Gene

KWMTBOMO10848

Pre Gene Modal

BGIBMGA008364

Annotation

PREDICTED:_REST_corepressor_isoform_X3_[Papilio_xuthus]

Location

Bomo_Chr18(-):5355190-5359927      View in EpiBrowser

Full name

REST corepressor      

Alternative Name

CoREST

Transcription factor

MYB

Location in the cell

Nuclear   Reliability : 3.523

CDS

ATGGTTCTAGCAGAACGAAGTAATGATGTTCGAAACGGGAAGCGGTCAAGGGGGCCAAGCCCCAATGGTCATGGAAGTCCAGATTCAAGTTCGGATGAAGAAAATGTAGTACCGTTTGCAGCCGAAAAGATTCGGGTTGGTCGGGATTACCAAGCAGTCTGTCCAGAATTGGAACCAGTTGAAGCAAGAAGACCAGACTTAATTTCTGATAGGGCTCTGCTTGTCTGGTCGCCAACTACTGAGATAGCTGATATCAAATTGGATGAATATATTACAACAGCTAAAGAAAAATATGGTTATAATGGTGAACAAGCTCTTGGTATGCTCTTCTGGCACAAGCATGATCTTAATCGTGCATCATTGGATCTTGCAAACTTCACACCATTTCCTGATGAGTGGACAGTGGAGGACAAGGTGTTATTTGAACAAGCTTTTCAGTTTCATGGTAAAAGCTTTCATCGAATACGTCAAATGCTTCCAGATAAATCTATTGCATCTTTAGTCAAATACTATTATTCATGGAAGAAAACAAGAGCACGTACTTCCTTAATGGATGTTGTTGGTGAAGGGCGAAATGCTGCAAGCTCAGGGTCTGGAAAAAAAGAGTCTGGGACTACATCTGAACCTGGCGGCTCAGACAAAGAATCTGACAATGATGAAAAGGTACAACAAAACAAGCAGCAATTGAGCGCCATGAAACGCAAAGTTGGCGATACTGGAGTGGAGGATTACCGTCCTGGCGAGCCTCCTGCCAAGATAAATTCACGTTGGACAAATGACGAATTACTCATGGCCGTTACTGCAGTAAGAAAGTACGGTAAGGAACTTATCTTGGAGAACTCCCTTTGCTGTGGCGGTAACAAAATAAATTTTGTACGTGACAAATAA

Protein

MVLAERSNDVRNGKRSRGPSPNGHGSPDSSSDEENVVPFAAEKIRVGRDYQAVCPELEPVEARRPDLISDRALLVWSPTTEIADIKLDEYITTAKEKYGYNGEQALGMLFWHKHDLNRASLDLANFTPFPDEWTVEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRARTSLMDVVGEGRNAASSGSGKKESGTTSEPGGSDKESDNDEKVQQNKQQLSAMKRKVGDTGVEDYRPGEPPAKINSRWTNDELLMAVTAVRKYGKELILENSLCCGGNKINFVRDK

Description

Essential component of a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited by Ttk88 and probably acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. May serve as a molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval.

Subunit

Component of a complex that contains at least Rpd3, CoRest and Su(var)3-3/Hdm. Interacts with neuronal repressor ttk/Ttk88.

Similarity

Belongs to the CoREST family.

Keywords

Alternative splicing   Chromatin regulator   Coiled coil   Complete proteome   Nucleus   Phosphoprotein   Reference proteome   Repeat   Repressor   Transcription   Transcription regulation  

Feature

chain  REST corepressor
splice variant  In isoform 2.

Uniprot

A0A2A4K9A8   A0A2W1BR93   H9JFR7   A0A212EW08   A0A2A4K8H2   A0A2A4K8N8   + More
A0A2H1WN35   A0A2A4K9J2   A0A194PGW2   D2A064   A0A1I8M1Q7   T1PBR0   A0A1Y1K5V9   A0A194QSS1   W8BQ39   A0A034W9G7   A0A0A1WL46   A0A0K8TKM1   A0A1I8NWR0   U5EQ84   A0A1L8DGE5   A0A0L7KRJ7   B3NVP2   B4PZH4   Q59E36   A0A1W4WQJ4   A0A1W4WPI9   A0A0N8P243   A0A1W4VUS2   Q17M84   B4MA37   A0A0Q9WP20   Q59E36-4   A0A3B0KAQ5   A0A1Y1KAM5   A0A139WJB2   W8BIL6   A0A0L7RI93   A0A1B0DG41   A0A182TW84   A0A182N535   Q7QC78   E2BWA1   W8CAT6   A0A1B6E6Q8   A0A182K191   A0A2J7PL06   A0A023EVK7   A0A195DWG3   A0A182GVN2   A0A1I8M1Q3   A0A182IM06   F4X132   A0A1B6E7D2   A0A182QVL8   A0A182VB33   A0A067RLA0   A0A0L0BRK8   A0A1B6CTF4   A0A182HSW8   A0A182RGY2   A0A182XHY7   A0A182VWQ3   A0A084VAN0   A0A1B6BZ51   A0A2M4AW31   A0A0A1XI16   A0A2M4ASF9   A0A0K8WJB9   A0A2M4AUG5   M9PJR2   A0A034W6U3   W8BW02   Q59E36-3   A0A0R1EAT3   A0A182MCU5   A0A1A9VWZ2   A0A182YHK4   A0A1B6K8A3   A0A1L8DG32   A0A0Q5TJS9   A0A0P9AX75   A0A1B0ASU1   A0A1B0FLM9   A0A034W8H3   A0A1A9XYG8  

Pubmed

28756777    19121390    22118469    26354079    18362917    19820115    + More
25315136    28004739    24495485    25348373    25830018    26369729    26227816    17994087    17550304    10731132    12537572    12537569    15306652    17372656    18327897    17510324    12364791    20798317    24945155    26483478    21719571    24845553    26108605    24438588    12537568    12537573    12537574    16110336    17569856    17569867    25244985    18057021   

EMBL

NWSH01000028    PCG80576.1    KZ150058    PZC74273.1    BABH01001791    AGBW02012095    + More
OWR45688.1    PCG80575.1    PCG80577.1    ODYU01009812    SOQ54480.1    PCG80574.1    KQ459604    KPI92631.1    KQ971338    EFA01740.2    KA646202    AFP60831.1    GEZM01094222    JAV55798.1    KQ461196    KPJ06586.1    GAMC01005433    JAC01123.1    GAKP01008519    GAKP01008516    JAC50433.1    GBXI01015164    JAC99127.1    GDAI01002925    JAI14678.1    GANO01004410    JAB55461.1    GFDF01008583    JAV05501.1    JTDY01006763    KOB65710.1    CH954180    EDV46707.2    CM000162    EDX02130.2    AE014298    BT023817    AY060226    AY118507    CH902621    KPU81684.1    CH477208    EAT47760.1    CH940655    EDW66096.2    KRF82558.1    OUUW01000031    SPP89802.1    GEZM01094223    JAV55797.1    KYB27992.1    GAMC01005430    JAC01126.1    KQ414584    KOC70580.1    AJVK01015164    AJVK01015165    AAAB01008859    EAA08204.4    GL451103    EFN80005.1    GAMC01005431    JAC01125.1    GEDC01003680    JAS33618.1    NEVH01024529    PNF17016.1    GAPW01000532    JAC13066.1    KQ980204    KYN17250.1    JXUM01091414    KQ563913    KXJ73079.1    GL888525    EGI59843.1    GEDC01003481    JAS33817.1    AXCN02000175    KK852559    KDR21390.1    JRES01001467    KNC22656.1    GEDC01020546    JAS16752.1    APCN01000372    ATLV01004133    KE524190    KFB35024.1    GEDC01031008    JAS06290.1    GGFK01011659    MBW44980.1    GBXI01003690    JAD10602.1    GGFK01010379    MBW43700.1    GDHF01002228    GDHF01001091    JAI50086.1    JAI51223.1    GGFK01011041    MBW44362.1    AGB95546.1    GAKP01008518    JAC50434.1    GAMC01005432    JAC01124.1    KRK06579.1    KRK06582.1    AXCM01001329    GECU01000027    JAT07680.1    GFDF01008737    JAV05347.1    KQS30089.1    KQS30090.1    KPU81685.1    JXJN01002998    JXJN01002999    JXJN01003000    CCAG010001342    CCAG010001343    GAKP01008517    JAC50435.1   

Proteomes

UP000218220    UP000005204    UP000007151    UP000053268    UP000007266    UP000095301    + More
UP000053240    UP000095300    UP000037510    UP000008711    UP000002282    UP000000803    UP000192223    UP000007801    UP000192221    UP000008820    UP000008792    UP000268350    UP000053825    UP000092462    UP000075902    UP000075884    UP000007062    UP000008237    UP000075881    UP000235965    UP000078492    UP000069940    UP000249989    UP000075880    UP000007755    UP000075886    UP000075903    UP000027135    UP000037069    UP000075840    UP000075900    UP000076407    UP000075920    UP000030765    UP000075883    UP000078200    UP000076408    UP000092460    UP000092444    UP000092443   

PRIDE

H9JFR7    Q59E36   

Pfam

PF01448   ELM2        + More
PF00249   Myb_DNA-binding
PF16092   DUF4821

Interpro

IPR001005   SANT/Myb        + More
IPR017884   SANT_dom       
IPR009057   Homeobox-like_sf       
IPR000949   ELM2_dom       
IPR038884   CFAP61       
IPR036188   FAD/NAD-bd_sf       
IPR032151   CFAP61_N       
IPR000679   Znf_GATA       

SUPFAM

SSF46689   SSF46689        + More
SSF51905   SSF51905       

Gene 3D

3.50.50.60    

CDD

cd00167  SANT

ProteinModelPortal

A0A2A4K9A8   A0A2W1BR93   H9JFR7   A0A212EW08   A0A2A4K8H2   A0A2A4K8N8   + More
A0A2H1WN35   A0A2A4K9J2   A0A194PGW2   D2A064   A0A1I8M1Q7   T1PBR0   A0A1Y1K5V9   A0A194QSS1   W8BQ39   A0A034W9G7   A0A0A1WL46   A0A0K8TKM1   A0A1I8NWR0   U5EQ84   A0A1L8DGE5   A0A0L7KRJ7   B3NVP2   B4PZH4   Q59E36   A0A1W4WQJ4   A0A1W4WPI9   A0A0N8P243   A0A1W4VUS2   Q17M84   B4MA37   A0A0Q9WP20   Q59E36-4   A0A3B0KAQ5   A0A1Y1KAM5   A0A139WJB2   W8BIL6   A0A0L7RI93   A0A1B0DG41   A0A182TW84   A0A182N535   Q7QC78   E2BWA1   W8CAT6   A0A1B6E6Q8   A0A182K191   A0A2J7PL06   A0A023EVK7   A0A195DWG3   A0A182GVN2   A0A1I8M1Q3   A0A182IM06   F4X132   A0A1B6E7D2   A0A182QVL8   A0A182VB33   A0A067RLA0   A0A0L0BRK8   A0A1B6CTF4   A0A182HSW8   A0A182RGY2   A0A182XHY7   A0A182VWQ3   A0A084VAN0   A0A1B6BZ51   A0A2M4AW31   A0A0A1XI16   A0A2M4ASF9   A0A0K8WJB9   A0A2M4AUG5   M9PJR2   A0A034W6U3   W8BW02   Q59E36-3   A0A0R1EAT3   A0A182MCU5   A0A1A9VWZ2   A0A182YHK4   A0A1B6K8A3   A0A1L8DG32   A0A0Q5TJS9   A0A0P9AX75   A0A1B0ASU1   A0A1B0FLM9   A0A034W8H3   A0A1A9XYG8  

PDB

4CZZ     E-value=3.48285e-53,     Score=525

KEGG

101740926    no KO assigned | (RefSeq) REST corepressor 1

GO

GO:0005634   GO:0003677   GO:0003714   GO:0003682   GO:0000122   GO:0017053   GO:0090309   GO:0061086   GO:0006325   GO:0045892   GO:2000619   GO:0043565   GO:0006355   GO:0008270   GO:0008134   GO:0003700   GO:0005667   GO:0044212   GO:0003676   GO:0005515   GO:0051028   GO:0005622   GO:0006810   GO:0003824  

PANTHER

PTHR21178  

Subcellular location

Nucleus  

Length:

295

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00148

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04408

outside

1  -  295

 

 

Pi

190.021884

Theta

189.630901

Tajima's D

-0.383928

CLR

108.099019

CSRT

0.267686615669217

Interpretation

Uncertain