Gene

KWMTBOMO10761  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA008399

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_symplekin_[Bombyx_mori]

Location

Bomo_Chr18(-):2566411-2579429      View in EpiBrowser

Full name

Symplekin      

Location in the cell

Nuclear   Reliability : 2.796

CDS

ATGTCGAATAAACACGGACACACGTCTAATACTACAGTACAAAATCAGCTAATACGATGGATAAACGATACTGGAATGGCGGAAGGAAACAAAAAAGCAGGCTTATTGAGAAAAGTCATAGAAGTTCTGCTACATCAAGGCTCGCAAATGATTCCAGTATACATGGAGAATATACTAAGCTACATCAGCGATAAAAATACAGACGTAAAGAAGCAGGTCGCGTATTTTGTTGAAGAGTTGAGTAAAAGTCACCCTGAACTTCTTCCCAAGATTGTCGCTCAGTTGCGTCTCCTACTCCTTGACCCAGTCATTGCGGTGCAGAAGAGGGCCATCCAAGCAGCCAGTATACTGTACCGTAATACGTTAATGTGGATCTGTAAAGGTGACGCTGAAGTATCGGAAATGAAACATGTATGGGAACATTTAACTGAATTAAAGTTGATGGTTTTAAACATGATCGACAGTGAGAATGAAGGTATCAGAACGCATTCCATTAAGTTCCTGGAAGAGGTTGTGCTCCGGCAAAGTCCCGGTGACATTGTTGATGCTGAATCCAGCTTGGATAGTCTACCATCAGATGTTCCTTTTATCAATAGAAAAGCTCTCGAAGAGGAATCTGACCATATCTTCAAACTACTGGTCAAATTTCATAATTCACAGCACATATCAAGTGTAAACCTGATGGCTTGTATGACAACGCTATGTTCTTTAGCAAAATTCCGTCCTAAATACTTGCCCCGAGTCATACAAGCACTAGGCGATCTTCACACGACACTACCTCCAACTCTATCGCAGTCTCAAGTCAATTCAGTCAGGAAACATCTCAAAATGCAGATATTGAATTTAATAAAACAATCAACTTCTAATGAGATGATGCCGCAGTTGACACAATTGCTAATTGATATCGGAATGACAGCACAAGAGATTAATAAGGCGGTACCGAAAGAGAAAAGAAACAAACGCTTAGGGGAAATTAGGAATGGGGATACACCATCTAAACGGTTCAGAATCGATTCACCTCAAAGTAATAGTCAAGGTAGCGACAGTAACAGCCGTAGTGAATTCATGTATGACGATGACAGCCAGTCAAGCATCACGAAGCCTTCGGCAACAGAAGACAGTATCCTCGAAGGCTTAAATTCTGTGGACAATGTTGTTAATCTTGTCATGAAAACATTGCAGAATTGTCTACCAGATAACATGCCGCCCTCGTTCACAAATGATTACAAGCCAATACCTAACTCTGGTAGCAAAGTACAAAAGAAGAACTTGGCTAAAATGTTGATGAGCTTAATAAGAGGTGAATCAGAAAATACACAAATAGTTACACAATCAATGGAGGTAGATACACAACCTAACCAGACAGTATTACAACAGAGCTTATCCGATATAGCTGCGAAAATACCGTTAATAAGGGAAGATGATGAGAAAACTACCCTCAAAAATGCTGTAGCTAAATTACAAGAGTCAACAAAAGACAGGCAGATAGAGAGTGCGGTTTCTAAACTAATGGAAGAAACGAGACAGGAACATTTGAAGGAGGAAGAGAGGAAAGCAAAGGAGAAAGAGAAACCGGTTCCTCCACCTACTCCGACGGTGCCTAAACTGAAACAGAAAGTGAAGCTATTGAAACTACAGGAAATAACACGGCCCATCCCAAAAGAAATAAAGCAAAAGTTGATACTGCAGGCCGTTGAGAGGATTTTAAATGCGGAAAAAGACGCCGCTATCGGTGGAGCCGAACAGATCCGGGCCAAATTCATCACGATATTCGCTTCGAGTTACACGCCGGAAACGCGCGATCTAGTACTGAATTACATTTTAGACAATCCCGCCGAGCGCATCAACCTCGCTTTGAAGTGGTTATATGAAGAATACGCATTCATGCAGGGCTTTAACCGACATCCGGTGACCCTACAACCGAAACTGCACGAGAAGCACGATCAAAACTACAACCAGTTGCTCTGTGCTCTGGTCACCCAGATATCCGAGAGAGGCGACCCTGTCATGGAAGGATGCAAAGATGTTTTACTAAGGAAGATATATTTGGAGAGTCCGGTGATCACGGACGAGGCCCTGGATTATTTGAAGCACTTGGTCACTGAAGATCAGGTGGCTCTGCTGGCTTTGGAGTTGCTAGAGGAATTGTGTTTGATGAGACCACCTCGGGCACACAAATATGTGACATCGTTGGTCTGTCATGTTTTGAGCGAAAATGAGGAAATCCGCGATATAGCTTTGAAAGCTACCATCAAAGTTTACAAACGTGGCTCAGAAGCTGTTAAGAAAGTCATCGAGAAACACGCTCTCCTGTACTTAGGGTTCATATCGTTGAATCATCCGCCCCCTGAACTTTCAAGCACCAGAACTAGGATCATGTGGAATGAGAATTTACATAAGCTGTGCTTGAATTTAGTTGTGGCGCTCTTCCCAGAAAAAGAAGGACTACTGATGGAAATAGCAAGGATATACGGCAGCTCCGGTGCAGAGGCGAAGCGCGTTGTACTGCGAACCATCGAGGGTCCGATCCGGGCGATGGTGTCCAAGGACCTGCCCGACAACGAGTTCGACGAGGACGACGCCACGCTGCGCCCCGCCTTCAGGGAACTGCTCGAGAACTGTCCCCGAGGAGCAGAGACTCTGCTCACCAGACTAGTGCATATACTGACCGAGAAAGTGCCTCCAACAGCCGAACTAGTGTCGAAAGTACGAGACATATACGCCACCAGAGTGTCCGACGTTAGATTCTTGATCCCCGTGCTCACCGGACTGTCAAAGAGAGAGATCGTGGCAGCCCTACCGAAACTAATCAAGCTCAACCCTGCCGTCGTGAAGGAGGTGTTCAACAAGCTGTTGGGAATCAACGGCACGTACGACGAGCAGTCGCCCGGTAGGTGGCGCCACCGACGCGGGTCTGAGAGAGAGAGAGAAAGAGAGAGCATACTTTATTGCTCACCAAAACACTATTAA

Protein

MSNKHGHTSNTTVQNQLIRWINDTGMAEGNKKAGLLRKVIEVLLHQGSQMIPVYMENILSYISDKNTDVKKQVAYFVEELSKSHPELLPKIVAQLRLLLLDPVIAVQKRAIQAASILYRNTLMWICKGDAEVSEMKHVWEHLTELKLMVLNMIDSENEGIRTHSIKFLEEVVLRQSPGDIVDAESSLDSLPSDVPFINRKALEEESDHIFKLLVKFHNSQHISSVNLMACMTTLCSLAKFRPKYLPRVIQALGDLHTTLPPTLSQSQVNSVRKHLKMQILNLIKQSTSNEMMPQLTQLLIDIGMTAQEINKAVPKEKRNKRLGEIRNGDTPSKRFRIDSPQSNSQGSDSNSRSEFMYDDDSQSSITKPSATEDSILEGLNSVDNVVNLVMKTLQNCLPDNMPPSFTNDYKPIPNSGSKVQKKNLAKMLMSLIRGESENTQIVTQSMEVDTQPNQTVLQQSLSDIAAKIPLIREDDEKTTLKNAVAKLQESTKDRQIESAVSKLMEETRQEHLKEEERKAKEKEKPVPPPTPTVPKLKQKVKLLKLQEITRPIPKEIKQKLILQAVERILNAEKDAAIGGAEQIRAKFITIFASSYTPETRDLVLNYILDNPAERINLALKWLYEEYAFMQGFNRHPVTLQPKLHEKHDQNYNQLLCALVTQISERGDPVMEGCKDVLLRKIYLESPVITDEALDYLKHLVTEDQVALLALELLEELCLMRPPRAHKYVTSLVCHVLSENEEIRDIALKATIKVYKRGSEAVKKVIEKHALLYLGFISLNHPPPELSSTRTRIMWNENLHKLCLNLVVALFPEKEGLLMEIARIYGSSGAEAKRVVLRTIEGPIRAMVSKDLPDNEFDEDDATLRPAFRELLENCPRGAETLLTRLVHILTEKVPPTAELVSKVRDIYATRVSDVRFLIPVLTGLSKREIVAALPKLIKLNPAVVKEVFNKLLGINGTYDEQSPGRWRHRRGSERERERESILYCSPKHY

Description

Component of a protein complex required for cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA.

Subunit

Interacts with Cpsf73 and Cpsf100 forming a core cleavage factor required for both polyadenylated and histone mRNA processing. Interacts with Slbp and Lsm11.

Similarity

Belongs to the Symplekin family.

Keywords

3D-structure   Coiled coil   Complete proteome   mRNA processing   Nucleus   Reference proteome   Repeat   RNA-binding  

Feature

chain  Symplekin

Uniprot

H9JFV2   A0A2A4JBI5   A0A2H1VCZ9   A0A212FCK9   A0A0N1IP64   A0A1E1WJQ7   + More
A0A212F7B0   A0A194PD64   A0A0L7L8R9   A0A2J7QFW6   E0VQ07   A0A151JQH5   F4W5L8   K7IU32   A0A182GJ60   Q17I55   A0A151I253   A0A146L2G3   A0A1B0ESZ5   A0A1W4UJU2   B0WVE7   A0A2R5L7R2   B4QXJ2   A0A084W6K3   B4PUX6   B4I467   A0A0A1WZ23   A0A1Q3F1T5   B3P2J3   A0A1Q3F080   Q8MSU4   Q7QCG6   A0A182LEI4   A0A182TL26   A0A182HSH7   A0A182USV9   B3LWE7   A0A0N8DVW1   B4G491   A0A0P5QXE2   A0A0P5KVQ8   A0A0P6FCV8   A0A182IR14   A0A0T6AXR2   A0A0P6EDG3   B4NK95   A0A0P5GAJ4   Q297L3   A0A0P6IRX1   A0A0P4YLI3   B4LYQ1   A0A0P6FXH0   A0A0P5Z2Y0   A0A0P6IC67   A0A034VV96   A0A1E1XRG5   A0A164YWS4   A0A0P5K921   E9GTR9   A0A023GMD5   A0A182XAN7   W8BBF0   A0A3B0JRY1   A0A0P6B049   A0A1I8MGP9   A0A1B0GEA9   A0A1I8PAP9   A0A1A9Z6Y3   A0A1A9YL74   A0A0L0CD71   A0A1E1X9R8   A0A1A9X1T0   A0A0P5NTQ6   A0A0N8D301   A0A1A9US56   A0A0A9Y5G0   A0A0P5LX38   A0A1B0C585   A0A0P5XVC4   L9L838   A0A293N1G3  

Pubmed

19121390    22118469    26354079    26227816    20566863    21719571    + More
20075255    26483478    17510324    26823975    17994087    24438588    17550304    25830018    10731132    12537572    12537569    18042462    19450530    19576221    12364791    14747013    17210077    20966253    15632085    25348373    29209593    21292972    24495485    25315136    26108605    28503490    25401762    23385571   

EMBL

BABH01001574    BABH01001575    BABH01001576    BABH01001577    NWSH01002143    PCG69058.1    + More
ODYU01001878    SOQ38697.1    AGBW02009168    OWR51479.1    KQ460556    KPJ13980.1    GDQN01003839    JAT87215.1    AGBW02009901    OWR49608.1    KQ459606    KPI90948.1    JTDY01002196    KOB71902.1    NEVH01014841    PNF27475.1    DS235387    EEB15463.1    KQ978642    KYN29485.1    GL887655    EGI70515.1    AAZX01016310    JXUM01069354    KQ562548    KXJ75644.1    CH477242    EAT46374.1    KQ976543    KYM80966.1    GDHC01015888    JAQ02741.1    AJWK01005336    AJWK01005337    AJWK01005338    AJWK01005339    AJWK01005340    DS232125    EDS35552.1    GGLE01001393    MBY05519.1    CM000364    EDX11778.1    ATLV01020836    KE525308    KFB45847.1    CM000160    EDW97783.1    CH480821    EDW55010.1    GBXI01010624    JAD03668.1    GFDL01013546    JAV21499.1    CH954181    EDV47943.1    GFDL01014089    JAV20956.1    AE014297    AY118592    AAF51962.2    AAM49961.1    AAAB01008859    EAA08083.5    APCN01000279    CH902617    EDV43780.1    GDIQ01086780    JAN07957.1    CH479179    EDW25129.1    GDIQ01146616    GDIQ01111917    GDIQ01110927    GDIQ01108126    GDIQ01047903    GDIQ01044298    JAL40799.1    GDIQ01178601    JAK73124.1    GDIQ01061791    JAN32946.1    LJIG01022555    KRT79951.1    GDIQ01064943    JAN29794.1    CH964272    EDW84025.1    GDIQ01265369    JAJ86355.1    CM000070    EAL28192.1    GDIQ01006568    JAN88169.1    GDIP01227758    JAI95643.1    CH940650    EDW66978.1    GDIQ01052305    JAN42432.1    GDIP01050734    JAM52981.1    GDIQ01032203    JAN62534.1    GAKP01012583    GAKP01012578    GAKP01012575    GAKP01012572    JAC46369.1    GFAA01001529    JAU01906.1    LRGB01000868    KZS15691.1    GDIQ01213538    JAK38187.1    GL732564    EFX77164.1    GBBM01000426    JAC34992.1    GAMC01010553    JAB96002.1    OUUW01000007    SPP83152.1    GDIP01021908    JAM81807.1    CCAG010012181    JRES01000562    KNC30191.1    GFAC01003193    JAT95995.1    GDIQ01148077    JAL03649.1    GDIP01073839    JAM29876.1    GBHO01016200    GBRD01006947    JAG27404.1    JAG58874.1    GDIQ01166845    JAK84880.1    JXJN01025888    GDIP01066776    JAM36939.1    KB320473    ELW71131.1    GFWV01021481    MAA46209.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000037510    + More
UP000235965    UP000009046    UP000078492    UP000007755    UP000002358    UP000069940    UP000249989    UP000008820    UP000078540    UP000092461    UP000192221    UP000002320    UP000000304    UP000030765    UP000002282    UP000001292    UP000008711    UP000000803    UP000007062    UP000075882    UP000075902    UP000075840    UP000075903    UP000007801    UP000008744    UP000075880    UP000007798    UP000001819    UP000008792    UP000076858    UP000000305    UP000076407    UP000268350    UP000095301    UP000092444    UP000095300    UP000092445    UP000092443    UP000037069    UP000091820    UP000078200    UP000092460    UP000011518   

PRIDE

H9JFV2    Q8MSU4   

Pfam

PF12295   Symplekin_C        + More
PF11935   DUF3453
PF09797   NatB_MDM20

Interpro

IPR022075   Symplekin_C        + More
IPR021850   Symplekin/Pta1       
IPR011989   ARM-like       
IPR032460   Symplekin/Pta1_N       
IPR016024   ARM-type_fold       
IPR019183   N-acetylTrfase_B_cplx_non-cat       
IPR011990   TPR-like_helical_dom_sf       
IPR013026   TPR-contain_dom       

SUPFAM

SSF48371   SSF48371        + More
SSF48452   SSF48452       

Gene 3D

1.25.10.10    

ProteinModelPortal

H9JFV2   A0A2A4JBI5   A0A2H1VCZ9   A0A212FCK9   A0A0N1IP64   A0A1E1WJQ7   + More
A0A212F7B0   A0A194PD64   A0A0L7L8R9   A0A2J7QFW6   E0VQ07   A0A151JQH5   F4W5L8   K7IU32   A0A182GJ60   Q17I55   A0A151I253   A0A146L2G3   A0A1B0ESZ5   A0A1W4UJU2   B0WVE7   A0A2R5L7R2   B4QXJ2   A0A084W6K3   B4PUX6   B4I467   A0A0A1WZ23   A0A1Q3F1T5   B3P2J3   A0A1Q3F080   Q8MSU4   Q7QCG6   A0A182LEI4   A0A182TL26   A0A182HSH7   A0A182USV9   B3LWE7   A0A0N8DVW1   B4G491   A0A0P5QXE2   A0A0P5KVQ8   A0A0P6FCV8   A0A182IR14   A0A0T6AXR2   A0A0P6EDG3   B4NK95   A0A0P5GAJ4   Q297L3   A0A0P6IRX1   A0A0P4YLI3   B4LYQ1   A0A0P6FXH0   A0A0P5Z2Y0   A0A0P6IC67   A0A034VV96   A0A1E1XRG5   A0A164YWS4   A0A0P5K921   E9GTR9   A0A023GMD5   A0A182XAN7   W8BBF0   A0A3B0JRY1   A0A0P6B049   A0A1I8MGP9   A0A1B0GEA9   A0A1I8PAP9   A0A1A9Z6Y3   A0A1A9YL74   A0A0L0CD71   A0A1E1X9R8   A0A1A9X1T0   A0A0P5NTQ6   A0A0N8D301   A0A1A9US56   A0A0A9Y5G0   A0A0P5LX38   A0A1B0C585   A0A0P5XVC4   L9L838   A0A293N1G3  

PDB

6NPW     E-value=2.05113e-58,     Score=576

KEGG

101739316    K06100 symplekin | (RefSeq) symplekin

PATHWAY

03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0061689   GO:0006378   GO:0006398   GO:0005847   GO:0035363   GO:0005634   GO:0003723   GO:0005488   GO:0009055   GO:0051536   GO:0050660   GO:0046872   GO:0051537   GO:0003824   GO:0016614   GO:0005506  

PANTHER

PTHR15245:SF20  

Subcellular location

Nucleus   Concentrates in the histone locus body.   With evidence from 5 publications.

Length:

989

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01956

Exp number, first 60 AAs:

0.00495

Total prob of N-in:

0.00099

outside

1  -  989

 

 

Pi

334.86676

Theta

202.631333

Tajima's D

2.101755

CLR

0.146095

CSRT

0.897955102244888

Interpretation

Uncertain