Gene

KWMTBOMO10829  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008447

Annotation

hypothetical_protein_KGM_03155_[Danaus_plexippus]

Location

Bomo_Chr18(+):4248090-4255464      View in EpiBrowser

Full name

Nuclear RNA export factor 1      

Alternative Name

Protein small bristles
Protein tip-associating

Location in the cell

Mitochondrial   Reliability : 2.218

CDS

ATGCCAAAACGTGGCGGTGGAAGGAATAGAAATTGGAAGGCTGATACTGACCATTTTGAACACGATGACCGTGTCAATAGTGTGCCGAGACATGTCAGTTTTAAACCTGGAGCTAAAGGAAAAAATAAATTTCGAACTTGGAAAAATCCTTTAGCCCTCCTTGATGATGATATTGACATGGGTAGTTCTGCTCTTCAAGGACCGGTCCGGAAAAGTTCTTTCAGGGGACGTGGGAGAATGTACTCTCCAGCTCCGCAAGGAAGCCACGGACACACTAAAAAGAAATTTATTCCTGGTGTACTGCCTTGGTACCAAATAATCATTCCATATGGAGCAAAACATGAAAAAGATGTTATCCTCCGAGCCTTGTTGGGTTTTCTTTCACCCGACATATTCATTCCACATTACTATAAAGTCAATGGAAATGCTGCAGTATTCTATGTTGATGATGTCAAAACAGCTGAAAAACTTTATAATGCTGATAGAAAGATCACTATGTCAGATGGTTTTAAGTTAATTGTTATTGTGAGGAATGCTGTTCCAAACATGGCCATTGACGCTGCCATGAAAGAGAAGATGAAATTGACAATGGCGAAGAGGTATAATGCTACAACTAAGGCATTAGATTTAACAAAATTCCATGCTGATCCAGATCTAGAAGATATATTTTGTGCACTGTTCCGTCCAATGATAATGTTGGCTGCTATAGATATAATAGCAGAGAATATTCCAGACATAGAAGCTTTGAACCTAAATGATAATAAGCTTCATGGTTTGCAGCATCTCAAGGTTTTGTCTTCAAAGCTCAAGAATTTGAAAATATTGTATATGGGCGATAATAGGATTCCATTCCTTGGATCACTGGACCCAATCAGATCATTACCGCTAGTTGAGCTATACCTCAAAGGAAACCCACTGGTGAACAGGTTTCATGATCACGAAATCTACATAAGTGATGTCCGGAAGAAGTTTCCCAAGCTGACAAGATTGGATGGCGCGGATCTTCCACCGGCTATTGGATTCGACGTAGCTGAAGATATGGGACTTCCCCCTCGGCAACAATCGTTCCTGGTAGACCCGGCGGGTCAGGATCTTGTCAGGGAGTTTCTCACTCAATACTATGCGATATACGACTCGGAATCTCGGCAACCACTTCTAGAGGCGTACCATGAAAATGCTACAATGTCGATGGCTGCAAATTATTTAACTAATGACAGCAGGAATTCTACGACAACTAGGTTAAACTCTTACATATCGAACAGCCGTAATTTAACCCGAATAACAGAAAGGGAGTCGAGAAGGCGTTACCTACGTACCGGAAAGCTGCAAGTAGTCTCCTTTCTATCAGATCTGCCAAAAACAACACACGATTTAATGGGTTTTGCTGTCGACTTACTAGTCTTTACTCCGGCCATGATCGTCCTTACAATGAACGGTGTGTTCAAAGAAACGAACACTCCCAATAACCCGATGCGTTCGTTTCATCGGACGTTCGTGATAGTTTCAAATGCGAATGGCGGCTTCTCAATCATCAACGATATGTTATATATCACGAATACTACTAAAGAACAGGAGGATAAGGCCTTTTCAACGGGTACTGTAGAACCGATTCCACCTACTCCAGCGCCCACGCCTACTCCTACTCCCACGCTCGCAGCTGGGACGCCAGATGATTCTCAGAAGATGCAGCTACTCAACATGCTTGGTCAACAAACTGGAATGAATGAGCATTGGAGTATCAATTGTCTTCAAGAAACTGGCTGGGATTTGCAAAGGGCTATGTTCATCTTTAATCAACTACACTCCGAAGGCAAGATACCGCCTGAAGCCTTTGTAAAGTGA

Protein

MPKRGGGRNRNWKADTDHFEHDDRVNSVPRHVSFKPGAKGKNKFRTWKNPLALLDDDIDMGSSALQGPVRKSSFRGRGRMYSPAPQGSHGHTKKKFIPGVLPWYQIIIPYGAKHEKDVILRALLGFLSPDIFIPHYYKVNGNAAVFYVDDVKTAEKLYNADRKITMSDGFKLIVIVRNAVPNMAIDAAMKEKMKLTMAKRYNATTKALDLTKFHADPDLEDIFCALFRPMIMLAAIDIIAENIPDIEALNLNDNKLHGLQHLKVLSSKLKNLKILYMGDNRIPFLGSLDPIRSLPLVELYLKGNPLVNRFHDHEIYISDVRKKFPKLTRLDGADLPPAIGFDVAEDMGLPPRQQSFLVDPAGQDLVREFLTQYYAIYDSESRQPLLEAYHENATMSMAANYLTNDSRNSTTTRLNSYISNSRNLTRITERESRRRYLRTGKLQVVSFLSDLPKTTHDLMGFAVDLLVFTPAMIVLTMNGVFKETNTPNNPMRSFHRTFVIVSNANGGFSIINDMLYITNTTKEQEDKAFSTGTVEPIPPTPAPTPTPTPTLAAGTPDDSQKMQLLNMLGQQTGMNEHWSINCLQETGWDLQRAMFIFNQLHSEGKIPPEAFVK

Description

Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm.

Subunit

Interacts with Nxt1 (PubMed:11780633). Interacts with ZC3H3 (PubMed:19364924). Forms a complex with Nup358/RanBP2, RanGAP and Nxt1 (PubMed:14729961).

Miscellaneous

Mutations affect the morphogenesis of embryonic neurons, embryonic muscle and adult sensory bristles. This is thought to be due to reduced rate of protein synthesis as the mRNA is not efficiently being exported out of the nucleus.

Similarity

Belongs to the NXF family.

Keywords

Complete proteome   Cytoplasm   Leucine-rich repeat   mRNA transport   Nucleus   Phosphoprotein   Reference proteome   Repeat   RNA-binding   Transport  

Feature

chain  Nuclear RNA export factor 1

Uniprot

H9JG00   A0A2H1V3Z6   A0A2A4JRF2   A0A2W1BX74   A0A212EIB5   A0A194PC93   + More
A0A194QNQ4   S4PL34   Q17MK6   A0A023EVP0   B0W492   A0A1W4WFT6   A0A1Q3F1M5   D6WXF5   A0A182P4G9   A0A182JY74   A0A0T6AVG7   A0A1J1J376   A0A182XWJ9   W5J6Q9   Q7QK79   A0A182F8A7   A0A182LQM6   A0A182HZL8   A0A182URD2   A0A182UHI9   A0A182NMU6   A0A182WZH1   A0A182VYC2   A0A182RFW4   A0A182H3Y3   A0A2J7R106   A0A182MWZ3   U5EYT0   A0A182JAF5   A0A1I8M6E3   T1PBQ0   A0A067R6A1   A0A1I8PJB2   N6U8C5   A0A1I8PJF1   A0A1A9X5U0   A0A1A9ZED0   A0A1B0B6B6   B4M2H0   X2D8J9   A0A336LAD5   A0A2A3ENU9   A0A088A7U4   A0A3L8DKR4   A0A1B6GNB8   A0A1B6IB65   A0A0N0BG26   F4WQW9   A0A1B0GJV7   A0A1B0GB42   A0A026WJ15   A0A0K8TNF8   A0A1A9VUD6   A0A1B6E508   A0A1L8DH92   A0A0P5ZCJ2   A0A0P5N3C9   A0A0P5HFF1   B4IDU3   A0A0P5J901   W8BWX8   A0A195BRQ2   A0A158NTK4   A0A0P5YVG7   A0A0V0G8F7   E9IDJ4   A0A0N8DLI5   A0A0P6E1Z5   A0A1Y1K5G0   A0A232ENF4   E9HQD3   B3NVE0   B4N284   Q9U1H9   A0A1W4V1F8   E9HPR7   A0A1B6BZ28   E0VI83   A0A0R1EC40   A0A1W4UNM3   B4PY01   A0A0N8EKW5   A0A023FBN9   A0A1A9XLN0   A0A0N8E7Q7   A0A1B0AGY8   A0A0Q5TIX1   A0A1A9UFA2   A0A0Q9WXV9   A0A1W4UP66   B4L4P1   B4JKG4  

Pubmed

19121390    28756777    22118469    26354079    23622113    17510324    + More
24945155    18362917    19820115    25244985    20920257    23761445    12364791    14747013    17210077    20966253    26483478    25315136    24845553    23537049    17994087    30249741    21719571    24508170    26369729    24495485    21347285    21282665    28004739    28648823    21292972    11780634    11779805    11780633    10731132    12537572    12537569    14729961    18327897    19364924    20566863    17550304    25474469   

EMBL

BABH01001715    ODYU01000386    SOQ35082.1    NWSH01000790    PCG74184.1    KZ149919    + More
PZC77797.1    AGBW02014677    OWR41211.1    KQ459606    KPI90891.1    KQ461196    KPJ06605.1    GAIX01004240    JAA88320.1    CH477205    EAT47918.1    GAPW01000466    JAC13132.1    DS231836    EDS33177.1    GFDL01013647    JAV21398.1    KQ971361    EFA07988.1    LJIG01022713    KRT79098.1    CVRI01000067    CRL06807.1    ADMH02001967    ETN60147.1    AAAB01008799    EAA03703.5    APCN01001986    JXUM01108387    JXUM01108388    JXUM01108389    JXUM01108390    JXUM01108391    KQ565226    KXJ71205.1    NEVH01008214    PNF34518.1    AXCM01009602    GANO01000143    JAB59728.1    KA645393    AFP60022.1    KK852672    KDR18790.1    APGK01035707    KB740928    ENN77920.1    JXJN01009046    JXJN01009047    CH940651    EDW65874.1    KC854410    AHK06057.1    UFQS01001420    UFQT01001420    SSX10798.1    SSX30479.1    KZ288203    PBC33408.1    QOIP01000007    RLU20896.1    GECZ01026813    GECZ01025835    GECZ01025093    GECZ01021037    GECZ01013454    GECZ01013268    GECZ01011708    GECZ01009100    GECZ01007415    GECZ01006513    GECZ01005837    GECZ01004490    GECZ01002808    JAS42956.1    JAS43934.1    JAS44676.1    JAS48732.1    JAS56315.1    JAS56501.1    JAS58061.1    JAS60669.1    JAS62354.1    JAS63256.1    JAS63932.1    JAS65279.1    JAS66961.1    GECU01023548    GECU01002794    JAS84158.1    JAT04913.1    KQ435793    KOX74188.1    GL888275    EGI63482.1    AJWK01022411    CCAG010006535    KK107198    EZA55621.1    GDAI01001935    JAI15668.1    GEDC01010841    GEDC01004311    JAS26457.1    JAS32987.1    GFDF01008271    JAV05813.1    GDIP01045664    JAM58051.1    GDIQ01170572    GDIQ01151822    GDIQ01068657    JAK99903.1    GDIQ01227639    JAK24086.1    CH480830    EDW45751.1    GDIQ01209304    JAK42421.1    GAMC01012851    JAB93704.1    KQ976424    KYM88634.1    ADTU01025989    GDIP01066102    JAM37613.1    GECL01001893    JAP04231.1    GL762454    EFZ21385.1    GDIP01021967    JAM81748.1    GDIQ01070304    JAN24433.1    GEZM01096426    JAV54915.1    NNAY01003174    OXU19868.1    GL732718    EFX66035.1    CH954180    EDV46128.1    CH963925    EDW78473.2    AJ251947    AJ272389    AJ272390    AJ318090    AE014298    AY069415    GL732710    EFX66242.1    GEDC01030771    JAS06527.1    DS235184    EEB13089.1    CM000162    KRK07052.1    EDX02973.1    GDIQ01016748    JAN77989.1    GBBI01000374    JAC18338.1    GDIQ01053612    JAN41125.1    KQS29834.1    CH933810    KRF94084.1    EDW07519.2    CH916370    EDW00067.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000008820    + More
UP000002320    UP000192223    UP000007266    UP000075885    UP000075881    UP000183832    UP000076408    UP000000673    UP000007062    UP000069272    UP000075882    UP000075840    UP000075903    UP000075902    UP000075884    UP000076407    UP000075920    UP000075900    UP000069940    UP000249989    UP000235965    UP000075883    UP000075880    UP000095301    UP000027135    UP000095300    UP000019118    UP000091820    UP000092445    UP000092460    UP000008792    UP000242457    UP000005203    UP000279307    UP000053105    UP000007755    UP000092461    UP000092444    UP000053097    UP000078200    UP000001292    UP000078540    UP000005205    UP000215335    UP000000305    UP000008711    UP000007798    UP000000803    UP000192221    UP000009046    UP000002282    UP000092443    UP000009192    UP000001070   

PRIDE

H9JG00    Q9U1H9   

Pfam

PF02136   NTF2        + More
PF09162   Tap-RNA_bind
PF03943   TAP_C
PF12799   LRR_4
PF13855   LRR_8
PF06212   GRIM-19
PF00474   SSF

Interpro

IPR030217   NXF_fam        + More
IPR018222   Nuclear_transport_factor_2_euk       
IPR009060   UBA-like_sf       
IPR035979   RBD_domain_sf       
IPR032675   LRR_dom_sf       
IPR032710   NTF2-like_dom_sf       
IPR002075   NTF2       
IPR015245   Tap_RNA-bd       
IPR005637   TAP_C_dom       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR001611   Leu-rich_rpt       
IPR025875   Leu-rich_rpt_4       
IPR038377   Na/Glc_symporter_sf       
IPR009346   GRIM-19       
IPR001734   Na/solute_symporter       
IPR018212   Na/solute_symporter_CS       
IPR003603   U2A'_phosphoprotein32A_C       

SUPFAM

SSF46934   SSF46934        + More
SSF54928   SSF54928       
SSF54427   SSF54427       

Gene 3D

3.30.70.330     3.80.10.10     1.20.1730.10    

CDD

cd14342  UBA_TAP-C
cd00780  NTF2

ProteinModelPortal

H9JG00   A0A2H1V3Z6   A0A2A4JRF2   A0A2W1BX74   A0A212EIB5   A0A194PC93   + More
A0A194QNQ4   S4PL34   Q17MK6   A0A023EVP0   B0W492   A0A1W4WFT6   A0A1Q3F1M5   D6WXF5   A0A182P4G9   A0A182JY74   A0A0T6AVG7   A0A1J1J376   A0A182XWJ9   W5J6Q9   Q7QK79   A0A182F8A7   A0A182LQM6   A0A182HZL8   A0A182URD2   A0A182UHI9   A0A182NMU6   A0A182WZH1   A0A182VYC2   A0A182RFW4   A0A182H3Y3   A0A2J7R106   A0A182MWZ3   U5EYT0   A0A182JAF5   A0A1I8M6E3   T1PBQ0   A0A067R6A1   A0A1I8PJB2   N6U8C5   A0A1I8PJF1   A0A1A9X5U0   A0A1A9ZED0   A0A1B0B6B6   B4M2H0   X2D8J9   A0A336LAD5   A0A2A3ENU9   A0A088A7U4   A0A3L8DKR4   A0A1B6GNB8   A0A1B6IB65   A0A0N0BG26   F4WQW9   A0A1B0GJV7   A0A1B0GB42   A0A026WJ15   A0A0K8TNF8   A0A1A9VUD6   A0A1B6E508   A0A1L8DH92   A0A0P5ZCJ2   A0A0P5N3C9   A0A0P5HFF1   B4IDU3   A0A0P5J901   W8BWX8   A0A195BRQ2   A0A158NTK4   A0A0P5YVG7   A0A0V0G8F7   E9IDJ4   A0A0N8DLI5   A0A0P6E1Z5   A0A1Y1K5G0   A0A232ENF4   E9HQD3   B3NVE0   B4N284   Q9U1H9   A0A1W4V1F8   E9HPR7   A0A1B6BZ28   E0VI83   A0A0R1EC40   A0A1W4UNM3   B4PY01   A0A0N8EKW5   A0A023FBN9   A0A1A9XLN0   A0A0N8E7Q7   A0A1B0AGY8   A0A0Q5TIX1   A0A1A9UFA2   A0A0Q9WXV9   A0A1W4UP66   B4L4P1   B4JKG4  

PDB

6E5U     E-value=6.47891e-85,     Score=802

KEGG

101739030    K14284 nuclear RNA export factor | (RefSeq) nuclear RNA export factor 1

PATHWAY

03008    Ribosome biogenesis in eukaryotes - Bombyx mori (domestic silkworm)
03013    RNA transport - Bombyx mori (domestic silkworm)
03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)

GO

GO:0005634   GO:0005737   GO:0006406   GO:0003723   GO:0051028   GO:0016973   GO:0047485   GO:0031965   GO:0005654   GO:0046833   GO:0022857   GO:0016021   GO:0005635   GO:0051168   GO:0000166   GO:0005515   GO:0005622   GO:0006810   GO:0003824   GO:0003676  

PANTHER

PTHR10662  

Subcellular location

Nucleus   Localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm.   With evidence from 6 publications.
Nucleoplasm   Localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm.   With evidence from 6 publications.
Cytoplasm   Localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm.   With evidence from 6 publications.
Nucleus envelope   Localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm.   With evidence from 6 publications.

Length:

613

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

10.7481

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02207

outside

1  -  613

 

 

Pi

161.700471

Theta

156.656173

Tajima's D

0.158823

CLR

10.338115

CSRT

0.418579071046448

Interpretation

Uncertain