Gene

KWMTBOMO10946  Validated by peptides from experiments

Annotation

PREDICTED:_probable_methylmalonate-semialdehyde_dehydrogenase_[acylating]?_mitochondrial_[Plutella_xylostella]

Location

Bomo_Chr18(-):7848683-7858112      View in EpiBrowser

Full name

Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial      

Location in the cell

Mitochondrial   Reliability : 3.296

CDS

ATGGCATCGGCGATCTTAAAGTTATTAAAATCTGAATCCCAGCTCGTACTGCGTCGCTCATATAGCAGCTCTGCTCCAACCACAAAGCTGTATATTGATGGACAATATGTAGATTCAAAAACTACCAATTGGATTGAGCTGACCAACCCAGCAACTAATGAAGTAATTGGCAGGGTGCCAGAGGCAACTCAGGATGAATTGACTTCCGCTTTGGATGCAGCCAAGAGGGCCTATAAGACATGGAGCAAAAGTACTGTTTTGACTCGTCAACAGCTAATGTTCAAATTTGCTCGGCTACTGAGAGAAAATCAGAGCAAATTGGCTGCTAAAATCACTGAAGAGCAAGGGAAAACTATAGCCGATGCTGAGGGCGATGTGCTTCGAGGAATTCAGTCAGTGGAGCATTGCTGTAGCATCACATCGCTTCAGCTCGGCGACAGCATCCAAAACATCGCCAAAGACATGGACACGCATAGCTACAAGGTGCCACTTGGAGTTGTTGGAGGTGTTGCAGCCTTCAATTTCCCGGTGATGATCCCACTGTGGATGTTCCCGCCAGCGCTGGTAACCGGAAACACGTGTATAATCAAGCCTTCTGAGCAGGATCCTGGAGCCACGCTCATGATGATGGAGCTCCTTCAGGAAGCCGGGGCTCCTCCGGGCGTTGTTAATATCATTCACGGGACACACGGTGCGGTGAACTTCATATGCGACCAGCCGGAGATCAAGGCCGTATCCTTCGTCGGTGGCGACGCCGCCGGAAAACACATCTACACTAGAGCTTCGGCTGCTGGCAAACGTGTCCAAAGCAACATGGGCGCCAAGAATCACGGGGTGATAATGCCGGACGCGAACAAGGAGCACACGCTCAACCAGCTCGCCGGCGCGGCCTTCGGAGCGGCCGGTCAACGGTGCATGGCGCTCAGCACTGCGGTCTTTGTCGGCAGTGCTAAGGAGTGGATCCCTGACCTGGTGAAGCGTGCGCAAGCTTTGAAGGTCAATGCGGGTCACGTGCCCGGCACCGACGTGGGGCCCGTCATCTCGGTAGCCGCCAAGGACAGAATCTTAAGGCTTGTGGAGTCAGGTGTAAAGGAAGGCGCTAAATTGGCTCTCGACGGTCGCGCGGTCAAAGTACCCGGATTCGAGAAAGGCAATTTCGTCGGGCCCACTATCATCACCGACGTGACGCCGAGCATGGAGTGTTACAAAGAGGAAATATTCGGGCCGGTTCTCGTCTGTCTGTTCGTTGAGACCCTCGACGAAGCGATTCAGATGATCAACTCAAACCCGTACGGGAATGGAACGGCTATTTTCACCACTAATGGTGCGACGGCTAGGAAGTTCTCCGCGGATATCGACGTCGGTCAAGTGGGCGTCAACGTGCCCATTCCCGTGCCGCTGTCGATGTTCTCGTTTTCGGGAACGCGCGGCAGTTTTCTGGGAACGAACCACTTCTGCGGGAAGCAGGGCCTCGACTTCTACACCGAACTGAAGACGGTCGTCTCGTTCTGGCGGGAGAGCGACGTGTCGCACGCGAAACCGGCCGTGTCTATGCCCACACAACAATAG

Protein

MASAILKLLKSESQLVLRRSYSSSAPTTKLYIDGQYVDSKTTNWIELTNPATNEVIGRVPEATQDELTSALDAAKRAYKTWSKSTVLTRQQLMFKFARLLRENQSKLAAKITEEQGKTIADAEGDVLRGIQSVEHCCSITSLQLGDSIQNIAKDMDTHSYKVPLGVVGGVAAFNFPVMIPLWMFPPALVTGNTCIIKPSEQDPGATLMMMELLQEAGAPPGVVNIIHGTHGAVNFICDQPEIKAVSFVGGDAAGKHIYTRASAAGKRVQSNMGAKNHGVIMPDANKEHTLNQLAGAAFGAAGQRCMALSTAVFVGSAKEWIPDLVKRAQALKVNAGHVPGTDVGPVISVAAKDRILRLVESGVKEGAKLALDGRAVKVPGFEKGNFVGPTIITDVTPSMECYKEEIFGPVLVCLFVETLDEAIQMINSNPYGNGTAIFTTNGATARKFSADIDVGQVGVNVPIPVPLSMFSFSGTRGSFLGTNHFCGKQGLDFYTELKTVVSFWRESDVSHAKPAVSMPTQQ

Description

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).

Catalytic Activity

2-methyl-3-oxopropanoate + CoA + H2O + NAD(+) = H(+) + hydrogencarbonate + NADH + propanoyl-CoA
3-oxopropanoate + CoA + NAD(+) = acetyl-CoA + CO2 + NADH
3-oxopropanoate + CoA + NADP(+) = acetyl-CoA + CO2 + NADPH

Subunit

Homotetramer.

Similarity

Belongs to the aldehyde dehydrogenase family.

Keywords

Complete proteome   Mitochondrion   NAD   Oxidoreductase   Reference proteome   Transit peptide   Alternative splicing  

Feature

chain  Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
splice variant  In isoform A.

Uniprot

A0A212FCD8   I4DMC8   A0A194PN47   A0A2W1BK47   A0A2A4J7U3   A0A194RRW7   + More
S4PKI2   U5EUW1   A0A182IRL8   A0A1L8E2I7   Q17M80   A0A023ETJ6   A0A182XHX7   A0A182VWR2   A0A182VA95   A0A182TG60   A0A084VAP2   A0A182LEZ0   A0A182HSV9   Q7QC84   A0A1L8E2S9   A0A182N4V4   A0A1I8PJ02   A0A182MJI7   A0A182YHL4   A0A182P982   A0A182JZ74   A0A2J7PG61   A0A1L8EFN7   A0A182RGX2   A0A182QWJ8   T1E867   A0A2M4BK89   T1P9M5   A0A182FSB4   A0A182SQR9   A0A0L0CHF9   A0A2M3YYR2   W5JA91   A0A2M4A0N5   A0A2M3ZFI7   A0A0M4EU10   A0A2M4A229   B0WSQ7   A0A1Q3FKZ1   A0A1W4V8D5   B4MAJ9   B3MSF3   B4I926   B3P971   B4PX02   A0A1L8EBR3   Q7KW39   I0B1N8   B4L668   B4R7E7   B4NCQ5   B4JM08   Q29HB2   A0A034WNG4   A0A224YTE8   A0A3B0KRJ4   A0A131YMU9   A0A0K8V8N8   A0A1J1HJY4   A0A067QPJ5   Q7KW39-2   A0A0A1X2P7   W8BE83   A0A336M0R0   B4GY04   A0A0N8EQ03   A0A0P5EQI7   A0A0P5VKV8   A0A0P5MF92   A0A0P4ZVA4   A0A1Z5KWX0   A0A0P5MNL3   A0A0P5AQT1   A0A0P4ZN91   A0A0P5PFK7   A0A0P5LBJ1   A0A0P5EKC6   A0A0P5E2J8   V5IF88   A0A0P5AHP3   A0A0P5M625   A0A0P5JA01   A0A0P5BFD6   A0A1A9W8R5   A0A0P5M2I5   A0A0P6E113   A0A0P4ZU12   T1IIJ5   E9GHJ1   A0A0P6A917   E0VIN4   A0A131Y2Q8   A0A0P4ZUH7   A0A1L8EAL5  

Pubmed

22118469    22651552    26354079    28756777    23622113    17510324    + More
24945155    26483478    24438588    20966253    12364791    25244985    25315136    26108605    20920257    23761445    17994087    17550304    10731132    12537572    10731137    15632085    25348373    28797301    26830274    24845553    25830018    24495485    28528879    25765539    21292972    20566863   

EMBL

AGBW02009208    OWR51377.1    AK402446    BAM19068.1    KQ459604    KPI92545.1    + More
KZ150127    PZC73100.1    NWSH01002487    PCG68197.1    KQ459765    KPJ20065.1    GAIX01004480    JAA88080.1    GANO01001278    JAB58593.1    GFDF01001134    JAV12950.1    CH477208    EAT47764.1    JXUM01034772    JXUM01034773    JXUM01092490    GAPW01000960    KQ563990    KQ561036    JAC12638.1    KXJ72967.1    KXJ79938.1    ATLV01004135    KE524190    KFB35036.1    APCN01000368    AAAB01008859    GFDF01001128    JAV12956.1    AXCM01001791    NEVH01025635    PNF15320.1    GFDG01001390    JAV17409.1    AXCN02000010    GAMD01003033    JAA98557.1    GGFJ01004326    MBW53467.1    KA644633    AFP59262.1    JRES01000394    KNC31681.1    GGFM01000649    MBW21400.1    ADMH02001952    ETN60333.1    GGFK01001046    MBW34367.1    GGFM01006512    MBW27263.1    CP012528    ALC48485.1    GGFK01001469    MBW34790.1    DS232075    EDS34016.1    GFDL01006798    JAV28247.1    CH940655    EDW66258.1    CH902622    EDV34708.1    CH480825    EDW43707.1    CH954183    EDV45367.2    CM000162    EDX00788.2    GFDG01002744    JAV16055.1    AE014298    AL009147    AY069284    AAF45510.2    CAA15632.1    BT133399    AFH55498.1    CH933812    EDW05864.1    CM000366    EDX16758.1    CH964239    EDW82614.1    CH916371    EDV91769.1    CH379064    EAL31846.1    GAKP01003055    JAC55897.1    GFPF01009710    MAA20856.1    OUUW01000019    SPP89269.1    GEDV01008797    JAP79760.1    GDHF01017354    JAI34960.1    CVRI01000006    CRK87858.1    KK853778    KDQ78911.1    GBXI01009267    JAD05025.1    GAMC01009603    JAB96952.1    UFQT01000386    SSX23814.1    CH479196    EDW27631.1    GDIQ01005244    JAN89493.1    GDIP01156503    JAJ66899.1    GDIP01113353    GDIP01043262    LRGB01002580    JAL90361.1    KZS06852.1    GDIQ01160416    JAK91309.1    GDIP01210935    JAJ12467.1    GFJQ02007410    JAV99559.1    GDIQ01176610    JAK75115.1    GDIP01195783    JAJ27619.1    GDIP01210936    JAJ12466.1    GDIQ01235199    GDIQ01129281    JAL22445.1    GDIQ01176609    JAK75116.1    GDIP01158588    JAJ64814.1    GDIP01147346    GDIP01147344    JAJ76058.1    GANP01008862    JAB75606.1    GDIP01199038    JAJ24364.1    GDIQ01184208    JAK67517.1    GDIQ01204903    JAK46822.1    GDIP01185435    JAJ37967.1    GDIQ01185954    JAK65771.1    GDIQ01081145    JAN13592.1    GDIP01208541    JAJ14861.1    JH430174    GL732545    EFX80854.1    GDIP01032597    JAM71118.1    DS235201    EEB13240.1    GEFM01003034    JAP72762.1    GDIP01208542    JAJ14860.1    GFDG01003137    JAV15662.1   

Proteomes

UP000007151    UP000053268    UP000218220    UP000053240    UP000075880    UP000008820    + More
UP000069940    UP000249989    UP000076407    UP000075920    UP000075903    UP000075902    UP000030765    UP000075882    UP000075840    UP000007062    UP000075884    UP000095300    UP000075883    UP000076408    UP000075885    UP000075881    UP000235965    UP000075900    UP000075886    UP000095301    UP000069272    UP000075901    UP000037069    UP000000673    UP000092553    UP000002320    UP000192221    UP000008792    UP000007801    UP000001292    UP000008711    UP000002282    UP000000803    UP000009192    UP000000304    UP000007798    UP000001070    UP000001819    UP000268350    UP000183832    UP000027135    UP000008744    UP000076858    UP000091820    UP000000305    UP000009046   

PRIDE

Q7KW39    I0B1N8    Q29HB2    V5IF88   

Pfam

PF00171   Aldedh        + More
PF03265   DNase_II
PF00462   Glutaredoxin
PF10367   Vps39_2
PF00780   CNH
PF10366   Vps39_1

Interpro

IPR016162   Ald_DH_N        + More
IPR015590   Aldehyde_DH_dom       
IPR016161   Ald_DH/histidinol_DH       
IPR010061   MeMal-semiAld_DH       
IPR016160   Ald_DH_CS_CYS       
IPR016163   Ald_DH_C       
IPR004947   DNase_II       
IPR002109   Glutaredoxin       
IPR033658   GRX_PICOT-like       
IPR004480   Monothiol_GRX-rel       
IPR036249   Thioredoxin-like_sf       
IPR001180   CNH_dom       
IPR032914   Vam6/VPS39/TRAP1       
IPR019453   VPS39/TGF_beta_rcpt-assoc_2       
IPR019452   VPS39/TGF_beta_rcpt-assoc_1       
IPR000547   Clathrin_H-chain/VPS_repeat       

SUPFAM

SSF53720   SSF53720        + More
SSF52833   SSF52833       

Gene 3D

3.40.309.10     3.40.605.10    

CDD

cd07085  ALDH_F6_MMSDH
cd03028  GRX_PICOT_like

ProteinModelPortal

A0A212FCD8   I4DMC8   A0A194PN47   A0A2W1BK47   A0A2A4J7U3   A0A194RRW7   + More
S4PKI2   U5EUW1   A0A182IRL8   A0A1L8E2I7   Q17M80   A0A023ETJ6   A0A182XHX7   A0A182VWR2   A0A182VA95   A0A182TG60   A0A084VAP2   A0A182LEZ0   A0A182HSV9   Q7QC84   A0A1L8E2S9   A0A182N4V4   A0A1I8PJ02   A0A182MJI7   A0A182YHL4   A0A182P982   A0A182JZ74   A0A2J7PG61   A0A1L8EFN7   A0A182RGX2   A0A182QWJ8   T1E867   A0A2M4BK89   T1P9M5   A0A182FSB4   A0A182SQR9   A0A0L0CHF9   A0A2M3YYR2   W5JA91   A0A2M4A0N5   A0A2M3ZFI7   A0A0M4EU10   A0A2M4A229   B0WSQ7   A0A1Q3FKZ1   A0A1W4V8D5   B4MAJ9   B3MSF3   B4I926   B3P971   B4PX02   A0A1L8EBR3   Q7KW39   I0B1N8   B4L668   B4R7E7   B4NCQ5   B4JM08   Q29HB2   A0A034WNG4   A0A224YTE8   A0A3B0KRJ4   A0A131YMU9   A0A0K8V8N8   A0A1J1HJY4   A0A067QPJ5   Q7KW39-2   A0A0A1X2P7   W8BE83   A0A336M0R0   B4GY04   A0A0N8EQ03   A0A0P5EQI7   A0A0P5VKV8   A0A0P5MF92   A0A0P4ZVA4   A0A1Z5KWX0   A0A0P5MNL3   A0A0P5AQT1   A0A0P4ZN91   A0A0P5PFK7   A0A0P5LBJ1   A0A0P5EKC6   A0A0P5E2J8   V5IF88   A0A0P5AHP3   A0A0P5M625   A0A0P5JA01   A0A0P5BFD6   A0A1A9W8R5   A0A0P5M2I5   A0A0P6E113   A0A0P4ZU12   T1IIJ5   E9GHJ1   A0A0P6A917   E0VIN4   A0A131Y2Q8   A0A0P4ZUH7   A0A1L8EAL5  

PDB

5TJR     E-value=2.16967e-118,     Score=1090

KEGG

101737113    K00140 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase

PATHWAY

00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
00410    beta-Alanine metabolism - Bombyx mori (domestic silkworm)
00562    Inositol phosphate metabolism - Bombyx mori (domestic silkworm)
00640    Propanoate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0004491   GO:0016021   GO:0004531   GO:0006573   GO:0018478   GO:0005739   GO:0019859   GO:0045454   GO:0009055   GO:0015035   GO:0005623   GO:0016192   GO:0006886   GO:0006574   GO:0006210   GO:0000062   GO:0006206   GO:0008152   GO:0016491   GO:0016620   GO:0005839   GO:0051603   GO:0051028   GO:0005622   GO:0006810   GO:0003824   GO:0055114  

PANTHER

PTHR43866   PTHR12894  

Subcellular location

Mitochondrion  

Length:

522

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

14.28517

Exp number, first 60 AAs:

0.00036

Total prob of N-in:

0.63159

outside

1  -  522

 

 

Pi

151.854746

Theta

160.65364

Tajima's D

0.191707

CLR

2.262863

CSRT

0.430728463576821

Interpretation

Uncertain