SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO10791  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA008387
Annotation
Cleavage_and_polyadenylation_specificity_factor_[Operophtera_brumata]
Full name
Integrator complex subunit 11      
Location in the cell
Cytoplasmic   Reliability : 2.671
 

Sequence

CDS
ATGCCGGATATTAAGATTACGCCACTCGGAGCGGGCCAGGATGTTGGTCGGAGCTGCATCTTGCTAACCATGGGTGGCAAAAACATAATGTTAGATTGTGGTATGCATATGGGCTACAACGATGAAAGAAGATTTCCTGATTTCTCTTACATTGTCCCGGAAGGCCCTATAACGAGTCAGATTGACTGCGTTATTATATCACATTTTCACCTAGATCACTGCGGTGCACTGCCCTATATGTCCGAAATGATTGGTTATACCGGCCCTATTTACATGACACACCCGACTAAAGCCATAGCACCAATCCTTCTCGAGGATATGAGGAAAGTCGCAGTGGAGCGCAAAGGTGAGTCAAACTTCTTCACTTCCCAAATGATTAAAGATTGTATGAAAAAAGTGACAGCTGTGACTCTCCATCAATCAGTAATGGTGGATAATGAATTAGAAATCAAAGCTTATTACGCAGGACATGTCTTAGGAGCTGCAATGTTCTGGATCAGAGTAGGGTCACAATCTGTGGTTTACACAGGTGATTACAACATGACACCTGATAGGCACTTAGGAGCCGCCTGGATTGACAAATGTAGACCTGATCTGCTCATAACAGAATCCACATATGCAACAACCATAAGAGATTCAAAACGCTGTCGTGAAAGAGATTTTCTCAAAAAAGTTCATGAATGTGTAGAAAAAGGAGGTAAGGTTCTGATTCCGGTGTTTGCATTAGGAAGGGCACAGGAACTTTGTATTTTATTGGAAACATATTGGGATCGTATGAATCTTAAATATCCAGTTTACTTTGCTCTTGGACTGACAGAAAAAGCAAACAATTACTATAAAATGTTTATAACATGGACCAATCAAAAAATAAGAAAGACATTTGTTCAAAGAAATATGTTTGACTTTAAGCATATTAAACCATTTGACAAGACATACATTGATAATCCCGGTGCTATGGTAGTTTTTGCTACGCCTGGAATGTTGCATGCTGGATTGTCACTAAACATCTTTAAGAAATGGGCTCCTTATGAGCAGAACATGGTGATTATGCCAGGATTCTGTGTGCAAGGCACAGTCGGACACAAGATCCTCAATGGAGCAAAGAAGGTTGAATTTGAAAACAGACAAGTGGTTGAAGTTAAAATGGCAGTAGAATACATGTCATTTTCAGCTCATGCTGATGCAAAAGGAATTATGCAATTGATACAATATTGTGAACCCAAAAATGTATTGTTGGTACATGGTGAAGCTCAAAAAATGGAGTTTTTGAAAGATAAAATAGAGAAGGAATTCAAAATTAGTTGTTTTATGCCAGCTAATGGTGAAACATGTGTTATAAATACTCCAACAACCATTCCTATTGATGTCTCGTTGAGGTTGCTGAAAGCTGAAGCAGTGAGATACAATGCCCAACCACCTGATCCAAAACGCAGGCGAGTTGTTAATGGGATTCTGTGTGTGAAAGATAACAGGCTATCATTACTAGACATTGATGAGATGTGTGATGAAATCGGAATAAACAGGCATATCATTAGATTCACAAGTACAGTTCGTTTTGAGGATCCGGGGCCAGCTATCAAGACTGCTGAAAAATTGCAGAATTTACTGACGGAAAAATTAGAAGGCTGGACTATAACTATATCGGAAGGAAACATATCAGTTGAGTCAGTACTCATCAAGGTAGAAGGTGAAGATGATAGCACAAAAAACATTTATGTTTCTTGGACAAACCAAGACGAAGACTTAGGTAGCTATATATTAGGGCTCCTGCAATCAATGGTTCAATATAGTCCAATGAAAGAATAA
Protein
MPDIKITPLGAGQDVGRSCILLTMGGKNIMLDCGMHMGYNDERRFPDFSYIVPEGPITSQIDCVIISHFHLDHCGALPYMSEMIGYTGPIYMTHPTKAIAPILLEDMRKVAVERKGESNFFTSQMIKDCMKKVTAVTLHQSVMVDNELEIKAYYAGHVLGAAMFWIRVGSQSVVYTGDYNMTPDRHLGAAWIDKCRPDLLITESTYATTIRDSKRCRERDFLKKVHECVEKGGKVLIPVFALGRAQELCILLETYWDRMNLKYPVYFALGLTEKANNYYKMFITWTNQKIRKTFVQRNMFDFKHIKPFDKTYIDNPGAMVVFATPGMLHAGLSLNIFKKWAPYEQNMVIMPGFCVQGTVGHKILNGAKKVEFENRQVVEVKMAVEYMSFSAHADAKGIMQLIQYCEPKNVLLVHGEAQKMEFLKDKIEKEFKISCFMPANGETCVINTPTTIPIDVSLRLLKAEAVRYNAQPPDPKRRRVVNGILCVKDNRLSLLDIDEMCDEIGINRHIIRFTSTVRFEDPGPAIKTAEKLQNLLTEKLEGWTITISEGNISVESVLIKVEGEDDSTKNIYVSWTNQDEDLGSYILGLLQSMVQYSPMKE

Summary

Description
Catalytic component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (By similarity). Mediates the snRNAs 3' cleavage (By similarity). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
Subunit
Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14. Within the complex, interacts with IntS12.
Similarity
Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
Keywords
Complete proteome   Cytoplasm   Hydrolase   Nucleus   Reference proteome  
Feature
chain  Integrator complex subunit 11
EC Number
3.1.27.-
EMBL
BABH01001612    NWSH01001369    PCG71513.1    ODYU01002318    SOQ39659.1    JTDY01001817    + More
KOB72797.1    AGBW02009218    OWR51326.1    GAIX01004384    JAA88176.1    KQ459606    KPI90921.1    KQ460556    KPJ14009.1    AJWK01025650    AJWK01025651    GFDF01008341    JAV05743.1    GEZM01086240    JAV59657.1    KK852854    KDR15001.1    PYGN01000487    PSN45526.1    CH477314    EAT43837.1    GGFK01007584    MBW40905.1    DS232162    EDS36462.1    KQ971352    EFA06334.1    APGK01035338    KB740923    KB632333    ENN78279.1    ERL92707.1    KQ981523    KYN40346.1    ADMH02001134    ETN63983.1    KQ979657    KYN19907.1    KQ976731    KYM76194.1    GFDL01012978    JAV22067.1    ADTU01007008    AXCM01000135    GL442815    EFN62951.1    KQ982580    KYQ54467.1    AXCN02000659    LBMM01003507    KMQ93447.1    KQ434809    KZC06667.1    KK107054    EZA61587.1    AAAB01008980    EAA13845.4    APCN01001701    CM000160    EDW98258.1    CH902623    EDV30573.1    CM000364    EDX14889.1    KQ976755    KYN08598.1    CH480819    EDW53398.1    AE014297    AY061097    AAL28645.1    CH954182    EDV53188.1    KA648479    AFP63108.1    KZ288209    PBC32992.1    CH940652    EDW59007.1    JRES01001623    KNC21362.1    UFQS01001164    UFQT01000573    UFQT01001164    SSX09301.1    SSX25388.1    SSX29203.1    GAMC01002798    JAC03758.1    CM000070    EAL27312.1    NNAY01000550    OXU27732.1    AAZX01002635    CH964232    EDW81175.1    GDHF01031107    JAI21207.1    GL445305    EFN89859.1    CH479179    EDW23817.1    KQ435843    KOX71282.1    GBYB01015019    JAG84786.1    GEHC01001203    JAV46442.1    CH933806    EDW16249.1    CP012526    ALC48059.1    GDHC01019018    JAP99610.1    KQ764051    OAD54615.1    OUUW01000007    SPP82913.1    CH916377    EDV90788.1    KK854825    PTY19048.1    GECL01000899    JAP05225.1    ACPB03015950    GBBI01002631    JAC16081.1    GEBQ01004817    JAT35160.1    GDAI01002879    JAI14724.1    GEDC01022799    GEDC01016998    JAS14499.1    JAS20300.1    JXUM01023801    KQ560671    KXJ81343.1    GFTR01007216    JAW09210.1    GAKP01005289    JAC53663.1    DS235339    EEB14934.1    GBHO01006417    JAG37187.1    GGFJ01003927    MBW53068.1    GGFJ01003928    MBW53069.1    ABJB010582038    DS711851    EEC05985.1    GEFM01003880    JAP71916.1    NEDP02001979    OWF52067.1   
Pfam
PF10996   Beta-Casp        + More
PF07521   RMMBL
PF16661   Lactamase_B_6
PF02290   SRP14
PF06862   UTP25
PF01156   IU_nuc_hydro
PF03810   IBN_N
Interpro
IPR001279   Metallo-B-lactamas        + More
IPR041897   INTS11-like_MBL-fold       
IPR022712   Beta_Casp       
IPR036866   RibonucZ/Hydroxyglut_hydro       
IPR011108   RMMBL       
IPR003210   Signal_recog_particle_SRP14       
IPR010678   Digest_organ_expansion_fac-prd       
IPR009018   Signal_recog_particle_SRP9/14       
IPR001589   Actinin_actin-bd_CS       
IPR036452   Ribo_hydro-like       
IPR001910   Inosine/uridine_hydrolase_dom       
IPR001494   Importin-beta_N       
IPR021133   HEAT_type_2       
IPR016024   ARM-type_fold       
IPR011989   ARM-like       
IPR040122   Importin_beta       
SUPFAM
SSF56281   SSF56281        + More
SSF54762   SSF54762       
SSF53590   SSF53590       
SSF48371   SSF48371       
PDB
2I7V     E-value=7.96634e-94,     Score=879

Ontologies

Topology

Subcellular location
Nucleus  
Cytoplasm  
Length:
601
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.35016
Exp number, first 60 AAs:
0.00883
Total prob of N-in:
0.00330
outside
1  -  601
 
 

Population Genetic Test Statistics

Pi
281.325673
Theta
214.06771
Tajima's D
1.012663
CLR
0.003245
CSRT
0.660416979151042
Interpretation
Uncertain
Copyright@ 2018-2023    Any Comments and suggestions mail to:zhuzl@cqu.edu.cn   渝ICP备19006517号

渝公网安备 50010602502065号