Gene

KWMTBOMO10777  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008424

Annotation

PREDICTED:_protein_maelstrom_homolog_[Bombyx_mori]

Location

Bomo_Chr18(+):2822000-2837254      View in EpiBrowser

Full name

Protein maelstrom homolog      

Transcription factor

HMG

Location in the cell

Nuclear   Reliability : 2.953

CDS

ATGCCAAAAAAGAAGACCCCACAAAATCCATTTTTCTTCTTCATGATGGACTATAGGAAAGAACAAGCAGAAATAGGCATAAAATATGCCAACACCAAGGAATTAGCTGAAGCCGCTGGTCCTGTATGGCAGAACTTAAGGCCTACATTAAAAGCAAAATATGAAGAGAAAGCTAAGAATGAAAAAGAAAAGAACAAACAAACTGGAACTAAGTTCACGTCGACCGGCATACCTATAAAAGTAATAGAACAACAACAGAGAGAAATGAAGAATGCTGAAGATAATGAAAAAAAAGACATACAGAATATTGTGAAGCTCAAGGTGTTTGATCAAAGTATAAAAACTGAAGATTTTTATGTGATTGACGTGAACTCATACTGCAAAGCTAATGGTGATTATTTAATCGGAGAGTTCACCGTGACTCAATTCAGTCTGCAGGATGGTGTCAAAAATAGCTACCATGAAACTATTATTCCAAGTTGTGTACCGGTTGGATATATGTTTGATGTGAAACTGGGTGCTGAAGAGTTCGGCCTGGAGATGCCCGGCACCGATGACGCAGGACCCAACTACATACAAATACTGGCCAACATCATCGACTACTTGAAGCAGAAGGATCGGACTGTGCAAGTCTTGCCACCGATGTTCACGTTGCCGGAGAAGGTGGACGCAGTGCAGAACTTCATCTCACAGATGTGTAATTGTGCGACCGAAGACGACTCGCTGTTCCGTATATACAAACTAGACACGTTTTTCTTCACTCTGATCAACGCTATCAGCAGTCATCACGACGAGGGCTTCCCTAAGGAGTCGTTGGCGCTCACGCAGCTGACCAAGGACCTGTTCGACTACACACCGGGGATCGCGTGTGAGCGTCACGAGTCGCTGGACAGAAGCAACGTTTGCACAACGTCCCGCGTCAAACGTTGGGTGTTCACGATCCTGGACCGCTGCTGCCCGCTACTGGGGATTCCCCTGCAGCCGGGGAAGCACCTGCCCTTCGACTACGACATCAACGGCATCCTGATTTTTAAAGAAGAAAGGAAGACAAGAGCCGCTCCCTCTGTGCCTCGTACGGCCACCGCCTCGAGTAACTCATCCTTTATCAACGACTCTTTGAATGAATCCTTCCAAAGCTTGAACGTTACCGGCGAGACCGCCGCGTCGGGCTCGGCGCCGGGCAGGAGGGTGCACAAGCCGCTGCGCATGCCGCGTACCGACTATTCTCAGCGGATTCAGCAGGCTCCCGAACTGACGGAGGCTAACTTCCCGACGCTCACGGGGCACGGCCGAGGGCGTGGTCTGACCAGGAGCAACAATTGA

Protein

MPKKKTPQNPFFFFMMDYRKEQAEIGIKYANTKELAEAAGPVWQNLRPTLKAKYEEKAKNEKEKNKQTGTKFTSTGIPIKVIEQQQREMKNAEDNEKKDIQNIVKLKVFDQSIKTEDFYVIDVNSYCKANGDYLIGEFTVTQFSLQDGVKNSYHETIIPSCVPVGYMFDVKLGAEEFGLEMPGTDDAGPNYIQILANIIDYLKQKDRTVQVLPPMFTLPEKVDAVQNFISQMCNCATEDDSLFRIYKLDTFFFTLINAISSHHDEGFPKESLALTQLTKDLFDYTPGIACERHESLDRSNVCTTSRVKRWVFTILDRCCPLLGIPLQPGKHLPFDYDINGILIFKEERKTRAAPSVPRTATASSNSSFINDSLNESFQSLNVTGETAASGSAPGRRVHKPLRMPRTDYSQRIQQAPELTEANFPTLTGHGRGRGLTRSNN

Description

Plays a central role during gametogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons (By similarity).

Similarity

Belongs to the maelstrom family.

Keywords

Complete proteome   Cytoplasm   Developmental protein   Differentiation   DNA-binding   Meiosis   Nucleus   Reference proteome   RNA-mediated gene silencing  

Feature

chain  Protein maelstrom homolog

Uniprot

A0A0H5AXR2   A0A212ETL5   S4PDX9   A0A3S2LSC5   A0A194PE20   A0A0N1IP66   + More
A0A2H1WIG8   A0A2P8Z899   A0A2J7PG07   A0A067QTJ5   A0A2P8YWD1   A0A182PRJ3   A0A069DU44   A0A1B6J7Z9   A0A224XJV4   B0W2W6   A0A1B0EZW0   A0A1B0D1X9   B0W494   A0A2P8Z8A9   A0A1B6G106   A0A0V0G7H6   A0A1Q3F079   A0A1Q3F023   E0VM85   A0A1Q3F073   A0A1Q3EZN9   A0A182Q4Y0   A0A182I042   A0A182LH32   Q7PYM9   A0A1S4G6Y0   A0A1B6KNM8   A0A0P4VWA8   A0A182G7Y4   A0A182XBA0   A0A182KB73   A0A182V656   A0A182U671   A0A2M3ZJN9   A0A182G7Y5   A0A023EXL8   A0A1W4WEJ8   A0A1B0CVR1   A0A182FNR3   A0A2M4AWW2   A0A2M4AXC4   A0A2M4BLZ2   A0A2M4BLY9   A0A2M4BMU7   A0A1L8DAP5   A0A0A9Y2N6   A0A1L8DB70   V5GTW6   A0A0T6B2H4   W5JJY8   A0A1I8PJ21   A0A182H175   A0A182IIY3   A0A182NCG6   A0A182IKG6   U5EVE7   A0A084VJ51   T1H9A4   A0A1Q3EW40   Q16YA8   A0A170YYN4   A0A1I8PQG2   A0A182W4I5   A0A1B6CQG3   A0A0K8VZK8   A0A084VHB0   N6U553   A0A084VTZ5   A0A2J7QTC0   U4U4D0   A0A026WCS1   A0A1A9WKI0   A0A1Y1LH61   A0A0C9R9V5   A0A154PA32   T1PAS7   A0A182S6Z3   A0A2J7PV15   A0A034WUS8   A0A182YJT8   A0A1B0D8T9   A0A088ASY7   A0A310SH33   A0A1I8MZI2   A0A1B0B350   A0A182R9G6   A0A1A9ZXQ9  

Pubmed

25865890    25778731    22118469    23622113    26354079    29403074    + More
24845553    26334808    20566863    20966253    12364791    14747013    17210077    27129103    26483478    24945155    25401762    26823975    20920257    23761445    24438588    17510324    23537049    24508170    28004739    25315136    25348373    25244985   

EMBL

LC032360    BAR94546.1    AGBW02012556    OWR44833.1    GAIX01004767    JAA87793.1    + More
RSAL01000295    RVE42830.1    KQ459606    KPI90934.1    KQ460556    KPJ13996.1    ODYU01008884    SOQ52858.1    PYGN01000150    PSN52729.1    NEVH01025635    PNF15261.1    KK853289    KDR08911.1    PYGN01000323    PSN48553.1    GBGD01001454    JAC87435.1    GECU01012418    JAS95288.1    GFTR01006318    JAW10108.1    DS231829    AJVK01008640    AJVK01022452    AJVK01022453    DS231836    EDS33179.1    PSN52718.1    GECZ01013641    JAS56128.1    GECL01002738    JAP03386.1    GFDL01014091    JAV20954.1    GFDL01014142    JAV20903.1    DS235297    EEB14491.1    GFDL01014093    JAV20952.1    GFDL01014278    JAV20767.1    AXCN02000016    APCN01002042    AAAB01008987    EAA01399.5    GEBQ01026924    GEBQ01014586    GEBQ01012899    JAT13053.1    JAT25391.1    JAT27078.1    GDKW01000199    JAI56396.1    JXUM01047242    JXUM01047243    JXUM01047244    JXUM01047245    JXUM01047246    JXUM01047247    KQ561512    KXJ78325.1    GGFM01007990    MBW28741.1    JXUM01047249    KXJ78326.1    GAPW01000379    JAC13219.1    AJWK01031027    AJWK01031028    GGFK01011953    MBW45274.1    GGFK01011927    MBW45248.1    GGFJ01004959    MBW54100.1    GGFJ01004958    MBW54099.1    GGFJ01004957    MBW54098.1    GFDF01010674    JAV03410.1    GBHO01026062    GBHO01026061    GBHO01026060    GBHO01019819    GBRD01016798    GBRD01016797    GDHC01019645    GDHC01011782    GDHC01009800    GDHC01007297    GDHC01004372    JAG17542.1    JAG17543.1    JAG17544.1    JAG23785.1    JAG49029.1    JAP98983.1    JAQ06847.1    JAQ08829.1    JAQ11332.1    JAQ14257.1    GFDF01010412    JAV03672.1    GALX01003384    JAB65082.1    LJIG01016088    KRT81651.1    ADMH02001019    ETN64416.1    JXUM01102761    KQ564750    KXJ71798.1    GANO01001894    JAB57977.1    ATLV01013431    KE524855    KFB37995.1    ACPB03005809    GFDL01015559    JAV19486.1    CH477519    GEMB01002807    JAS00391.1    GEDC01021529    JAS15769.1    GDHF01008045    JAI44269.1    ATLV01013150    KE524842    KFB37354.1    APGK01049250    KB741146    ENN73697.1    ATLV01016572    ATLV01016573    KE525094    KFB41439.1    NEVH01011196    PNF31828.1    KB631697    ERL85441.1    KK107263    EZA53862.1    GEZM01055727    JAV72964.1    GBYB01003596    JAG73363.1    KQ434857    KZC08796.1    KA645255    AFP59884.1    NEVH01021187    PNF20150.1    GAKP01000865    JAC58087.1    AJVK01027729    KQ761208    OAD57991.1    JXJN01007770   

Proteomes

UP000007151    UP000283053    UP000053268    UP000053240    UP000245037    UP000235965    + More
UP000027135    UP000075885    UP000002320    UP000092462    UP000009046    UP000075886    UP000075840    UP000075882    UP000007062    UP000069940    UP000249989    UP000076407    UP000075881    UP000075903    UP000075902    UP000192223    UP000092461    UP000069272    UP000000673    UP000095300    UP000075880    UP000075884    UP000030765    UP000015103    UP000008820    UP000075920    UP000019118    UP000030742    UP000053097    UP000091820    UP000076502    UP000095301    UP000075901    UP000076408    UP000005203    UP000092460    UP000075900    UP000092445   

PRIDE

B0W2W6    Q16YA8   

Pfam

PF09011   HMG_box_2        + More
PF13017   Maelstrom
PF03256   ANAPC10

Interpro

IPR024970   Maelstrom        + More
IPR036910   HMG_box_dom_sf       
IPR009071   HMG_box_dom       
IPR039259   Protein_maelstrom       
IPR008979   Galactose-bd-like_sf       
IPR016901   APC10/Doc1       
IPR004939   APC_su10/DOC_dom       

SUPFAM

SSF47095   SSF47095        + More
SSF49785   SSF49785       

Gene 3D

1.10.30.10     2.60.120.260    

CDD

cd08366  APC10

ProteinModelPortal

A0A0H5AXR2   A0A212ETL5   S4PDX9   A0A3S2LSC5   A0A194PE20   A0A0N1IP66   + More
A0A2H1WIG8   A0A2P8Z899   A0A2J7PG07   A0A067QTJ5   A0A2P8YWD1   A0A182PRJ3   A0A069DU44   A0A1B6J7Z9   A0A224XJV4   B0W2W6   A0A1B0EZW0   A0A1B0D1X9   B0W494   A0A2P8Z8A9   A0A1B6G106   A0A0V0G7H6   A0A1Q3F079   A0A1Q3F023   E0VM85   A0A1Q3F073   A0A1Q3EZN9   A0A182Q4Y0   A0A182I042   A0A182LH32   Q7PYM9   A0A1S4G6Y0   A0A1B6KNM8   A0A0P4VWA8   A0A182G7Y4   A0A182XBA0   A0A182KB73   A0A182V656   A0A182U671   A0A2M3ZJN9   A0A182G7Y5   A0A023EXL8   A0A1W4WEJ8   A0A1B0CVR1   A0A182FNR3   A0A2M4AWW2   A0A2M4AXC4   A0A2M4BLZ2   A0A2M4BLY9   A0A2M4BMU7   A0A1L8DAP5   A0A0A9Y2N6   A0A1L8DB70   V5GTW6   A0A0T6B2H4   W5JJY8   A0A1I8PJ21   A0A182H175   A0A182IIY3   A0A182NCG6   A0A182IKG6   U5EVE7   A0A084VJ51   T1H9A4   A0A1Q3EW40   Q16YA8   A0A170YYN4   A0A1I8PQG2   A0A182W4I5   A0A1B6CQG3   A0A0K8VZK8   A0A084VHB0   N6U553   A0A084VTZ5   A0A2J7QTC0   U4U4D0   A0A026WCS1   A0A1A9WKI0   A0A1Y1LH61   A0A0C9R9V5   A0A154PA32   T1PAS7   A0A182S6Z3   A0A2J7PV15   A0A034WUS8   A0A182YJT8   A0A1B0D8T9   A0A088ASY7   A0A310SH33   A0A1I8MZI2   A0A1B0B350   A0A182R9G6   A0A1A9ZXQ9  

PDB

5AF0     E-value=5.63486e-154,     Score=1396

KEGG

101739880    K18411 protein maelstrom | (RefSeq) protein maelstrom homolog

GO

GO:0060964   GO:0003677   GO:0046872   GO:0005634   GO:0051321   GO:0005737   GO:0007275   GO:0030154   GO:0031047   GO:0007283   GO:0045892   GO:0043186   GO:0043565   GO:0034587   GO:0007140   GO:0016021   GO:0005680   GO:0031145  

PANTHER

PTHR21358  

Subcellular location

Cytoplasm   Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.   With evidence from 1 publications.
Nucleus   Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.   With evidence from 1 publications.

Length:

440

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00450999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01335

outside

1  -  440

 

 

Pi

189.368412

Theta

143.037444

Tajima's D

0.590922

CLR

0.131723

CSRT

0.537973101344933

Interpretation

Uncertain