Gene

KWMTBOMO10916

Annotation

proteasome_alpha_3_subunit_[Bombyx_mori]

Location

Bomo_Chr18(-):6670512-6677473      View in EpiBrowser

Full name

Proteasome subunit alpha type       + More
Proteasome endopeptidase complex      

Location in the cell

Cytoplasmic   Reliability : 2.652

CDS

ATGAGTTCTATCGGAACTGGCTATGACCTATCGGCTTCTCAATTTTCTCCTGATGGTCGCGTTTTCCAAGTGGAATATGCTGCAAAGGCTGTAGAAAATTCTGGAACAGTAATTGGCCTCCGAGGAAAAGACGGAGTGGTATTTGCTGTTGAGAAGTTAATCACATCCAAACTGTATGAACCTGGCGCAAACAAGAGGATATTCCATATTGATGAACATGTTGGCATGGCTGTCGCAGGGCTCATATCAGATGCAAGACAAATTGTCGAGACTGCTCGTTCAGAGGCATCAAACTACAGATCTCAGTATGGCAGTCCAGTACCACTGAAGTATTTAAATGAACGAGTTTCAATGTACATGCACGCATACACACTATACAGCGCTGTTCGGCCATATGGTTGCTCAGTCGTTATGGGCACATGGACAGACTATGAAGGCCCTCAGATGTATATGCTAGATCCCAGTGGTGTATCTTTTTCATATTTTGGTTGCGCAGTCGGAAAAGCCAAACAGGCAGCAAAAACAGAGATAGAAAAGCTAAAACTTGGAGACCTCACAGTGAAGGAGCTTGTGAGAGAAGCCGCTAGAATTATCTATCTTGTACATGATGAACTAAAAGATAAGCAGTTTGAGCTGGAGTTGTCTTGGGTTTCGAAAGACACGAAGGGTCGCCATGAGCTGGTTCCGCGTGAGCTCGCCACCGAAGCAGAGAACCAAGCTAAACAGGCTCTTGCTGATATTGAAGATTCAGATGAAGGAGAGATGTGA

Protein

MSSIGTGYDLSASQFSPDGRVFQVEYAAKAVENSGTVIGLRGKDGVVFAVEKLITSKLYEPGANKRIFHIDEHVGMAVAGLISDARQIVETARSEASNYRSQYGSPVPLKYLNERVSMYMHAYTLYSAVRPYGCSVVMGTWTDYEGPQMYMLDPSGVSFSYFGCAVGKAKQAAKTEIEKLKLGDLTVKELVREAARIIYLVHDELKDKQFELELSWVSKDTKGRHELVPRELATEAENQAKQALADIEDSDEGEM

Description

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.

Catalytic Activity

Cleavage of peptide bonds with very broad specificity.

Subunit

The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

Similarity

Belongs to the peptidase T1A family.
Belongs to the G-protein coupled receptor 1 family.
Belongs to the UDP-glycosyltransferase family.

Uniprot

Q1HQ44   A0A2A4J8C2   A0A2W1BDQ7   A0A194PN82   A0A212F8U7   A0A1E1WGR6   + More
B2DBN8   S4PH61   A0A3S2L319   A0A0C9R691   A0A0N0BDS2   A0A2J7PWA0   A0A026W2X3   A0A158NGJ8   A0A151X1S9   E2BR97   A0A0T6B429   A0A0J7K1E1   E2ATL4   A0A1B6D194   A0A1W4WUU2   A0A023F9V8   A0A195DQJ6   A0A088AP06   E9IDY9   A0A195BXW8   A0A195EU44   A0A1Y1LYZ7   A0A1B1ZGH4   A0A212EQU0   A0A0P4VKU2   R4FNC4   A0A224XVW1   A0A0V0G5Y8   A0A1B6GTG8   A0A0A9YLA3   E9FYX7   A0A1B6MGG5   A0A2A3EQM0   D1ZZB6   A0A0P5IS80   A0A2P6K993   A0A0P5G3L5   A0A0P6CJV5   A0A0P5MPD7   A0A0P6CN59   A0A131Y0L0   B7PNN1   A0A0P5MR06   A0A0P5JUZ7   A0A0P5P768   A0A0P6G188   G9C5F2   T1JNT1   A0A0P6GJZ9   A0A023GGX0   A0A087SV27   G3MMG5   A0A0N8C7X5   A0A2R5LGB9   A0A0K8RKM3   A0A224YG46   A0A131YRB9   A0A131XMU9   A0A0P5N1M6   L7M7U4   A0A1Z5LBV0   A0A023FUV1   A0A3S4QKJ2   A0A226EQY9   A0A1E1X9Y7   A0A0L7QPU0   A0A293LHL9   A0A3R7SYE8   C3Y0B8   I1TLI5   C1BF68   B5XGI9   A0A0P4XYR5   A0A1W5AW99   A0A3B4DGN1   A0A2B4SGP9   W5MSR8   W5JYN0   A0A315W1F9   C1BLU4   I3JYD3   H2M390   A0A3P9LLQ8   J3JYN3   A0A2I0UFE9   E3TC48   A0A0P4VNE7   A0A194AM89   A0A3Q2CLV2   A0A3B3DWF1   A0A3P8VWA8   A0A060WGZ9   B5X5D8   A0A3S2NRP4  

EC Number

3.4.25.1

Pubmed

28756777    26354079    22118469    18712529    23622113    24508170    + More
30249741    21347285    20798317    25474469    21282665    28004739    27464714    27129103    25401762    26823975    21292972    18362917    19820115    21835214    22216098    28797301    26830274    28049606    25576852    28528879    28503490    18563158    22361323    24755649    20433749    25329095    29703783    25186727    17554307    22516182    20634964    29451363    24487278   

EMBL

DQ443208    ABF51297.1    NWSH01002643    PCG67774.1    KZ150315    PZC71447.1    + More
KQ459604    KPI92575.1    AGBW02009667    OWR50164.1    GDQN01004861    JAT86193.1    AB264723    BAG30797.1    GAIX01003382    JAA89178.1    RSAL01000198    RVE44527.1    GBYB01002261    JAG72028.1    KQ435859    KOX70598.1    NEVH01020936    PNF20606.1    KK107519    QOIP01000009    EZA49384.1    RLU18567.1    ADTU01001608    KQ982585    KYQ54363.1    GL449936    EFN81786.1    LJIG01015966    KRT82017.1    LBMM01016914    KMQ84268.1    GL442629    EFN63210.1    GEDC01017854    JAS19444.1    GBBI01000928    JAC17784.1    KQ980612    KYN15097.1    GL762556    EFZ21167.1    KQ976398    KYM92788.1    KQ981979    KYN31399.1    GEZM01045074    JAV77938.1    KU756280    ANX99823.1    AGBW02013211    OWR43863.1    GDKW01000877    JAI55718.1    ACPB03021727    GAHY01000623    JAA76887.1    GFTR01004183    JAW12243.1    GECL01003415    JAP02709.1    GECZ01004041    JAS65728.1    GBHO01011208    GBRD01013401    GDHC01014255    JAG32396.1    JAG52425.1    JAQ04374.1    GL732527    EFX87695.1    GEBQ01004964    JAT35013.1    KZ288193    PBC34007.1    KQ971338    EFA02345.1    GDIQ01210422    GDIQ01123550    LRGB01001151    JAK41303.1    KZS13437.1    MWRG01019710    PRD22879.1    GDIQ01246748    JAK04977.1    GDIQ01090163    JAN04574.1    GDIQ01155389    JAK96336.1    GDIQ01090162    JAN04575.1    GEFM01003791    JAP72005.1    ABJB010267734    DS753779    EEC08203.1    GDIQ01152589    JAK99136.1    GDIQ01194726    JAK56999.1    GDIQ01137001    JAL14725.1    GDIQ01040034    JAN54703.1    HQ851393    AEV89771.1    AFFK01014262    GDIQ01042682    JAN52055.1    GBBM01002201    JAC33217.1    KK112090    KFM56716.1    JO843066    AEO34683.1    GDIQ01106059    JAL45667.1    GGLE01004339    MBY08465.1    GADI01002173    JAA71635.1    GFPF01005500    MAA16646.1    GEDV01006753    JAP81804.1    GEFH01001700    JAP66881.1    GDIQ01152590    JAK99135.1    GACK01005806    JAA59228.1    GFJQ02002098    JAW04872.1    GBBL01001714    JAC25606.1    NCKU01005401    RWS04622.1    LNIX01000002    OXA60042.1    GFAC01003120    JAT96068.1    KQ414804    KOC60652.1    GFWV01008258    MAA32987.1    QCYY01001002    ROT81221.1    GG666478    EEN66191.1    JF834155    AFE88208.1    BT073247    FR904415    ACO07671.1    CDQ62692.1    BT050158    BT058648    BT060362    ACI69959.1    ACN10361.1    ACN12722.1    GDIP01235000    JAI88401.1    LSMT01000098    PFX27672.1    AHAT01003872    NHOQ01000541    PWA29759.1    BT075573    ACO09997.1    AERX01040125    AERX01040126    BT128362    AEE63320.1    KZ505805    PKU44768.1    GU587927    ADO27884.1    GDRN01112096    JAI56733.1    GELH01000598    GELH01000597    JAS03675.1    FR904536    CDQ66256.1    BT046257    ACI66058.1    CM012458    RVE57648.1   

Proteomes

UP000218220    UP000053268    UP000007151    UP000283053    UP000053105    UP000235965    + More
UP000053097    UP000279307    UP000005205    UP000075809    UP000008237    UP000036403    UP000000311    UP000192223    UP000078492    UP000005203    UP000078540    UP000078541    UP000015103    UP000000305    UP000242457    UP000007266    UP000076858    UP000001555    UP000054359    UP000285301    UP000198287    UP000053825    UP000283509    UP000001554    UP000193380    UP000087266    UP000192224    UP000261440    UP000225706    UP000018468    UP000018467    UP000005207    UP000001038    UP000265180    UP000265200    UP000265020    UP000261560    UP000265120   

PRIDE

Q1HQ44    A0A088AP06    B7PNN1    G3MMG5    L7M7U4   

Pfam

PF10584   Proteasome_A_N        + More
PF00227   Proteasome
PF00201   UDPGT
PF00001   7tm_1

Interpro

IPR023332   Proteasome_alpha-type        + More
IPR029055   Ntn_hydrolases_N       
IPR000426   Proteasome_asu_N       
IPR037555   Proteasome_alpha_3       
IPR001353   Proteasome_sua/b       
IPR017452   GPCR_Rhodpsn_7TM       
IPR039186   Opsin_invertebrate       
IPR000276   GPCR_Rhodpsn       
IPR002213   UDP_glucos_trans       
IPR035595   UDP_glycos_trans_CS       

SUPFAM

SSF56235   SSF56235       

Gene 3D

3.60.20.10    

CDD

cd14969  7tmA_Opsins_type2_animals

ProteinModelPortal

Q1HQ44   A0A2A4J8C2   A0A2W1BDQ7   A0A194PN82   A0A212F8U7   A0A1E1WGR6   + More
B2DBN8   S4PH61   A0A3S2L319   A0A0C9R691   A0A0N0BDS2   A0A2J7PWA0   A0A026W2X3   A0A158NGJ8   A0A151X1S9   E2BR97   A0A0T6B429   A0A0J7K1E1   E2ATL4   A0A1B6D194   A0A1W4WUU2   A0A023F9V8   A0A195DQJ6   A0A088AP06   E9IDY9   A0A195BXW8   A0A195EU44   A0A1Y1LYZ7   A0A1B1ZGH4   A0A212EQU0   A0A0P4VKU2   R4FNC4   A0A224XVW1   A0A0V0G5Y8   A0A1B6GTG8   A0A0A9YLA3   E9FYX7   A0A1B6MGG5   A0A2A3EQM0   D1ZZB6   A0A0P5IS80   A0A2P6K993   A0A0P5G3L5   A0A0P6CJV5   A0A0P5MPD7   A0A0P6CN59   A0A131Y0L0   B7PNN1   A0A0P5MR06   A0A0P5JUZ7   A0A0P5P768   A0A0P6G188   G9C5F2   T1JNT1   A0A0P6GJZ9   A0A023GGX0   A0A087SV27   G3MMG5   A0A0N8C7X5   A0A2R5LGB9   A0A0K8RKM3   A0A224YG46   A0A131YRB9   A0A131XMU9   A0A0P5N1M6   L7M7U4   A0A1Z5LBV0   A0A023FUV1   A0A3S4QKJ2   A0A226EQY9   A0A1E1X9Y7   A0A0L7QPU0   A0A293LHL9   A0A3R7SYE8   C3Y0B8   I1TLI5   C1BF68   B5XGI9   A0A0P4XYR5   A0A1W5AW99   A0A3B4DGN1   A0A2B4SGP9   W5MSR8   W5JYN0   A0A315W1F9   C1BLU4   I3JYD3   H2M390   A0A3P9LLQ8   J3JYN3   A0A2I0UFE9   E3TC48   A0A0P4VNE7   A0A194AM89   A0A3Q2CLV2   A0A3B3DWF1   A0A3P8VWA8   A0A060WGZ9   B5X5D8   A0A3S2NRP4  

PDB

3UNH     E-value=2.687e-97,     Score=905

KEGG

732922    K02727 20S proteasome subunit alpha 7 [EC:3.4.25.1] | (RefSeq) proteasome alpha 3 subunit

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0019773   GO:0006511   GO:0004298   GO:0005737   GO:0005634   GO:0043161   GO:0005839   GO:0010499   GO:0010498   GO:0045202   GO:0004175   GO:0016758   GO:0016021   GO:0004930   GO:0051603   GO:0051028   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR11599:SF10  

Subcellular location

Cytoplasm  
Nucleus  

Length:

255

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.20305

Exp number, first 60 AAs:

7e-05

Total prob of N-in:

0.02642

outside

1  -  255

 

 

Pi

242.341785

Theta

152.36064

Tajima's D

2.633676

CLR

0.885815

CSRT

0.955602219889006

Interpretation

Uncertain