Gene

KWMTBOMO10789

Pre Gene Modal

BGIBMGA008431

Annotation

PREDICTED:_inhibin_beta_chain?_partial_[Bombyx_mori]

Location

Bomo_Chr18(+):2970688-2977101      View in EpiBrowser

Full name

Inhibin beta chain      

Alternative Name

Activin beta chain

Location in the cell

Extracellular   Reliability : 1.194 Mitochondrial   Reliability : 1.088 Nuclear   Reliability : 1.453

CDS

ATGAAAGAGGATGATCACAACTCACAACGGAGACAATCACTGGAAAGAGCAACAGAACTTCAGAACAACAGAACAGCAATCAGTCCGACTCTGAACGGACAAAGATTGATCGAGTTCCGGCTCGGCCAGGAGGGCGACTCGAATCGAGGGGAGGGACTGGAGGTCGCTTCCGCCGAACTCATGGTGCGCGCCGAGACGGTGCCCCATGCGCGGCACCTGCGCTATACGCTGTGGGCCTTCACCGTCGGAGACAACGCGACCGTCGGCGCGCTCGCCGGCGCCACGAGGAGGGACGCGGCGCGCGCTTGGCAGCGGCTCGATGTGACCGCGGCTGCGCAGCGCTGGGCCGCCGCCGGGGCGCTGACGCCGCTGCGTCTGCTGTTGGACTGCAGCGGGTGCGGCGGCCGCGTGCGCCTGCGGCTGGGCGGCGGACAGGCGGCGCGGCCCTTGCTGCGTCTTCGCCTGATGCCGCCGCCCGCTCGTCGTCGACGGGCGCTGGACTGCGACGGGTCGGAGCATGGCCGGTGTTGTCGACAGACCTACTACGTGAGCTTCCGCGCGCTCGGCTGGGACGACTGGATCGTCGCGCCAGAGGGCTACTACGCCAACTACTGTCGTGGGGCCTGCGCGCCCTTCCTCAACTACCACTCGCAAGTGGTGGAGGCGGCGCGGCTCGAGCGCGCCGCGTGCTGTGCGCCTGTGCGCTTTTCGGCGCTGTCGCTCATCTACTTCGGCGCCGACTCGAACATCATCAAACGTGACCTGCCCGAGATGGTGGTCGAGGAGTGCGACTGCCCGTAG

Protein

MKEDDHNSQRRQSLERATELQNNRTAISPTLNGQRLIEFRLGQEGDSNRGEGLEVASAELMVRAETVPHARHLRYTLWAFTVGDNATVGALAGATRRDAARAWQRLDVTAAAQRWAAAGALTPLRLLLDCSGCGGRVRLRLGGGQAARPLLRLRLMPPPARRRRALDCDGSEHGRCCRQTYYVSFRALGWDDWIVAPEGYYANYCRGACAPFLNYHSQVVEAARLERAACCAPVRFSALSLIYFGADSNIIKRDLPEMVVEECDCP

Description

Controls several aspects of neuronal morphogenesis; essential for optic lobe development, EcR-B1 expression in larval brains, mushroom body remodeling, dorsal neuron morphogenesis and motoneuron axon guidance. Ligands Actbeta and daw act redundantly through the Activin receptor Babo and its transcriptional mediator Smad2 (Smox), to regulate neuroblast numbers and proliferation rates in the developing larval brain.

Subunit

Homodimer or heterodimer; disulfide-linked.

Similarity

Belongs to the TGF-beta family.

Keywords

Cleavage on pair of basic residues   Complete proteome   Developmental protein   Disulfide bond   Glycoprotein   Growth factor   Reference proteome   Secreted   Signal  

Feature

chain  Inhibin beta chain

Uniprot

H9JFY4   A0A212FC65   A0A0N1PIX3   A0A0L7LBD4   A0A1B0GID9   A0A067RFS6   + More
A0A1S3D6N1   A0A2J7PJR1   A0A2P8Z9S3   A0A2R7WM44   D2A422   U4UA25   K7IVN3   E2C3J0   A0A158P356   A0A195CDA4   A0A195EZL3   A0A026WXS5   A0A195DN26   T1I4N3   A0A3L8E2R8   A0A2S2PKN5   A0A2H8TV86   J9KCT9   A0A2S2Q675   A0A154PJ56   A0A0J9S1D6   A0A0J9S166   A0A087ZS78   A0A310SST3   A0A0Q9XFD8   N6TEJ7   A0A0Q9XRU3   A0A0R1EC83   B4PW45   O61643   A0A1W4V580   B3P9P6   B4L7C6   B4IKR2   A0A0N8NZU7   A0A0P9BLR6   A0A3B0K6M1   B4MEZ5   B4JZN5   D0Z798   A0A151WYV9   Q29CT1   A0A2R5LC94   T1JDG1  

Pubmed

19121390    22118469    26354079    26227816    24845553    29403074    + More
18362917    19820115    23537049    20075255    20798317    21347285    24508170    30249741    22936249    17994087    17550304    10731132    12537572    12537569    12095682    9618266    12581521    18171686    18057021    15632085    23185243   

EMBL

BABH01001606    AGBW02009218    OWR51324.1    KQ460556    KPJ14007.1    JTDY01001817    + More
KOB72798.1    AJWK01013757    KK852498    KDR22706.1    NEVH01024946    PNF16575.1    PYGN01000134    PSN53245.1    KK854977    PTY20070.1    KQ971348    EFA05602.2    KB631865    ERL86800.1    GL452320    EFN77528.1    ADTU01007753    KQ977935    KYM98690.1    KQ981905    KYN33566.1    KK107087    EZA59949.1    KQ980713    KYN14278.1    ACPB03011117    ACPB03011118    QOIP01000001    RLU26753.1    GGMR01017380    MBY29999.1    GFXV01005273    MBW17078.1    ABLF02028224    ABLF02028225    ABLF02028228    GGMS01004016    MBY73219.1    KQ434931    KZC11843.1    CM002916    KMZ07378.1    KMZ07377.1    KQ760382    OAD60698.1    CH933813    KRG07280.1    APGK01041006    APGK01041007    KB740986    ENN76158.1    KRG07281.1    CM000161    KRK04993.1    EDW99350.1    KRK04990.1    KRK04991.1    KRK04992.1    AE014135    AY121686    AF454392    AF054822    CH954184    EDV45209.1    EDW10920.2    KRG07282.1    KRG07283.1    CH480855    EDW52652.1    CH902645    KPU75316.1    CH902665    KPU72656.1    OUUW01000017    SPP88933.1    CH940665    EDW71096.2    KRF85342.1    KRF85343.1    KRF85344.1    CH916380    EDV90901.1    CM000831    ACY70530.1    KQ982649    KYQ53082.1    CH475412    EAL29247.2    KRT05385.1    GGLE01003018    MBY07144.1    JH432105   

Proteomes

UP000005204    UP000007151    UP000053240    UP000037510    UP000092461    UP000027135    + More
UP000079169    UP000235965    UP000245037    UP000007266    UP000030742    UP000002358    UP000008237    UP000005205    UP000078542    UP000078541    UP000053097    UP000078492    UP000015103    UP000279307    UP000007819    UP000076502    UP000005203    UP000009192    UP000019118    UP000002282    UP000000803    UP000192221    UP000008711    UP000001292    UP000007801    UP000268350    UP000008792    UP000001070    UP000075809    UP000001819   

PRIDE

H9JFY4    O61643   

Pfam

PF00019   TGF_beta        + More
PF00688   TGFb_propeptide

Interpro

IPR017948   TGFb_CS        + More
IPR015615   TGF-beta-rel       
IPR029034   Cystine-knot_cytokine       
IPR001839   TGF-b_C       
IPR001111   TGF-b_propeptide       

SUPFAM

SSF57501   SSF57501       

Gene 3D

2.10.90.10    

ProteinModelPortal

H9JFY4   A0A212FC65   A0A0N1PIX3   A0A0L7LBD4   A0A1B0GID9   A0A067RFS6   + More
A0A1S3D6N1   A0A2J7PJR1   A0A2P8Z9S3   A0A2R7WM44   D2A422   U4UA25   K7IVN3   E2C3J0   A0A158P356   A0A195CDA4   A0A195EZL3   A0A026WXS5   A0A195DN26   T1I4N3   A0A3L8E2R8   A0A2S2PKN5   A0A2H8TV86   J9KCT9   A0A2S2Q675   A0A154PJ56   A0A0J9S1D6   A0A0J9S166   A0A087ZS78   A0A310SST3   A0A0Q9XFD8   N6TEJ7   A0A0Q9XRU3   A0A0R1EC83   B4PW45   O61643   A0A1W4V580   B3P9P6   B4L7C6   B4IKR2   A0A0N8NZU7   A0A0P9BLR6   A0A3B0K6M1   B4MEZ5   B4JZN5   D0Z798   A0A151WYV9   Q29CT1   A0A2R5LC94   T1JDG1  

PDB

5HLY     E-value=1.20933e-17,     Score=218

KEGG

101740148    K22687 inhibin beta B chain | (RefSeq) inhibin beta chain

PATHWAY

04350    TGF-beta signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0005576   GO:0008083   GO:0005615   GO:0042981   GO:0060395   GO:0043408   GO:0048468   GO:0005160   GO:0005125   GO:0010862   GO:0016021   GO:0048813   GO:0003676   GO:0005634   GO:0008270   GO:0005785   GO:0006886   GO:0006810   GO:0016614   GO:0005506   GO:0003824  

PANTHER

PTHR11848  

Subcellular location

Secreted  

Length:

266

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.70911

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.18926

outside

1  -  266

 

 

Pi

221.43362

Theta

180.532052

Tajima's D

0.635876

CLR

0.229444

CSRT

0.557122143892805

Interpretation

Uncertain