SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO10894
Pre Gene Modal
BGIBMGA008348
Annotation
PREDICTED:_Niemann-Pick_C1_protein-like_[Papilio_polytes]
Full name
NPC intracellular cholesterol transporter 1 homolog 1b       + More
NPC intracellular cholesterol transporter 1      
Alternative Name
Niemann-Pick type protein homolog 1b
Niemann-Pick C1 protein
Location in the cell
PlasmaMembrane   Reliability : 4.863
 

Sequence

CDS
ATGAATTTTTTTATAACGCTCGTTCTTGTGTTTTTGTATACAAGCGATGTGAAGGCGAAATGTCGATTTCGCGGTGAGTGCATTGAAATAGCAGGCCATGCAAAACCTTGCCCTGTGGATATTGAAGCAAGACCTGTCGTAGAAGGACTGTCGCCAGCAGATGCCGAAGAAATCGTTGACATTTTAACTGAAAGATGTCCTAGTCTTGTTTTCGATGAAAATGGTGATAAGAAGCCATTCAATGAAATCTTAACTTGCTGTGAACCCGTCCAAATCAGGAAGCTATCGGAGAGCTTAATGTTGGCCGATGGTATCCTGGGCCGTTGTCCAACATGCTTAAGAAATTTCGCCAGACAAATTTGTGAGATGAACTGTTCTCCTGATCAATCTCGTTTCGTTGATGTCTACACTGAAGTATCAGGAGGTGTCCGATATGTGAACGAAATCGATTATAGACTTTATGAACCGTTTATGTTGGGAGCTCACGCATCGTGTGCCGGCGTTATAATTCCACAAACGGGCTTACCAGCAATTAACATGATGTGTGGCAATGCAGTTGTTTGTGATGCTGATGCATGGTTTGGATTTACTGGAGATACCTCAAGCAATCCAATGGCACCGGTGCAAGTTAACTTTTTAAGGTGGCCTACACCCGAAGACTCAATGAATGCGCCTGCTCCACAGTGTAACGAAACCGCAGAAGGTGATCTTCCATGTAGTTGCGTTGATTGCGCTGCGATGTGCCCAACTGGGACTGAGCCCGTTGTTCCTGAAATTTGTACTGTTCTAGACGTTCACTGCGTTGGTTTCGCAGTTGGTATTACGGTATTTGTAATAACAACTATAATATTCATTATTTTAACGCTACTAGAATACCGTAAGCTAAGGAAAGTTGAAACCAAGACTCCGTTACCGGCCGATGTTCAAAGGTTTACAGTATTTTTCCAAAATCTATTTGCGAAGATTGGTGTTTTTGCCGCAAACAATCCTATACTTATAATAATGGTAACCTCGTGGGTATCAATAGGTGTGTTATATGGCGCTTTTAGTCTTAACATAACTTCGAATCCTATTGAACTTTGGTCTTCACCAGTATCCCGCAGTCGAGAGCAATTAAATTATTTCAATACTAGATTTGGTCCTTTTTACCGTGCGGCACAAGTTTTCTTGCAGTTCAAAGGATTGGAGCCATTTGAAGTAGATAATGTGACATATGGATCTGCATTTAGAATTGAAGCTATTCATGAATTGATCAAATTAGAAGATGAAATTTATAAAATTGGAAAAGATGACGGTGGTGTTTCACTAGAACAGGTTTGTTATGCTCCTAATCGTCCCAGAGGGGGAGAACAAAGACTTGATCAATGTGTTTCGATGTCTGTATCTGTATACTTCGGTCAGGATAGGGATAACATCAATGAAAATACCTATTTAGATCAAATACAAAATTGTCTGAACAATCACTATGCACTCAACTGCTTAGCATCATGGGGAGGTGGTTCCGAACCTGAGATTACTTTTGGAGGTTTCGAAGGAAACAACATTCTTAGTGCTGACACGCTTCTTATTAACTTTCCAATTACAAACTTCATGTTAGAGGAAGATTTGAGACCTGTCTTGGAATGGGAGCAGAAATTCATAGATCTATTGCATGACTACAGAGACAACTGGAAGTCAGATTTCGTTGAAGTGGCTTTCGGAACCGAAAGATCAATCGAAGATGAGATTCGACGGGTTTCAGTTGCGGAAATTTTGCCGATTTCGATAAGCTACATTATAATGTTTATATATGTTATTATAGCGTTAGGAAATGTAAGGCACTGTAAGACGTGGTTACTTGATAGTAAAATAGTAGTAGCAGCTGGTAGTATTGTCGTAGTACTCCTTTCCATTGGATGTGCTTTAGGCTTAATGGGCTACACAGGTATTACAACAACCTTATTGGCCATTAATGTTATACCTTTCTTCATTCTTTCAGTTGGTATTGACAACGTTTTCTTAATGGTGAATACATTGCACGATATTCAGAACGATCTTAAATCATACGATGACTATAACGAAAATTTTAGTTTTTCAAAGAAACGTAGTTTCGTTTTTGAAAAGATGATGAGTGCAGTCGGCCCTTCCATATTTGTTTCATCAGTAACCCAAATTACTTGTTTTGGTATTGGAAGTATAACTAATTTCCCAGCTGTTCAAACATTTGCTGTATTTGCGAGTTTTTCCTTAACTTTCCTATTTGTATTTCAAATCACGACTGTGGTAGCGATTTTGTCCCTTGATTACAAACGTGTGTCGCAAAACCGCCCTGATCTATTTTGCTGTATTCGAAAGAAGATTCTTAATGATGACGATCCTTTAAATTCTGAAACTCCTTATAAGAGTATCACGAAAAGACTCATGAAGCCTTATTCTAAATTTTTACTAAACTGGAAGACAAAGATCATTGTTGCTATTTTGTTTATGCTGTTGGTATCTACTAGTGTTGTTTTGATTCCACAAGTGGAAATTGGTTTAGACCAAGAAATGAGTTTGCCAACCGATTCTTATGTATATAGTTATTTAGTAGCAGTTAGTAAGCTTTTACGTCTTGGACCCCCGGTATATTTTGTTCTTAAGGCTGGCTTAGACTTTTCAAACACAAATCATCAAAATGTTATCTGCGGTGGTCAATTATGTTATGATGATTCTCTATTCACTCAAGTGTTTTTAGCTTCTCAACATAGCAGCATCACTAGGATTTCAAAAAGTTCTAATTCATGTACAGATAACTCCCCTGAATGTGCTTTCTGTACTATAGGAAGGGACGAATGGGCCAACGGATTACGTCCCAGTTCAGAAGCGTTTAAGAGATATATTCCATTCTTTTTGCGAGATGAACCGACTCCAACCTGCAATAAAGGGGGTCTTGCGAGTTATGCAAATGCCGTGAATTATTTACTTGATTCTGAAGGACATGCCACTGTGCGTGACACTAATTTCATGGCTTACCACACTTCAGTAAGTACATCTTCAGATTATATCGAAGCAGTAAAGTATGGATATGAAATCAGTGATAGTATAACTGCAGCCATAAAGAAACGCACAGGTCTAGATGTGGAAGTGTTTCCATATTCAATATTTTACGTTTACTATGAACAATACCTAACCATATGGGGTGATACGTTTGCAGCTCTAGGCTATTGTCTCATTGGTGCATTGGTTATCAATTTACTAGCATCTGGATTCAATTTCTTAACAACTTTTGCCGTTATATTTACGGCGATTTTGGTTGTCATAAACATGATGGGCGTTATGTACATTTGGAATATTCCTTTAAACGCTGTGTCTTGTGTTAACTTAGTTGTTTCTATCGGTATTGCTGTTGAGTTCTGCAGTCACATTGCCTATGCATTCGATTCGAGTACTCGTCCCGCAGATGAAAGAGTACAAGATGCGTTACAAAAGATAGGTTCGACAGTTATTACTGGTATTACATTTACGAATATACCTATTATTGTTTTAGCGTTCTCATACACGCAAGTAATAGAGGTATTTTTCTTTAGAATGTTCTTTACTTTGATAATATTGGGATTCTTACACGGGATGGTCTTCTTCCCTGTATTGTTAAGCTACCTGAACAATTTAAGGAACAAATAA
Protein
MNFFITLVLVFLYTSDVKAKCRFRGECIEIAGHAKPCPVDIEARPVVEGLSPADAEEIVDILTERCPSLVFDENGDKKPFNEILTCCEPVQIRKLSESLMLADGILGRCPTCLRNFARQICEMNCSPDQSRFVDVYTEVSGGVRYVNEIDYRLYEPFMLGAHASCAGVIIPQTGLPAINMMCGNAVVCDADAWFGFTGDTSSNPMAPVQVNFLRWPTPEDSMNAPAPQCNETAEGDLPCSCVDCAAMCPTGTEPVVPEICTVLDVHCVGFAVGITVFVITTIIFIILTLLEYRKLRKVETKTPLPADVQRFTVFFQNLFAKIGVFAANNPILIIMVTSWVSIGVLYGAFSLNITSNPIELWSSPVSRSREQLNYFNTRFGPFYRAAQVFLQFKGLEPFEVDNVTYGSAFRIEAIHELIKLEDEIYKIGKDDGGVSLEQVCYAPNRPRGGEQRLDQCVSMSVSVYFGQDRDNINENTYLDQIQNCLNNHYALNCLASWGGGSEPEITFGGFEGNNILSADTLLINFPITNFMLEEDLRPVLEWEQKFIDLLHDYRDNWKSDFVEVAFGTERSIEDEIRRVSVAEILPISISYIIMFIYVIIALGNVRHCKTWLLDSKIVVAAGSIVVVLLSIGCALGLMGYTGITTTLLAINVIPFFILSVGIDNVFLMVNTLHDIQNDLKSYDDYNENFSFSKKRSFVFEKMMSAVGPSIFVSSVTQITCFGIGSITNFPAVQTFAVFASFSLTFLFVFQITTVVAILSLDYKRVSQNRPDLFCCIRKKILNDDDPLNSETPYKSITKRLMKPYSKFLLNWKTKIIVAILFMLLVSTSVVLIPQVEIGLDQEMSLPTDSYVYSYLVAVSKLLRLGPPVYFVLKAGLDFSNTNHQNVICGGQLCYDDSLFTQVFLASQHSSITRISKSSNSCTDNSPECAFCTIGRDEWANGLRPSSEAFKRYIPFFLRDEPTPTCNKGGLASYANAVNYLLDSEGHATVRDTNFMAYHTSVSTSSDYIEAVKYGYEISDSITAAIKKRTGLDVEVFPYSIFYVYYEQYLTIWGDTFAALGYCLIGALVINLLASGFNFLTTFAVIFTAILVVINMMGVMYIWNIPLNAVSCVNLVVSIGIAVEFCSHIAYAFDSSTRPADERVQDALQKIGSTVITGITFTNIPIIVLAFSYTQVIEVFFFRMFFTLIILGFLHGMVFFPVLLSYLNNLRNK

Summary

Description
Important for cholesterol absorption at the midgut epithelium. Acts only in the early steps of sterol absorption, prior to Npc1a-dependent intracellular sterol trafficking.
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment (PubMed:9211849, PubMed:9927649, PubMed:10821832, PubMed:18772377, PubMed:27238017, PubMed:12554680). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:9211849, PubMed:9927649, PubMed:18772377, PubMed:19563754, PubMed:27238017, PubMed:28784760). Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (PubMed:19563754). Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).
(Microbial infection) Acts as an endosomal entry receptor for ebolavirus.
Subunit
Interacts (via the second lumenal domain) with NPC2 (PubMed:18772377, PubMed:27238017, PubMed:27551080). Interacts with TMEM97 (PubMed:19583955). Interacts with TIM1 (PubMed:25855742).
(Microbial infection) Interacts with ebolavirus glycoprotein.
Similarity
Belongs to the patched family.
Keywords
Cell membrane   Cholesterol metabolism   Complete proteome   Disulfide bond   Glycoprotein   Lipid metabolism   Membrane   Reference proteome   Signal   Steroid metabolism   Sterol metabolism   Transmembrane   Transmembrane helix   3D-structure   Alternative splicing   Disease mutation   Endosome   Host cell receptor for virus entry   Host-virus interaction   Lysosome   Niemann-Pick disease   Polymorphism   Receptor  
Feature
chain  NPC intracellular cholesterol transporter 1 homolog 1b
splice variant  In isoform 2.
sequence variant  In NPC1; dbSNP:rs747049347.
EMBL
KQ461196    KPJ06548.1    KQ459604    KPI92595.1    NWSH01000044    PCG80278.1    + More
KZ149999    PZC75350.1    JTDY01002944    KOB70440.1    BABH01001863    BABH01001864    BABH01001865    BABH01001866    GDQN01001810    JAT89244.1    ODYU01013065    SOQ59732.1    AP017483    BBB06736.1    MG492013    AYA73999.1    AGBW02013764    OWR42857.1    UFQT01001474    SSX30718.1    AXCM01005583    CH477589    EAT38583.1    JRES01000984    KNC26440.1    ATLV01013553    KE524867    KFB38094.1    CH933810    EDW07007.2    GFDF01002661    JAV11423.1    GFDF01002660    JAV11424.1    GFDF01002669    JAV11415.1    AE014298    KQ981019    KYN10247.1    GAMC01006635    JAB99920.1    KQ971357    KYB26045.1    KQ983206    KYQ46679.1    KQ981953    KYN32399.1    KQ976760    KYN08494.1    GEZM01102128    JAV51946.1    GL888408    EGI61420.1    NNAY01000911    OXU25955.1    GEZM01102125    JAV51949.1    JR037260    AEY57664.1    KZ288215    PBC32491.1    JR037261    AEY57665.1    APGK01025710    APGK01025711    KB740600    ENN80120.1    DS235873    EEB19581.1    DS235816    EEB17553.1    ATLV01021379    ATLV01021380    ATLV01021381    ATLV01021382    KE525317    KFB46421.1    ENN80121.1    JXUM01024284    KQ560685    KXJ81281.1    AKHW03000230    KYO48265.1    APGK01056781    KB741277    ENN71121.1    AJWK01018887    AJWK01018888    AJWK01018889    AJWK01018890    LSYS01003169    OPJ83373.1    OPJ83374.1    KL884815    KGL72244.1    OPJ83375.1    KK719137    KFO61541.1    GAAZ01001621    GBKC01002383    GBKD01001446    JAA96322.1    JAG43687.1    JAG46172.1    GFFV01000432    JAV39513.1    GL888206    EGI65127.1    GFDF01007330    JAV06754.1    GFDF01007331    JAV06753.1    GFDF01007339    JAV06745.1    GFDF01002747    JAV11337.1    AEYP01011843    HAAF01001168    CCP72994.1    KL391117    KFP91660.1    AADN05000027    GAMT01000689    GAMT01000688    GAMT01000687    GAMS01000344    GAMS01000343    GAMS01000342    JAB11172.1    JAB22793.1    AANG04003548    GAMR01006953    GAMR01006952    GAMR01006951    GAMQ01004369    GAMQ01004368    GAMQ01004367    GAMP01006860    GAMP01006859    JAB26979.1    JAB37482.1    JAB45896.1    AB971140    BAQ08368.1    KU695564    ANN44507.1    AF002020    AF157379    AF157365    AF157366    AF157367    AF157368    AF157369    AF157370    AF157371    AF157372    AF157373    AF157374    AF157375    AF157376    AF157377    AF157378    AF338230    AH009108    AK293779    AC010853    AC026634    BC063302    AAEX03005455    AF503633    AAM27450.1    AB209048    BAD92285.1    AF503634    AAM27451.1    ABLF02019318    ABLF02019320    ABLF02019324    AHAT01004140   
Pfam
PF16414   NPC1_N        + More
PF02460   Patched
PF12349   Sterol-sensing
Interpro
IPR032190   NPC1_N        + More
IPR000731   SSD       
IPR003392   Ptc/Disp       
IPR004765   NPC1-like       
PDB
5U74     E-value=4.0088e-173,     Score=1566

Ontologies

Topology

Subcellular location
Cell membrane  
Late endosome membrane  
Lysosome membrane  
SignalP
Position:   1 - 19,         Likelihood:  0.994720
 
 
Length:
1212
Number of predicted TMHs:
14
Exp number of AAs in TMHs:
312.66185
Exp number, first 60 AAs:
0.00804
Total prob of N-in:
0.01626
outside
1  -  267
TMhelix
268  -  290
inside
291  -  323
TMhelix
324  -  346
outside
347  -  583
TMhelix
584  -  606
inside
607  -  617
TMhelix
618  -  640
outside
641  -  644
TMhelix
645  -  667
inside
668  -  703
TMhelix
704  -  726
outside
727  -  735
TMhelix
736  -  758
inside
759  -  814
TMhelix
815  -  837
outside
838  -  849
TMhelix
850  -  872
inside
873  -  1047
TMhelix
1048  -  1069
outside
1070  -  1078
TMhelix
1079  -  1101
inside
1102  -  1107
TMhelix
1108  -  1130
outside
1131  -  1149
TMhelix
1150  -  1172
inside
1173  -  1183
TMhelix
1184  -  1206
outside
1207  -  1212
 
 

Population Genetic Test Statistics

Pi
249.90183
Theta
224.601551
Tajima's D
0.295551
CLR
0.245024
CSRT
0.451427428628569
Interpretation
Uncertain
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