Gene

KWMTBOMO10895

Pre Gene Modal

BGIBMGA008348

Annotation

Niemann-Pick_C1_protein_[Papilio_machaon]

Location

Bomo_Chr18(-):6177928-6181660      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 4.804

CDS

ATGGAAGCTGTAAGTCATGTACAAGGTCTTCATGGGGAGGAAGCCGAACAAGCGATTGGAATTTTAGCCAACCGATGTCCTCATATGGTTTACGATGATGAAGGTAATATTAAACCATACGAAGAAATACTGACCTGCTGTGAGCCGATTCAAGTCATGAAGCTTTCGAGCGATTTAGCGTTGGGCGAAGGCGTTCTAGGCCGCTGTCCCACTTGCTTCAGAAACTTTGTAAGACAAATTTGCGAGATGTACTGCTCCCCTGACCAGTCTCGATTTGTGGAAGTTCATACAGAAATTGGCCCCAACAACATTGAGTATGTGGAAGCGGTTGACTACAGACTTCACGAGCCATTTATGCTGACAGCCTTCGAATCTTGCTCTGATGTTATCGTTCCTCAGACCGGTCTTCCAGCTGTTAACATGATGTGTGGCAGTGCAGTTGTATGCGATGCAGACGCGTGGTTCAAATTTACTGGCGACACTGCAGGCAACCCCATGGCACCACTTCAAATAAACTTTCAGAGATGGCCGACAGAAGAGGATTCAATGAATGTAGTTGCACTACCATGTACCGAAACTATGGAAGGTGATCTTCCGTGCAGTTGTGTTGATTGCAGTGCAATGTGTCCGGTAGGAAATAACGTTACCTATGGACCTGCATTTAGAATTGAAGCATTGCGAGAATTAGTACATCTAGAAAATAAAATCAAAAATATTGGTCGAGAACAAAGAGGTGTAACTTTAGAGGAAGTTTGCTATGCGCCTATTAGGTCCAGAGGAGCAAAGAAAGAATTAGATCAATGTGTTTATTTATCTGCATCCGTTTATTTAGGTGAAAATAGAAACGATATCGATGAAAACACTTATCTTGACGACATACAAAGCTGTTTGAACAACTTTTTTTCCTTTGACTGCTTGGCAAATTGGGGAGGAGGTGCGGAACCTGAGGCAGTTTTCGGAGGCTTTGAAGGTGATGATGTCTTGAGCGCTAATACATTGATCATTAATTTTCCTATTACCAATTTTAATTTAGAAGAAAACCTCCGTCCTGTTTTGGAATGGGAAGAGAAATTCATTGAACTTATGCAAAACTATGAAGCTTCCGGTAAATCAGATTATGTCGAAGTGGCTTTTGGAGCCGAAAGATCAATCGAAGACGAAATCAGGAGAGTTTCAGTAGCAGAAGCTGTACCGATCGCTATTAGTTATTTAATAATGTTTATTTATGTGACGTTGGCTCTAGGAAACATTAGATACTGTAGGACATGGCTCATTGATAGTAAAATATTGGTTGCTATAGGTAGTATTGTTGTTGTTGTTATCTCTATTATTTGTGCCATGGGTGTCATGGGTTATGCGAATTTCACAACTACTCTATTAGCAATAAATGTGATTCCGTTCTTCATACTTTCAGTAGGCATAGATAACGTATTCCTTATGATCAATACGTTACACGATATACAAAGTAATGTTAAAGAATACGAGGACTATGATGAGTCTTTTAGTTTTGAGAAAAAAAAGAGATTTATTTTCGAAAAAATGATGGGCAGTGTTGGCCCCTCAATGTTTGTGTCTTCTGTAACGCAAATCACCTGTTTCGCAATTGGTAGTATCACTGATGTTCCAGCGGTGGCAACATTTTCTGTATTTGCTAGCTTATCTTTGACTTTTCTTTTTATATTTCAGATAACAGCAGTTGTCGGTATACTATCATTAGACTACAAAAGAGTCGCTCAAAAACGTGTCGATATTTTTCCTTGCATTCGTAGTAAAATTTCAATGGATAGCGATCACGATCCTCCACACGTCAGTATAATGAATAGATTTATGATATTGTATTCTGATATAATTACGAATTGGAAAGTAAGAATTGTTGTTGTAATTTTCTTTATGATCATTTTATCTCTGAGTATTATTGCGGTTCCACATTTAGAAGTAGGCTTAGACCAAGAAATGGCTTTACCGACTGACTCATACGTATATAGATATTTAGTTGCTGTCAGTGAACTATTGCGTCTCGGCCCACCAGTTTATTTTGTATTAAAAGCTGGTTTAGACTTTACTAATCCGGATCACCAAAACGTTATTTGCGGAACCCAGCTGTGTTACGAAGATTCATTAATTACACAAATATTTCTAGCTGCTCAGCACAGTGAAATAACCTATATAGCAAGAAGCTCAAATTCTTGGCTGGATGACTTCTTTGATTGGTCCAGCTTACCCGGGACTTGTTGTAAATATAACGTTACCGATAATGGGTTTTGTCAAACTTTAGATACTTCTCCAGAGTGCGCCTATTGTTCGATAAGCAGGAATGAATGGTCTAACGGCCTCAGACCCAGTAAAGAGGCGTTCGAAACATTTTTACCTTTTTTCCTACAAGACGAACCAAGCCAAGTCTGCACTAAGGGAGGGTTGGCAAGTTACTCAAGCAGTGTTAATTATTTACTTGATTCTGAAGGTCGTGCCATTGTCCATGATACGAATTTTATGGCATATCAAACGGCGCTGAGCAGGTCGCCAGACTTCATCAATGCTGTGAAATATGGTTATGAGATTAGTGATAACATCACTGCCGCTATCCGGAAGCACACAGGTATGGATGTTGAAGTTTTTCCTTATTCCGTGTTTTACGTGTTTTTTGAGCAATACCTGAATATTTGGTCGGACACGTTTGCAGCGTTAGGTTTTTCAGTTTTGGGTGCTTTAGCAATAAACCTGTTAGCGTCTGGGTTTAACTTTTTGACGAGTTTCGCTGTTATATTGACTGCTGTCATGGTCGTGATCGATATGATGGGCGTAATGTATATTTGGAATATACCGCTCAATCCAGTGTCTTGCATTAATCTTATCGTGTCTATTGGTATATCGGTTGAATTTTGTAGTCATATTGCATACGCTTATGCGACAAGTCGTCGTCCAGACCACGAGAGAGTGAAAGATGCAATACAAAAAGTCGGCTCCACTGTTATTACTGGAATTACATTTACGAACATACCAATTGTAGTTTTAGCATTTTCTCACACTGAAGTTATAGAAGTGTTCTTCTTTAGGATGTTTTTTAGTCTGATAATACTAGGGTTCTTGCATGGGTTGGTGTTTTTCCCTGCTCTGCTGTTATTCCTCAATAATATAAAAACGAGATCGTTTTAA

Protein

MEAVSHVQGLHGEEAEQAIGILANRCPHMVYDDEGNIKPYEEILTCCEPIQVMKLSSDLALGEGVLGRCPTCFRNFVRQICEMYCSPDQSRFVEVHTEIGPNNIEYVEAVDYRLHEPFMLTAFESCSDVIVPQTGLPAVNMMCGSAVVCDADAWFKFTGDTAGNPMAPLQINFQRWPTEEDSMNVVALPCTETMEGDLPCSCVDCSAMCPVGNNVTYGPAFRIEALRELVHLENKIKNIGREQRGVTLEEVCYAPIRSRGAKKELDQCVYLSASVYLGENRNDIDENTYLDDIQSCLNNFFSFDCLANWGGGAEPEAVFGGFEGDDVLSANTLIINFPITNFNLEENLRPVLEWEEKFIELMQNYEASGKSDYVEVAFGAERSIEDEIRRVSVAEAVPIAISYLIMFIYVTLALGNIRYCRTWLIDSKILVAIGSIVVVVISIICAMGVMGYANFTTTLLAINVIPFFILSVGIDNVFLMINTLHDIQSNVKEYEDYDESFSFEKKKRFIFEKMMGSVGPSMFVSSVTQITCFAIGSITDVPAVATFSVFASLSLTFLFIFQITAVVGILSLDYKRVAQKRVDIFPCIRSKISMDSDHDPPHVSIMNRFMILYSDIITNWKVRIVVVIFFMIILSLSIIAVPHLEVGLDQEMALPTDSYVYRYLVAVSELLRLGPPVYFVLKAGLDFTNPDHQNVICGTQLCYEDSLITQIFLAAQHSEITYIARSSNSWLDDFFDWSSLPGTCCKYNVTDNGFCQTLDTSPECAYCSISRNEWSNGLRPSKEAFETFLPFFLQDEPSQVCTKGGLASYSSSVNYLLDSEGRAIVHDTNFMAYQTALSRSPDFINAVKYGYEISDNITAAIRKHTGMDVEVFPYSVFYVFFEQYLNIWSDTFAALGFSVLGALAINLLASGFNFLTSFAVILTAVMVVIDMMGVMYIWNIPLNPVSCINLIVSIGISVEFCSHIAYAYATSRRPDHERVKDAIQKVGSTVITGITFTNIPIVVLAFSHTEVIEVFFFRMFFSLIILGFLHGLVFFPALLLFLNNIKTRSF

Uniprot

H9JFQ1   A0A194QLW8   A0A194PNA1   A0A2W1BRF3   A0A2A4K8N4   A0A0L7L4U8   + More
A0A1E1WQJ6   A0A2H1X3B1   A0A385NIS6   A0A2Z5U732   A0A212EN21   A0A0K8V6W5   A0A0K8WJE9   A0A0K8VI49   A0A0K8W2V5   A0A0A1WH39   A0A0A1WIT2   W8AQJ5   W8B0I9   A0A1A9UD14   A0A1B0AH79   A0A1I8M5Y1   A0A1A9Y128   A0A1B0FEI5   A0A1B0C3R6   V5GT10   V5GP54   A0A1B0C696   A0A336MXX7   A0A1A9WHG4   U4UCF2   N6TS49   B4KJH6   A0A232F5K7   D2CG00   A0A139WDV5   A0A182RV52   A0A0A9XLA8   A0A0P8Y4I3   B3MPM8   A0A182LVL1   A0A0A1XIU0   A0A182W4Q6   A0A1B0CML6   A0A182QGM2   B4L379   A0A1S4FMJ9   Q16VL3   A0A034WI75   A0A182Y7H1   A0A0K8UN34   A0A0L0C295   A0A0N0BJK7   A0A182FJQ6   A0A084VJF0   A0A1L8DK46   A0A1L8DXZ7   A0A1L8DJW6   A0A1I8PCF8   A0A1L8DK92   U5EYU3   A0A0K8S3E0   A0A0K8SKT4   N6UHN8   A0A0K8S3D6   A0A0K8S4S7   A0A146LVZ5   N6UEG8   A0A0A9Z5I2   A0A1I8PCD8   A0A1I8PC77   A0A0A9X1U0   A0A146KUJ8   A0A154PRE1   B4M8H0   A0A139WDS2   T1H800   A0A182IA55   B4H144   A0A069DY01   A0A1I8MBW9   A0A151WFS6   Q7PS03   A0A182V5U4   A0A195D7R0   A0A182NDR6   A0A151I7K5   A0A151JN89   A0A1I8MBW8   A0A182JGB1   A0A067RJQ3   A0A1I8MBX0   A0A0C9QGJ1   A0A0C9PN45   A0A026WQF9   A0A182SKJ1   A0A3B0KEF7   V9IBI8   A0A224X9R7   V9I9A8  

Pubmed

19121390    26354079    28756777    26227816    22118469    25830018    + More
24495485    25315136    23537049    17994087    28648823    18362917    19820115    25401762    18057021    17510324    25348373    25244985    26108605    24438588    26823975    26334808    12364791    24845553    24508170   

EMBL

BABH01001863    BABH01001864    BABH01001865    BABH01001866    KQ461196    KPJ06548.1    + More
KQ459604    KPI92595.1    KZ149999    PZC75350.1    NWSH01000044    PCG80278.1    JTDY01002944    KOB70440.1    GDQN01001810    JAT89244.1    ODYU01013065    SOQ59732.1    MG492013    AYA73999.1    AP017483    BBB06736.1    AGBW02013764    OWR42857.1    GDHF01020819    GDHF01017640    JAI31495.1    JAI34674.1    GDHF01012848    GDHF01001051    JAI39466.1    JAI51263.1    GDHF01013777    JAI38537.1    GDHF01006925    JAI45389.1    GBXI01016090    GBXI01000437    JAC98201.1    JAD13855.1    GBXI01015530    JAC98761.1    GAMC01019808    GAMC01019807    GAMC01019806    JAB86748.1    GAMC01019805    GAMC01019804    GAMC01019803    JAB86751.1    CCAG010014196    JXJN01025092    GALX01005083    JAB63383.1    GALX01005084    JAB63382.1    JXJN01026512    UFQT01001474    SSX30718.1    KB632196    ERL89983.1    APGK01056781    KB741277    ENN71121.1    CH933807    EDW13556.2    NNAY01000911    OXU25955.1    KQ971357    EFA11848.2    KYB26045.1    GBHO01022097    JAG21507.1    CH902620    KPU73871.1    EDV32276.1    KPU73872.1    KPU73873.1    KPU73874.1    KPU73875.1    AXCM01005583    GBXI01003430    JAD10862.1    AJWK01018887    AJWK01018888    AJWK01018889    AJWK01018890    AXCN02001386    CH933810    EDW07007.2    CH477589    EAT38583.1    GAKP01005112    JAC53840.1    GDHF01024313    JAI28001.1    JRES01000984    KNC26440.1    KQ435713    KOX79311.1    ATLV01013553    KE524867    KFB38094.1    GFDF01007339    JAV06745.1    GFDF01002747    JAV11337.1    GFDF01007331    JAV06753.1    GFDF01007330    JAV06754.1    GANO01001810    JAB58061.1    GBRD01018084    JAG47743.1    GBRD01011903    JAG53921.1    APGK01025710    APGK01025711    KB740600    ENN80121.1    GBRD01018089    GBRD01011904    JAG47738.1    GBRD01018087    GBRD01018083    JAG47740.1    GDHC01007404    JAQ11225.1    ENN80120.1    GBHO01030844    GBHO01030842    GBHO01030841    GBHO01006534    GBRD01018090    GBRD01018086    JAG12760.1    JAG12762.1    JAG12763.1    JAG37070.1    JAG47737.1    GBHO01030846    GBHO01030845    GBHO01001040    GBHO01001039    GBRD01018085    GBRD01011902    JAG12758.1    JAG12759.1    JAG42564.1    JAG42565.1    JAG47742.1    GDHC01019802    JAP98826.1    KQ435078    KZC14443.1    CH940654    EDW57496.1    KYB26017.1    ACPB03008313    ACPB03008314    APCN01001124    CH479201    EDW29960.1    GBGD01000124    JAC88765.1    KQ983206    KYQ46679.1    AAAB01008846    EAA06340.6    KQ976760    KYN08494.1    KQ978411    KYM94111.1    KQ978858    KYN27920.1    KK852428    KDR24042.1    GBYB01002584    JAG72351.1    GBYB01002583    JAG72350.1    KK107128    EZA58282.1    OUUW01000011    SPP86700.1    JR037260    AEY57664.1    GFTR01008772    JAW07654.1    JR037261    AEY57665.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000037510    UP000007151    + More
UP000078200    UP000092445    UP000095301    UP000092443    UP000092444    UP000092460    UP000091820    UP000030742    UP000019118    UP000009192    UP000215335    UP000007266    UP000075900    UP000007801    UP000075883    UP000075920    UP000092461    UP000075886    UP000008820    UP000076408    UP000037069    UP000053105    UP000069272    UP000030765    UP000095300    UP000076502    UP000008792    UP000015103    UP000075840    UP000008744    UP000075809    UP000007062    UP000075903    UP000078542    UP000075884    UP000078492    UP000075880    UP000027135    UP000053097    UP000075901    UP000268350   

PRIDE

H9JFQ1   

Pfam

PF16414   NPC1_N        + More
PF02460   Patched
PF12349   Sterol-sensing

Interpro

IPR032190   NPC1_N        + More
IPR003392   Ptc/Disp       
IPR000731   SSD       
IPR004765   NPC1-like       

ProteinModelPortal

H9JFQ1   A0A194QLW8   A0A194PNA1   A0A2W1BRF3   A0A2A4K8N4   A0A0L7L4U8   + More
A0A1E1WQJ6   A0A2H1X3B1   A0A385NIS6   A0A2Z5U732   A0A212EN21   A0A0K8V6W5   A0A0K8WJE9   A0A0K8VI49   A0A0K8W2V5   A0A0A1WH39   A0A0A1WIT2   W8AQJ5   W8B0I9   A0A1A9UD14   A0A1B0AH79   A0A1I8M5Y1   A0A1A9Y128   A0A1B0FEI5   A0A1B0C3R6   V5GT10   V5GP54   A0A1B0C696   A0A336MXX7   A0A1A9WHG4   U4UCF2   N6TS49   B4KJH6   A0A232F5K7   D2CG00   A0A139WDV5   A0A182RV52   A0A0A9XLA8   A0A0P8Y4I3   B3MPM8   A0A182LVL1   A0A0A1XIU0   A0A182W4Q6   A0A1B0CML6   A0A182QGM2   B4L379   A0A1S4FMJ9   Q16VL3   A0A034WI75   A0A182Y7H1   A0A0K8UN34   A0A0L0C295   A0A0N0BJK7   A0A182FJQ6   A0A084VJF0   A0A1L8DK46   A0A1L8DXZ7   A0A1L8DJW6   A0A1I8PCF8   A0A1L8DK92   U5EYU3   A0A0K8S3E0   A0A0K8SKT4   N6UHN8   A0A0K8S3D6   A0A0K8S4S7   A0A146LVZ5   N6UEG8   A0A0A9Z5I2   A0A1I8PCD8   A0A1I8PC77   A0A0A9X1U0   A0A146KUJ8   A0A154PRE1   B4M8H0   A0A139WDS2   T1H800   A0A182IA55   B4H144   A0A069DY01   A0A1I8MBW9   A0A151WFS6   Q7PS03   A0A182V5U4   A0A195D7R0   A0A182NDR6   A0A151I7K5   A0A151JN89   A0A1I8MBW8   A0A182JGB1   A0A067RJQ3   A0A1I8MBX0   A0A0C9QGJ1   A0A0C9PN45   A0A026WQF9   A0A182SKJ1   A0A3B0KEF7   V9IBI8   A0A224X9R7   V9I9A8  

PDB

5U74     E-value=2.38185e-150,     Score=1369

KEGG

NA   

GO

GO:0016021   GO:0005319   GO:0045456   GO:0007291   GO:0032374   GO:0016125   GO:0007591   GO:0007391   GO:0007417   GO:0030299   GO:0007422   GO:0006508   GO:0043565   GO:0003676   GO:0005515   GO:0051028   GO:0005622   GO:0006810   GO:0003824  

Length:

1050

Number of predicted TMHs:

11

Exp number of AAs in TMHs:

253.89171

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00034

outside

1  -  395

TMhelix

396  -  418

inside

419  -  429

TMhelix

430  -  452

outside

453  -  456

TMhelix

457  -  479

inside

480  -  516

TMhelix

517  -  539

outside

540  -  548

TMhelix

549  -  571

inside

572  -  621

TMhelix

622  -  644

outside

645  -  886

TMhelix

887  -  909

inside

910  -  915

TMhelix

916  -  938

outside

939  -  947

TMhelix

948  -  970

inside

971  -  982

TMhelix

983  -  1005

outside

1006  -  1019

TMhelix

1020  -  1042

inside

1043  -  1050

 

 

Pi

254.698024

Theta

206.234463

Tajima's D

0.738129

CLR

0.023356

CSRT

0.589320533973301

Interpretation

Uncertain