Gene

KWMTBOMO10780  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008426

Annotation

PREDICTED:_26S_proteasome_non-ATPase_regulatory_subunit_1_[Amyelois_transitella]

Location

Bomo_Chr18(+):2862280-2866272      View in EpiBrowser

Full name

26S proteasome non-ATPase regulatory subunit 1      

Alternative Name

26S proteasome regulatory complex subunit p110
26S proteasome regulatory subunit RPN2

Location in the cell

Cytoplasmic   Reliability : 2.371

CDS

ATGAACATCACGTCTGCCGCGGGGATTATTTCCCTGCTCGATGAGCCCATGTCTGAAGTTAAAGAATTCGCTCTGAAGAGGTTGGACAACATCGTCGATGAGTTTTGGCCAGAAATATCTGAATCTATCGAGAAAATAGAAATCCTGCACGAAGACAAAATTTTCTCCCAGCATCAGCTAGCCGCATTAGTAGCCAGTAAAGTGTACTATCATTTAGGAGCATTTGAAGATTCTTTGACATACGCGCTCGGGGCTGGAGATCTTTTCGACGTGAACGCGAGAAACGAATATGTCGACACTACGATCGCAAAAGCGATCGACTTTTACACTCAAAAGAGAAAGGCTCTCTTTGTGGATAGTTCTGCTGAACTAATTGATCACCGTCTTGAAGACATCGTGAATCGCATGTTCCAGAGGTGCCTTGAAGATGGACAATACAGACAAGCGCTTGGCTTAGCATTGGAGACGCGCCGTATGGATATTTTCGAGGAATCTATTATGAAATCTGATGATATACCAGGAATGCTTCAGTACGCTTTCACAGTAGCAATGAGTCTCCTCCAAAATAAGGGCTTCCGCAGCACTGTACTCCGTTCCTTAGTAACTTTATATAAGGGCCTCAATGTGCCCGATTATGTAAATATGTGCCAGTGTCTTATCTTCTTGGAAGATCCACTAGCTGTAGCAGAGATCCTTGACAAGCTAACACATGGACCACAAGAGTCCGTGTTAATGGCATATCAAATAGCCTTTGATTTGTATGACTCTGCAACTCAACAGTTCTTGGGCAGAGTCTTACAGGCTCTTAGGTGTACTGCACCTATTCCTAGTGCCTTAGGTGGCAAACCACAACCTCAAGGTGGACCTTTCCCAGAATCGTCAATGGAAGTTGACCAACCAGCAACCGAAGAAACCAAAAAGCCAGAGAGAGACATTGACAGTCTAAGTGATGAAGAGAAAGAGCATCAAAAAAGAGTTGAAAAATTGATTTCCATATTAGGAGGAGATGTATCTATAGGCCTCCAACTTCAGTTCTTAATCAGATCTAACCATGCCGATATGCTCATCTTAAAGAACACCAAAGATGCTATAAGGGTATCTATCTGCCACACGGCGACAGTAATAGCCAATGCGTTTATGCATGCAGGTACAACCAGTGATCAGTTTCTTAGGGACAACTTGGAGTGGCTTGCGAGAGCTACAAATTGGGCTAAGTTAACTGTTACAGCTTCTCTAGGAGTAATACATAGGGGTCACGAGAATGAATCCTTAGCTCTCATGCAATCATATCTGCCAAAAGAGGCAGGGCCATCTTCTGGTTATTCAGAAGGAGGTGGTCTCTATGCCTTAGGTTTGATCCATGCTAACCATGGAGCAAACATTATTGATTATCTTTTAACTCAGCTTAAAGATGCACAGAATGAGATGGTAAGACATGGAGGCTGCCTGGGTCTGGGCTTAGCTGCCATGGGCACACATAGACAGGATGTTTATGAACAGCTCAAGTTTAATCTGTATCAAGATGATGCTGTCACAGGAGAAGCAGCAGGTATTGCTATGGGTATGGTCATGCTAGGTTCTAGACATGCTGCTGCCATAGAAGATATGGTTGCCTATGCACAAGAAACACAGCATGAAAAGATCTTGAGAGGCCTTGCTGTTGGCATTGCTTTTACCATGTATGGAAGATTAGAAGAGGCTGATGCTCTGGTTCAGCAACTATTGAGAGACAAAGATCCATTATTGCGACGTGCTGGTTGCTACACTATAGCAACTGCTTATTGTGGCACTGGCAACAATGATTCCATCAGGACTTTGCTTCATGTAGCAGTATCAGATGTTAATGATGATGTTCGTAGGGCAGCTGTGACAGCTTTAGGATTTTTGTTATTTAGAACCCCAGAACAATGTCCCTCAGTAGTGTCGTTGCTGGCTGAATCGTACAATCCTCATGTTCGTTACGGCGCCGCCATGGCTCTGGGTATTGCCTGCGCTGGTACTGGGAATCGTGATGCCATTGGACTCTTGGAACCAATGGTTAAATTCGATCCTGTTAACTTTGTGAGGCAAGGCGCACTAATTGCTTCAGCCATGATTCTCATACAGCAAACCGAAGCGTTATGTCCGAAAGTAACTTATTTCCGTCAACTGTACGCACAAGTTATTTCAAACAAACACGAAGATGTTATGGCGAAGTTCGGAGCAATTTTAGCTCAAGGTATTATCGACGCTGGCGGCCGTAATGTTACCGTTTCACTCCAAAATAGAACTGGGCACATGAATATGCTTGCAGTCGTTGGTATGCTGGTATTTACCCAGTACTGGTATTGGTTCCCACTTGCACACTGCTTATCGCTTGCCTTTACACCAACGTGTATTATTTCACTTAACTCCGATCTTAAAATGCCTCAATTGGAACTGAAGTCCAACTCTAAGCCCTCGCTTTACGCGTATCCAGCTCCGTTGGAAGAAAAGAAACGTGAGGAAAGAGAGAGGGTTACCACTGCTGTGCTAAGTATTGCAGCTGCTAAAGCTCGTAGAAGGGCGCACGGAACTGACGGTTCGGCGAGCAGTGTCACTTCATCTACAACTTCTAAAATGGAAGTTGATGAGGAAGAGAAAAAACCCTCTAAATCCCCTAATATCACAGTTCATAGTAAATCCGATAAAGATGCTCCTAAAGATGCTAAGAAAGACGAAAAAGAAGCAGAGGACAAGGAAGCTAAAGAAAAGAAAGAACCAGAACCGACGTTTGAAATCTTGAGTAATCCTGCCAGAGTGATGAGACAGCAATTGAAGAATTTAACTATTGTCGAGGGTTCAGGTTTCACCCCTTTAAAGGATATCACTATTGGAGGTATTGTCATGTTGAACCACACCGGTGAAGGAGAACAAGTCCTGGTTGAGCCGGTTGCCGCATTCGGCCCGAAGGCAGAGGAAGAGAAGGAGCCTGAACCCCCAGAGCCTTTTGAATATCTGGATGATTGA

Protein

MNITSAAGIISLLDEPMSEVKEFALKRLDNIVDEFWPEISESIEKIEILHEDKIFSQHQLAALVASKVYYHLGAFEDSLTYALGAGDLFDVNARNEYVDTTIAKAIDFYTQKRKALFVDSSAELIDHRLEDIVNRMFQRCLEDGQYRQALGLALETRRMDIFEESIMKSDDIPGMLQYAFTVAMSLLQNKGFRSTVLRSLVTLYKGLNVPDYVNMCQCLIFLEDPLAVAEILDKLTHGPQESVLMAYQIAFDLYDSATQQFLGRVLQALRCTAPIPSALGGKPQPQGGPFPESSMEVDQPATEETKKPERDIDSLSDEEKEHQKRVEKLISILGGDVSIGLQLQFLIRSNHADMLILKNTKDAIRVSICHTATVIANAFMHAGTTSDQFLRDNLEWLARATNWAKLTVTASLGVIHRGHENESLALMQSYLPKEAGPSSGYSEGGGLYALGLIHANHGANIIDYLLTQLKDAQNEMVRHGGCLGLGLAAMGTHRQDVYEQLKFNLYQDDAVTGEAAGIAMGMVMLGSRHAAAIEDMVAYAQETQHEKILRGLAVGIAFTMYGRLEEADALVQQLLRDKDPLLRRAGCYTIATAYCGTGNNDSIRTLLHVAVSDVNDDVRRAAVTALGFLLFRTPEQCPSVVSLLAESYNPHVRYGAAMALGIACAGTGNRDAIGLLEPMVKFDPVNFVRQGALIASAMILIQQTEALCPKVTYFRQLYAQVISNKHEDVMAKFGAILAQGIIDAGGRNVTVSLQNRTGHMNMLAVVGMLVFTQYWYWFPLAHCLSLAFTPTCIISLNSDLKMPQLELKSNSKPSLYAYPAPLEEKKREERERVTTAVLSIAAAKARRRAHGTDGSASSVTSSTTSKMEVDEEEKKPSKSPNITVHSKSDKDAPKDAKKDEKEAEDKEAKEKKEPEPTFEILSNPARVMRQQLKNLTIVEGSGFTPLKDITIGGIVMLNHTGEGEQVLVEPVAAFGPKAEEEKEPEPPEPFEYLDD

Description

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

Subunit

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).

Similarity

Belongs to the proteasome subunit S1 family.

Keywords

Alternative splicing   Complete proteome   Direct protein sequencing   Phosphoprotein   Proteasome   Reference proteome   Repeat  

Feature

chain  26S proteasome non-ATPase regulatory subunit 1
splice variant  In isoform B.

Uniprot

A0A2A4J4L9   A0A2H1W0Q6   A0A212ETL7   A0A3S2TDE2   A0A0N1IHD5   A0A194PCC3   + More
A0A1Y1LWY3   A0A182GGV4   A0A182GCZ1   A0A182QI93   Q17GS7   A0A1S4F345   U5EZB8   A0A182RPD3   A0A182P2L9   A0A182M3M5   A0A182VRT0   A0A182IQ81   A0A1Q3F7S0   A0A182WSV8   B0WHS6   A0A1L8DSW1   W5J7R6   A0A1L8DTE1   A0A2M4A606   A0A182FNK1   A0A2M4BBI5   A0A2M4BBK6   A0A0C9QZ65   A0A336MJX1   A0A1A9Y8Y9   A0A1A9V941   A0A1B0BGT1   A0A1B0G973   A0A1B0AGP8   A0A3L8DKX1   A0A158NMH3   D3TNJ0   A0A151JW54   A0A1A9WTQ9   A0A1I8NXP0   N6TU34   A0A1Q3F7I5   A0A195AZT6   A0A195CW03   B4K5W8   A0A0L7LJU1   T1PAM5   A0A1W4UIP4   B4NFM4   B4PQ60   B4HZ72   A0A084W312   A0A0B4KHE9   Q9V3P6   A0A0B4KI10   A0A182XUZ7   B4MBT7   A0A182N7C7   B3P5K1   A0A151WUT8   A0A182HLR2   A0A182VH90   A0A1B6C4U5   A0A182TRH7   A0A026WFH5   Q7PY49   A0A182JU48   A0A2M4A5L8   A0A2P8XR50   W8AWT3   A0A034VUA6   A0A232FBX0   A0A0K8V7J3   K7IPB1   A0A0A1WQ05   A0A0L0CEV3   A0A1B6GG98   B3M1I7   A0A0M3QY66   B4JYI2   A0A3B0K6D6   A0A2L2XVN8   A0A182LA62   B5DYD3   A0A069DZN6   A0A224XJ34   A0A0P4VTW8   A0A023F4B3   E0VDU8   A0A087SVX7   A0A2S2Q2S8   A0A2H8TNJ6   J9JRM2   A0A0A9WRY6   A0A0K8S9P2   A0A293MXK4   A0A1Z5KUL7   A0A0V0G415   A0A0P5RGH1  

Pubmed

22118469    26354079    28004739    26483478    17510324    20920257    + More
23761445    30249741    21347285    20353571    23537049    17994087    26227816    25315136    17550304    24438588    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    10893261    11157774    12537569    18327897    25244985    24508170    12364791    14747013    17210077    29403074    24495485    25348373    28648823    20075255    25830018    26108605    26561354    20966253    15632085    26334808    27129103    25474469    20566863    25401762    26823975    28528879   

EMBL

NWSH01003288    PCG66618.1    ODYU01005346    SOQ46094.1    AGBW02012556    OWR44836.1    + More
RSAL01000298    RVE42794.1    KQ460556    KPJ13999.1    KQ459606    KPI90931.1    GEZM01044900    JAV78053.1    JXUM01062546    KQ562204    KXJ76426.1    JXUM01160558    KQ573741    KXJ67908.1    AXCN02000143    CH477256    EAT45860.1    GANO01001077    JAB58794.1    AXCM01001440    GFDL01011476    JAV23569.1    DS231939    EDS27943.1    GFDF01004528    JAV09556.1    ADMH02002001    ETN60021.1    GFDF01004529    JAV09555.1    GGFK01002737    MBW36058.1    GGFJ01001273    MBW50414.1    GGFJ01001272    MBW50413.1    GBYB01005987    JAG75754.1    UFQT01000671    SSX26358.1    JXJN01013985    CCAG010000643    QOIP01000007    RLU20559.1    ADTU01020488    ADTU01020489    ADTU01020490    ADTU01020491    ADTU01020492    ADTU01020493    EZ422992    ADD19268.1    KQ981676    KYN38150.1    APGK01018904    KB740085    KB632303    ENN81538.1    ERL91804.1    GFDL01011519    JAV23526.1    KQ976697    KYM77545.1    KQ977231    KYN04717.1    CH933806    EDW16205.1    JTDY01000907    KOB75476.1    KA645787    AFP60416.1    CH964251    EDW83091.2    CM000160    EDW98329.2    CH480819    EDW53329.1    ATLV01019778    KE525279    KFB44606.1    AE014297    AGB96438.1    AF145303    AF186594    AF312231    AY069503    BT001598    BT044102    AGB96437.1    CH940656    EDW58558.2    CH954182    EDV53251.1    KQ982727    KYQ51606.1    APCN01000911    GEDC01028979    JAS08319.1    KK107238    EZA54812.1    AAAB01008987    EAA01256.5    GGFK01002720    MBW36041.1    PYGN01001493    PSN34480.1    GAMC01015998    JAB90557.1    GAKP01013290    JAC45662.1    NNAY01000447    OXU28321.1    GDHF01017528    JAI34786.1    GBXI01013375    JAD00917.1    JRES01000501    KNC30747.1    GECZ01008436    JAS61333.1    CH902617    EDV43278.2    CP012526    ALC47143.1    CH916377    EDV90744.1    OUUW01000005    SPP81186.1    IAAA01005931    LAA00171.1    CM000070    EDY67585.2    GBGD01000325    JAC88564.1    GFTR01008385    JAW08041.1    GDKW01000506    JAI56089.1    GBBI01002366    JAC16346.1    DS235088    EEB11554.1    KK112194    KFM57016.1    GGMS01002820    MBY72023.1    GFXV01003938    MBW15743.1    ABLF02016086    GBHO01032387    GDHC01006042    JAG11217.1    JAQ12587.1    GBRD01015932    JAG49894.1    GFWV01020815    MAA45543.1    GFJQ02008164    JAV98805.1    GECL01003700    JAP02424.1    GDIQ01120373    JAL31353.1   

Proteomes

UP000218220    UP000007151    UP000283053    UP000053240    UP000053268    UP000069940    + More
UP000249989    UP000075886    UP000008820    UP000075900    UP000075885    UP000075883    UP000075920    UP000075880    UP000076407    UP000002320    UP000000673    UP000069272    UP000092443    UP000078200    UP000092460    UP000092444    UP000092445    UP000279307    UP000005205    UP000078541    UP000091820    UP000095300    UP000019118    UP000030742    UP000078540    UP000078542    UP000009192    UP000037510    UP000095301    UP000192221    UP000007798    UP000002282    UP000001292    UP000030765    UP000000803    UP000076408    UP000008792    UP000075884    UP000008711    UP000075809    UP000075840    UP000075903    UP000075902    UP000053097    UP000007062    UP000075881    UP000245037    UP000215335    UP000002358    UP000037069    UP000007801    UP000092553    UP000001070    UP000268350    UP000075882    UP000001819    UP000009046    UP000054359    UP000007819   

PRIDE

Q9V3P6   

Pfam

PF01851   PC_rep        + More
PF18004   RPN2_C

Interpro

IPR011989   ARM-like        + More
IPR016642   26S_Psome_Rpn2       
IPR002015   Proteasome/cyclosome_rpt       
IPR016024   ARM-type_fold       
IPR035266   PSMD1       
IPR040623   RPN2_C       

SUPFAM

SSF48371   SSF48371       

Gene 3D

1.25.10.10    

ProteinModelPortal

A0A2A4J4L9   A0A2H1W0Q6   A0A212ETL7   A0A3S2TDE2   A0A0N1IHD5   A0A194PCC3   + More
A0A1Y1LWY3   A0A182GGV4   A0A182GCZ1   A0A182QI93   Q17GS7   A0A1S4F345   U5EZB8   A0A182RPD3   A0A182P2L9   A0A182M3M5   A0A182VRT0   A0A182IQ81   A0A1Q3F7S0   A0A182WSV8   B0WHS6   A0A1L8DSW1   W5J7R6   A0A1L8DTE1   A0A2M4A606   A0A182FNK1   A0A2M4BBI5   A0A2M4BBK6   A0A0C9QZ65   A0A336MJX1   A0A1A9Y8Y9   A0A1A9V941   A0A1B0BGT1   A0A1B0G973   A0A1B0AGP8   A0A3L8DKX1   A0A158NMH3   D3TNJ0   A0A151JW54   A0A1A9WTQ9   A0A1I8NXP0   N6TU34   A0A1Q3F7I5   A0A195AZT6   A0A195CW03   B4K5W8   A0A0L7LJU1   T1PAM5   A0A1W4UIP4   B4NFM4   B4PQ60   B4HZ72   A0A084W312   A0A0B4KHE9   Q9V3P6   A0A0B4KI10   A0A182XUZ7   B4MBT7   A0A182N7C7   B3P5K1   A0A151WUT8   A0A182HLR2   A0A182VH90   A0A1B6C4U5   A0A182TRH7   A0A026WFH5   Q7PY49   A0A182JU48   A0A2M4A5L8   A0A2P8XR50   W8AWT3   A0A034VUA6   A0A232FBX0   A0A0K8V7J3   K7IPB1   A0A0A1WQ05   A0A0L0CEV3   A0A1B6GG98   B3M1I7   A0A0M3QY66   B4JYI2   A0A3B0K6D6   A0A2L2XVN8   A0A182LA62   B5DYD3   A0A069DZN6   A0A224XJ34   A0A0P4VTW8   A0A023F4B3   E0VDU8   A0A087SVX7   A0A2S2Q2S8   A0A2H8TNJ6   J9JRM2   A0A0A9WRY6   A0A0K8S9P2   A0A293MXK4   A0A1Z5KUL7   A0A0V0G415   A0A0P5RGH1  

PDB

6MSK     E-value=0,     Score=2961

KEGG

101746253    K03032 26S proteasome regulatory subunit N2 | (RefSeq) 26S proteasome non-ATPase regulatory subunit

PATHWAY

03050    Proteasome - Bombyx mori (domestic silkworm)

GO

GO:0008540   GO:0030234   GO:0042176   GO:0000502   GO:0007623   GO:0008063   GO:0005654   GO:0005829   GO:0043161   GO:0008270   GO:0005838   GO:0034515   GO:0005634   GO:0016021   GO:0005488   GO:0005785   GO:0006886   GO:0006810   GO:0016614   GO:0005506   GO:0003824  

PANTHER

PTHR10943:SF2  

Length:

995

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.88494

Exp number, first 60 AAs:

0.00028

Total prob of N-in:

0.00314

outside

1  -  995

 

 

Pi

251.05917

Theta

233.843926

Tajima's D

0.244253

CLR

0.044104

CSRT

0.437778111094445

Interpretation

Uncertain