8   Q5I085   Q6GQL2   A0A2I0US19   A0A218UW58   A0A0S7KRU2   G1KIW6   A0A0B8RQ66   A0A1W7RDE9   T1E4U8   J3S0H7   U3FW09   A0A3Q0CW64   A0A250YFL0   A0A1J0N213   A0A1S3EYZ1   H0VAY6   A0A2K6C145   A0A2K6KHF2   L5KTG1   A0A2K5VEA0   K9IJA5   G1LET8   G1RZE5   A0A0D9RE27   G3SW90   A0A3Q2HEA5   A0A2U3V6V6   A0A340YHP4   A0A096P0A8   F7AJD1   A0A2Y9SAP0   A0A2K6QEJ4   A0A2U3YDE7   A0A2K5MSN5   A0A2Y9IEY6   A0A3Q7T4E9   F7BDA3   A0A1S2ZSM5   A0A3P4M0G5   M3Z2R4   A0A2K5RMM3   A0A2K6S1I8   A0A2Y9R8S4   A0A2J8VNA3   A0A2U3VJ48   A0A2Y9HP77   M3XDH6   A0A341A9E4   A0A3Q7U171  

PDB

1S70     E-value=0,     Score=1691

KEGG

101737641    K06269 serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] | (RefSeq) serine/th

PATHWAY

03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)

GO

GO:0004722   GO:0046872   GO:0000164   GO:0072357   GO:0005634   GO:0005737   GO:0004721   GO:0004620   GO:0016021   GO:0000784   GO:0005886   GO:0050115   GO:0042752   GO:0030155   GO:0005829   GO:0019901   GO:0051301   GO:0007049   GO:0032922   GO:0005977   GO:0043153   GO:0016787   GO:0008152   GO:0016491   GO:0016620   GO:0005839   GO:0051603   GO:0051028   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR21325  

Subcellular location

Cytoplasm  
Nucleus  

Length:

324

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00491999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01174

outside

1  -  324

 

 

Pi

220.682638

Theta

182.916556

Tajima's D

0.605235

CLR

0.030887

CSRT

0.543572821358932

Interpretation

Uncertain