Gene

KWMTBOMO10945

Pre Gene Modal

BGIBMGA008338

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_uncharacterized_protein_LOC101746575_[Bombyx_mori]

Location

Bomo_Chr18(-):7839771-7847262      View in EpiBrowser

Full name

Deoxyribonuclease-2-alpha      

Alternative Name

Acid DNase
Deoxyribonuclease II alpha
Lysosomal DNase II
R31240_2

Location in the cell

Extracellular   Reliability : 1.372

CDS

ATGTCTCTTTTAAAATTGTTTTTGTTTGCATTTTTTATAAATGATTCCCTGTGTCTCACCCCGCAGTGCAGAAATGAGAAAGGGGAACCTATTGATTGGTTTTACGTATACAAATTACCGAGGGAACGTAATCACCTTAACCCTTTAGTGCGCAGAGGAGTCGCATATATGCATCTCACTCCATCTAAATTAAGAGGGGGTTGGATCATGTCGGATCTAGCTATCAGCGATCCTAGGTCCATGGTTGGCAGGACGCTGGCTCCTTTATATCAGGACAAAAACATCATATCGCTTGTATACAATGACCAGCCGCCAGCAACTGAGTACCAACCCGATATATTACAATCTGTCGCCGATATGTATTCAAAAAGCAAAAGAGGTCAAACGAAGCAATCAAACTTAAAAAAGTATAAAAAGTTCAAGCTCGGCGACAAATACTACGATGATTACGATCTTGCCGAAATGTGCAAGATGCATTCGAAATATATGAAGACGCGCGTCGAAAACGGTCATACAAAAGGAGTGATACTGGGGGACAAGTTCACGTCTCTTTGGCTGGTGCATTCTGTGCCTAGGTTCCCGCCGATACCTGATTTGATTCACGGCCTAAACGTGAGCGGCTACGATTACCCAACAACGGGAATGAAATACGGGCAGTCTTTTCTTTGTGTCTCCGTTCAAACGTCGACGCTGAACCAAATCGCCACACAGCTAAAATACAACGAACCCCTGATCGCCTATTACAGTTTACCGCAAGAGTTTGAAAGCGAACTACCGAATTTGGTCGACGTAGTCCACAATAAGACGATTGATGCTTCTCCGTGGTACCACATCGAAAGCTTCGAGACATTGGTCGGTCGTAAGTTCCTCTCGTTTGCGAAGAGCGCTATGTTCAACGATGACCTGTACAGTGGTCTGGTCGCGGAGGTCTTACAGTCCGATCTACTCGTCGAGTCCTGGACCAACGGGCCCGGGACTTTGGACTCGGAATGCACAAGGAACTTCCAGGTGAGGAACATTGAACGGATAAAGTTTCCGATAGCGAAAATGTCTTTTACGTCACACAATGATCATTCGAAGTGGGCAGTCGCCGTCGCTCACAAGATGCACAACAGTCAAGACACTAAAGTCGCCGACTATTGGGTCTGCGTCGGCGATATTAATAGAGCGTTGCCACAGGAATCTCGTGGAGGCGGCACCGTGTGCACTTCAGGACCGATACTATGGGGGAACTTCGCGCATTTAATTGACTCTGTACAAACTTGTAACTAA

Protein

MSLLKLFLFAFFINDSLCLTPQCRNEKGEPIDWFYVYKLPRERNHLNPLVRRGVAYMHLTPSKLRGGWIMSDLAISDPRSMVGRTLAPLYQDKNIISLVYNDQPPATEYQPDILQSVADMYSKSKRGQTKQSNLKKYKKFKLGDKYYDDYDLAEMCKMHSKYMKTRVENGHTKGVILGDKFTSLWLVHSVPRFPPIPDLIHGLNVSGYDYPTTGMKYGQSFLCVSVQTSTLNQIATQLKYNEPLIAYYSLPQEFESELPNLVDVVHNKTIDASPWYHIESFETLVGRKFLSFAKSAMFNDDLYSGLVAEVLQSDLLVESWTNGPGTLDSECTRNFQVRNIERIKFPIAKMSFTSHNDHSKWAVAVAHKMHNSQDTKVADYWVCVGDINRALPQESRGGGTVCTSGPILWGNFAHLIDSVQTCN

Catalytic Activity

Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.

Miscellaneous

Not required for the generation of the characteristic DNA fragmentation observed in apoptotic cells, but for the degradation of DNA from dying cells.

Similarity

Belongs to the DNase II family.

Keywords

Alternative splicing   Apoptosis   Complete proteome   Developmental protein   Disulfide bond   Endonuclease   Glycoprotein   Hydrolase   Lysosome   Nuclease   Polymorphism   Reference proteome   Signal  

Feature

chain  Deoxyribonuclease-2-alpha
splice variant  In isoform 2.
sequence variant  In dbSNP:rs36075196.

Uniprot

A0A2A4J8U9   A0A2W1BCY0   A0A3S2LH77   A0A212FCA5   A0A194PGM8   A0A2H1WHY2   + More
A0A1E1WAH4   A0A194RRW7   A0A2J7QXD5   N6UUX9   N6TMW8   T1EEA4   A0A1Y1KIE0   A0A1B6FE63   U4UDV6   U4UFT9   A0A0L7R5D3   A0A158NG69   A0A336M4X5   A0A151XAK4   A0A1B6LW25   A0A026W4Q6   A0A195E757   D2A075   A0A0N7ZD78   A0A091CPH8   A0A3Q7V4J8   A0A0A9X005   A0A384DSD3   G5BYW5   F7IAL5   H2NXQ1   A0A146L020   G3QLI8   A0A2R9AXV7   Q16M58   A0A154PPA5   A0A2I3GU79   A0A2K5WB63   A0A2K6D584   A0A3Q7RBB7   M3XZL3   M3VUU5   G7NLB9   W8BGC2   B3KQS9   A0A024R7F4   O00115   A0A2I3TWP9   A0A2K5KBL2   A0A0A0MWU5   A0A2K6P3L0   H0UUQ3   A0A3Q7NBD6   I7GHD7   G1TGM9   H9EXU4   A0A3B4CIB4   J9JHU4   A0A1Q3EV99   I7G926   A0A2Y9L9B1   F1PSR6   H3B5Z9   D2HG13   A0A2U3VUE3   G1M138   H0XYN2   A0A2K5N7U1   A0A1S4FWJ4   A0A034VJF3   A0A2K6A8M7   A0A2D4M3C3   A0A2U3XGK3   K7IRX6   A0A250YGE5   A0A2Y9IBG2   A0A0A1WFS8   G7PZJ0   E2A8P0   A0A182GC12   A0A232FCW1   A0A0K8UYV0   Q28DA6   V5H611   A0A1L8H2X6   A0A1B0DAG0   C0LQF2   A0A2K6FHZ1   R7USA3   A4IHV3   A0A1S3GNV5   V8PGW5   A0A091SL59   A0A1V4JZ81   A0A091N1Z4   L8YGU8  

EC Number

3.1.22.1

Pubmed

28756777    22118469    26354079    23537049    23254933    28004739    + More
21347285    24508170    30249741    18362917    19820115    25401762    24813606    21993625    26823975    22398555    22722832    17510324    17975172    22002653    24495485    16303743    11181995    9924608    9647784    9714827    9812984    9446563    14702039    15057824    15489334    11906178    12558498    12594037    12754519    19159218    24275569    25944712    16136131    25362486    21993624    17194215    25319552    16341006    9215903    20010809    25348373    20075255    28087693    25830018    20798317    26483478    28648823    27762356    20431018    24297900    23385571   

EMBL

NWSH01002487    PCG68196.1    KZ150127    PZC73099.1    RSAL01000123    RVE46629.1    + More
AGBW02009208    OWR51376.1    KQ459604    KPI92546.1    ODYU01008449    SOQ52074.1    GDQN01007088    JAT83966.1    KQ459765    KPJ20065.1    NEVH01009381    PNF33238.1    APGK01010999    APGK01011000    KB738366    ENN82637.1    APGK01029130    KB740724    ENN79373.1    AMQM01001368    KB097495    ESN96252.1    GEZM01082932    JAV61213.1    GECZ01021270    JAS48499.1    KB632278    ERL91237.1    ERL91238.1    KQ414654    KOC65971.1    ADTU01015035    UFQS01000166    UFQT01000166    SSX00688.1    SSX21068.1    KQ982339    KYQ57403.1    GEBQ01029072    GEBQ01012091    JAT10905.1    JAT27886.1    KK107487    QOIP01000006    EZA50029.1    RLU21664.1    KQ979568    KYN21023.1    KQ971338    EFA02962.2    GDRN01050141    JAI66488.1    KN125026    KFO19508.1    GBHO01033169    JAG10435.1    JH172486    GEBF01000035    EHB14476.1    JAO03598.1    ABGA01033317    ABGA01033318    NDHI03003638    PNJ13444.1    GDHC01017310    JAQ01319.1    CABD030111815    AJFE02048645    AJFE02048646    AJFE02048647    CH477879    EAT35413.1    KQ434998    KZC13284.1    ADFV01089303    AQIA01034404    AQIA01034405    AEYP01024428    AANG04004050    CM001271    EHH29692.1    GAMC01010592    JAB95963.1    AK075449    BAG52141.1    CH471106    EAW84322.1    AB008564    AF060222    AF045937    AF047016    AB004574    BT007047    AK297493    AK315358    AC020934    AD000092    BC010419    BC065209    AACZ04030658    GABC01009775    GABF01003763    GABD01003675    GABE01003281    NBAG03000278    JAA01563.1    JAA18382.1    JAA29425.1    JAA41458.1    PNI51174.1    AHZZ02013599    AAKN02038624    AB170800    BAE87863.1    JU323447    AFE67203.1    AAEX03012401    GFDL01015822    JAV19223.1    AB170812    BAE87875.1    AFYH01100535    AFYH01100536    GL192799    EFB28617.1    ACTA01017944    AAQR03140496    GAKP01016735    JAC42217.1    IACM01062722    IACM01062724    LAB27845.1    GFFW01002118    JAV42670.1    GBXI01016731    JAC97560.1    CM001294    EHH59260.1    GL437652    EFN70227.1    JXUM01053530    KQ561780    KXJ77565.1    NNAY01000421    OXU28515.1    GDHF01020548    JAI31766.1    CR855609    CAJ81448.1    GALX01000233    JAB68233.1    CM004470    OCT90457.1    AJVK01013292    FJ752529    ACN63522.1    AMQN01007301    AMQN01007302    KB300390    ELU06802.1    AAMC01089086    BC135708    AAI35709.1    AZIM01000122    ETE73206.1    KK477241    KFQ59377.1    LSYS01005497    OPJ77405.1    KK840336    KFP82962.1    KB358908    ELV14310.1   

Proteomes

UP000218220    UP000283053    UP000007151    UP000053268    UP000053240    UP000235965    + More
UP000019118    UP000015101    UP000030742    UP000053825    UP000005205    UP000075809    UP000053097    UP000279307    UP000078492    UP000007266    UP000028990    UP000286642    UP000261680    UP000291021    UP000006813    UP000008225    UP000001595    UP000001519    UP000240080    UP000008820    UP000076502    UP000001073    UP000233100    UP000233120    UP000286640    UP000000715    UP000011712    UP000005640    UP000002277    UP000233080    UP000028761    UP000233200    UP000005447    UP000286641    UP000001811    UP000261440    UP000002254    UP000248482    UP000008672    UP000245340    UP000008912    UP000005225    UP000233060    UP000233140    UP000245341    UP000002358    UP000248481    UP000009130    UP000000311    UP000069940    UP000249989    UP000215335    UP000186698    UP000092462    UP000233160    UP000014760    UP000008143    UP000081671    UP000190648    UP000011518   

PRIDE

B3KQS9    A0A024R7F4    O00115    J9JHU4    F1PSR6    C0LQF2    + More

Pfam

PF03265   DNase_II        + More
PF00171   Aldedh
PF05046   Img2

Interpro

IPR004947   DNase_II        + More
IPR016160   Ald_DH_CS_CYS       
IPR016163   Ald_DH_C       
IPR010061   MeMal-semiAld_DH       
IPR016161   Ald_DH/histidinol_DH       
IPR015590   Aldehyde_DH_dom       
IPR016162   Ald_DH_N       
IPR007740   Ribosomal_L49/IMG2       

SUPFAM

SSF53720   SSF53720       

Gene 3D

3.40.309.10     3.40.605.10    

CDD

cd07085  ALDH_F6_MMSDH

ProteinModelPortal

A0A2A4J8U9   A0A2W1BCY0   A0A3S2LH77   A0A212FCA5   A0A194PGM8   A0A2H1WHY2   + More
A0A1E1WAH4   A0A194RRW7   A0A2J7QXD5   N6UUX9   N6TMW8   T1EEA4   A0A1Y1KIE0   A0A1B6FE63   U4UDV6   U4UFT9   A0A0L7R5D3   A0A158NG69   A0A336M4X5   A0A151XAK4   A0A1B6LW25   A0A026W4Q6   A0A195E757   D2A075   A0A0N7ZD78   A0A091CPH8   A0A3Q7V4J8   A0A0A9X005   A0A384DSD3   G5BYW5   F7IAL5   H2NXQ1   A0A146L020   G3QLI8   A0A2R9AXV7   Q16M58   A0A154PPA5   A0A2I3GU79   A0A2K5WB63   A0A2K6D584   A0A3Q7RBB7   M3XZL3   M3VUU5   G7NLB9   W8BGC2   B3KQS9   A0A024R7F4   O00115   A0A2I3TWP9   A0A2K5KBL2   A0A0A0MWU5   A0A2K6P3L0   H0UUQ3   A0A3Q7NBD6   I7GHD7   G1TGM9   H9EXU4   A0A3B4CIB4   J9JHU4   A0A1Q3EV99   I7G926   A0A2Y9L9B1   F1PSR6   H3B5Z9   D2HG13   A0A2U3VUE3   G1M138   H0XYN2   A0A2K5N7U1   A0A1S4FWJ4   A0A034VJF3   A0A2K6A8M7   A0A2D4M3C3   A0A2U3XGK3   K7IRX6   A0A250YGE5   A0A2Y9IBG2   A0A0A1WFS8   G7PZJ0   E2A8P0   A0A182GC12   A0A232FCW1   A0A0K8UYV0   Q28DA6   V5H611   A0A1L8H2X6   A0A1B0DAG0   C0LQF2   A0A2K6FHZ1   R7USA3   A4IHV3   A0A1S3GNV5   V8PGW5   A0A091SL59   A0A1V4JZ81   A0A091N1Z4   L8YGU8  

PDB

5UNB     E-value=1.7404e-23,     Score=271

KEGG

101746575    K01158 deoxyribonuclease II [EC:3.1.22.1] | (RefSeq) uncharacterized LOC101746575

PATHWAY

04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0004531   GO:0016021   GO:0004491   GO:0006309   GO:0006412   GO:0003735   GO:0005840   GO:0050776   GO:0030218   GO:0000737   GO:0006259   GO:0070062   GO:0005764   GO:0003677   GO:0006810   GO:0051603   GO:0005839   GO:0051028   GO:0005622   GO:0003824  

PANTHER

PTHR10858   PTHR43866  

Subcellular location

Lysosome  

SignalP

Position:   1 - 18,         Likelihood:  0.881881

 

 

Length:

423

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01099

Exp number, first 60 AAs:

0.00095

Total prob of N-in:

0.00039

outside

1  -  423

 

 

Pi

181.15608

Theta

164.032076

Tajima's D

0.457566

CLR

0.420117

CSRT

0.504424778761062

Interpretation

Uncertain