Gene

KWMTBOMO10909

Pre Gene Modal

BGIBMGA008484

Annotation

putative_inositol_1?3?4-triphosphate_5/6_kinase_[Danaus_plexippus]

Location

Bomo_Chr18(+):6381441-6387971      View in EpiBrowser

Full name

Inositol-tetrakisphosphate 1-kinase      

Location in the cell

Cytoplasmic   Reliability : 1.34 Nuclear   Reliability : 1.008 PlasmaMembrane   Reliability : 1.618

CDS

ATGGAAAGTAACTCGTTTAATGAAACGATCGGTATATGGATATCCGACAAAAAGAGCCAAAAACTTAATTGGAAAGAATTAATTAATACATGCGCTGCGTTTAACTATAATGTTGTCAAGTTGGATTTAGATCAATCTTTAGATGACCAAGCACGAATAGACGTGTTCCTTCACAAACTCACTGATATTATAGCAGCTGCTGATCAAGGGGATCCAAAAGCATCGATAATAATCAACCGAGTGGAACAGTTTTTATCAAATCATCCAGAAATCGTTGTCATCGATCCCTTAGAAAGTGTCAGGATTTTACTGAATAGAAATTGTTACTATTCGATACTCCAGGATGAAACGTCTTTCTCAAACCAAGGGATATTCACACCTAATTTTGCAGAGTTCACGTATAATGTAATAGAAAGGAATATTGAAATAATGAAACAGAGAGGCGTCACATTTCCATTAGTTTGCAAACCTACATTAGCGCACGGTTCGAAGTCTGCACATGAAATGGTAATAATATTTAATGAAAAGGATCTTGGTGCTTGCAAACCGCCATGTGTTGTGCAAAGTTTTGTGAACCACAATGCTGTCCTCCATAAAGTATTTTTAGTAGGAGATCGATACCACATCTGTGAGCGGCCAAGCATTAAAAATTTTACATCATCCGAAAATTTGGATCCAATATATTACAGTACCGGGGAGGTCATCAATTGGATATTTAAAGCTGGTAGGCGTACGAAGTGCTATCCCCATAACATAACCACATATATTGTCTACAGATTTTGA

Protein

MESNSFNETIGIWISDKKSQKLNWKELINTCAAFNYNVVKLDLDQSLDDQARIDVFLHKLTDIIAAADQGDPKASIIINRVEQFLSNHPEIVVIDPLESVRILLNRNCYYSILQDETSFSNQGIFTPNFAEFTYNVIERNIEIMKQRGVTFPLVCKPTLAHGSKSAHEMVIIFNEKDLGACKPPCVVQSFVNHNAVLHKVFLVGDRYHICERPSIKNFTSSENLDPIYYSTGEVINWIFKAGRRTKCYPHNITTYIVYRF

Description

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.

Catalytic Activity

1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)

Cofactor

Mg(2+)

Subunit

Monomer.

Similarity

Belongs to the ITPK1 family.

Feature

chain  Inositol-tetrakisphosphate 1-kinase

Uniprot

H9JG37   A0A2W1BPU4   A0A2H1VBL6   A0A212F8P9   A0A1E1WJ36   A0A194QME8   + More
A0A194PGR7   A0A2J7PEI4   A0A2J7PEI6   D2A1U2   T1HI46   A0A1W4W6D3   A0A2S2Q6A0   A0A023F3E0   A0A2J7PSR2   A0A0P4VNS0   A0A2H8THT3   A0A069DSJ4   A0A1B6MHQ6   A0A2R7W2S8   A0A067QWY4   A0A1B6G3F3   J9JK17   A0A1B6HI43   A0A1B6HVI2   E1ZWB4   A0A1Y1L2D3   A0A1Y1L2P2   F4WX36   A0A154PJ25   A0A158NCI3   A0A0A9Y7G0   A0A195BXD4   A0A195ELL6   A0A0K8SQ66   A0A195FAD1   E2BBW2   A0A3L8DHQ0   A0A026X179   N6TRB2   J3JU34   A0A151X0F6   A0A151IQT5   A0A2J7PEI7   H2T0A5   A0A088AAM3   H3DJ06   A0A3P8UHF1   K7J9R5   A0A3Q0T5G9   A0A0S7GTR7   A0A3Q3X045   A0A3Q1AZJ1   A0A3B5ADP3   A0A1A8N7L4   A0A1A8N2H6   A0A1A8E7R8   A0A1A8A1T3   A0A3B3HPP4   A0A3P9M0E3   A0A3Q1JFK6   A0A1A8H7Q9   I3KW72   A0A0T6B184   A0A3Q1JMA6   A0A0S7GTU5   A0A3Q4GM20   A0A2I4BN11   A0A3P8UHD7   A0A3Q1JFN4   A0A0F8C6R1   A0A2I4BMX4   A0A3B4X019   A0A3B4T6Q8   A0A3B3D4P3   A0A3Q3DN98   G3NZR8   A0A2I4BMW6   A0A3Q3GB12   A0A3Q3JDI0   A0A1B6CW31   A0A3Q3L3Z6   A0A3B4T6I8   A0A3B4X000   A0A0S7GWK4   A0A3P8QSY7   A0A3P9BLT3   A0A1V4KAX8   A0A1U7SLW0   A0A0L7QP61   A0A3B3YY89   A0A3B4H9I9   A0A3Q3A6S8   A0A0S7GTP6   A0A1D5NV90   A0A226ESF8   A0A3B4A6T4   M4AGL1   A0A3P9PIG6   G1KI84  

EC Number

2.7.1.134

Pubmed

19121390    28756777    22118469    26354079    18362917    19820115    + More
25474469    27129103    26334808    24845553    20798317    28004739    21719571    21347285    25401762    26823975    30249741    24508170    23537049    22516182    21551351    15496914    24487278    20075255    17554307    25186727    25835551    29451363    15592404    25463417    23542700   

EMBL

BABH01001884    BABH01001885    BABH01001886    KZ149999    PZC75337.1    ODYU01001676    + More
SOQ38229.1    AGBW02009692    OWR50107.1    GDQN01004035    JAT87019.1    KQ461196    KPJ06534.1    KQ459604    KPI92581.1    NEVH01026094    PNF14750.1    PNF14751.1    KQ971338    EFA02124.1    ACPB03008780    GGMS01003927    MBY73130.1    GBBI01002899    JAC15813.1    NEVH01021924    PNF19372.1    GDKW01000258    JAI56337.1    GFXV01001775    MBW13580.1    GBGD01001831    JAC87058.1    GEBQ01004524    JAT35453.1    KK854263    PTY13899.1    KK853150    KDR10607.1    GECZ01012799    JAS56970.1    ABLF02020150    ABLF02020152    GECU01036116    GECU01033374    JAS71590.1    JAS74332.1    GECU01029071    GECU01022143    JAS78635.1    JAS85563.1    GL434791    EFN74518.1    GEZM01066507    JAV67843.1    GEZM01066506    JAV67844.1    GL888417    EGI61279.1    KQ434908    KZC11308.1    ADTU01011907    ADTU01011908    GBHO01018119    GDHC01015325    JAG25485.1    JAQ03304.1    KQ976396    KYM92955.1    KQ978691    KYN29170.1    GBRD01010874    JAG54950.1    KQ981727    KYN37004.1    GL447175    EFN86786.1    QOIP01000008    RLU19722.1    KK107034    EZA62042.1    APGK01057768    APGK01057769    APGK01057770    KB741281    ENN70861.1    BT126746    AEE61708.1    KQ982614    KYQ53834.1    KQ976759    KYN08554.1    PNF14753.1    AAZX01001623    AAZX01014080    GBYX01448959    JAO32524.1    HAEH01000416    HAEI01006639    SBR64847.1    HAEF01003131    HAEG01000111    SBR63315.1    HADZ01006128    HAEA01012664    SBQ41144.1    HADY01010607    HAEJ01011662    SBP49092.1    HAEC01012034    SBQ80251.1    AERX01030261    AERX01030262    LJIG01016261    KRT81132.1    GBYX01448949    JAO32534.1    KQ042668    KKF12127.1    GEDC01019608    JAS17690.1    GBYX01448960    JAO32523.1    LSYS01003973    OPJ81544.1    KQ414843    KOC60339.1    GBYX01448950    JAO32533.1    AADN04000016    LNIX01000002    OXA60542.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000053268    UP000235965    UP000007266    + More
UP000015103    UP000192223    UP000027135    UP000007819    UP000000311    UP000007755    UP000076502    UP000005205    UP000078540    UP000078492    UP000078541    UP000008237    UP000279307    UP000053097    UP000019118    UP000075809    UP000078542    UP000005226    UP000005203    UP000007303    UP000265120    UP000002358    UP000261340    UP000261620    UP000257160    UP000261400    UP000001038    UP000265180    UP000265200    UP000265040    UP000005207    UP000261580    UP000192220    UP000261360    UP000261420    UP000261560    UP000264820    UP000007635    UP000261660    UP000261600    UP000261640    UP000265100    UP000265160    UP000190648    UP000189705    UP000053825    UP000261480    UP000261460    UP000264800    UP000000539    UP000198287    UP000261520    UP000002852    UP000242638    UP000001646   

PRIDE

H9JG37   

Pfam

PF17927   Ins134_P3_kin_N        + More
PF05770   Ins134_P3_kin

Interpro

IPR040464   InsP(3)kin_ATP-grasp        + More
IPR041429   ITPK1_N       
IPR008656   Inositol_tetrakis-P_1-kinase       
IPR011761   ATP-grasp       

ProteinModelPortal

H9JG37   A0A2W1BPU4   A0A2H1VBL6   A0A212F8P9   A0A1E1WJ36   A0A194QME8   + More
A0A194PGR7   A0A2J7PEI4   A0A2J7PEI6   D2A1U2   T1HI46   A0A1W4W6D3   A0A2S2Q6A0   A0A023F3E0   A0A2J7PSR2   A0A0P4VNS0   A0A2H8THT3   A0A069DSJ4   A0A1B6MHQ6   A0A2R7W2S8   A0A067QWY4   A0A1B6G3F3   J9JK17   A0A1B6HI43   A0A1B6HVI2   E1ZWB4   A0A1Y1L2D3   A0A1Y1L2P2   F4WX36   A0A154PJ25   A0A158NCI3   A0A0A9Y7G0   A0A195BXD4   A0A195ELL6   A0A0K8SQ66   A0A195FAD1   E2BBW2   A0A3L8DHQ0   A0A026X179   N6TRB2   J3JU34   A0A151X0F6   A0A151IQT5   A0A2J7PEI7   H2T0A5   A0A088AAM3   H3DJ06   A0A3P8UHF1   K7J9R5   A0A3Q0T5G9   A0A0S7GTR7   A0A3Q3X045   A0A3Q1AZJ1   A0A3B5ADP3   A0A1A8N7L4   A0A1A8N2H6   A0A1A8E7R8   A0A1A8A1T3   A0A3B3HPP4   A0A3P9M0E3   A0A3Q1JFK6   A0A1A8H7Q9   I3KW72   A0A0T6B184   A0A3Q1JMA6   A0A0S7GTU5   A0A3Q4GM20   A0A2I4BN11   A0A3P8UHD7   A0A3Q1JFN4   A0A0F8C6R1   A0A2I4BMX4   A0A3B4X019   A0A3B4T6Q8   A0A3B3D4P3   A0A3Q3DN98   G3NZR8   A0A2I4BMW6   A0A3Q3GB12   A0A3Q3JDI0   A0A1B6CW31   A0A3Q3L3Z6   A0A3B4T6I8   A0A3B4X000   A0A0S7GWK4   A0A3P8QSY7   A0A3P9BLT3   A0A1V4KAX8   A0A1U7SLW0   A0A0L7QP61   A0A3B3YY89   A0A3B4H9I9   A0A3Q3A6S8   A0A0S7GTP6   A0A1D5NV90   A0A226ESF8   A0A3B4A6T4   M4AGL1   A0A3P9PIG6   G1KI84  

PDB

2QB5     E-value=2.81446e-51,     Score=508

KEGG

101744563    K00913 inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase [EC:2.7.1.159 2

PATHWAY

00562    Inositol phosphate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
04070    Phosphatidylinositol signaling system - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0052725   GO:0052726   GO:0047325   GO:0032957   GO:0000287   GO:0052746   GO:0005737   GO:0046872   GO:0000825   GO:0016324   GO:0070266   GO:0021915   GO:0005622   GO:0005515   GO:0051028   GO:0006810   GO:0003824  

PANTHER

PTHR14217  

Length:

260

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00292

Exp number, first 60 AAs:

0.00037

Total prob of N-in:

0.04946

outside

1  -  260

 

 

Pi

39.262336

Theta

15.010874

Tajima's D

-1.680709

CLR

17.208155

CSRT

0.0364481775911204

Interpretation

Uncertain