Gene

KWMTBOMO10925

Annotation

PREDICTED:_methylenetetrahydrofolate_reductase_[Amyelois_transitella]

Location

Bomo_Chr18(-):7333627-7334972      View in EpiBrowser

Full name

Methylenetetrahydrofolate reductase      

Location in the cell

Cytoplasmic   Reliability : 1.938

CDS

ATGTCATCAGAAAGAAAGAAAATAACCGACTTAATAAACATTCCCGGTTTCACTTTCTCTTTCGAGTTAACTCCGAATATATGTGAAGATGAAATCAATGCTTTGGAGATGAGCCCTGTGTTTTTCTCCGTAACATGGCACGCGAAGGCTCACCAATGTAAAAATCTGGAAATCGATCCACTTCAAACTGTGCGTCTTCTCAAGAGTAAAGGAAAAAATGTTTTATTGCATTTAACATGTGATATGCTCAGAATGAGCTATTTGGACCAACTCTTGATATTTTTAAAAGAACAAGACATTTGTAATTTGTTCGTTATATTAGGAGACAATTACAACCCTGACACATCTGACTTCAAAAGCACTACAGAACTTATTAAGTACATTCGAGAGAAAACAGGGGATTACTTCTGCATAGGCATAGCTGGTTTTCCAGATTGTTCAGATGAAAAATTATTGCAATTGAAGCAAAAATTGGAAAATGGTGCTGACTTTATCGTTACTCAAGCGTTTTTCGAACCTGAAGTTCTAAAGAAATTCATCGAACAATGTGAAAATTGCGGTATTAAAGCTCCTATATTACCAGGAGTGTTTCTATTCGAAAACTATGATCAATTAGCAAAATTTCTAAATATGTGCAAAGGAAAAGTTTCTGATAATTTCGTTAATATTATAAAGAGTAAAGAGCAATCAGGGGCTCCCTGCAGTGAAGTAATCAAGAAAATGGTTCAAGATTTAAAAGAACAAATTAATATAAATCATTTCCATTTTTTTACTATGAACAAGATGCAAAGTGTTTGTAATTTGATTAAGCAATTAGGATGA

Protein

MSSERKKITDLINIPGFTFSFELTPNICEDEINALEMSPVFFSVTWHAKAHQCKNLEIDPLQTVRLLKSKGKNVLLHLTCDMLRMSYLDQLLIFLKEQDICNLFVILGDNYNPDTSDFKSTTELIKYIREKTGDYFCIGIAGFPDCSDEKLLQLKQKLENGADFIVTQAFFEPEVLKKFIEQCENCGIKAPILPGVFLFENYDQLAKFLNMCKGKVSDNFVNIIKSKEQSGAPCSEVIKKMVQDLKEQININHFHFFTMNKMQSVCNLIKQLG

Catalytic Activity

(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH

Cofactor

FAD

Similarity

Belongs to the methylenetetrahydrofolate reductase family.

Uniprot

A0A2A4JS11   A0A2W1BY62   A0A2H1WIX9   A0A212FC88   A0A1B6D4U1   A0A1X2GYQ0   + More
A0A3M8NU89   D3PDD9   A0A1R2CNI0   A0A0S4IQL6   A0A0D0YDP7   E6QYL4   W1Q8J0   A0A1B7SPC2   A0A1M8A7J1   A0A1R2CNL7   A0A1D2NAR3   A0A0D0U2U5   A0A1E4TAE8   A0A095C412   A0A0D0YLZ6   A0A0L6UF40   A0A3M2BS92   A0A1X2ID59   F0WFI8   A0A1C7NT58   A0A024GR41   A0A1Y2I0I9   E3KZT2   A0A163J4B7   A0A0C9MHV1   A0A2N5TJ88   A0A1X7UHX6   A0A0D0UAI2   A0A381YJN5   A0A195FBA4   S9WEM6   S2J0V7   A0A168PSA8   A0A3M1X6U7   G7E669   A0A0D6EIJ6   A0A382EYT7   M5E942   A0A1G1P7H9   B3S098   A0A1H6FFJ7   I1CGQ8   A0A180G623   A0A1C7NCB8   A0A369RSN5   A0A194S994   A0A357KNB1   A0A0C4F8N8   A0A226BPH5   A0A2S4UZR6   A0A225ZZ47   J9VMK3   S7ZD18   A0A367IS79   Q5KN82   F5HHA5   A0A2G5B6Z1   A0A1Q5T8D3   A0A099NZC4   A0A058Z2L4   A0A1V2LHJ3   A0A2U9R2H8   A0A1Y3AKT6   A0A078ABA5   A0A2J7QG57   A0A091E8U9   A0A1Y1XWP5   A0A151X708   A0A0J9X2J3   A0A1X1QNN8   A0A1X1QIY8   A0A1Y1VWB6   A0A2J7QG60   A0A1Y5EVU5   A0A1X0NM13   A0A0L0V4U4   A0A0J6FF77   E9DEV7   C5PJM0   A0A0F7TFY8   A0A1S9RKA1   A0A3D3L0R3   C5K575   A0A0J6YI68   J3K515   A0A1B9HUA7   A0A168HIF7   A0A0L0V3W1   A0A1X2HD73   A0A2E7NGZ8   H6C648   G4TRD0  

EC Number

1.5.1.20

Pubmed

28756777    22118469    20189949    21304167    24279325    27535936    + More
27289101    21750662    21536894    23560078    21478649    27774985    18719581    19578406    30042472    26441909    30148503    24743168    23383313    29674435    15653466    25977457    25159171    28385833    28652349    19717792    20516208    29337314    24496724    28348446    22022265   

EMBL

NWSH01000789    PCG74192.1    KZ149920    PZC77760.1    ODYU01008976    SOQ53025.1    + More
AGBW02009208    OWR51359.1    GEDC01016576    JAS20722.1    MCGT01000001    ORX63211.1    RHFJ01000032    RNE92688.1    AP011529    BAI80612.1    MPUH01000215    MPUH01000100    OMJ86148.1    OMJ90572.1    CYKH01000465    CUF96765.1    KN848684    KIR79390.1    CP000286    ADV19914.1    AEOI02000010    ESW96367.1    AECK01000001    OBA18329.1    LT671824    SHO78381.1    OMJ90556.1    LJIJ01000123    ODN02155.1    KN847898    KIR42518.1    KV453843    ODV88732.1    KQ410559    KGB75332.1    KN848873    KIR83834.1    LAVV01012739    KNZ46380.1    RFGN01000247    RMH18781.1    MCGE01000016    ORZ13542.1    FR824128    CCA19970.1    LUGH01000001    OBZ91906.1    CAIX01000267    CCI49003.1    MCFL01000005    ORZ39493.1    DS178326    EFP89813.2    LT551507    SAL97083.1    DF836315    GAN02672.1    PGCI01000529    PLW25562.1    KN847990    KIR45258.1    UINC01018398    SVA77244.1    KQ981693    KYN37661.1    ATMH01001816    EPY34155.1    KE124062    EPB83701.1    AMYB01000001    OAD08145.1    RFHC01000043    RMG60873.1    BABT02000150    GAA98329.1    CENE01000004    CEQ39701.1    UINC01046738    SVB55133.1    HE999557    CCU99140.1    MHGR01000029    OGX37801.1    DS985246    EDV24348.1    FMSV02000549    SEH08413.1    CH476741    EIE87638.1    ADAS02000253    OAV87909.1    LUGH01000319    OBZ86216.1    NOWV01000311    RDD36813.1    KQ474077    KPV75966.1    DOIT01000150    HBS26377.1    ADAS01011344    AMKP01000002    OWZ80938.1    PKSL01000137    POW02743.1    AMKX01000042    OWZ59666.1    CP003820    AFR92890.1    KB644410    EPS28159.1    PJQM01005984    RCH80479.1    AE017341    AAW41236.1    AAEY01000005    EAL22953.1    KZ303513    PIA14778.1    MNBE01000698    OKO96448.1    JQFK01000026    KGK37955.1    KB932208    KCV68470.1    MQVM01000045    NHMM01000006    ONH71012.1    OUT21069.1    CP028774    AWU75515.1    MUJZ01072353    OTF69069.1    CCKQ01006752    CDW78068.1    NEVH01014835    PNF27577.1    KN122257    KFO31606.1    MCFE01000396    ORX90153.1    KQ982472    KYQ56114.1    CCBN010000001    CDO51209.1    LWTL01000119    ORU92716.1    LWTM01000077    ORU91059.1    MCFE01001138    ORX65503.1    PNF27574.1    MAAP01000101    OUR87464.1    NBCO01000034    ORC85568.1    AJIL01000126    KNE93974.1    DS268111    KMM68978.1    GL636502    EFW15168.1    ACFW01000052    EER22919.1    CDHK01000001    CEJ53898.1    LJBN01000158    OOQ85972.1    DPYO01000056    HCN24239.1    GG670562    EER20497.1    DS028096    KMP06603.1    GG704913    EAS29456.3    KI894015    OCF46857.1    AMYB01000009    OAC98825.1    KNE93975.1    MCGN01000005    ORY96741.1    PBQH01000063    MBO08423.1    JH226135    EHY59194.1    CAFZ01000259    CCA73873.1   

Proteomes

UP000218220    UP000007151    UP000242146    UP000274052    UP000001520    UP000054272    + More
UP000007805    UP000008673    UP000078553    UP000186303    UP000094527    UP000053392    UP000029445    UP000054399    UP000037035    UP000267695    UP000193560    UP000093000    UP000053237    UP000193411    UP000008783    UP000078561    UP000053815    UP000235392    UP000007879    UP000053819    UP000078541    UP000014254    UP000077051    UP000273354    UP000009131    UP000009022    UP000236724    UP000009138    UP000005240    UP000253843    UP000053890    UP000198234    UP000239156    UP000198225    UP000010091    UP000019376    UP000253551    UP000002149    UP000001435    UP000242474    UP000186955    UP000029867    UP000030693    UP000189274    UP000195871    UP000249293    UP000235965    UP000028990    UP000193498    UP000075809    UP000242525    UP000193616    UP000193416    UP000192257    UP000054564    UP000054567    UP000002497    UP000009084    UP000042958    UP000190744    UP000054565    UP000001261    UP000094020    UP000242180    UP000007304    UP000007148   

Pfam

PF02219   MTHFR        + More
PF04194   PDCD2_C

Interpro

IPR003171   Mehydrof_redctse        + More
IPR029041   FAD-linked_oxidoreductase-like       
IPR004621   Fadh2_euk       
IPR004620   MTHF_reductase_bac       
IPR007320   PDCD2_C       

SUPFAM

SSF51730   SSF51730       

CDD

cd00537  MTHFR

ProteinModelPortal

A0A2A4JS11   A0A2W1BY62   A0A2H1WIX9   A0A212FC88   A0A1B6D4U1   A0A1X2GYQ0   + More
A0A3M8NU89   D3PDD9   A0A1R2CNI0   A0A0S4IQL6   A0A0D0YDP7   E6QYL4   W1Q8J0   A0A1B7SPC2   A0A1M8A7J1   A0A1R2CNL7   A0A1D2NAR3   A0A0D0U2U5   A0A1E4TAE8   A0A095C412   A0A0D0YLZ6   A0A0L6UF40   A0A3M2BS92   A0A1X2ID59   F0WFI8   A0A1C7NT58   A0A024GR41   A0A1Y2I0I9   E3KZT2   A0A163J4B7   A0A0C9MHV1   A0A2N5TJ88   A0A1X7UHX6   A0A0D0UAI2   A0A381YJN5   A0A195FBA4   S9WEM6   S2J0V7   A0A168PSA8   A0A3M1X6U7   G7E669   A0A0D6EIJ6   A0A382EYT7   M5E942   A0A1G1P7H9   B3S098   A0A1H6FFJ7   I1CGQ8   A0A180G623   A0A1C7NCB8   A0A369RSN5   A0A194S994   A0A357KNB1   A0A0C4F8N8   A0A226BPH5   A0A2S4UZR6   A0A225ZZ47   J9VMK3   S7ZD18   A0A367IS79   Q5KN82   F5HHA5   A0A2G5B6Z1   A0A1Q5T8D3   A0A099NZC4   A0A058Z2L4   A0A1V2LHJ3   A0A2U9R2H8   A0A1Y3AKT6   A0A078ABA5   A0A2J7QG57   A0A091E8U9   A0A1Y1XWP5   A0A151X708   A0A0J9X2J3   A0A1X1QNN8   A0A1X1QIY8   A0A1Y1VWB6   A0A2J7QG60   A0A1Y5EVU5   A0A1X0NM13   A0A0L0V4U4   A0A0J6FF77   E9DEV7   C5PJM0   A0A0F7TFY8   A0A1S9RKA1   A0A3D3L0R3   C5K575   A0A0J6YI68   J3K515   A0A1B9HUA7   A0A168HIF7   A0A0L0V3W1   A0A1X2HD73   A0A2E7NGZ8   H6C648   G4TRD0  

PDB

6FCX     E-value=1.18279e-24,     Score=279

KEGG

101735471    K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] | (RefSeq) methylenetetrahydrofolat

PATHWAY

00670    One carbon pool by folate - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0035999   GO:0006555   GO:0004489   GO:0005829   GO:0009086   GO:0008652   GO:0006730   GO:0071949   GO:0005737   GO:0005488   GO:0004298   GO:0005839   GO:0051603   GO:0051028   GO:0005622   GO:0006810   GO:0003824   GO:0055114  

Length:

273

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02455

Exp number, first 60 AAs:

0.00189

Total prob of N-in:

0.15199

outside

1  -  273

 

 

Pi

151.379119

Theta

198.491802

Tajima's D

-0.591167

CLR

124.117215

CSRT

0.216389180540973

Interpretation

Uncertain