Gene

KWMTBOMO10827

Annotation

PREDICTED:_serine/threonine-protein_kinase_minibrain_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr18(-):4127719-4143039      View in EpiBrowser

Full name

Serine/threonine-protein kinase minibrain      

Location in the cell

Nuclear   Reliability : 2.807

CDS

ATGTTACGTTCCGAAAAAGTATATTACGCGAAGAAAAAACGGAGAGCGCAGCAGTACCTGGGCGAGGATGGCTCGCACAAGAAGGAGAAGAAGTTATACAATGACGGTTACGATGACGATAATCACGATTATATTATTAAGCAGGGAGAGAAGTTCCTCGACCGGTACGAGATCTCCTCACCGATCGGAAAGGGATCATTTGGACAGGTTGTGAAAGCGTATGACCACGAGGAACAGTGTCAAGTAGCGATAAAAATTATTAAGAATAAGAAGCCTTTCCTAAATCAGGCACAAATAGAAGTCAAGTTACTAGAAATGATGAACAGAGCGGATGCTGAGAATAAGTATTATATAGTAAAACTGAAACGTCACTTTATGTGGCGGAACCACCTGTGCCTAGTGTTCGAGTTATTATCGTACAACCTTTACGACTTGCTCCGAAACACAAACTTCCGAGGTGTTTCACTGAACCTAACGCGGAAGTTTGCGCAGCAACTATGCACCGCGCTTCTGTTCCTTAGTCAACCAGAGTTAAATATAATTCACTGTGATCTTAAACCAGAAAATATATTACTATGTAATCCAAAACGGTCAGCGATAAAAATCGTGGACTTCGGCAGTTCCTGTCAACTAGGACAAAGGATATACCAGTACATCCAGTCGAGGTTCTACAGGTCGCCGGAAGTATTATTAGGGATCCCGTACGATCTCGCGATAGACATGTGGTCGCTCGGCTGTATATTGGTCGAGATGCACACGGGCGAGCCACTCTTCAGCGGGGCCAACGAAGTCGATCAGATGAACAAGATCGTCGAGGTTCTCGGAATGCCACCGGATCATTTACTAGATCAGGCACACAAAACGAGAAAGTTCTTCGAAAAACTGCCGGCGTCTGACGGCGGTGGTTACGTTTTGAAGAAAGTCAATGGAAAAGATGGAAGCGGGTACAGAAAGTATCGAGCGCCCGGCACGAGGCGGCTCCACGACATCCTCGGCGTGGAGGGAGGAGGTCCGGCGGCCCGACGACGCGGCGAGCCCGGGCACTCCGTCTCCGACTACCTTAAGTTTAAGGACCTTATACTCCGCATGCTGGAGTACGACCCGAAACAGCGCGTGACCCCCTACTACGCGTTACAGCACAACTTCTTCAAGCGGACCGCGGACGAGTCCACCAACACGCAGCAGCAGGCCACCTCGCACCACCAGCACGGTGCAGTCGCGGGCGTTGGACGTGTGTGGGGCGCCGAGCGCATGGATGTGGAAAGCGCGCGGCGCGATGACGACATGCTGCCCGCAGTTTGCACGCACAGCCCCGTCGCTATACACTAG

Protein

MLRSEKVYYAKKKRRAQQYLGEDGSHKKEKKLYNDGYDDDNHDYIIKQGEKFLDRYEISSPIGKGSFGQVVKAYDHEEQCQVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSQPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGMPPDHLLDQAHKTRKFFEKLPASDGGGYVLKKVNGKDGSGYRKYRAPGTRRLHDILGVEGGGPAARRRGEPGHSVSDYLKFKDLILRMLEYDPKQRVTPYYALQHNFFKRTADESTNTQQQATSHHQHGAVAGVGRVWGAERMDVESARRDDDMLPAVCTHSPVAIH

Description

Role in the specific control of proper proliferation of optic lobe neuronal progeny.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

Keywords

Alternative splicing   ATP-binding   Complete proteome   Developmental protein   Differentiation   Kinase   Neurogenesis   Nucleotide-binding   Nucleus   Polymorphism   Reference proteome   Transferase  

Feature

chain  Serine/threonine-protein kinase minibrain
splice variant  In isoform C.

Uniprot

A0A2W1BRX5   A0A2H1V7G6   A0A2A4JHL7   A0A194PIH6   F5HMZ6   A0A2M4A0T0   + More
A0A182XGI2   A0A2M4B975   Q7PL23   A0A1Y9IUX8   A0A1Y9IVC3   A0A182Y457   A0A2M4CRQ0   A0A2M4CRW5   A0A182HZU4   A0A2M4CS68   F5HMZ7   A0A182K964   A0A2M4A1I7   A0A2M4BBK7   A0A182RNW6   A0A2M3ZFF0   A0A2M4CK37   W5JAF5   F5HMZ8   A0A182Q465   A0A1S4G6S6   A0A182N689   A0A084W3H9   A0A1B6F8E6   A0A182UFL8   A0A1Q3EU33   Q17FM4   E0VL86   Q17FM3   A0A1B6KQA7   T1DJG0   A0A336LRQ8   A0A224X9I1   B0WTA7   A0A182JJQ6   A0A1I8NPB4   A0A336K4G2   A0A1I8N744   A0A1I8NPB8   A0A1I8N735   A0A154P6X2   A0A3B0JVE4   B4GW13   A0A2A3E0D4   A0A0L7QWE1   V9II60   A0A088AN80   A0A3B0K2R3   K7IR41   A0A0C9Q5A0   W8AXV6   A0A146LST5   A0A0A1WP88   W8BKM4   A0A0A9VT26   Q29G75   A0A0C9QZM2   A0A0A1XLU7   A0A1A9W8U5   A0A0L0BYS3   B4JJZ9   A0A0A9VXE5   A0A0Q5T3S2   B3NWY9   A0A0K8TG95   B4Q2L6   A0A195ET37   A0A1W4UN33   B4R6Q2   W8BX94   A0A0R1EBK9   P49657   A0A1W4V234   Q9VX06   A0A158NGB0   A0A0A9W1Y5   A0A151IIQ0   A0A3B0JQF5   A0A195B483   A0A0K8TFQ6   A0A0A9VUI9   A0A0K8W195   A0A1A9VRI6   A0A0R1EJN4   A0A0M5J187   A0A0Q5T411   A0A0K8UWN4   A0A0Q5THS9   P49657-3   B4L6D0   A0A1B0B8A8   X2JFM3   A0A0R1ECE7   B4I6L0  

EC Number

2.7.12.1

Pubmed

28756777    26354079    12364791    14747013    17210077    25244985    + More
20920257    23761445    17510324    24438588    20566863    24330624    25315136    17994087    20075255    24495485    26823975    25830018    25401762    15632085    26108605    17550304    7857639    10731132    12537572    12537568    12537573    12537574    16110336    17569856    17569867    21347285   

EMBL

KZ149919    PZC77798.1    ODYU01001053    SOQ36761.1    NWSH01001535    PCG70930.1    + More
KQ459606    KPI90895.1    AAAB01008987    EGK97377.1    GGFK01001048    MBW34369.1    GGFJ01000442    MBW49583.1    EAA43038.5    GGFL01003836    MBW68014.1    GGFL01003837    MBW68015.1    APCN01002013    GGFL01003833    MBW68011.1    EGK97379.1    GGFK01001336    MBW34657.1    GGFJ01001276    MBW50417.1    GGFM01006535    MBW27286.1    GGFL01001544    MBW65722.1    ADMH02001839    ETN60966.1    EGK97378.1    AXCN02000273    ATLV01020027    ATLV01020028    ATLV01020029    KE525292    KFB44773.1    GECZ01023257    JAS46512.1    GFDL01016221    JAV18824.1    CH477270    EAT45319.1    DS235271    EEB14142.1    EAT45320.1    GEBQ01026370    JAT13607.1    GALA01000286    JAA94566.1    UFQS01000056    UFQT01000056    SSW98721.1    SSX19107.1    GFTR01007430    JAW08996.1    DS232083    EDS34335.1    SSW98722.1    SSX19108.1    KQ434827    KZC07573.1    OUUW01000003    SPP77689.1    CH479193    EDW26858.1    KZ288488    PBC25225.1    KQ414716    KOC62849.1    JR048695    AEY60735.1    SPP77688.1    GBYB01009228    JAG78995.1    GAMC01012725    JAB93830.1    GDHC01008434    JAQ10195.1    GBXI01013458    GBXI01006865    JAD00834.1    JAD07427.1    GAMC01012727    GAMC01012724    JAB93831.1    GBHO01044730    GBRD01001398    GDHC01000811    JAF98873.1    JAG64423.1    JAQ17818.1    CH379064    EAL32235.3    GBYB01009229    JAG78996.1    GBXI01002360    JAD11932.1    JRES01001143    KNC25175.1    CH916370    EDV99901.1    GBHO01044731    GBRD01001396    GDHC01018712    JAF98872.1    JAG64425.1    JAP99916.1    CH954180    KQS30012.1    EDV46536.1    GBRD01001395    JAG64426.1    CM000162    EDX02657.1    KQ981979    KYN31415.1    CM000366    EDX18251.1    GAMC01012726    JAB93829.1    KRK06886.1    X70794    X70798    X70799    AE014298    BT015255    AAF48778.2    ADTU01001580    ADTU01001581    ADTU01001582    ADTU01001583    ADTU01001584    ADTU01001585    ADTU01001586    GBHO01044729    GBRD01001400    JAF98874.1    JAG64421.1    KQ977474    KYN02520.1    SPP77690.1    KQ976625    KYM79080.1    GBRD01001399    JAG64422.1    GBHO01044728    GBRD01001397    JAF98875.1    JAG64424.1    GDHF01007401    JAI44913.1    KRK06887.1    CP012528    ALC49331.1    KQS30013.1    GDHF01021220    JAI31094.1    KQS30011.1    CH933812    EDW05926.2    JXJN01009885    AHN59863.1    KRK06885.1    CH480823    EDW55958.1   

Proteomes

UP000218220    UP000053268    UP000007062    UP000076407    UP000075920    UP000076408    + More
UP000075840    UP000075881    UP000075900    UP000000673    UP000075886    UP000075884    UP000030765    UP000075902    UP000008820    UP000009046    UP000002320    UP000075880    UP000095300    UP000095301    UP000076502    UP000268350    UP000008744    UP000242457    UP000053825    UP000005203    UP000002358    UP000001819    UP000091820    UP000037069    UP000001070    UP000008711    UP000002282    UP000078541    UP000192221    UP000000304    UP000000803    UP000005205    UP000078542    UP000078540    UP000078200    UP000092553    UP000009192    UP000092460    UP000001292   

PRIDE

P49657    Q9VX06    X2JFM3   

Pfam

PF00069   Pkinase

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR008271   Ser/Thr_kinase_AS       
IPR000719   Prot_kinase_dom       
IPR028318   DYRK1A/B_MNB       
IPR017441   Protein_kinase_ATP_BS       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

A0A2W1BRX5   A0A2H1V7G6   A0A2A4JHL7   A0A194PIH6   F5HMZ6   A0A2M4A0T0   + More
A0A182XGI2   A0A2M4B975   Q7PL23   A0A1Y9IUX8   A0A1Y9IVC3   A0A182Y457   A0A2M4CRQ0   A0A2M4CRW5   A0A182HZU4   A0A2M4CS68   F5HMZ7   A0A182K964   A0A2M4A1I7   A0A2M4BBK7   A0A182RNW6   A0A2M3ZFF0   A0A2M4CK37   W5JAF5   F5HMZ8   A0A182Q465   A0A1S4G6S6   A0A182N689   A0A084W3H9   A0A1B6F8E6   A0A182UFL8   A0A1Q3EU33   Q17FM4   E0VL86   Q17FM3   A0A1B6KQA7   T1DJG0   A0A336LRQ8   A0A224X9I1   B0WTA7   A0A182JJQ6   A0A1I8NPB4   A0A336K4G2   A0A1I8N744   A0A1I8NPB8   A0A1I8N735   A0A154P6X2   A0A3B0JVE4   B4GW13   A0A2A3E0D4   A0A0L7QWE1   V9II60   A0A088AN80   A0A3B0K2R3   K7IR41   A0A0C9Q5A0   W8AXV6   A0A146LST5   A0A0A1WP88   W8BKM4   A0A0A9VT26   Q29G75   A0A0C9QZM2   A0A0A1XLU7   A0A1A9W8U5   A0A0L0BYS3   B4JJZ9   A0A0A9VXE5   A0A0Q5T3S2   B3NWY9   A0A0K8TG95   B4Q2L6   A0A195ET37   A0A1W4UN33   B4R6Q2   W8BX94   A0A0R1EBK9   P49657   A0A1W4V234   Q9VX06   A0A158NGB0   A0A0A9W1Y5   A0A151IIQ0   A0A3B0JQF5   A0A195B483   A0A0K8TFQ6   A0A0A9VUI9   A0A0K8W195   A0A1A9VRI6   A0A0R1EJN4   A0A0M5J187   A0A0Q5T411   A0A0K8UWN4   A0A0Q5THS9   P49657-3   B4L6D0   A0A1B0B8A8   X2JFM3   A0A0R1ECE7   B4I6L0  

PDB

6EJ4     E-value=2.69078e-163,     Score=1477

KEGG

101738805    K08825 dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1] | (RefSeq) serine/

GO

GO:0004712   GO:0046777   GO:0005524   GO:0004674   GO:0004713   GO:0045666   GO:0043195   GO:0007399   GO:2000253   GO:0008355   GO:0035331   GO:0007632   GO:0007611   GO:0045786   GO:0045927   GO:0004860   GO:0006468   GO:1900244   GO:0007623   GO:0045887   GO:0004672   GO:0005634   GO:0016491   GO:0046872   GO:0009374   GO:0003677   GO:0004075   GO:0003824  

PANTHER

PTHR24058:SF12  

Subcellular location

Nucleus  

Length:

442

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.50874

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03417

outside

1  -  442

 

 

Pi

193.042993

Theta

178.367768

Tajima's D

0.432596

CLR

0.14537

CSRT

0.492275386230688

Interpretation

Uncertain