Gene

KWMTBOMO10773

Pre Gene Modal

BGIBMGA008395

Annotation

PREDICTED:_delta-like_protein_1_[Bombyx_mori]

Location

Bomo_Chr18(-):2764219-2765099      View in EpiBrowser

Full name

Delta-like protein       + More
Delta-like protein B      
Delta-like protein C      

Location in the cell

Extracellular   Reliability : 2.136

CDS

ATGTTGTCACTACCAAATTTAGAACCAATTTGTGCAGCGAACTGTCACAGCGAGAGGGGCTTCTGTCGGCGTCCCGGGGAATGCCGCTGCAAGGTCGGCTGGACCGGGCCCACGTGCGCGCAGTGCCACAGGTACCCTGGCTGCAAGCACGGAACTTGCAGGAAGCCTTGGGAGTGTATCTGCAAAAAGGGCTGGGGAGGAATGCTGTGTGACGAAGGTGAGTTTTAA

Protein

MLSLPNLEPICAANCHSERGFCRRPGECRCKVGWTGPTCAQCHRYPGCKHGTCRKPWECICKKGWGGMLCDEGEF

Description

Putative Notch ligand involved in the mediation of Notch signaling.
Acts as a ligand for Notch receptors and is involved in primary neurogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation.
Acts as a ligand for Notch receptors and is involved in somitogenesis. Can activate Notch receptors. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.

Keywords

Calcium   Complete proteome   Developmental protein   Differentiation   Disulfide bond   EGF-like domain   Glycoprotein   Membrane   Neurogenesis   Notch signaling pathway   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix   Ubl conjugation  

Feature

chain  Delta-like protein

Uniprot

H9JFU8   A0A3S2NLG9   A0A2H1VJ88   A0A2A4JR51   A0A194PCC7   I4DJ83   + More
A0A0N0PCG8   A0A212ETQ4   A0A2J7QLV8   A0A1I8PB87   A0A182NC65   W5JJZ3   A0A1B0DG68   A0A1I8MRK7   Q17IN2   A0A336LHW1   A0A1S4F1B8   A0A182WFV9   A0A0K8VB06   A0A0A1WMS8   A0A182RYW0   A0A034WVX6   A0A182WUN4   A0A182U5Y4   A0A182KCR2   A0A182KKC3   U4U1J1   A0A182UQG4   A0A182HVU1   A0A182PJ98   A0A182GGA6   A0A182FKD6   A0A182MDB1   D2A0G9   Q7QGY2   A0A067RJ30   A0A084WQA9   A0A182IWL1   A0A182YKN3   A0A182SV86   A0A2S2P900   A0A0K8W2B8   A0A161MR17   A0A1B6HDI0   A0A1S4N2N7   B0X8Q5   E0W3E6   A0A1B0A1B0   A0A1B6EQ11   A0A1B6LUF6   A0A1B0G9S4   W8B1I0   W8AXK5   A0A1A9VWM8   J9JWS8   A0A2S2Q6W0   J3JXN7   A0A2H8TZD5   U4UGD5   A0A3B1ISZ0   A0A3B1K7P8   W5KPC7   A0A1A9WWW1   A0A0L0C381   A0A1Y1KKZ3   A0A3B0K5Y3   B4H4T9   B4MSI0   A0A3P8YLV6   T1IPW5   Q29I00   A0A2D0QCF8   A0A3B4DQL0   W5KGW2   A0A3P8YLP6   A0A3B4VBM2   Q1LYD2   O57409   A0A3B4WWN9   A0A3B4VBN9   A0A3B4X6T1   A0A3N0Y074   A0A060YM88   B4PYV7   A0A1S3RLH3   A0A3Q3DVC3   A0A1S3QDA7   Q9VZ44   B4JXB2   G3Q9T1   B3NVC3   B4MAN3   L8HSS5   A0A1W4V2L9   A0A2R8QUE3   A4JYS0   Q9IAT6   A0A3Q1K3S9   A0A3Q2XGU1   A0A3B4BGD1  

Pubmed

19121390    26354079    22651552    22118469    20920257    23761445    + More
25315136    17510324    25830018    25348373    20966253    23537049    26483478    18362917    19820115    12364791    14747013    17210077    24845553    24438588    25244985    20566863    24495485    22516182    25329095    26108605    28004739    17994087    25069045    15632085    9425132    12530964    24755649    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22751099    23594743    10585570    11100729    25463417   

EMBL

BABH01001586    BABH01001587    BABH01001588    RSAL01000295    RVE42832.1    ODYU01002872    + More
ODYU01002873    SOQ40891.1    SOQ40893.1    NWSH01000842    PCG73890.1    KQ459606    KPI90936.1    AK401351    BAM17973.1    KQ460556    KPJ13994.1    AGBW02012556    OWR44831.1    NEVH01013241    PNF29570.1    ADMH02000906    ETN64702.1    AJVK01059319    CH477238    EAT46528.1    UFQT01000011    SSX17592.1    GDHF01033893    GDHF01016277    GDHF01008994    JAI18421.1    JAI36037.1    JAI43320.1    GBXI01013973    GBXI01005251    JAD00319.1    JAD09041.1    GAKP01000440    JAC58512.1    KB630786    ERL83870.1    APCN01001416    JXUM01061469    JXUM01061470    KQ562151    KXJ76561.1    AXCM01004569    KQ971338    EFA01689.2    AAAB01008823    EAA05540.4    KK852478    KDR23028.1    ATLV01025458    KE525389    KFB52403.1    GGMR01013275    MBY25894.1    GDHF01007062    JAI45252.1    GEMB01001958    JAS01219.1    GECU01034960    JAS72746.1    AAZO01007376    DS232497    EDS42647.1    DS235882    EEB20152.1    GECZ01029758    JAS40011.1    GEBQ01012677    JAT27300.1    CCAG010014160    GAMC01015674    GAMC01015667    JAB90888.1    GAMC01015673    GAMC01015668    JAB90887.1    ABLF02037278    GGMS01004273    MBY73476.1    BT128007    AEE62969.1    GFXV01007880    MBW19685.1    KB632126    ERL88955.1    JRES01000955    KNC26803.1    GEZM01083945    JAV60920.1    OUUW01000025    SPP89614.1    CH479209    EDW32701.1    CH963851    EDW75069.2    JH431265    CH379064    EAL31606.2    CU458990    CAM73251.1    AF006488    BC076414    RJVU01055763    ROK74152.1    FR913631    CDQ92677.1    CM000162    EDX02035.1    AE014298    BT122182    AAF47984.1    ADE58552.1    CH916376    EDV95388.1    CH954180    EDV46111.1    CH940655    EDW66292.2    JH883261    ELR46918.1    AL935335    CU458991    CAM73252.1    AF146429   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000053240    UP000007151    + More
UP000235965    UP000095300    UP000075884    UP000000673    UP000092462    UP000095301    UP000008820    UP000075920    UP000075900    UP000076407    UP000075902    UP000075881    UP000075882    UP000030742    UP000075903    UP000075840    UP000075885    UP000069940    UP000249989    UP000069272    UP000075883    UP000007266    UP000007062    UP000027135    UP000030765    UP000075880    UP000076408    UP000075901    UP000002320    UP000009046    UP000092445    UP000092444    UP000078200    UP000007819    UP000018467    UP000091820    UP000037069    UP000268350    UP000008744    UP000007798    UP000265140    UP000001819    UP000221080    UP000261440    UP000261420    UP000000437    UP000261360    UP000193380    UP000002282    UP000087266    UP000264820    UP000000803    UP000001070    UP000007635    UP000008711    UP000008792    UP000192221    UP000265040    UP000261520   

PRIDE

H9JFU8    O57409    Q9VZ44    Q9IAT6   

Pfam

PF00008   EGF        + More
PF00053   Laminin_EGF
PF00561   Abhydrolase_1
PF07974   EGF_2
PF01414   DSL
PF12661   hEGF
PF07657   MNNL
PF03031   NIF

Interpro

IPR002049   Laminin_EGF        + More
IPR013032   EGF-like_CS       
IPR000742   EGF-like_dom       
IPR001881   EGF-like_Ca-bd_dom       
IPR001774   DSL       
IPR016024   ARM-type_fold       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR029058   AB_hydrolase       
IPR000073   AB_hydrolase_1       
IPR013111   EGF_extracell       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR018097   EGF_Ca-bd_CS       
IPR011651   Notch_ligand_N       
IPR004274   FCP1_dom       
IPR036412   HAD-like_sf       
IPR023214   HAD_sf       

SUPFAM

SSF48371   SSF48371        + More
SSF57184   SSF57184       
SSF53474   SSF53474       
SSF56784   SSF56784       

Gene 3D

3.40.50.1820     3.40.50.1000    

ProteinModelPortal

H9JFU8   A0A3S2NLG9   A0A2H1VJ88   A0A2A4JR51   A0A194PCC7   I4DJ83   + More
A0A0N0PCG8   A0A212ETQ4   A0A2J7QLV8   A0A1I8PB87   A0A182NC65   W5JJZ3   A0A1B0DG68   A0A1I8MRK7   Q17IN2   A0A336LHW1   A0A1S4F1B8   A0A182WFV9   A0A0K8VB06   A0A0A1WMS8   A0A182RYW0   A0A034WVX6   A0A182WUN4   A0A182U5Y4   A0A182KCR2   A0A182KKC3   U4U1J1   A0A182UQG4   A0A182HVU1   A0A182PJ98   A0A182GGA6   A0A182FKD6   A0A182MDB1   D2A0G9   Q7QGY2   A0A067RJ30   A0A084WQA9   A0A182IWL1   A0A182YKN3   A0A182SV86   A0A2S2P900   A0A0K8W2B8   A0A161MR17   A0A1B6HDI0   A0A1S4N2N7   B0X8Q5   E0W3E6   A0A1B0A1B0   A0A1B6EQ11   A0A1B6LUF6   A0A1B0G9S4   W8B1I0   W8AXK5   A0A1A9VWM8   J9JWS8   A0A2S2Q6W0   J3JXN7   A0A2H8TZD5   U4UGD5   A0A3B1ISZ0   A0A3B1K7P8   W5KPC7   A0A1A9WWW1   A0A0L0C381   A0A1Y1KKZ3   A0A3B0K5Y3   B4H4T9   B4MSI0   A0A3P8YLV6   T1IPW5   Q29I00   A0A2D0QCF8   A0A3B4DQL0   W5KGW2   A0A3P8YLP6   A0A3B4VBM2   Q1LYD2   O57409   A0A3B4WWN9   A0A3B4VBN9   A0A3B4X6T1   A0A3N0Y074   A0A060YM88   B4PYV7   A0A1S3RLH3   A0A3Q3DVC3   A0A1S3QDA7   Q9VZ44   B4JXB2   G3Q9T1   B3NVC3   B4MAN3   L8HSS5   A0A1W4V2L9   A0A2R8QUE3   A4JYS0   Q9IAT6   A0A3Q1K3S9   A0A3Q2XGU1   A0A3B4BGD1  

PDB

4XLW     E-value=1.14494e-16,     Score=205

KEGG

101739742    no KO assigned | (RefSeq) delta-like protein 1

GO

GO:0005509   GO:0016021   GO:0016020   GO:0007154   GO:0016298   GO:0044255   GO:0005112   GO:0005886   GO:0045746   GO:0007275   GO:0007219   GO:0030901   GO:0021536   GO:0030154   GO:0035907   GO:0001757   GO:0002244   GO:0060842   GO:0042802   GO:0061056   GO:0048471   GO:0048514   GO:0021514   GO:0005737   GO:0030165   GO:0048666   GO:0060218   GO:0001756   GO:0005515   GO:0006508   GO:0008237   GO:0050660   GO:0046872   GO:0051537   GO:0003824   GO:0016614   GO:0005506  

Subcellular location

Membrane  

Length:

75

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02922

outside

1  -  75

 

 

Pi

58.110576

Theta

102.418806

Tajima's D

-1.356658

CLR

180.662552

CSRT

0.07999600019999

Interpretation

Uncertain