Gene

KWMTBOMO10776

Pre Gene Modal

BGIBMGA008394

Annotation

PREDICTED:_alpha-(1?6)-fucosyltransferase_[Papilio_xuthus]

Location

Bomo_Chr18(-):2789453-2821199      View in EpiBrowser

Full name

Alpha-(1,6)-fucosyltransferase      

Location in the cell

Cytoplasmic   Reliability : 1.192 Nuclear   Reliability : 1.261

CDS

ATGAAGAATTATTCAAATGGTCACGTAACGATACATGATTATTTTATGATGTACTTTGCGAAATGGAAGCGAGTCGCCGTCGTATTGCTCGCCGTTTGGATTGTCGTCACCTATTTAGTCATATCGCCTTTAAGATGCAGCGGCAATTCAGATGAGATCCCCGACGTCCAGGAGAGGTTGAAGCGGATGTCTTCGGAGCTGGAAGTCCTGTGGCAGAGAAACAGTAAGCTCATAGCGCAGATAAAGAAGTCTTCAGGGCCCAATGGCAATCTTAAAGATTTGGATCCGGCGTTTTGGAACCTTGAAGCGGGACTTGGTCCGTCAGAGGAATACGAGAATCTCAGGAGGAGGATCCACTCGAATACAAAGGAGTTCTGGTACTACGCGAACCATGAGCTCGGGAAGTTGATGCACGAGAGTGACAAGGAAGCGAAAATACGAGCGATTTTGGAACAACTGTCTGATAGGAAAAGCACATTACTGTCTGATCAAGAAAAACTATCGGAAATGGATGGTTACCACGAGTGGAGGCAACTAGAGGCGGCCAACGTCAGCGACCTTGTCCAGAGGAGGTTGCACTATTTACAGAACCCGCCGGATTGTAGGGAGGCAAGGAAACTTATATGCAACTTGAATAAGGGCTGCGGCTTCGGCTGTCAACTCCACCACATAGTGTACTGCCTTATATTCGCTTACGCCACCGAGAGGACTCTAATCCTGAACTCGAAGGGGTGGCGGTACAACACTAAAGGATGGGAGTACGTCTTCCATCCGATATCGGAGAGCTGTTTGTCTTCGTACGACGATAAAGTCGTGCAGTGGCCAGTTTCATACGACGCGAAAGTGGTTTCGCTACCGTTTATAGATTCCATATCGCAGAAGCCCAAGTTCTTGCCGCTGGCTGTGCCTAAAGACTTGGCTCATAGGATAGTCCGCTTCAACGGCGATCCGTCGTCGTGGTGGGTCGGGCAAATGCTGAAGTTCGTCCTGAAGCCGCGCCTGCCGATGCAGAAGGCGATCAACGACACAATAGCCAAAATGAATTTCAAATCTCCCATAGTCGGGGTTCACATACGCCGCACCGATAAAGTTGGAACCGAAGCCGCCTTCCACCACATACACGAGTACATGGCGCACGTGAAGGACTATTACGACCAGCTAGAGCTGACCCGGCCCGTCGACGTCCGGAGAGTGTATCTAGCCACAGACGACGCTAATGTGCTAGACGACGCCCGACAAAAGTATCCGGAGTACACGTTCTTAGGGGATCCGTCGATAGCGAAGACGGCGGCCACTCACCGTAGATACACGCCGCTCTCGCTTACTGGCCTACTGGTGGATCTACACATGCTGGCCATGTGCGATTACTTAGTGTGTACATTTAGCAGTCAAGTGGGTCGAGTGGCGTACGAAATGATGCAGTCGAACAGAGTGGACGCGTCAAACAGCTTCTTCTCGTTAGATGACATTTACTACTTCGGTGGACAAAACGCGCACGACAGGGTGGCCATCATGCAGAACCACGGCGGGAAAAACGAGGATATATCTTTTGAGGTGGGCGATAAAATAGGAGTGGCCGGCAACCATTGGAACGGATACGGACGCGGAACTAACAAGAGAACGAATATGAACGGTCTGATCCCTTGGTACAAGACTGCCGATCATCTGGTGTTGTACCCGTTTCCGGAATACAAACAGGTGCCTATTTATTCAGAAACGAGCCAAAAGAACGTTTAA

Protein

MKNYSNGHVTIHDYFMMYFAKWKRVAVVLLAVWIVVTYLVISPLRCSGNSDEIPDVQERLKRMSSELEVLWQRNSKLIAQIKKSSGPNGNLKDLDPAFWNLEAGLGPSEEYENLRRRIHSNTKEFWYYANHELGKLMHESDKEAKIRAILEQLSDRKSTLLSDQEKLSEMDGYHEWRQLEAANVSDLVQRRLHYLQNPPDCREARKLICNLNKGCGFGCQLHHIVYCLIFAYATERTLILNSKGWRYNTKGWEYVFHPISESCLSSYDDKVVQWPVSYDAKVVSLPFIDSISQKPKFLPLAVPKDLAHRIVRFNGDPSSWWVGQMLKFVLKPRLPMQKAINDTIAKMNFKSPIVGVHIRRTDKVGTEAAFHHIHEYMAHVKDYYDQLELTRPVDVRRVYLATDDANVLDDARQKYPEYTFLGDPSIAKTAATHRRYTPLSLTGLLVDLHMLAMCDYLVCTFSSQVGRVAYEMMQSNRVDASNSFFSLDDIYYFGGQNAHDRVAIMQNHGGKNEDISFEVGDKIGVAGNHWNGYGRGTNKRTNMNGLIPWYKTADHLVLYPFPEYKQVPIYSETSQKNV

Description

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.

Catalytic Activity

GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc}-L-asparaginyl-[protein]

Similarity

Belongs to the glycosyltransferase 23 family.

Feature

chain  Alpha-(1,6)-fucosyltransferase

Uniprot

A0A060PLD2   H9JFU7   A0A2A4JPZ2   A0A194PIL8   R4L884   A0A0N1I7K9   + More
A0A212ETJ9   A0A0A1TKV6   A0A1Y1L2Q9   A0A139WIJ8   D2A2U6   A0A182JQS5   A0A1B6CPN6   A0A2P8YME2   A0A182MUF6   A0A182VCR0   A0A182XBM1   A0A182TYT5   A0A182I0F5   Q7PYD8   A0A2J7QLV9   A0A0P4Z061   A0A0P6HXG2   A0A164L1R6   E9HF16   A0A0A1TKW5   A0A182YJU6   B4MAI6   B4L679   A0A182SAJ5   A0A182Q8X1   A0A1Q3FF33   A0A067RGX4   A0A182INY9   A0A182PC20   A0A0M4EML8   A0A182N5X1   A0A1L8E215   A0A023EV61   U5EZ81   B0WME2   A0A182G1U2   A0A336LNK4   A0A1L8E2C2   N6T2L9   B4MT17   A0A1L8E233   A0A2M4A0D1   A0A034VSZ3   A0A2S2QB72   A0A084VRW7   W5J3H7   A0A0P6DDA9   A0A0A1X468   A0A2M3YYP9   A0A2M3ZDZ8   A0A182FQK7   A0A2M4BHX1   A0A2S2QAD6   Q16ZK5   A0A1W4XMA5   A0A0K8UIV4   A0A182VQX6   W8BPV9   A0A1J1IY37   A0A2M4BHX2   A0A2S2P711   A0A0P5W4L6   B4JM16   A0A087SYF1   A0A1I8M9H5   A0A1A9YMH3   A0A1B0BDK8   A0A1B0FAZ8   X1XL71   A0A0A1TTF2   A0A2H8TE61   A0A0P5TI54   A0A1B0A828   A0A0L0BVR5   A0A1A9WVK8   A0A182KM43   A0A293MSG4   A0A1B0GKV9   A0A1I8NTE8   A0A1A9UW33   A0A0N0BIS4   A0A1B6KQG1   W4WWN8   A0A2A3EDG2   A0A195CJ35   A0A195F151   A0A1B6JXJ5   A0A195B2I4   A0A182R1I4   A0A195E6L9   F4X6S2   A0A088AHL8   A0A1W4WBG7   A0A0L7RIK4  

EC Number

2.4.1.68

Pubmed

24973708    19121390    26354079    25333276    22118469    28004739    + More
18362917    19820115    29403074    12364791    14747013    17210077    21292972    25244985    17994087    24845553    24945155    26483478    23537049    25348373    24438588    20920257    23761445    25830018    17510324    24495485    25315136    26108605    20966253    21347285    21719571   

EMBL

AB848715    BAO96240.1    BABH01001589    BABH01001590    BABH01001591    NWSH01000842    + More
PCG73889.1    KQ459606    KPI90935.1    KC538901    KC538902    AGL08712.1    KQ460556    KPJ13995.1    AGBW02012556    OWR44832.1    BK008802    DAA64658.1    GEZM01066303    JAV67979.1    KQ971339    KYB27749.1    EFA02784.1    GEDC01021851    JAS15447.1    PYGN01000494    PSN45403.1    AXCM01000371    APCN01002074    AAAB01008987    EAA01061.5    NEVH01013241    PNF29584.1    GDIP01219931    JAJ03471.1    GDIQ01014149    JAN80588.1    LRGB01003216    KZS03721.1    GL732633    EFX69666.1    BK008814    DAA64668.1    CH940655    EDW66245.1    CH933812    EDW05875.1    AXCN02000190    GFDL01008890    JAV26155.1    KK852478    KDR23027.1    CP012528    ALC49021.1    GFDF01001314    JAV12770.1    GAPW01000717    JAC12881.1    GANO01001268    JAB58603.1    DS231997    EDS30999.1    JXUM01006333    JXUM01006334    KQ560213    KXJ83815.1    UFQT01000095    SSX19724.1    GFDF01001315    JAV12769.1    APGK01046982    APGK01046983    KB741073    ENN74379.1    CH963851    EDW75256.1    GFDF01001313    JAV12771.1    GGFK01000955    MBW34276.1    GAKP01014289    JAC44663.1    GGMS01005784    MBY74987.1    ATLV01015783    KE525036    KFB40711.1    ADMH02002134    ETN58391.1    GDIQ01088149    JAN06588.1    GBXI01008829    JAD05463.1    GGFM01000643    MBW21394.1    GGFM01005957    MBW26708.1    GGFJ01003518    MBW52659.1    GGMS01005495    MBY74698.1    CH477489    EAT40069.1    GDHF01025677    GDHF01025507    GDHF01020054    JAI26637.1    JAI26807.1    JAI32260.1    GAMC01015052    GAMC01015051    JAB91504.1    CVRI01000063    CRL04476.1    GGFJ01003519    MBW52660.1    GGMR01012595    MBY25214.1    GDIP01104950    JAL98764.1    CH916371    EDV91777.1    KK112528    KFM57890.1    JXJN01012514    CCAG010001425    ABLF02016140    ABLF02016142    BK008810    DAA64664.1    GFXV01000581    MBW12386.1    GDIP01125955    JAL77759.1    JRES01001264    KNC24088.1    GFWV01019004    MAA43732.1    AJWK01033779    KQ435727    KOX77864.1    GEBQ01026302    GEBQ01001618    JAT13675.1    JAT38359.1    BK008808    DAA64662.1    KZ288282    PBC29524.1    KQ977754    KYN00079.1    KQ981864    KYN34295.1    GECU01003780    JAT03927.1    KQ976662    KYM78502.1    KQ979568    KYN20840.1    GL888818    EGI57854.1    KQ414584    KOC70561.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000007266    + More
UP000075881    UP000245037    UP000075883    UP000075903    UP000076407    UP000075902    UP000075840    UP000007062    UP000235965    UP000076858    UP000000305    UP000076408    UP000008792    UP000009192    UP000075901    UP000075886    UP000027135    UP000075880    UP000075885    UP000092553    UP000075884    UP000002320    UP000069940    UP000249989    UP000019118    UP000007798    UP000030765    UP000000673    UP000069272    UP000008820    UP000192223    UP000075920    UP000183832    UP000001070    UP000054359    UP000095301    UP000092443    UP000092460    UP000092444    UP000007819    UP000092445    UP000037069    UP000091820    UP000075882    UP000092461    UP000095300    UP000078200    UP000053105    UP000005205    UP000242457    UP000078542    UP000078541    UP000078540    UP000075900    UP000078492    UP000007755    UP000005203    UP000192221    UP000053825   

PRIDE

H9JFU7   

Pfam

PF14604   SH3_9        + More
PF02752   Arrestin_C
PF00339   Arrestin_N
PF00226   DnaJ
PF06320   GCN5L1

Interpro

IPR027350   GT23_dom        + More
IPR036028   SH3-like_dom_sf       
IPR035653   Fut8_SH3       
IPR015827   Fut8       
IPR001452   SH3_domain       
IPR014752   Arrestin_C       
IPR011021   Arrestin-like_N       
IPR011022   Arrestin_C-like       
IPR014756   Ig_E-set       
IPR001623   DnaJ_domain       
IPR036869   J_dom_sf       
IPR009395   BLOC1S1       

SUPFAM

SSF50044   SSF50044        + More
SSF81296   SSF81296       
SSF46565   SSF46565       

Gene 3D

2.60.40.640     1.10.287.110    

CDD

cd11792  SH3_Fut8
cd06257  DnaJ

ProteinModelPortal

A0A060PLD2   H9JFU7   A0A2A4JPZ2   A0A194PIL8   R4L884   A0A0N1I7K9   + More
A0A212ETJ9   A0A0A1TKV6   A0A1Y1L2Q9   A0A139WIJ8   D2A2U6   A0A182JQS5   A0A1B6CPN6   A0A2P8YME2   A0A182MUF6   A0A182VCR0   A0A182XBM1   A0A182TYT5   A0A182I0F5   Q7PYD8   A0A2J7QLV9   A0A0P4Z061   A0A0P6HXG2   A0A164L1R6   E9HF16   A0A0A1TKW5   A0A182YJU6   B4MAI6   B4L679   A0A182SAJ5   A0A182Q8X1   A0A1Q3FF33   A0A067RGX4   A0A182INY9   A0A182PC20   A0A0M4EML8   A0A182N5X1   A0A1L8E215   A0A023EV61   U5EZ81   B0WME2   A0A182G1U2   A0A336LNK4   A0A1L8E2C2   N6T2L9   B4MT17   A0A1L8E233   A0A2M4A0D1   A0A034VSZ3   A0A2S2QB72   A0A084VRW7   W5J3H7   A0A0P6DDA9   A0A0A1X468   A0A2M3YYP9   A0A2M3ZDZ8   A0A182FQK7   A0A2M4BHX1   A0A2S2QAD6   Q16ZK5   A0A1W4XMA5   A0A0K8UIV4   A0A182VQX6   W8BPV9   A0A1J1IY37   A0A2M4BHX2   A0A2S2P711   A0A0P5W4L6   B4JM16   A0A087SYF1   A0A1I8M9H5   A0A1A9YMH3   A0A1B0BDK8   A0A1B0FAZ8   X1XL71   A0A0A1TTF2   A0A2H8TE61   A0A0P5TI54   A0A1B0A828   A0A0L0BVR5   A0A1A9WVK8   A0A182KM43   A0A293MSG4   A0A1B0GKV9   A0A1I8NTE8   A0A1A9UW33   A0A0N0BIS4   A0A1B6KQG1   W4WWN8   A0A2A3EDG2   A0A195CJ35   A0A195F151   A0A1B6JXJ5   A0A195B2I4   A0A182R1I4   A0A195E6L9   F4X6S2   A0A088AHL8   A0A1W4WBG7   A0A0L7RIK4  

PDB

2DE0     E-value=1.0373e-138,     Score=1266

KEGG

101745965    K00717 glycoprotein 6-alpha-L-fucosyltransferase [EC:2.4.1.68] | (RefSeq) alpha-(1,6)-fucosyltransfe

PATHWAY

00510    N-Glycan biosynthesis - Bombyx mori (domestic silkworm)
00533    Glycosaminoglycan biosynthesis - keratan sulfate - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0008424   GO:0032580   GO:0016021   GO:0033578   GO:0006487   GO:0036071   GO:0046921   GO:0031083   GO:0005515   GO:0006508   GO:0008237   GO:0050660   GO:0046872   GO:0051537   GO:0003824   GO:0016614   GO:0005506  

Subcellular location

  

Length:

578

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

19.9231

Exp number, first 60 AAs:

19.60344

Total prob of N-in:

0.98941

POSSIBLE N-term signal

sequence

inside

1  -  24

TMhelix

25  -  44

outside

45  -  578

 

 

Pi

243.012399

Theta

164.206865

Tajima's D

1.528415

CLR

0.375151

CSRT

0.793710314484276

Interpretation

Uncertain